Related by context. All words. (Click for frequent words.) 74 MoxDuo IR 72 MoxDuo TM IR 72 CIMZIA TM 71 ALGRX 71 novel oral anticoagulant 71 MoxDuo 69 proton pump inhibitor PPI 69 CorVue ™ 69 ruxolitinib 69 Targretin capsules 69 Linjeta TM 69 ACUROX ® 69 ACTEMRA TM 69 CIP TRAMADOL ER 69 sargramostim 68 Panzem R 68 bicifadine 68 forodesine 68 icatibant 68 torezolid phosphate 68 ARCOXIA 68 Dyloject TM 68 Urocidin 68 alvimopan 68 desvenlafaxine succinate 68 maximally tolerated dose 68 Ophena TM 68 oral rivaroxaban 68 PROMACTA 68 BLA filing 68 CRMD# 68 biologic DMARD 68 release cysteamine bitartrate 68 Dual Opioid 67 Androxal TM 67 teriflunomide 67 GRALISE 67 oxymorphone ER 67 acyclovir Lauriad R 67 injectable formulations 67 OMAPRO 67 NasalFent 67 Chemophase 67 CIMZIA ™ 67 Firazyr 67 intravenous acetaminophen 67 Simulect 67 AeroLEF TM 67 octreotide acetate 67 generation purine nucleoside 67 Zenvia ™ 67 Ereska 67 herpetic keratitis 67 TBC# 67 Zemplar Capsules 67 Panzem R NCD 67 TNF alpha inhibitor 67 ZOLINZA 67 Cimzia TM 67 Vaxfectin R 67 HCl capsules 67 MAGE A3 ASCI 67 azilsartan medoxomil 67 Phase Ib study 67 indiplon capsules 67 regorafenib 67 Keppra XR 67 Zingo TM 67 Tekamlo 66 xanthine oxidase inhibitor 66 Dabigatran etexilate 66 miconazole Lauriad ® 66 Raptiva r 66 trospium 66 FIRAZYR 66 liposomal formulation 66 Alvesco R 66 sitaxsentan 66 certolizumab 66 Archexin 66 REMINYL ® 66 oral prodrug 66 oral methylnaltrexone 66 DexaSite 66 elotuzumab 66 briakinumab 66 RAPAFLO 66 orally inhaled 66 phase IIb study 66 CINQUIL 66 clevidipine 66 Octreolin 66 MoxDuo ® IR 66 Benazepril 66 GAMMAGARD 66 AZILECT R 66 relapsed MM 66 AGILECT R 66 casopitant 66 Raptiva ® 66 ZEGERID Capsules 66 KAPIDEX 66 efficacy tolerability 66 IONSYS TM 66 BENICAR HCT 66 custirsen 66 Tekturna HCT 66 GLP toxicology studies 66 Genz # 66 opioid induced bowel dysfunction 66 Twinrix 66 divalproex sodium 66 INVEGA ® 66 pegylated interferon alpha 66 rilonacept 66 Tasimelteon 66 Amrubicin 66 Arikace 66 OMNARIS Nasal Spray 66 CANCIDAS 66 omacetaxine mepesuccinate 66 Pruvel 66 Tarceva TM 66 YONDELIS 66 successfully commercialize Iluvien 66 ARB telmisartan 66 VIAject R 66 PEGylated interferon 66 Bezielle 66 PRT# 66 IRX 2 65 sufentanil 65 oral ridaforolimus 65 severe gastroparesis 65 samalizumab 65 Entereg alvimopan 65 Zelrix 65 Frova ® 65 torsemide ER 65 Aloxi injection 65 IV acetaminophen 65 SPRIX ® 65 Plenaxis TM 65 pegylated interferon alfa 65 Phenoptin 65 FROVA 65 MGN# 65 TriRima 65 PrevOnco ™ 65 Pegasys peginterferon alfa 2a 65 viral kinetics 65 Neurodex 65 MoxDuo ® 65 histamine dihydrochloride 65 Instanyl 65 MVax 65 Pazopanib 65 Evoltra ® 65 Oral NKTR 65 nitazoxanide 65 salmeterol fluticasone 65 CCX# 65 HZT 65 cystinosis patients 65 Degarelix 65 BRILINTA 65 APTIVUS ritonavir 65 PDE4 inhibitor 65 selective A2A adenosine receptor 65 SILENOR 65 MAA