Related by context. All words. (Click for frequent words.) 63 CVD mortality 62 HNSCC 61 colorectal adenoma 60 onset diabetes mellitus 60 histologic subtype 60 colorectal neoplasia 60 tumor histology 60 metabolic syndrome MetS 60 urinary cadmium 60 comorbid illnesses 60 prostate cancer CaP 59 elevated LDH 59 hyperhomocysteinemia 59 MGUS 59 carotid plaques 59 distal colon cancer 59 histological subtypes 59 serum cotinine levels 59 systolic blood pressures 59 sociodemographic factors 59 coronary calcification 59 beta carotene supplementation 58 hepatocellular carcinomas 58 perimenopausal women 58 nondiabetic patients 58 elevated triglyceride levels 58 tertiles 58 mucinous 58 serum lipid levels 58 lowest tertile 58 hypercoagulable 58 obesity sedentary lifestyle 58 familial pancreatic cancer 58 squamous cell histology 58 diabetes hypertension hyperlipidemia 58 multivariate analyzes 58 colorectal polyp 58 elevated IOP 58 cardio respiratory fitness 58 advanced adenomas 57 thyrotropin levels 57 hypertensives 57 salivary cotinine 57 hydroxyvitamin D concentrations 57 depressive symptomatology 57 oesophageal adenocarcinoma 57 CTEPH 57 clinicopathologic 57 macroalbuminuria 57 metaplasia 57 HIV HCV coinfected 57 autonomic dysfunction 57 NAT2 57 non menthol smokers 57 prevalences 57 highest tertile 57 metachronous 57 multivariate adjustment 57 interstitial lung abnormalities 57 hepatic cirrhosis 57 multivariable analysis 57 MMSE scores 57 bronchoalveolar lavage 57 IPAH 57 smoke menthol cigarettes 57 Multivariate logistic regression 57 pulmonary dysfunction 57 testicular tumors 57 HbA 1c levels 57 neurosensory 57 proliferative retinopathy 57 β blockers 57 obstructive coronary artery 57 calculi 57 multivariate logistic regression 57 inflammatory rheumatic 57 squamous cell lung cancer 57 ECOG PS 57 adnexal mass 57 HLA DRB1 SE 56 renal cell carcinomas 56 spirometric 56 F FDG PET 56 serum GGT 56 subclinical hyperthyroidism 56 upper aerodigestive tract 56 triacylglycerol concentrations 56 CHD mortality 56 multiple logistic regression 56 T1DM 56 postintervention 56 BLLs 56 serous ovarian cancer 56 comorbid depression 56 logistic regression model 56 nodal metastasis 56 atherogenic dyslipidemia 56 arterial thickening 56 differential gene expression 56 advanced adenoma 56 liver transplant recipients 56 colorectal neoplasms 56 multivariable adjusted 56 gallstone disease 56 hormone receptor status 56 carcinoids 56 conditional logistic regression 56 malignant polyps 56 atopic 56 cryptogenic 56 plasma homocysteine 56 elevated CRP 56 albumin excretion rate 56 KRAS mutation 56 severe periodontitis 56 LV dysfunction 56 polyp recurrence 56 HER2 overexpression 56 carotid stenosis 56 interstitial fibrosis 56 hyperplastic polyps 56 SUVmax 56 nonalcoholic steatohepatitis 56 LDL cholesterol concentrations 56 Subgroup analyzes 56 esophageal squamous cell carcinoma 56 HOMA IR 56 nonmelanoma skin cancers 56 choroidal neovascularization 56 neoplasias 56 alanine aminotransferase ALT 56 familial clustering 56 impaired glucose metabolism 56 angiographically 56 haematologic 55 brain infarcts 55 gross hematuria 55 hepatic steatosis 55 serum selenium 55 elevated fasting glucose 55 serum homocysteine 55 transferrin saturation 55 odds ratios ORs 55 nonsmall cell lung cancer 55 INTERHEART 55 hamartomas 55 oral pharyngeal 55 adenomatous polyps 55 histological subtype 55 exhaled carbon monoxide 55 gastric carcinoma 55 potential confounders 55 MetS 55 Multivariate analyzes 55 confidence interval #.#-#.