Related by context. All words. (Click for frequent words.) 64 comparator arm 63 Targretin capsules 63 Engerix B 63 oral diclofenac 62 ARCOXIA 62 Gliadel Wafer 62 PegIntron 62 rFVIIa 62 Dalbavancin 62 MoxDuo IR 62 OZURDEX ® 62 saline placebo 62 ZACTIMA 62 Medidur TM FA 61 ALGRX 61 Dabigatran etexilate 61 PROMACTA 61 Increlex R 61 oral ridaforolimus 61 micafungin 61 CYPHER Stent 61 active comparator 61 T Pred 61 XIENCE V stent 61 bovine thrombin 60 hoFH 60 herpetic keratitis 60 prucalopride 60 melphalan prednisone 60 CANCIDAS 60 subcutaneously administered 60 CIMZIA TM 60 Tarceva TM 60 Amrubicin 60 TYGACIL 60 MoxDuo TM IR 60 PROMUS Element Stent 60 Augment Injectable 60 ELIQUIS 60 Phase IIIb clinical 60 RE LY ® 60 Phase IIb III 60 GEM OS1 60 ULORIC 60 Brinavess 60 Firazyr 60 phase IIb clinical 60 treatment naive genotype 59 VIAject ® 59 Dual Opioid 59 Thrombin 59 argatroban 59 cleavable linker 59 Traficet EN 59 Contrave# 59 Zirgan 59 REMICADE infliximab 59 zoledronate 59 XIENCE TM 59 Noxafil 59 everolimus eluting stents 59 dabigatran etexilate 59 certolizumab 59 Hycamtin 59 recurrent GBM 59 YERVOY 59 DAPT 59 unfractionated heparin UFH 59 Pemetrexed 59 SIR Spheres 59 TAXOTERE R 59 CINTREDEKIN BESUDOTOX 59 REMINYL ® 59 DexaSite 59 Metricath Gemini 59 APTIVUS 59 VIAject ™ 59 NATRECOR R 59 OMS# 59 plus prednisone 59 thymalfasin 59 insulin detemir 59 double blinded placebo 59 sunitinib malate 59 multicenter randomized controlled 59 BRILINTA 59 mRCC 59 Zavesca R 59 Sanvar 59 CAELYX 59 Emezine 59 nab paclitaxel 59 Medidur FA 59 divalproex sodium 59 PREZISTA r 59 Onrigin 59 ARB telmisartan 59 bolus dose 59 sevelamer 59 ibandronate 59 Dacogen decitabine 59 mertansine 59 clodronate 59 pain palliation 59 MabCampath 59 BRIM2 59 Emselex 59 thorough QT 59 HCl capsules 58 fenofibric acid 58 placebo dexamethasone 58 oral ribavirin 58 antithrombotics 58 UPLYSO 58 PEG interferon 58 Fludara 58 relapsing multiple sclerosis 58 Elitek 58 idraparinux 58 Lucentis monotherapy 58 CHAMPION PCI 58 somatostatin analogue 58 TELCYTA 58 Fanapt ® 58 VIAject R 58 DEB# 58 diclofenac sodium 58 Onrigin TM 58 PEG Intron 58 EmbraceAC 58 pegylated interferon alpha 58 randomized blinded 58 everolimus eluting stent 58 CERVARIX 58 Prospective Randomized 58 Androgel R 58 Eliquis 58 Embolic Protection Device 58 piperacillin tazobactam 58 CorVue ™ 58 antiarrhythmic drug 58 definite stent thrombosis 58 CIP TRAMADOL ER 58 Pennsaid R 58 Camptosar ® 58 PREOS 58 etanercept Enbrel 58 ritonavir boosted 58 Vascular Wrap 58 XIENCE V Everolimus Eluting 58 IFN alfa 58 rFSH 58 PrevOnco 58 sevelamer carbonate 58 oral rivaroxaban 58 capsule formulation 58 romidepsin 58 carboplatin paclitaxel 58 MoxDuo 58 teriflunomide 58 GRALISE 58 mg eq 58 docetaxel Taxotere ® 58 MMX mesalamine 58 Randomised 58 SUTENT ® 58 interferon beta 1b 58 tipranavir 58 Ereska 58 EDEMA3 58 sevelamer hydrochloride 58 tacrolimus ointment 58 atorvastatin #mg 58 PREOS R 58 novel oral anticoagulant 58 