submission 65 SinuNase ™ 65 Ketotransdel 65 ARCALYST ® 65 intranasal formulation 65 LibiGel ® 65 BAL# [002] 65 Sumatriptan Succinate 65 PREOS R 65 desvenlafaxine 65 capsule formulation 65 Fortical R 65 vernakalant 65 EDARBI 65 DepoDur TM 65 gemcitabine cisplatin 65 ICA # 65 Hematide ™ peginesatide 65 dosing cohort 65 pharmacokinetic PK study 65 alvespimycin 65 Pegasys plus Copegus 65 postoperative ileus POI 65 vaginal lidocaine 65 basal insulin analogue 65 MIRCERA 65 Civacir 65 Biologic License Application BLA 65 LymphoStat B belimumab 65 proprietary transdermal patch 65 liver resection surgeries 65 Vfend 65 IBS C 65 Pharmacokinetic parameters 65 reduce serum phosphate 65 SinuNase TM 65 LEP ETU 65 SUCCEED trial 65 NGX# 65 rALLy trial 65 paliperidone palmitate 65 pain palliation 65 metastatic CRC 65 clonidine hydrochloride 65 RAPTIVA 65 adenosine injection 65 vernakalant hydrochloride 65 oral talactoferrin 65 EOquin 65 oxypurinol 65 SPRYCEL ® 65 OvaRex R 65 Spiegelmer ® 64 PATANASE R nasal spray 64 HCD# [002] 64 Brinavess 64 5 HT3 antagonist 64 pomalidomide 64 Darunavir 64 plasma kallikrein inhibitor 64 Advagraf 64 GLP1 agonist 64 receptor tyrosine kinase inhibitor 64 Noxafil 64 PASI scores 64 Cimzia ® certolizumab pegol 64 evaluating tivozanib 64 Fidaxomicin 64 Traficet EN 64 dopamine partial agonist 64 Troxatyl 64 5 lipoxygenase inhibitor 64 Cipralex ® 64 Cellegesic 64 metaglidasen 64 plus prednisone prednisolone 64 vapreotide acetate 64 intermittent dosing 64 biologic therapy 64 atacicept 64 dose cohort 64 ribavirin RBV 64 Augment Injectable 64 subcutaneous PRO 64 sulfonylurea glimepiride 64 SUSTENNA TM 64 ONTAK 64 Omigard 64 GLASSIA 64 Nabi HB Intravenous 64 EOquin TM 64 vidofludimus 64 XL# SAR# 64 pegylated interferon peg IFN 64 Vilazodone 64 EDEMA3 trial 64 OSMOPREP 64 venlafaxine ER 64 MYCAMINE 64 PREOS 64 R# #mg BID 64 PHX# 64 Elagolix 64 bosutinib 64 XP# XP# 64 zonisamide SR 64 Entereg R 64 paliperidone ER 64 sevelamer carbonate 64 Icatibant 64 Acetavance TM 64 leukotriene receptor antagonist 64 Combunox 64 Linjeta ™ 64 Golimumab 64 Dacogen injection 64 Excellarate 64 Toctino ® alitretinoin 64 Pennsaid R 64 CAELYX 64 USL# 64 Phase #b/#a trial 64 APTIVUS 64 Rhucin ® 64 inhaled iloprost 64 CRp 64 T Pred 64 CINTREDEKIN BESUDOTOX 64 Trobalt 64 DEB# 64 faropenem 64 Extina 64 Duromist ™ 64 oral renin inhibitor 64 zileuton CR 64 Ketotransdel TM 64 Anthim 64 IV APAP 64 balsalazide 64 TWYNSTA 64 Zoraxel TM 64 Silodosin 64 #mg dose [002] 64 ORENCIA ® 64 BYSTOLIC 64 Febuxostat 64 R#/MEM # 64 HepeX B 64 Plenaxis R 64 Gamunex C 64 tezampanel 64 FLECTOR R Patch 64 recombinant PSMA vaccine 64 Azilect ® 64 alicaforsen enema 64 RLY# 64 RSD# 64 pharmacodynamic properties 64 AMEVIVE 64 rhIGF-I/rhIGFBP-3 64 Besivance 64 Alzhemed TM 64 Capesaris 64 fusion enhancers 64 Solulin 64 Sular ® 64 BEMA Granisetron 64 pioglitazone HCl 64 