# 55 nicotine metabolite 55 latent celiac disease 55 abnormal lipid 55 nonmelanoma 55 telomere lengths 55 HER2 expression 55 TT genotype 55 #,# DCB 55 homocysteine concentrations 55 CARDIA 55 covariate 55 thicker carotid arteries 55 gastric cardia 55 prognostic significance 55 univariate analyzes 55 Triglyceride levels 55 abstinent alcoholics 55 axillary node dissection 55 colonic polyps 55 glycated hemoglobin levels 55 FDG uptake 55 leukocyte counts 55 malignant neoplasm 55 bronchogenic carcinoma 55 antigen PSA levels 55 basal cell nevus syndrome 55 metabolite concentrations 55 systolic dysfunction 55 neoplasm 55 hypertension diabetes mellitus 55 distal colon 55 MMSE score 55 hepatorenal syndrome 55 echocardiographic parameters 55 retrospective cohort 55 androgen excess 55 subclinical hypothyroidism 55 serum parathyroid hormone 55 oropharyngeal cancer 55 sociodemographic variables 55 proband 55 nephropathy 55 advanced neoplasia 55 histologically 55 prostate cancer PCa 55 Cotinine 55 psychiatric morbidity 55 #OHD levels 55 androgen deficiency 55 seropositivity 55 postmenopausal hormone 55 NAFLD 55 serum lactate 55 polypoid lesions 55 mammographically 55 triglyceride concentrations 55 aminotransferases 55 noncardiac 55 CIN3 + 55 lipid lowering agents 55 nonseminoma 55 parkinsonism 55 carotid atherosclerosis 55 recurrent acute pancreatitis 55 albumin excretion 55 preeclamptic 55 intracerebral haemorrhage 55 dyslipidemia hypertension 55 hyperplastic 55 aberrant methylation 55 atrophic gastritis 55 mutated K ras 55 Heritability 54 transaminase levels 54 psychiatric comorbidities 54 residual confounding 54 lipid concentrations 54 rheumatoid factor 54 lung resection 54 affective psychosis 54 nondemented 54 gastric adenocarcinoma 54 Insulin sensitivity 54 rCBF 54 serum urate levels 54 SLNB 54 abdominal adiposity 54 grade gliomas 54 elevated serum creatinine 54 SNP rs# [002] 54 troponin T 54 cervical neoplasia 54 KRAS mutations occur 54 abnormal lipid levels 54 aminotransferase levels 54 diastolic pressures 54 schizophreniform disorder 54 etiologic 54 premalignant 54 proliferative diabetic retinopathy 54 NHANES III 54 utero exposure 54 hypercholesterolaemia 54 sCJD 54 cirrhotic liver 54 mIU L 54 hypertension hypercholesterolemia 54 thyroid nodules 54 hepatic fat 54 familial aggregation 54 pT2 54 CC genotype 54 carotid bruit 54 microbleeds 54 CARDIA study 54 blood glucose concentrations 54 serum albumin 54 coronary stenosis 54 flavanol cocoa 54 VaD 54 ductal breast cancer 54 Sjögren syndrome 54 serum estradiol 54 chronic periodontitis 54 covariates 54 neurodevelopmental outcome 54 aortic atherosclerosis 54 tHcy 54 CRP concentrations 54 SE alleles 54 primary hyperparathyroidism 54 esophageal gastric 54 thyroid nodule 54 inversely associated 54 lipid elevations 54 multivariate regression 54 skeletal metastases 54 tertile 54 hematopoietic cancers 54 specific antigen PSA 54 Genetic susceptibility 54 chronic pancreatitis 54 endometrial hyperplasia 54 hydroxyvitamin D levels 54 parous women 54 estrogen receptor ER 54 dyslipidaemia 54 gonococcal 54 cellularity 54 lymphocytic 54 orofacial clefts 54 metabolic dysregulation 54 olfactory dysfunction 54 shorter telomere length 54 chronic hepatitis cirrhosis 54 PSA nadir 54 CP CPPS 54 bacteriuria 54 cranial irradiation 54 APOE e4 gene 54 bronchial hyperresponsiveness 54 folate concentrations 54 coronary stenoses 54 glomerular filtration 54 artery calcification 54 preserved ejection fraction 54 microscopic hematuria 54 non squamous NSCLC 54 Endothelial function 54 cTnT 54 abdominal