Related by context. All words. (Click for frequent words.) 55 DEEP AF 55 Anavex #-# 55 NeoDisc 55 fusion enhancers 55 TriActiv 55 ProDisc L 55 Ketotransdel 54 GEM #S 54 XP #L 54 pain palliation 53 epigenetic therapeutics 53 novel oral anticoagulant 53 TriReme 53 bioresorbable polymer 53 Stabilimax 53 regenerative therapy 53 PDE# inhibitors 53 EECP ® therapy 53 Neovasc Reducer 52 HuMax TAC 52 systemic RNAi 52 BioSTAR R 52 Cooled ThermoTherapy 52 Visian Toric ICL 52 MediGene focuses 52 injectable pharmaceuticals 52 successfully commercialize Iluvien 52 PerClot 52 Emezine 52 eSVS MESH 52 Surfaxin LS 52 therapeutics diagnostics 51 Elast Eon 51 neural prosthetic 51 INTERCEPT red 51 BioControl 51 SEPET TM 51 Reloxin R 51 implantables 51 Brinavess 51 OraTest R 51 PresbyLens ® 51 Bema Fentanyl 51 MAXY VII 51 Nektar proprietary 51 CardioWest TAH t 51 Trifecta valve 51 Myoblast Program 51 Q#IR 51 sirtuin modulators 51 CytoSorb 51 Urocidin TM 51 Bioral Amphotericin B 50 OvaRex R 50 injectable formulations 50 Toric IOL 50 MONOVISC 50 therapeutic radiopharmaceuticals 50 Fully Covered Stent 50 Abstral ® 50 Vascular Wrap TM 50 Spiegelmer 50 dermaPACE TM 50 oral transmucosal 50 percutaneous valve 50 bioabsorbable polymers 50 HepaGam B 50 Cardio Vascu Grow 50 LentiVector 50 liver resection surgeries 50 PCA3 assay 50 CytoSorb TM 50 monoclonal antibody therapeutics 50 Cumulase 50 novel therapeutic modality 50 recombinant biopharmaceutical 50 StemEx R 50 XTRAC laser 50 RIGScan CR 50 Voraxaze 50 electrophysiology EP 50 oral taxane 50 accommodating intraocular lens 50 CryoSeal 50 IoGen ™ 50 Urocidin 50 eTag assays 49 Bellicum 49 orthopedic biomaterials 49 intranasal insulin product 49 Asubio 49 QTinno TM 49 Flutiform TM 49 Monoclonal antibody 49 ospemifene 49 AdhTAP 49 clot retrieval 49 CytoSorb ™ 49 protein biochip 49 VESTAsync 49 Enjuvia 49 ReN# 49 subsidiary Cira Biosciences 49 SURFAXIN 49 PharmFilm 49 Premarket Approval 49 ATD TM gel 49 Targretin capsules 49 TOCOSOL 49 ATD gel 49 NexACT ® 49 easypod 49 Geron telomerase 49 predictive toxicology 49 cryosurgical 49 Vaxfectin R 49 Monovisc 49 Puricase PEG uricase 49 OsteoSponge ® SC 49 immunology neuroscience 49 CorNova 49 orally disintegrating 49 SYNERGY Stent 49 Alvesco R 49 pharmacogenomic testing 49 Sonolith i move 49 RIGScan ™ 49 rALLy clinical trial 49 immunosuppressant therapies 49 CyPath R 49 Strattice 49 ADME properties 49 orthoPACE TM 49 peptide therapeutics 49 tPEMF tm 49 candidate deforolimus 49 Somatuline Depot 49 intravascular stent 49 Endoscopic Ablation System 49 peripheral vascular stent 49 Theranostics 49 punctal plug delivery 49 Mobi C 49 Alequel ™ 49 vivo potency 49 GIPET 49 isoform selective 49 immunotherapeutic approaches 48 REPEL CV 48 Discovery Labs KL4 48 therapeutic monoclonal antibodies 48 orthoPACE ™ 48 rhThrombin 48 postmarket surveillance 48 catheters guidewires 48 immuno inflammatory 48 TOCOSOL Camptothecin 48 Levulan ® PDT 48 ColorectAlert TM 48 ViaMetrics E 48 PHER O2 48 Alair System 48 mesenchymal stem cell 48 therapeutic