XIENCE V PROMUS Stent 58 trabectedin 58 Approvable 58 Vernakalant 58 sargramostim 58 HCV SPRINT 58 Phase III Psoriasis 58 ADVANCE PD 58 MoxDuo ® 58 Fibrillex TM 58 Doxil ® 58 Irinotecan 58 Proxinium TM 57 ROCKET AF 57 BioSTAR ® 57 gadobutrol 57 Ixempra 57 Epirubicin 57 TNF alpha inhibitor 57 doripenem 57 ARIXTRA 57 IV Busulfex 57 CIP ISOTRETINOIN 57 Aptivus ® 57 CaPre TM 57 CCX# B 57 Ketotransdel 57 tapentadol IR 57 CIMZIA ™ 57 PROCRIT R 57 Solesta 57 Mg Uk 57 APTIVUS r 57 voclosporin 57 GAMMAGARD 57 atazanavir ritonavir 57 TroVax ® 57 Phase III HEAT 57 SCH # 57 liposomal formulation 57 DepoDur TM 57 Tekturna HCT 57 Phase IIIb 57 ISENTRESS 57 PROVIGIL 57 pegylated interferon alfa 57 PROTECT AF 57 analgesic efficacy 57 efficacy tolerability 57 metoprolol succinate 57 PrandiMet 57 successfully commercialize Iluvien 57 regorafenib 57 icatibant 57 Virulizin R 57 imipenem 57 Sensipar 57 Resten NG 57 Orphan Status 57 pegylated interferon alfa 2b 57 NOXAFIL 57 Kahalalide F 57 placebo controlled Phase III 57 TORISEL 57 Cypher Stent 57 Alvesco R 57 Wellbutrin XL ® 57 refractory APL 57 #I TM# 57 edoxaban 57 inhaled treprostinil 57 Multicenter Automatic Defibrillator Implantation 57 multicenter multinational 57 EOquin 57 FIRAZYR 57 Certican 57 TMC# r 57 SPRIX ® 57 parecoxib 57 multicenter Phase II 57 oxycodone CR 57 Peg IFN 57 doxorubicin HCl liposome injection 57 titrated glipizide 57 boosted protease inhibitor 57 BeneFIX 57 TPV r 57 Cethromycin 57 salmeterol fluticasone 57 mg ustekinumab 57 Eloxatin R 57 Q#IR 57 multicentre randomized 57 mITT population 57 BCIRG 57 MyoCell 57 chlorambucil 57 mcg dose 57 Interferon alfa 57 CYT# QbG# 57 Acute Decompensated Heart Failure 57 Piperacillin 57 Wellbutrin XL R 57 controlled multicenter Phase 57 TheraCIM 57 Catena ® 57 BioSTAR R 57 mcg doses 57 Pazopanib 57 Parathyroid Hormone 57 Tipranavir 57 AGGRASTAT ® 57 budesonide foam 57 concurrent chemoradiation 56 fluoropyrimidine 56 Spiriva Handihaler 56 CYPHER stent 56 Hycamtin ® 56 Randomized Evaluation 56 sufentanil 56 maximal dose 56 Ceplene/IL-2 56 Glufosfamide 56 PrandiMet TM 56 methylnaltrexone 56 dacarbazine 56 torezolid 56 desvenlafaxine succinate 56 biologic DMARD 56 GW# [003] 56 prospective randomized multicenter 56 Zocor simvastatin 56 RezularTM 56 Nebido 56 ONGLYZA ™ 56 Phase Ib clinical 56 risedronate sodium tablets 56 MIRCERA 56 abacavir lamivudine 56 EOquin TM 56 ANCHOR trial 56 injectable formulations 56 reteplase 56 randomized multicenter 56 SPARLON 56 dose escalation phase 56 Fluconazole 56 Betaferon ® 56 dose Iluvien 56 telbivudine 56 histone deacetylase HDAC inhibitor 56 5 Fluorouracil 56 ketorolac 56 CIMZIA TM certolizumab pegol 56 Orphan Drug designations 56 CRp 56 oral deforolimus 56 ritonavir boosted atazanavir 56 CORDAPTIVE 56 Phase 2b kidney transplant 56 low dose cytarabine 56 CoFactor 56 HCV RESPOND 2 56 oxycodone HCl 56 Gabapentin GR 56 mycophenolate mofetil 56 prospective multicenter 56 Tumor Response 56 