irradiation 54 C. trachomatis 54 menthol smokers 54 penetrance 54 GSTM1 54 CIN2 + 54 cerebral infarction 54 adiponectin concentrations 54 chest radiography 54 #F FDG PET 53 chlamydial infection 53 granulomatous 53 seminomas 53 subclinical atherosclerosis 53 adenomatous polyp 53 oxygen saturations 53 multivariate Cox 53 urolithiasis 53 serum calcium 53 serum triglycerides 53 sonographic findings 53 lipid lowering medications 53 APOE genotype 53 serum folate concentrations 53 plasma lipids 53 cortical thinning 53 lignan intake 53 invasive ductal 53 fasting insulin 53 irregular menses 53 parkinsonian 53 Uveal melanoma 53 metabolic abnormalities 53 nonobstructive CAD 53 polypoid 53 serum creatinine levels 53 ocular toxicity 53 serum PSA 53 atopic disorders 53 precursor lesions 53 SGPT 53 extracapsular extension 53 macrovascular disease 53 serum vitamin D 53 Heavy menstrual bleeding 53 intracranial hemorrhage ICH 53 transaminase elevations 53 T1a 53 nasal polyposis 53 serum BDNF 53 % CI #.#-#.# [008] 53 cTnI 53 bivariate analyzes 53 gestational diabetes mellitus GDM 53 elevated LDL cholesterol 53 nonfasting triglyceride levels 53 amnestic MCI 53 colorectal cancer incidence 53 bronchoalveolar lavage BAL 53 serum PTH 53 bronchoalveolar 53 nonfasting triglycerides 53 alcoholic fatty liver 53 resected pancreatic cancer 53 fructose intolerance 53 Papillary 53 Rectal cancer 53 atherothrombotic disease 53 axial length 53 vitamin D inadequacy 53 hyperglycaemia 53 microvessel density 53 tumor subtypes 53 pT3 53 obese postmenopausal 53 microemboli 53 eosinophil count 53 amenorrhoea 53 neurodevelopmental outcomes 53 G6PD deficiency 53 Univariate analysis 53 NP CRNs 53 atherothrombosis 53 microalbuminuria 53 mmol liter 53 inhaled corticosteroid therapy 53 atopic asthma 53 timepoints 53 NMIBC 53 comorbid psychiatric disorders 53 colorectal carcinoma 53 diabetes mellitus hypertension 53 invasive lobular 53 microangiopathy 53 Radical prostatectomy 53 glucose insulin 53 locoregional recurrence 53 elevated triglycerides 53 precancerous polyp 53 pharmacodynamic parameters 53 mediastinal lymph nodes 53 malignant lymphoma 53 EGFR mutations 53 VLBW 53 thiopurine 53 histopathologic examination 53 lung metastasis 53 glycosylated hemoglobin HbA1c 53 thyroid carcinoma 53 nonobese 53 bladder cancers 53 nondiabetic 53 selenium intake 53 pretest probability 53 opacification 53 type2 diabetes 53 atheroma volume 53 neurocognitive functioning 53 osteosarcomas 53 primary aldosteronism 53 bullous 53 clinicopathological 53 leiomyomas 53 viral etiology 53 laryngeal cancer 53 cerebral vasospasm 53 follicular lymphoma FL 53 tanned indoors 53 alanine aminotransferase 53 nonexposed 53 situ LCIS 53 proximal colon 53 mesotheliomas 53 affective psychoses 53 dysglycemia 53 arteriolar 53 neurocognitive impairment 53 airflow obstruction 53 cotinine levels 53 chest radiographs 53 reflux esophagitis 53 preintervention 53 allergic eczema 53 ischemic cardiomyopathy 53 lobular cancer 53 EGFR mutation 53 colorectal tumors 53 intact parathyroid hormone 53 chronic HBV infection 53 intima media thickness 53 ß blockers 53 epithelial tumors 53 urothelial carcinoma 53 GH deficiency 53 lung lesions 53 HER2 amplification 53 umol L 53 lipid levels 53 biochemical abnormalities 53 carotid IMT 53 neovascular 53 prognostic factors 53 ALI ARDS 53 obstructive airway disease 53 #ng/ml 53 Nicotine dependence 53 logistic regression analysis 53 HDL2 53 HDL cholesterol triglycerides 53 noncalcified 53 aortic stiffness 53 adenoma 53 interstitial lung diseases 53 