monoclonal antibody 48 NV1FGF 48 Spiegelmer ® 48 Toraymyxin TM 48 BioCart ™ System 48 NovoTTF #A 48 nanomedical 48 metabonomics 48 immunotherapeutic vaccine 48 Behcet uveitis 48 opioid tolerant adult 48 Referenced EEG ® 48 Lymphoseek ® 48 Rubicon Filter 48 anticancer therapeutics 48 HepDirect R 48 orthobiologic 48 noninvasive diagnostic 48 photodisinfection 48 KIACTA ™ 48 Ferinject ® 48 Trobalt 48 MoxDuo IV 48 CTO recanalization 48 RIGScan 48 Alnylam RNAi 48 MGuard ™ 48 ophthalmic therapeutics 48 BiDil XR 48 Ceragenin ™ technology 48 optical biosensors 48 CMV vaccine 48 resorbable biomaterials 48 BioMatrix TM 48 ThromCat 48 EndoTAG TM 48 buccal delivery 48 commercialize DAVANAT ® 48 BioSTAR ® 48 bioimaging 48 Endo Ease 48 ACTCellerate TM 48 optimal dosing regimens 48 CryoSeal FS System 48 presbyopia correcting 48 backsheet component 48 VersaFilm 48 CardioWest artificial heart 48 Archexin 48 Apo AIMilano 48 OLEPTRO 48 HuCAL antibodies 47 VentrAssist 47 osteobiologic 47 angioplasty catheters 47 TAXUS Element Paclitaxel Eluting 47 IV APAP 47 HYC# 47 AFFITOME R 47 transmucosal 47 oligonucleotide therapeutics 47 oral transdermal 47 BEMA TM Fentanyl 47 NIOX 47 PolyTouch 47 Pagoclone 47 Cellulaze 47 PRESEPT study 47 disc arthroplasty 47 Neuromodulation System 47 Reconstructive Tissue Matrix 47 efficacy tolerability 47 Bioral 47 Promus Element stent 47 TYRX 47 bioseparation 47 Glybera R 47 stem cell therapeutics 47 orthoPACE 47 e2 Collector 47 SynCon TM 47 cell culturing genome 47 ClosureFAST catheter 47 Capsule endoscopy 47 DermaPrep 47 hematological indications 47 PMA submission 47 MALDI-TOF/TOF 47 IntuiTrak 47 monoclonal antibody therapies 47 topical dermatology 47 embolotherapy 47 Bioral ® 47 OraQuick HCV test 47 NADiA ProsVue 47 ProDisc C 47 Evoltra ® 47 Novosom 47 Calmare Therapy Treatment 47 vascular thrombosis 47 biosimilar versions 47 deforolimus 47 biomarker validation 47 CLIA waiver 47 Fentanyl TAIFUN R 47 treat GI GVHD 47 MGuard TM 47 PharmFilm R 47 hematologic oncology 47 protein biochips 47 MedPulser 47 DYSPORT 47 M Enoxaparin 47 ThyroTest ® 47 Frova ® 47 ATryn ® 47 Trofex 47 Retacrit 47 either acutely decompensated 47 craniomaxillofacial 47 NovoStent 47 incyclinide 47 tezampanel NGX# 47 Contura MLB 47 LVAS 47 EndoFLIP 47 Manja Bouman CEO 47 Novacor R 47 Raf kinase inhibitor 47 Visiogen Synchrony 47 AutoloGel tm 46 ACCU BREAK 46 DPX Survivac 46 Hemolung 46 Angiocept 46 Artelon R 46 Altrazeal R 46 CompuFlo 46 ONCONASE R 46 Visicol R 46 artificial cervical 46 TriGrid ™ 46 Radient Pharmaceutical current 46 Pfizer inhaled insulin 46 Elevess 46 CELLECTRA R 46 NeutroSpec TM 46 proprietary BEMA 46 oral PTH 46 Tß4 46 Nektar pulmonary 46 SpineAlign 46 PD2i Analyzer 46 RADIESSE R 46 surgical sealant 46 gepirone ER 46 inhibit EGFR 46 HCV protease inhibitors 46 siRNA therapeutics 46 EGRIFTA 46 ticagrelor Brilinta 46 brentuximab 46 Fentanyl Taifun 46 Promus Element 46 dermatological therapeutics 46 HeartWare System 46 Tomophase 46 EZ IO ® 46 Prodarsan R 46 spinal nonfusion 46 PrandiMet 46 