protease inhibitor PI 56 Taxotere ® 56 intravenous dosing 56 BrachySil TM 56 celgosivir 56 paliperidone ER 56 5mg dose 56 Darunavir 56 canakinumab 56 placebo controlled clinical 56 Mycophenolate Mofetil 56 vandetanib 56 daily subcutaneous injections 56 lanthanum carbonate 56 PARTNER Trial 56 BAY #-# 56 TAXUS Liberté stent 56 octreotide LAR 56 TWYNSTA 56 APRISO 56 PEP# ingenol mebutate Gel 56 Arixtra 56 conjugated estrogen 56 adalimumab Humira 56 lumiracoxib 56 XIAFLEX 56 dimeglumine 56 FDA defined valvulopathy 56 infusional 56 drotrecogin alfa activated 56 liposomal amphotericin B 56 IOP lowering 56 BAL# [002] 56 Teysuno 56 Teflaro 56 macrolide antibiotic 56 alteplase 56 NovoTTF 56 ertapenem 56 Nipent R 56 Gralise 56 fluvastatin 56 PROVENGE ® 56 FOSAMAX PLUS D 56 IIIa inhibitor 56 STELARA 56 darunavir r 56 Edoxaban 56 cisplatin vinorelbine 56 volociximab 56 Multiple Ascending Dose 56 myoblast therapy 56 Edwards SAPIEN valve 56 CIPN 56 GSK# [001] 56 Sanctura XR 56 galiximab 56 Torisel 56 elotuzumab 56 alefacept 56 Azathioprine 56 intradermal injection 56 Posaconazole 56 ticagrelor Brilinta 56 tenofovir emtricitabine 56 ritonavir boosted lopinavir 55 IRESSA 55 PEG IFN 55 CALGB # [002] 55 pomalidomide 55 Exforge HCT 55 Cancidas 55 iodixanol 55 Glybera R 55 topically administered 55 platelet inhibitor 55 Humalog ® 55 vidofludimus 55 aflibercept 55 vernakalant hydrochloride 55 Egrifta 55 colesevelam HCl 55 ezetimibe simvastatin 55 HBeAg seroconversion 55 blinded randomized 55 Zavesca ® 55 PEGylated interferon beta 1a 55 strontium ranelate 55 Ziprasidone 55 YONDELIS 55 glatiramer acetate 55 Lixivaptan 55 LIALDA 55 Zyclara 55 irbesartan 55 Roche Xeloda 55 Amoxicillin PULSYS Phase III 55 VIAject 55 HuMax CD4 55 levosimendan 55 QT QTc 55 goserelin 55 exenatide Byetta 55 ceftazidime 55 sNDAs 55 NPH insulin 55 Tacrolimus 55 tipranavir r 55 selective androgen receptor modulator 55 Phase III randomized controlled 55 TAXUS Liberte 55 Decitabine 55 amoxicillin clavulanate 55 CCX# 55 amrubicin 55 briakinumab 55 mg QD 55 PDE4 inhibitor 55 direct thrombin inhibitors 55 zonisamide SR 55 QTc prolongation 55 viral kinetic 55 immunomodulatory therapy 55 SEBIVO 55 Nexavar ® 55 VELCADE melphalan 55 AFRS TM 55 lanreotide 55 AEGR 55 somatostatin analog 55 INTELENCE 55 Protelos 55 MedPulser 55 locoregional disease 55 phase IIIb 55 rilpivirine 55 GP IIb IIIa inhibitor 55 clobazam 55 Granted Orphan Drug 55 polidocanol 55 Cloretazine 55 RHUCIN 55 oral prodrug 55 LEXIVA r 55 Anticalins ® 55 IFN α 55 meropenem 55 Navelbine ® 55 balsalazide 55 Zemplar Capsules 55 nicardipine 55 GP IIb IIIa inhibitors 55 estradiol gel 55 cinacalcet 55 Dasatinib 55 5-FU/LV 55 anagrelide 55 phase IIa clinical 55 Betaseron ® 55 MEND CABG II 55 mapatumumab 55 ENDEAVOR IV 55 LB# [003] 55 immune globulin intravenous 55 gemcitabine cisplatin 55 abiraterone acetate 55 Plasmin 55 BoNTA 55 calcipotriene 55 ATACAND 55 mg kg dose 55 TAXUS Stent 55 Lubiprostone 55 ribavirin