adenoma recurrence 53 diastolic BP 53 postoperative AF 53 leukoplakia 53 recurrent venous thromboembolism 53 median survivals 53 pharyngeal cancer 53 interobserver reliability 53 sociodemographic characteristics 53 serum cotinine 52 arterial hypertension 52 neutrophil counts 52 carotid plaque 52 NYHA functional class 52 allele frequencies 52 gestational diabetes mellitus 52 endothelial activation 52 serum uric acid 52 confounding variables 52 baseline LDH 52 nondepressed 52 ischemic lesions 52 highest quintile 52 cervical lymph nodes 52 HGPIN 52 coronary artery aneurysms 52 ejection fractions 52 chromosomal mutations 52 cardioembolic 52 liver metastasis 52 HRCT 52 colorectal bowel 52 univariate analysis 52 comorbidities 52 pathologic diagnosis 52 BMI ≥ 52 nonfatal MI 52 elevated ALT 52 abnormal lipids 52 adenoidectomy 52 statistically significant predictor 52 distant metastasis 52 atherogenic 52 cervical lesions 52 curability 52 obstructive coronary 52 anti JCV antibodies 52 pathologic fractures 52 BMI z 52 scintigraphic 52 Complication rates 52 postoperative hemorrhage 52 arteriography 52 % CI #.#-#.# [004] 52 Baseline characteristics 52 μmol L 52 prostate carcinoma 52 prostate abnormalities 52 perioperative morbidity 52 anal lesions 52 recurrent UTI 52 basal cell carcinoma BCC 52 chromosomal anomalies 52 gastric cancers 52 fluoroquinolone resistant 52 SHBG levels 52 obstructive lung 52 histologically confirmed 52 nonmetastatic 52 HIVAN 52 esophageal reflux 52 clinicopathological features 52 recurrent glioblastoma multiforme 52 baseline HbA1c 52 posttreatment 52 biochemical recurrence 52 Adjuvant chemotherapy 52 cardiovascular disease hypertension 52 neuropsychological impairment 52 psychiatric comorbidity 52 histopathological 52 euthyroid 52 Depressive symptoms 52 metabolizing enzyme 52 T2DM 52 p# mutations 52 PAOD 52 leukocyte count 52 rebleeding 52 lung nodule 52 hyperlipidemic 52 supratentorial 52 somatic symptoms 52 hormone receptor negative 52 nonadherent 52 breast carcinoma 52 cytologic 52 clinico pathological 52 chorioamnionitis 52 hypercalcaemia 52 postoperative morbidity 52 myocardial ischaemia 52 underwent resection 52 unfavorable prognostic 52 atopic sensitization 52 Hurthle cell 52 rs# [002] 52 % CI #.#-#.# [007] 52 BCR ABL mutations 52 APOE ε4 52 decompensated cirrhosis 52 CIN3 52 resectable 52 hypervascular 52 hemoglobin A1c levels 52 de ath 52 pretransplant 52 neovascular glaucoma 52 K ras mutations 52 airway hyperresponsiveness 52 metabolic dysfunction 52 syndromal 52 metabolic parameters 52 aneurysmal subarachnoid hemorrhage 52 antihypertensive therapy 52 histologic findings 52 μg L 52 carcinomatosis 52 ventricular tachyarrhythmia 52 protein excretion 52 hypovitaminosis D 52 flutamide 52 neoplastic lesions 52 Fasting plasma glucose 52 hyperlipemia 52 glomerular filtration rate 52 esophageal adenocarcinoma 52 monoclonal gammopathy 52 oral squamous cell 52 ovarian malignancy 52 EoE 52 carotid artery blockage 52 serum lipids 52 cardiac troponin 52 Elevated serum 52 plasma lipid 52 haematuria 52 colorectal adenocarcinoma 52 Hematologic 52 Genetic variants 52 symptomatic VTE 52 cerebral microbleeds 52 colorectal carcinomas 52 prostate carcinogenesis 52 #mmHg [001] 52 fibrosis progression 52 completely resected 52 POAG 52 relapsed MM 52 bronchoalveolar lavage fluid 52 MRSA isolates 52 spontaneous regression 52 thyroid dysfunction 52 histologic subtypes 52 colorectal carcinogenesis 52 interobserver 52 calcified plaques 52 CYP#A# gene 52 diabetes mellitus DM 52 left