Gralise 64 Xeloda ® 64 Certican 64 forodesine hydrochloride 64 PresbyLens ® 64 Fodosine 64 CCR5 antagonist 64 ULORIC 64 Ventavis 64 ospemifene 64 humanized interleukin 6 64 XOMA 3AB 64 Nebido 64 VAPRISOL 64 FACTIVE tablets 64 Crofelemer budesonide foam 64 subcutaneously administered 64 Vernakalant 64 nalbuphine ER 64 somatostatin analog 64 budesonide foam 64 HGS# 64 NSABP C 64 MAXY alpha 64 Perforomist ™ Inhalation Solution 64 transdermal estradiol gel 64 dalbavancin 64 tolerability profiles 64 Hycamtin ® 64 carbidopa levodopa 64 Peginterferon alfa 2b 64 Insulin PH# 64 pancreatic enzyme replacement 64 prospectively stratified 64 Bifeprunox 64 oxaliplatin Eloxatin 64 zolmitriptan 64 Plicera 64 Ganciclovir 63 Kepivance 63 deforolimus 63 protease inhibitor PI 63 aztreonam 63 Phase #/#a 63 DEXILANT 63 LIALDA 63 Allovectin 7 ® 63 prescribed proton pump 63 PEG PAL 63 SSRI SNRI 63 vinorelbine tartrate 63 omeprazole widely 63 pegylated alpha interferon 63 HuMax EGFr 63 AAG geldanamycin analog 63 CCR5 inhibitor 63 Eli Lilly Cymbalta 63 elagolix 63 THALOMID 63 GnRH antagonist 63 GEM OS2 63 TEMODAL 63 Glufosfamide 63 zileuton injection 63 Bepreve TM 63 adipiplon 63 relapsed MCL 63 pharmacokinetic characteristics 63 LCP AtorFen 63 Valdoxan 63 Phase 1a clinical 63 ACAPODENE 63 RhuDex ® 63 Gabapentin GR 63 eniluracil 63 opioid naïve 63 EMBEDA ™ 63 ezogabine 63 methylnaltrexone 63 Granisetron 63 CLARITY study 63 CAPHOSOL 63 RAPAFLO TM 63 dirucotide MBP# 63 phase IIb trial 63 docetaxel Taxotere ® 63 combinability 63 ACZ# 63 Sanctura XR 63 oral transmucosal 63 Xibrom TM 63 novel VDA molecule 63 refractory gout 63 IMiDs 63 Vimpat R 63 RoACTEMRA 63 postexposure 63 subsidiaries visit http:/www.apricusbio.com 63 BeneFIX 63 oral iron chelator 63 APRISO 63 ancrod 63 diabetic gastroparesis 63 pharmacodynamics PD 63 MACUGEN 63 NOXAFIL 63 overactive bladder AA# 63 tezampanel NGX# 63 ONGLYZA ™ 63 apremilast 63 balsalazide disodium 63 Cimzia R 63 OvaRex ® MAb 63 CONCERTA 63 INTELENCE 63 ganetespib 63 SNT MC# 63 AZX# 63 AstraZeneca Toprol XL 63 AzaSite Plus 63 BRIM2 63 SUTENT ® 63 SYNERGY Stent 63 DIFICID ™ 63 AZILECT ® 63 Zegerid OTC 63 Urocidin TM 63 Onbrez Breezhaler 63 Empatic ™ 63 dosage regimen 63 SPARLON 63 subcutaneous SC 63 Ambrisentan 63 HEPLISAV ™ 63 SVR# 63 Perforomist TM formoterol fumarate 63 topical ophthalmic 63 visilizumab 63 balsalazide tablet 63 CHOP chemotherapy 63 Emezine 63 NDA Submission 63 Warfarin Coumadin 63 Aptivus ® 63 post operative ileus 63 bupropion SR 63 alfa 2a 63 E1 INT TM 63 Durezol 63 lumiliximab 63 metoprolol succinate 63 diclofenac sodium 63 Tarsa oral calcitonin 63 PREGNANT Study 63 6R BH4 63 midstage clinical 63 AGILECT ® 63 oral levofloxacin 63 NP2 Enkephalin 63 inhaled liposomal ciprofloxacin 63 acetonide FA 63 BUPHENYL R 63 HuMax CD4 63 Levoleucovorin 63 sorafenib tablets 63 PEGylated anti 63 topical