Hedgehog inhibitor 46 Eon Mini 46 Lipofen 46 bardoxolone 46 BioSTAR TM 46 HCV antiviral 46 ProUroScan 46 Microcutter 46 ARIKACE ™ 46 patented Bioral 46 Angio Seal Evolution 46 oncolytics 46 Sonatherm 46 OnDose TM 46 PolyActive 46 delivery polymer matrix 46 peripheral arterial 46 Miracor 46 MediVas 46 XIENCE 46 VSEL technology 46 NerPharMa 46 BHT DNA 46 adrenergic regulation 46 Shire BioChem Inc. 46 Artelon 46 Nabi HB Intravenous 46 cannabinor 46 OraTest 46 Glassia 46 SILENOR 46 pen injector 46 dialysis catheters 46 TBC# 46 Enhanze Technology 46 BLA resubmission 46 nCounter 46 Orphan designation 46 Evoltra 46 Intraject 46 Endotis 46 Ivivi 46 sublingual tablets 46 Amikacin Inhale 46 PLAC test 46 adipiplon 46 protein hydrogel 46 NeuroFlo 46 tissue augmentation 46 GPR# agonists 46 regenerative stem cell 46 neurostimulators 46 Left ventricular assist 46 BEMA TM 46 STARFlex ® 46 StromaCel 46 genomic discoveries 46 MEDIHONEY Gel 46 automated radiopharmaceutical distribution 46 ALN RSV program 46 PFO closure 46 AMPK activators 46 dermaPACE 45 BIOCEUTICALS 45 Emboshield 45 biomarker assays 45 RONDEL ™ 45 bioabsorbable drug eluting 45 Smartlipo MPX 45 IONSYS TM 45 underarm testosterone 45 autoinjector 45 Benlysta belimumab 45 Scil 45 CB2 selective 45 Menaflex device 45 validating biomarkers 45 THR beta agonist 45 autologous cellular therapy 45 immunotherapeutics 45 Uracyst ® 45 HP Acthar R 45 InterStim Therapy 45 LC Bead 45 TAXUS Element Stent System 45 sterile lidocaine patch 45 OxyView TM 45 generic biopharmaceuticals 45 minimally invasive arthroscopic 45 macitentan 45 CELLECTRA ® 45 Cytori Celution System 45 AMID Stapler ™ 45 AERx iDMS 45 PROMUS Element Stent 45 uroNIRS 45 Cytori NASDAQ CYTX 45 Preotact R 45 DYSPORT TM 45 BioGlue Surgical Adhesive 45 biobetter 45 Tekmira lipid nanoparticle 45 OLpur TM MD 45 Zenpep 45 licenses bioactive coatings 45 Sylvie Gregoire President 45 ghrelin antagonist 45 MedTone 45 transdermal gel 45 implantable neurostimulation 45 MAA submission 45 Rescula 45 Abstral ™ 45 Calmare ® 45 VitiGam TM 45 JCR Pharmaceuticals 45 Mipomersen 45 Surgical Sealant 45 PCA3 prostate cancer 45 GLPG# 45 Genz # 45 Generx TM 45 transcervical sterilization 45 HAp 45 estrogen receptor modulators 45 OMAPRO 45 recombinant insulin 45 CONBRIZA 45 Cand5 45 SYCREST 45 MGN# 45 OSMOPREP 45 oilbody 45 MVax 45 endothelin antagonist 45 selective relaxant 45 Promist 45 biochemical profiling 45 Waterlase MD 45 hemodiafiltration HDF 45 topical hemostat 45 MGMT methylation 45 XIENCE PRIME 45 SmoothShapes XV 45 Angioblast 45 extracorporeal circulatory support 45 StomaphyX 45 enoxaparin sodium injection 45 UCB Keppra 45 SUMAVEL 45 pharmacotherapeutic 45 spinal fixation 45 SEPET 45 StarClose 45 OsseoFix 45 IlluminOss 45 Eurocor 45 therapeutic peptide 45 Fortigel 45 LabNow 45 OsseoSpeed 45 Plexur M 45 carotid stent 45 pharmacodynamic markers 45 Taxus Liberté 45 Celution TM 45 Intravail ® 45 proprietary NexACT R 45 Compellis 45 NurOwn ™ 45 SCIB1 45 Gestiva TM 45 Pipeline Embolization Device 45 Plicator 45 