ventricular systolic 52 plasma adiponectin 52 eNO 52 venous thromboembolic disease 52 HepG2 cells 52 asymptomatic carotid stenosis 52 epithelioid 52 smoked menthol cigarettes 52 AUDs 52 serum leptin 52 juvenile idiopathic arthritis JIA 52 oesophageal squamous cell carcinoma 52 IDDM 52 acute aortic dissection 52 lobar 52 multivariable analyzes 52 univariate 52 somatoform disorders 52 pancreatic adenocarcinoma 52 DAS# scores 52 HIV seropositive 52 adenocarcinomas 52 aspartate aminotransferase AST 52 colorectal adenomas 52 airway responsiveness 52 ABCB1 gene 52 Basal Cell 52 hereditary predisposition 52 radiosensitive 52 axillary lymph nodes 52 predisposing factor 52 glucose intolerance 52 RBC folate 51 subclinical disease 51 nonpregnant women 51 eccrine 51 diabetic kidney 51 eculizumab therapy 51 curative resection 51 nodal metastases 51 vascular dysfunction 51 colorectal polyps 51 cirrhotic 51 arterial thromboembolic events 51 viral titers 51 hypoperfusion 51 lobular breast cancer 51 dysplastic lesions 51 Lung transplantation 51 polytherapy 51 breast cancer subtypes 51 G allele 51 undergoing coronary angiography 51 breast endometrial 51 anterior temporal 51 lacunar 51 cerebral infarctions 51 malignant lesions 51 papillary renal cell carcinoma 51 hyperintense lesions 51 kg m² 51 arterial stiffening 51 atypical ductal hyperplasia 51 thyrotropin 51 idiopathic PAH 51 nonobese patients 51 asymptomatic bacteriuria 51 VTEs 51 exploratory endpoints 51 ventricular hypertrophy 51 chronic thromboembolic pulmonary 51 functional gastrointestinal disorders 51 prognostic variables 51 underwent radical prostatectomy 51 hemodialysis patients 51 aortic regurgitation 51 hemoglobin concentrations 51 stage IIIB 51 nutlin 3a 51 colorectal cancer CRC 51 geographic atrophy 51 hours postdose 51 pCR 51 symptomatic BPH 51 abnormal glucose tolerance 51 hematologic parameters 51 cardiovascular mortality 51 potentially modifiable 51 #.#ng/ml 51 precancerous cervical 51 renal cysts 51 Genetic predisposition 51 perioperative mortality 51 hormonal abnormalities 51 nonmelanoma skin cancer 51 hypoglycemic episodes 51 hsCRP levels 51 adenomatous 51 HBeAg 51 cerebral oxygenation 51 fluoroquinolone resistance 51 hemodilution 51 socioeconomic status SES 51 leucopenia 51 prefrontal regions 51 VLBW infants 51 MYH9 51 lymphovascular invasion 51 Subgroup analysis 51 SSc 51 waist circumference measurements 51 urinary tract symptoms LUTS 51 infarcts 51 HbA 1c 51 Exclusion criteria 51 VEGF expression 51 dysfunction LVSD 51 plasma homocysteine levels 51 intermittent exotropia 51 macrovascular complications 51 transient elastography 51 sleeve lobectomy 51 Meta analyzes 51 stage IIIb IV 51 coagulopathy 51 FeNO 51 estimated glomerular filtration 51 estimated GFR 51 myopia nearsightedness 51 postoperative atrial fibrillation 51 acetabular dysplasia 51 Colon polyps 51 neurological manifestations 51 pathologic 51 optic nerve sheath 51 comorbid psychiatric 51 T2 lesions 51 NSTE ACS 51 dietary acrylamide 51 lipid abnormalities 51 contralateral breast 51 neuropsychological deficits 51 atypical nevi 51 intraoperative complications 51 poor metabolizers 51 radiographic findings 51 immunocompetent 51 susceptibility loci 51 serum cortisol 51 mmHg diastolic 51 PCA3 scores 51 lymph node involvement 51 prospective multicenter study 51 fulminant hepatic failure 51 perfusion abnormalities 51 micronuclei 51 nanograms milliliter 51 comorbid disorders 51 metastatic lung cancer 51 PSADT 51 symptom exacerbation 51 Moderate drinkers 51 dense LDL 51 stress