RBV 55 Pioglitazone 55 bosutinib 55 factorial design 55 CRESTOR #mg 55 topical gel formulation 55 Kamada AAT 55 multicenter clinical 55 Orazol 55 peginterferon alfa 2b 55 ANDAs pending approval 55 Factor VIIa 55 ZFP TF 55 novel histone deacetylase 55 Tavocept 55 randomized Phase IIb 55 insulin lispro 55 MYDICAR 55 binary restenosis 55 Entocort EC 55 mesalazine 55 Zentase 55 sitagliptin Januvia 55 ximelagatran 55 enoxaparin Lovenox 55 GEM OS2 55 Omiganan 55 fosbretabulin 55 DiabeCell ® 55 Randomized Phase 55 MAb 55 Phase III confirmatory 55 MKC# MKC# PP 55 NeoRecormon 55 orBec 55 prednisolone acetate 55 composite endpoint 55 HBeAg negative 55 decitabine 55 AstraZeneca Toprol XL 55 #mg BID [003] 55 double blinded randomized 55 ACCORD Lipid 55 drug eluting stent DES 55 sirolimus eluting 55 latanoprost 55 multicenter randomized placebo controlled 55 ZYBRESTAT fosbretabulin 55 GORE TAG Device 55 difluprednate 55 peginterferon alpha 2a 55 pharmacokinetic PK study 55 plus dexamethasone 55 efavirenz EFV 55 PASI scores 55 dalteparin 55 receptor tyrosine kinase inhibitor 54 Pegylated Liposomal Doxorubicin 54 Aflibercept 54 cefepime 54 tesmilifene 54 Refractory Angina 54 tocilizumab 54 Allovectin 7 ® 54 octreotide 54 Pruvel 54 aspirin clopidogrel 54 PREZISTA ritonavir 54 Atrasentan 54 BLP# Liposome Vaccine 54 #:# randomization 54 Navelbine 54 ALTACE 54 Metformin HCl 54 Raptiva r 54 Acute Ischemic Stroke 54 SpideRX 54 Metvix 54 enfuvirtide 54 eluting stent 54 Phase #b/#a clinical 54 crizotinib PF # 54 randomized controlled Phase 54 TAXUS TM 54 cilengitide 54 Indaflex TM 54 PrevOnco ™ 54 TDF FTC 54 salmeterol fluticasone propionate 54 TREANDA 54 relapsed ovarian cancer 54 injectable diclofenac 54 Danazol 54 Leukine ® 54 prospective randomized placebo 54 T#I [002] 54 Xelox 54 Neurodex 54 FOSRENOL ® 54 BrachySil ™ 54 unresectable HCC 54 Zilver PTX stent 54 cariprazine 54 FOLPI 54 mitomycin 54 atazanavir Reyataz 54 XYOTAX TM 54 Combo Stent 54 levofloxacin 54 E1 INT TM 54 MEND CABG 54 ToGA 54 triamcinolone 54 oxycodone IR 54 tigecycline 54 inhaled AAT 54 ZYBRESTAT 54 heparins 54 DUROS 54 caspofungin 54 KRN# 54 paricalcitol 54 darunavir 54 TAXUS ATLAS 54 prospectively defined 54 renal artery stenting 54 ZYBRESTAT TM 54 Erlotinib 54 fallopian tube cancers 54 Multaq R 54 tazobactam 54 olmesartan 54 eprodisate Fibrillex TM 54 metastatic RCC 54 Aeroquin 54 Linjeta TM 54 atrasentan 54 mg subcutaneous 54 lasofoxifene 54 rFactor XIII 54 degarelix 54 vicriviroc 54 Xyfid 54 inhibitor RG# 54 Mipomersen 54 FOLFOX4 54 Arranon 54 darifenacin 54 Febuxostat 54 skeletal metastases 54 Kaletra lopinavir ritonavir 54 NOXAFIL Oral Suspension 54 Aciphex R 54 Sanofi Aventis Taxotere 54 conjugated estrogens 54 postoperative chemotherapy 54 MIST II 54 plus COPEGUS 54 AQ4N 54 gliclazide 54 #mg dose [002] 54 intravesical instillation 54 ABC/3TC 54 Cethrin 54 hydrochloride capsules 54 DU #b 54 Peginterferon 54 OsmoPrep 54 Ventavis ® 54 controlled multicenter 