developing topically administered 45 Medtronic spinal 45 Metricath Gemini 45 VaxImmune 45 small molecule PEGylation 45 TyRx 45 personalized immunotherapy 45 iScience 45 IVOB 45 basal insulins 45 OncoEMR 45 CigRx TM 45 Coronary stent 45 torsemide 45 Esbriet pirfenidone 45 Alexza Staccato 45 AN# novel 45 Loramyc TM 45 agent SRBA 45 Memryte 45 Ensysce 45 faropenem 45 oral picoplatin 45 multidose 45 Balloon Sinuplasty TM 45 ENJUVIA 45 Neo Kidney Augment 45 Med eMonitor System 45 urologic disorders 45 Nanobody R 45 MarrowXpress 44 PLAC Test 44 ComfortScan 44 Novacor LVAS 44 Medtronic DBS 44 vascular graft 44 BIOGUARD ™ 44 CDK inhibitors 44 Revo MRI 44 Ataluren 44 XOPENEX 44 inhibit metastasis 44 NEUGENE antisense 44 Canvaxin TM 44 biosensing 44 Unite Biomatrix 44 biochip 44 Hervé Hoppenot President 44 ophthalmic diagnostic 44 ClearLobby 44 safflower produced 44 PureGraft 44 SiMoA 44 Locteron controlled 44 Nasdaq PARD biopharmaceutical 44 Destination Therapy 44 Telatinib 44 PHX# 44 miRNA therapeutics 44 p# inhibitor 44 PREVU x LT 44 outlicensing 44 coronary drug eluting 44 candidate Zemiva TM 44 regenerative healing 44 Powerlink System 44 AneuRx 44 Pexeva 44 pancreatic enzyme replacement 44 LymphoStat B TM 44 orally inhaled migraine 44 Labguard ™ 44 MCOT TM 44 CCR2 antagonists 44 Orapred ODT 44 UltiMAb 44 pharmaceuticals biologics 44 collagen scaffold 44 AngioJet System 44 VenaCure 44 lung cancer chemoprevention 44 wilate ® 44 ophthalmic pharmaceutical 44 Triage BNP Test 44 aortic stent grafts 44 Neurologix gene 44 commercialization 44 Verigene System 44 INFUSE R 44 pharmacological chaperone 44 Abstral 44 VALSTAR 44 VersaFilm drug 44 SOLODYN 44 PARI Pharma focuses 44 Flutiform ™ 44 VNS Therapy TM 44 intravenous Remodulin 44 TG# [003] 44 proprietary electroporation 44 glucokinase activator 44 IDEV 44 varenicline tartrate 44 oral tyrosine kinase 44 DNA methylation biomarkers 44 STARFlex R 44 CompuDent R 44 topically delivered 44 BRILINTA 44 TAXUS Liberte 44 SARcode 44 TURBO Booster 44 PDE inhibitors 44 CIP TRAMADOL ER 44 pharmacogenomic tests 44 Bellicum Pharmaceuticals Inc. 44 OvaRex 44 systemic hypotension 44 postmarket safety 44 ProUroScan prostate imaging 44 genomic biomarkers 44 Allovectin 7 44 digitizing pathology 44 Inhaled nitric oxide 44 purinergic receptors P#X# 44 VBioPharma 44 fluorescence endoscopy 44 tezampanel 44 ReFacto 44 dermaceutical 44 Embosphere Microspheres 44 autoimmune cardiovascular 44 HIFU therapy 44 transmyocardial revascularization TMR 44 NDA resubmission 44 Personalized medicine 44 iroxanadine 44 AtriClip 44 PINK MBLTY 44 HydroFix 44 pharma ceutical 44 cellular reprogramming 44 MyoSure 44 NEXTERONE 44 Thorough QT 44 SonoLysis 44 PREVU x 44 HepaSphere Microspheres 44 sirtuin activators 44 Altrazeal ® 44 IND submission 44 commercialize microRNA 44 APR Labtec 44 Personalised medicine 44 Zoraxel TM 44 Testim R 44 TM Drug Eluting 44 Contour Threads 44 Cardica Microcutter XPRESS 44 proprietary transdermal 44 THALOMID 44 ZEVALIN ® 44 progressive metastatic prostate 44 Cardiac