echocardiography 51 HbA1C levels 51 IgA deficiency 51 visceral adiposity 51 exposed prenatally 51 thyroid hormone levels 51 coronary blockages 51 plasma triglycerides 51 elevated homocysteine 51 histopathologic 51 alcoholic liver 51 oxygen desaturation 51 neurodevelopmental impairment 51 atherosclerotic lesions 51 pulmonary nodules 51 glomerular 51 rhinosinusitis 51 lung adenocarcinomas 51 serum retinol 51 salivary cortisol 51 bowel polyps 51 Orthostatic hypotension 51 lung adenocarcinoma 51 aged ≥ 51 atypical hyperplasia 51 dyssynchrony 51 heterozygotes 51 infective endocarditis 51 DRD2 51 renal tumors 51 ictal 51 alexithymia 51 ADPKD 51 comorbid conditions 51 pulmonary metastasis 51 atypical neuroleptics 51 transrectal ultrasound guided 51 FDG PET 51 immunostaining 51 Coronary artery calcification 51 handgrip strength 51 cross sectionally 51 OGG1 51 Aortic stenosis 51 modifiable lifestyle 51 LVNC 51 abdominal distension 51 neurocognitive function 51 Histologic 51 extramedullary 51 nondiabetics 51 bronchopulmonary dysplasia 51 FDG PET imaging 51 Nonalcoholic fatty liver 51 monogenic 51 hematological parameters 51 gene polymorphism 51 Hb A1c 51 cardiomyopathies 51 external genital lesions 51 carcinoid 51 preoperative PSA 51 observational cohort 51 microscopic colitis 51 PTEN mutations 51 habitual snoring 51 logistic regression analyzes 51 vertebral fracture 51 Epidemiological studies 51 microvascular complications 51 dietary calcium intake 51 fasting glucose levels 51 COPD emphysema 51 HCV antibody 51 Haptoglobin 51 serum cholesterol 51 beta blocker therapy 51 PUFA intake 51 left ventricular hypertrophy 51 menthol cigarette smokers 51 IGRAs 51 H Pylori 51 lactate dehydrogenase 51 impaired insulin secretion 51 Homocysteine levels 51 MYH9 gene 51 Gram stain 51 metastatic lymph nodes 51 noncancer 51 serum HBV DNA 51 GBA mutations 51 nephrolithiasis 51 isolated systolic hypertension 51 Autoimmune hepatitis 51 macronutrient intake 51 HeFH 51 telomerase inhibition 51 Charlson comorbidity index 51 stone formers 51 follicular adenoma 51 genotypic resistance 51 elevated creatinine 51 cTnT levels 51 microalbumin 51 stage IIIA 51 nonpsychotic 51 CI #.#-#.# [002] 51 postoperative mortality 51 resected tumors 51 Comorbidities 51 neuritic 51 dietary antioxidants 51 Cognitive impairment 51 bacterial prostatitis 51 Plasma concentrations 51 brain lesions 51 nondiabetic subjects 51 TMP SMX 51 postoperative complications 51 chronic rhinosinusitis 51 recurrent VTE 51 histopathologic findings 51 persistent wheezing 51 mesangial 51 Multiple logistic regression 51 immunohistochemical staining 51 multivessel disease 51 % CI #.#-#.# [006] 51 aminotransferase 51 DRB1 * 51 nasopharyngeal carcinoma 51 neurologic complications 51 diabetes mellitus 51 hippocampal atrophy 51 antioxidant supplementation 51 inflammatory acne 51 platelet dysfunction 51 carcinoid tumor 51 myocardial dysfunction 51 cerebral oxygen saturation 50 remnant lipoproteins 50 caspofungin 50 ALT flares 50 apolipoprotein E gene 50 vascular reactivity 50 normotensive 50 nonfasting 50 transcatheter closure 50 polygenic 50 ROC curves 50 androgen suppression 50 phylloquinone 50 unmeasured confounders 50 serum biomarkers 50 endobronchial 50 EGFR mutation positive 50 periventricular 50 BRCA mutation carriers 50 Breslow thickness 50 histologic 50 perinatal outcomes 50 PM#.# exposure 50 nonalcoholic fatty liver 50 abacavir Ziagen 50 carbohydrate intolerance 50 myocardial infarctions 50 EDSS scores 50 nonsignificant difference 50 logistic regression models