54 amphotericin B 54 QTc 54 timolol maleate 54 PLAVIX ® 54 sorafenib Nexavar 54 Platinol 54 hereditary deficiency 54 FOLFOX regimen 54 oral vancomycin 54 prospective nonrandomized 54 Pivotal Trial 54 ascending dose 54 cefazolin 54 recurrent malignant glioma 54 BUPHENYL R sodium phenylbutyrate 54 Vascugel 54 adenosine injection 54 prospectively randomized 54 FOLFIRI 54 lopinavir r 54 Toremifene 54 fulvestrant 54 rivaroxaban 54 doxorubicin cyclophosphamide 54 SVR# 54 reboxetine 54 ancrod 54 mTOR inhibitors 54 Chemophase 54 Bayer Onyx 54 Visicol 54 Luteinizing Hormone Releasing Hormone 54 poor metabolizers 54 TAXUS V 54 multicenter clinical trials 54 refractory metastatic colorectal cancer 54 dacarbazine chemotherapy 54 subcutaneous SC 54 preclinical efficacy 54 Diamyd R 54 Simulect 54 dermaPACE TM 54 Abbokinase 54 Neupogen ® 54 Mimpara 54 miglustat 54 Non inferiority 54 lorvotuzumab mertansine 54 AZOR 54 PROCHYMAL 54 insulin glulisine 54 SILENOR 54 Initiated Phase 54 prulifloxacin 54 VIMOVO 54 RoACTEMRA 54 maximally tolerated dose 54 nilotinib 54 #mg dose [003] 54 glycoprotein IIb IIIa inhibitor 54 desvenlafaxine 54 thrombus aspiration 54 dose escalation clinical 54 beta 1a 54 interferon alfa 54 metastatic renal cell carcinoma 54 posaconazole 54 bendamustine 54 AXIRON ™ 54 Capecitabine 54 flutamide 53 Movectro 53 RAV# 53 darbepoetin alfa 53 HuMax EGFr 53 ARG# 53 #mg QD [002] 53 irinotecan cisplatin 53 targeted radiotherapeutic 53 solithromycin 53 docetaxel chemotherapy 53 ISTODAX ® 53 GnRH antagonist 53 orally administered inhibitor 53 Feasibility Trial 53 Xanafide 53 lopinavir r arm 53 Prilosec omeprazole 53 antidiabetes 53 nadolol 53 sirolimus eluting stent 53 Medtronic CoreValve 53 investigational antiplatelet 53 Delcath PHP System 53 Long Lesion 53 efficacy endpoint 53 vinorelbine 53 tamsulosin 53 pegylated liposomal doxorubicin 53 liposomal doxorubicin 53 Neovasc Reducer 53 Allovectin 7 53 CLL SLL 53 Genzyme Synvisc 53 dose dose escalation 53 EchoCRT 53 Melphalan 53 zidovudine lamivudine 53 EURIDIS 53 Premarket Approval 53 peginterferon alfa 2a 53 trials RCTs 53 nonsedating antihistamine 53 comparator PI r 53 MVax 53 oblimersen 53 Peginterferon Alfa 2a 53 IBS C 53 UCB Keppra 53 Metformin GR 53 Japanese Encephalitis Vaccine 53 mg Lucentis 53 calcitonin 53 ADP receptor antagonist 53 pegylated interferons 53 RhuDex ® 53 RHEO 53 Quinamed 53 fosamprenavir 53 chemoradiation therapy 53 Epivir HBV 53 ABSORB trial 53 percutaneous vertebroplasty 53 Capesaris 53 sirolimus stent 53 venlafaxine XR 53 gastrointestinal stromal tumors GIST 53 Zortress 53 NEVO ™ 53 biphasic insulin aspart 53 #mg doses [002] 53 NSABP 53 anastrazole 53 Novacor LVAS 53 prospective multicenter randomized 53 ONGLYZA 53 palonosetron 53 INVEGA ® 53 antiarrhythmic 53 CK # administered 53 CsA 53 DYSPORT 53 Recurrent Glioblastoma 53 Intravitreal 53 pancreatic enzyme replacement 53 tapentadol ER 53 Sibutramine Cardiovascular Outcomes 53 Lantus