Ablation System 44 Pierre Fabre Laboratories 44 surgical hemostat 44 metabolite identification 43 ESTRASORB 43 Oglemilast 43 cardioverter defibrillator 43 NCCN Drugs 43 theranostics 43 induced pluripotent 43 Xolegel 43 GentleWaves 43 CORTOSS 43 CLEARANT PROCESS R 43 dermaPACE ™ 43 XIAPEX 43 oral talactoferrin 43 peritoneal dialysis PD 43 Humanitarian Device Exemption 43 selective kinase inhibitors 43 RecoveryRx TM 43 MicuRx 43 OVA1 TM 43 SensiGen 43 Uracyst R 43 SuperStitch R 43 Liberte TM 43 peripheral stent 43 injectable depot 43 microbubble 43 Cerepro ® 43 OnControl 43 Captisol ® 43 collagen meniscus implant 43 treat atrial flutter 43 Onko Sure ™ 43 prefilled syringes 43 proprietary LNA 43 transcutaneous immunization TCI 43 Abbokinase 43 BeneFIX 43 pharmacogenetic testing 43 Nascobal 43 Hematide ™ peginesatide 43 Bioral Amphotericin B. 43 indiplon capsules 43 amifampridine phosphate 43 BioSurgery 43 Onko Sure TM 43 tricuspid valve repair 43 MethyPatch 43 Corus CAD 43 FIRAZYR 43 mass spectrometric 43 MEK inhibitors 43 Provecta TM 43 endomechanical 43 Lung Flute 43 AngioSculpt 43 DFine 43 cystinosis patients 43 PecFent 43 polymer conjugate technology 43 MedMira rapid 43 ZEGERID Capsules 43 BIOCIUS Life Sciences 43 Miikana 43 regorafenib 43 Omnicare pharmacy services 43 JenaValve 43 renin inhibition 43 Chimigen TM 43 biotherapy 43 preclinically 43 HVAD 43 ImmunGene 43 FM VP4 43 metaglidasen 43 pharmacogenomics pharmacogenetics 43 NovaSure endometrial ablation 43 cystic fibrosis bronchiectasis inhalation 43 mTOR inhibition 43 Phase III HEAT 43 mechanical circulatory 43 CobaCyte 43 buccal absorption 43 TKM PLK1 43 Tekmira SNALP technology 43 Sublative Rejuvenation 43 percutaneous aortic valve 43 SynerGraft 43 OsteoGram 43 Preotact 43 implantable biomedical 43 INVENT Pharmaceuticals 43 bioterrorism countermeasures 43 molecular chaperone regulation 43 Cyclosert 43 xMAP technology 43 potent suppressor 43 KL4 surfactant pipeline 43 Conformite Europeene 43 EvaMist 43 received CE Conformite 43 NasdaqGM SPPI 43 CollaFix ™ 43 2A/Furin technology 43 SuperAntibody 43 Européenne Mark 43 NexACT 43 IMC #F# 43 Nasdaq VRNM pioneer 43 multiplex assay 43 anatomical fixation 43 dental reconstructive 43 interferon beta therapy 43 Digene HPV test 43 Conformite Europeene CE 43 bionanotechnology 43 Purion ® 43 florbetapir 43 research anddevelopment 43 Onco LIFE 43 Melior Discovery 43 Xience Prime 43 CAMBRIDGE Mass. Alnylam Pharmaceuticals 43 Thoratec HeartMate II 43 SYSTEM 1E 43 Abiomed Impella 43 AtriCure Isolator 43 LidoSite 43 prostone 43 chemosensitivity 43 oral anticancer 43 Microwave Ablation System 43 Abbott BVS 43 anastomotic devices 43 Vashe Wound Therapy 43 lymphomas leukemias 43 TM Everolimus Eluting 43 therapeutic modality 43 hematology immunology 43 BioFocus DPI Galapagos 43 Ltd. Amex SVA 43 absorbable powder hemostat 43 Hemopurifier TM 43 proprietary PEGylation 43 Muraglitazar 43 Bioaccelerate compounds under 43 JUVISTA 43 Calci CLEAR 43 dilatation catheter 43 Orphan Drug status 43 Unifill TM