diclofenac 63 aplindore 63 QNEXA 63 targeted radiotherapeutic 63 docetaxel emulsion 63 PEGINTRON TM 63 phase Ib 63 NeuroSTAT ® 63 dosing frequency 63 analgesic efficacy 63 topical gel formulation 63 OMS# 63 canakinumab 63 HQK 63 Exforge HCT 63 Adlea 63 baminercept 63 Pivotal Phase III 63 fluticasone salmeterol 63 REG1 63 dirucotide 63 investigational hepatitis B 63 Reclast Aclasta 63 Amplimexon 63 JAK inhibitor 63 KAPVAY ™ 63 alefacept 63 Lamictal XR 63 Aloprim TM allopurinol sodium 63 Raptiva R 63 BEMA TM Fentanyl 63 orally inhaled migraine 63 PEG SN# 63 Fx #A 63 nonclinical studies 63 CIP ISOTRETINOIN 63 lenalidomide Revlimid R 63 TORISEL 63 Talabostat 63 EXALGO 63 CTAP# Capsules 63 OMNARIS 63 pregabalin Lyrica 63 Pegloticase 63 DOXIL 63 COLAZAL R 63 morphometric vertebral fractures 63 tecarfarin 63 TPI ASM8 63 Excellagen 63 RSD# oral 63 INC# 63 ADCS CGIC 63 glycoprotein IIb IIIa inhibitor 63 antiarrhythmic drug 63 NEXTERONE 63 dextromethorphan quinidine 63 risedronate sodium tablets 63 DDP# 63 tasimelteon 63 epoetin alpha 63 paclitaxel poliglumex 63 TAK #MR 63 ® natalizumab 63 Proquin XR 63 melphalan prednisone 63 oral deforolimus 63 Bayer Onyx 63 anagrelide 63 Androxal ® 63 Ophena 63 HEPLISAV TM 63 Testosterone MDTS ® 63 TELINTRA 63 Cinacalcet HCl 63 Eloxatin ® 63 guanfacine extended release 63 oral FTY# 63 riociguat 63 R sorafenib tablets 63 Shigamabs ® 63 INT# [002] 63 palonosetron 63 Cethromycin 63 DULERA 63 PROVENGE ® 63 Tracleer R 63 SILENOR TM 63 PNP inhibitor 63 solifenacin succinate 63 OncoVEX GM CSF 63 EMSAM 63 Cleviprex TM clevidipine 63 Danazol 63 Cefprozil 63 tolevamer 63 ELACYT 63 AGGRASTAT R 63 amphotericin B 63 REGN# 63 CERVARIX 63 topical antifungal 63 peg interferon 63 Xyrem ® 63 omega interferon 63 CONBRIZA 62 Cardio Vascu Grow 62 urocortin 2 62 lanthanum carbonate 62 haematologic 62 Tamibarotene 62 ACAPODENE TM 62 fluoropyrimidine 62 ARIKACE ™ 62 hylan GF 62 administered subcutaneously 62 oral diclofenac 62 otelixizumab 62 short acting bronchodilator 62 IMiDs ® compound 62 serotonin norepinephrine reuptake inhibitor 62 REBETOL combination therapy 62 Natalizumab 62 Lamictal ODT 62 multidose 62 eszopiclone 62 Namenda XR 62 Aryplase 62 Azedra 62 Voraxaze 62 KYNAPID 62 Allovectin 7 62 Rylomine 62 OMNARIS HFA 62 Vidaza azacitidine 62 APTIVUS r 62 Zavesca r 62 corticosteroid dose 62 TYGACIL 62 Phase 2a clinical trials 62 Cetuximab Erbitux 62 angiotensin analog 62 oral salmon calcitonin 62 zileuton 62 MAP# 62 PRADAXA 62 intravenous methylnaltrexone 62 M# rationally 62 Risperidone Oral Solution 62 Loramyc R 62 LymphoStat B TM 62 Soliris eculizumab 62 Matrix Phase 2b 62 Oracea TM 62 JNJ Q2 62 ISENTRESS 62 Dextofisopam 62 Arranon 62 Solazed 62 FASLODEX 62 octreotide 62 galiximab 62 Intravitreal injections 62 adalimumab Humira 62 temsirolimus Torisel ® 62 adult chronic ITP 62 non nucleoside HCV 62 