insulin 53 Phase IIA 53 virus HCV protease inhibitor 53 Phase III psoriasis 53 Enjuvia 53 Nasacort AQ 53 lacosamide 53 Lovaza ® 53 Pradefovir 53 Resolute DES 53 XIENCE 53 blood clot dissolver 53 PRIMO CABG 53 Adoxa 53 gemcitabine carboplatin 53 MedTone inhaler 53 transfemoral 53 Simvastatin tablets 53 Demineralized Bone Matrix 53 Telzir 53 viral kinetics 53 oral antidiabetic 53 Cloretazine R VNP#M 53 immunoconjugate 53 HCD# [002] 53 telaprevir dosed 53 luteinizing hormone releasing 53 Gonal f 53 relapsed CLL 53 #.#mg/dL 53 EVEREST II 53 Trobalt 53 FOSRENOL R 53 Adenuric R 53 BIO SET 53 Granulocyte Colony Stimulating Factor 53 anterior lumbar interbody fusion 53 Anidulafungin 53 mcg albinterferon alfa 2b 53 intravenous cyclophosphamide 53 randomized multicenter trial 53 acarbose 53 noninferiority 53 Rasilez HCT 53 pramlintide 53 TURBT 53 acitretin 53 non squamous histology 53 Levothyroxine Sodium 53 FVIIa 53 pan HDAC inhibitor 53 antitumor effect 53 INT# [002] 53 Spheramine 53 carbidopa levodopa 53 clevidipine 53 AZILECT ® 53 myopathy rhabdomyolysis 53 nelfinavir 53 antiplatelet drugs 53 Takeda Actos 53 Sirolimus eluting 53 interferon alfa 2b 53 zoledronic acid Zometa 53 AIR CF1 53 sirolimus eluting stents 53 Prograf ® 53 Daptomycin 53 pharmacologically active isomer 53 pramipexole dihydrochloride 53 zalutumumab 53 TAXUS Element Paclitaxel Eluting 53 Vectibix panitumumab 53 Sym# 53 investigational protease inhibitor 53 adjunctive placebo 53 darunavir ritonavir 53 Emboshield 53 methotrexate monotherapy 53 Rituxan MabThera 53 mcg QD 53 Phase 1b clinical 53 eribulin mesylate 53 Emtriva Viread 53 CentriMag 53 GetGoal Phase III 53 liver transplant recipients 53 TRADJENTA 53 Fast Track designations 53 placebo controlled clinical trials 53 gabapentin enacarbil 53 recombinant antithrombin product 53 GRN# 53 dose proportionality 53 Esbriet ® 53 tobramycin 53 ARIKACE 53 Gemzar gemcitabine 53 Genasense 53 factor Xa inhibitor 53 Severe Sepsis 53 multicenter prospective 53 TransMID 53 Ablation System 53 orBec R 53 pantoprazole 53 octreotide implant 53 ticagrelor 53 PREZISTA rtv 53 LPV r 53 LCP Tacro TM 53 pharmacodynamic properties 53 anti arrhythmic 53 StemEx 53 bivalirudin monotherapy 53 prospective randomized controlled 53 Femara letrozole 53 XGEVA 53 Taxotere chemotherapy 53 retapamulin 53 Velac 53 serum phosphorus 53 SmPC 53 pegylated alpha interferon 53 PhosLo 52 alpha 2a 52 TWYNSTA ® 52 Anavex #-# 52 Initiate Phase 52 dacetuzumab 52 Bortezomib 52 FOLFIRI alone 52 antiepileptics 52 BARACLUDE r 52 pharmacokinetics PK 52 PPAR gamma agonists 52 5 lipoxygenase inhibitor 52 drug eluting coronary stent 52 RLAI 52 vascular disrupting agent 52 CLINICAL PHARMACOLOGY 52 anti CD3 52 dose dexamethasone 52 #mg QD [001] 52 paclitaxel poliglumex 52 TRITON TIMI 52 azilsartan medoxomil 52 Ophena 52 selective receptor agonist 52 ISTODAX 52 VIR# 52 BST CarGel R 52 administered subcutaneously 52 timolol 52 dexmedetomidine 52 drug zotarolimus