syringe 43 Selective Electrochemical Tumor Ablation 43 GuideLiner catheter 43 ONCASPAR 43 Instanyl 43 AclarusDx ™ 43 NCCN Compendium 43 Nautilus Biotech 43 DMET 43 FlexStent ® 43 Axona 43 MSC SFM 43 Synavive ™ 43 OmniWave 43 Aorfix 43 surgical ablation 43 Transdel TM platform 43 TriGrid 43 MedAnywhere 43 ATS 3f Enable 42 CE Marked 42 microRNA biomarkers 42 CytoFabTM 42 interoperable EHRs 42 Cardiolite 42 disposable catheter 42 Axxent System 42 ® natalizumab 42 hematology analyzers 42 multiplex assays 42 coupled receptor GPCR 42 Mucotrol 42 Zensana TM 42 CollaFix TM 42 Ofirmev 42 specialty pharmaceuticals 42 Vaxfectin TM 42 AxioMed 42 OTCBB CVBT 42 molecular imaging radiopharmaceuticals 42 sirtuin inhibitors 42 Inc. Nasdaq ATRC 42 ResponseDX Lung ™ 42 Axxion TM 42 BLA submission 42 BioMatrix 42 XR EXpress 42 molecularly targeted therapies 42 human pluripotent stem 42 COLAL PRED 42 Daytrana ™ 42 Ceflatonin 42 Celadrin ® 42 Cobalamin ™ 42 Freezor 42 noninvasive imaging 42 MassARRAY platform 42 Eligard ® 42 ReN# stem cell 42 Sapien XT 42 Smac mimetic 42 NexStent 42 Angiox ® 42 Uracyst 42 ICA # 42 Aztreonam 42 XTRAC R 42 Retina Implant 42 DAC HYP 42 TLR antagonists 42 anterior capsulotomy 42 MagniFuse 42 Cobalamin 42 Pepducin 42 Nanobody ® 42 Induced pluripotent stem cells 42 FlutiformTM 42 MIVT proprietary 42 CCR5 inhibitors 42 advanced pulmonary liposome 42 Apitope 42 inpatient EHR 42 TELIGEN 42 novel peptide 42 hES 42 LNA TM 42 XmAb ® 42 Factor Xa inhibitors 42 alemtuzumab MS 42 chemopreventive agent 42 Medingo 42 Metoprolol Succinate 42 AbSorber 42 INTERCEPT platelet 42 Artificial pancreas 42 DCCR 42 Prednisporin TM 42 RNA therapeutics 42 Stem Cell Assurance 42 Occluder 42 Taclonex Scalp R 42 Mirasol PRT system 42 Diep Tran MD 42 CRD5 42 InFuse 42 SOLODYN R 42 PROMUS Element 42 Heartmate 42 Optical Coherence Tomography OCT 42 OMNARIS HFA 42 teratogenicity 42 coflex 42 Requires 4G 42 NeoVisc 42 Embolic Protection System 42 PROMUS TM 42 endovenous laser 42 Sanctura XR 42 ResponseDX ™ 42 neurosurgery spine 42 Inc. NASDAQ EVVV 42 Crystalens HD 42 PD2i ® algorithm 42 AppyScore TM 42 AMPLATZER ® 42 HistoRx AQUA 42 Plasma Converter TM 42 SurModics Pharmaceuticals 42 RyMed 42 Zolpimist 42 Xeomin 42 Thoratec HeartMate 42 proprietary transdermal patch 42 TEMODAL 42 Zegerid OTC 42 genomics proteomics 42 Angiox 42 molecular imprinting 42 biosimilar insulin 42 Endeavor drug eluting 42 CustomVue 42 SensiVida 42 Vitagel 42 Addrenex 42 OTC ZEGERID 42 FlexPen 42 neurodegenerative diseases Alzheimer disease 42 OmniPod System 42 Venofer ® 42 Hyaluron 42 PosiRx 42 Nanobodies ® 42 commercializing novel biotherapeutics 42 diagnostic biomarker 42 Exelixis compounds 42 MedicalCV 42 Staccato nicotine technology 42 Sopherion 42 Isis antisense 42 JUVEDERM TM 42 Nascobal ® 42 Invinsa 42 InterStim 42 favorable pharmacokinetic 42 NOXXON 42 HemoGenix 42 INRatio 42 SEASONIQUE 42 HEPLISAV TM hepatitis B 42 outlicense 42 DNA methylation profiling 42 OTCBB BIPH developer 42 Nitec 42 Berinert 42 highly selective adenosine