G#DT 62 INCB# [001] 62 intradermal injection 62 pegfilgrastim 62 Clevudine 62 CORDAPTIVE 62 Voltaren Gel 62 brand ciclesonide HFA 62 2A receptor agonist 62 Fortovase 62 MEND CABG II 62 romiplostim 62 phase IIa clinical 62 Ventavis ® 62 NPSP# 62 JANUVIA 62 drug ISA# 62 QRxPharma 62 TREANDA 62 virological response 62 Serdaxin 62 BEMA Buprenorphine 62 investigational pharmacologically unique 62 cannabinor 62 Phase 2b study 62 Rebif ® 62 tapentadol ER 62 Dementia Related Psychosis 62 Visian Toric ICL 62 Zenvia Phase III 62 Zolpimist 62 budesonide MMX 62 infusional 5-FU/LV 62 Generx TM 62 Edurant 62 DR Cysteamine 62 Keppra ® XR 62 GlaxoSmithKline Requip 62 Zaleplon Capsules 62 Proellex TM 62 MCyR 62 IMiDs ® 62 subcutaneous formulation 62 pitavastatin 62 LHRH antagonists 62 diabetic neuropathic pain 62 VersaFilm 62 pegylated interferons 62 ADAGIO study 62 Restanza 62 teduglutide 62 RAPAFLO R 62 gemtuzumab ozogamicin 62 IV bolus 62 Triapine R 62 dermaPACE TM 62 Torisel 62 Corlux 62 TYKERB 62 mg QD 62 Rapaflo 62 NUVIGIL 62 dose titration 62 im peramivir 62 Exelixis compounds 62 8mg/kg 62 Mipomersen 62 terlipressin 62 Seliciclib 62 bortezomib Velcade 62 urate lowering 62 lomitapide 62 Fibrillex 62 Genzyme Synvisc 62 Apoptone 62 budesonide inhalation suspension 62 budiodarone 62 ELIQUIS 62 immunomodulatory therapy 62 KADIAN ® 62 refractory chronic lymphocytic 62 reslizumab 62 Aganocide 62 CIMZIA TM certolizumab pegol 62 Zemplar 62 boosted protease inhibitor 62 Jevtana 62 VIMOVO 62 include Phenoptin TM 62 telaprevir VX 62 Rylomine TM 62 Orphan Drug designations 62 endothelin receptor antagonists 62 IND submission 62 ELADUR 62 XL# anticancer compounds 62 Dasatinib 62 class mGluR5 inhibitor 62 Evoltra 62 pegylated IFN 62 XOPENEX Inhalation Solution 62 Vertex hepatitis C 62 Diovan HCT 62 inhaled treprostinil 62 CYT# potent vascular disrupting 62 Tyrima 62 ALVESCO R 62 interferon beta 1b 62 rFSH 62 hematological toxicity 62 Orazol 62 Mg Usa 62 Alferon N 62 VELCADE melphalan 62 mometasone furoate 62 azelastine 62 Drug Eluting Stent System 62 anthracycline taxane 62 budesonide MMX Phase III 62 LEVAQUIN ® 62 Troxatyl TM 62 HCV protease inhibitors 62 Zavesca ® 62 opioid bowel dysfunction 62 non constipation irritable 62 crizotinib PF # 62 NVA# 62 NDA resubmission 62 pimecrolimus 62 Xelox 62 Pemetrexed 62 EXPAREL TM 62 TAFA# 62 Retacrit 62 rasagiline tablets 62 candidate TNFerade biologic 62 oxymorphone IR 62 Rigel R# 62 Altastaph 62 Zirgan 62 ibandronate 62 ENMD # 62 AMRIX 62 BCG refractory 62 Chrysalin 62 bardoxolone methyl 62 Hectorol R 62 Focalin XR 62 MUSE ® 62 Serdolect ® 62 Interferon beta 1b 62 Trofex 62 systemic corticosteroid 62 TO AVOID PREGNANCY WHILE 62 Aclasta Reclast 62 CG# [003] 62 Keppra XR TM 62 BiDil XR 62 Anavex #-# 62 alpha blocker 62 muscarinic receptor agonist 62 Dapagliflozin 62 Mycamine 62 Xanafide 62 Auxilium