Related by context. Frequent words. (Click for all words.) 66 daytime drowsiness 64 symptom severity 62 psychosocial functioning 62 daytime sleepiness 62 HRQOL 61 extrapyramidal symptoms 60 depression irritability 60 neuropsychiatric symptoms 60 excessive daytime sleepiness 60 Depressive symptoms 60 decrements 59 apnea hypopnea index 59 excessive sleepiness 58 comorbid conditions 58 fatigue irritability 58 subscales 58 somatic symptoms 58 affective disorders 58 mortality morbidity 58 psychomotor 57 Withdrawal symptoms 57 metabolic parameters 57 RLS symptoms 57 LUTS 57 HRQoL 57 inattention hyperactivity 57 HPA axis 56 Health Assessment Questionnaire 56 anxiety irritability 56 chronic musculoskeletal 56 symptomatology 56 apneas 56 hypoglycemic events 56 prolactin levels 56 tasimelteon 56 morbidity mortality 56 CI -#.# 56 Secondary endpoints include 56 covariate 56 hippocampal volume 56 clinically meaningful improvement 56 UPDRS 56 enuresis 56 Alzheimer Disease Assessment 55 hyperglycaemia 55 coadministration 55 dyskinesias 55 Spasticity 55 concomitant medications 55 hyperactivity impulsivity 55 nasal obstruction 55 arousals 55 interpersonal psychotherapy 55 Main Outcome Measures 55 QTc interval 55 Drowsiness 55 Secondary endpoints included 55 PANSS 55 ventilatory 55 Montgomery Asberg Depression 54 hypoxemia 54 Postoperative 54 cognitive domains 54 retinal thickness 54 sensory neuropathy 54 neuroleptics 54 nonadherence 54 glycemia 54 blood oxygenation 54 COPD exacerbations 54 lipid profiles 54 Outcomes Study 54 fatigue dizziness 54 QoL 54 dyspnea 54 dyspareunia 54 P = .# 54 Unified Parkinson Disease 54 platelet activation 53 metabolic acidosis 53 Global Impression 53 carbohydrate metabolism 53 dysmenorrhea 53 cerebrovascular events 53 GERD symptoms 53 serum concentrations 53 coagulopathy 53 Hyperactivity 53 Irritability 53 diastolic BP 53 lipid parameters 53 serum albumin 53 adrenal insufficiency 53 anhedonia 53 cardiometabolic risk 53 eszopiclone 53 Exclusion criteria 53 generalized anxiety disorder GAD 53 muscle rigidity 53 bowel dysfunction 53 p = .# [002]