transmucosal film 62 highly purified pasteurized 62 GLPG# 62 Phase IIb trials 62 PEG interferon 62 Gadavist 62 limiting toxicity DLT 62 hydrochloride capsules 62 sunitinib malate 62 granted Ortec 62 Meets Primary Endpoint 62 Natroba 62 Interferon alpha 62 PEGPH# 62 demonstrated clinically meaningful 62 DUROS 62 Orapred ODT 62 Budesonide foam crofelemer 62 aliskiren amlodipine 62 Clonicel 62 Survivin antagonist 62 R adalimumab 62 microbiological eradication 62 oxybutynin 62 oral vancomycin 62 ATL# [002] 62 Submits NDA 62 XIENCE V stent 62 Abstral ® 62 brentuximab vedotin SGN 62 efficacy endpoint 62 Known hypersensitivity 62 OROS ® 62 EmbraceAC 62 TroVax ® 62 BARACLUDE R 62 ARIKACE 62 elacytarabine 62 APTIVUS R 62 gastrointestinal toxicities 62 zolpidem tartrate sublingual tablet 62 Approvable 62 catheter occlusion 62 daptomycin 62 Pegasys ® 62 Generx ™ 62 pseudobulbar affect PBA 62 VFEND 62 intravenous dosing 62 cobiprostone 62 treprostinil 62 AeroLEF 62 Exalgo TM 62 Bicifadine 62 Roflumilast 62 inhaled corticosteroid ICS 62 systemic immunosuppressive drugs 62 Phase 2a trial 62 equi analgesic doses 62 sublingual formulation 62 Aztreonam 62 gemcitabine Gemzar ® 62 INVEGA SUSTENNA 62 DepoDur 62 Maribavir 62 novel histone deacetylase 62 antithrombotic 61 Ecallantide 61 VIRAMUNE XR 61 cidofovir 61 opioid naive 61 Lubiprostone 61 PSMA ADC 61 rNAPc2 61 Stedivaze 61 Fibrillex TM 61 dasatinib Sprycel ® 61 Vectical TM Ointment 61 FOLFOX4 61 nasal calcitonin product 61 OMS#HP 61 INFERGEN 61 transdermal fentanyl 61 Resolute DES 61 hematological parameters 61 paclitaxel Taxol ® 61 MOVIPREP R 61 oxycodone CR 61 dose escalation phase 61 ChronVac C R 61 DAVANAT 61 abiraterone acetate 61 VIAject ™ 61 vilazodone 61 GENERIC SILDENAFIL SOFT Generic 61 Vascular Wrap TM 61 OZURDEX ® 61 DORIBAX 61 ENTEREG ® 61 Locteron ® 61 Sufentanil 61 Oxytrex 61 Xyzal ® 61 FOLFOX6 chemotherapy regimen 61 registrational trial 61 Zenpep 61 lesinurad 61 Alequel ™ 61 TELCYTA 61 Anturol TM 61 TRILIPIX 61 Elitek 61 Phase III ADT 61 Betaferon R 61 TAXUS TM 61 PERLANE 61 HepaGam B 61 nasal bepotastine 61 PTH1 61 KRN# 61 VIRAMUNE 61 Phase IIb clinical trials 61 ritonavir boosted protease inhibitor 61 Zelapar 61 levocetirizine 61 levodopa carbidopa 61 Phase IIIb clinical 61 Tasigna prolongs 61 Taclonex Scalp R 61 SCH # 61 sodium Injection 61 IOP lowering 61 dacetuzumab 61 rhThrombin 61 #mg BID [001] 61 REG2 61 ABILIFY ® 61 Relivar 61 rufinamide 61 VALSTAR 61 imiquimod cream 61 Phase #b/#a 61 ixabepilone 61 indibulin 61 plus dexamethasone 61 Kamada AAT 61 SOLODYN 61 1mg 2mg 61 novel DACH platinum 61 ABSORB trial 61 Silenor ® doxepin 61 Pliaglis 61 Aptivus 61 BRINAVESS 61 zalutumumab 61 RIGScan CR 61 Intravail R 61 methylnaltrexone bromide 61 dextofisopam 61 secondary efficacy endpoint 61 transmucosal delivery system 61 Epanova 61 chlorambucil 61 CLIRS trial