multivariate logistic regression

Related by string. Multivariate logistic regression * Multivariate . multi variate : multivariate regression analysis . vitro diagnostic multivariate . multivariate analyzes / LOGISTICS . logistics . Logistics : Logistics Readiness Squadron . Quiet Logistics . Sunoco Logistics Partners LP / Regression . regressions : linear regression . regression analyzes . linear regression analysis * *

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(Click for frequent words.) 82 multiple logistic regression 81 conditional logistic regression 80 multivariable logistic regression 79 univariate 79 Logistic regression 78 multivariate analyzes 78 covariate 78 logistic regression model 78 logistic regression models 77 multivariate Cox 77 Multiple logistic regression 77 Multivariate logistic regression 77 logistic regression analysis 77 Univariate 76 logistic regression 76 covariates 76 logistic regression analyzes 75 multivariable Cox 75 Multivariate analysis 74 multivariable analysis 74 univariate analyzes 74 multiple linear regression 74 Poisson regression 74 bivariate 73 stepwise logistic regression 73 Multiple linear regression 72 Logistic regression analysis 72 multivariate regression 72 univariate analysis 72 Multivariable logistic regression 71 binary logistic regression 71 Univariate analysis 71 multivariate analysis 71 multivariate regression analysis 70 Descriptive statistics 70 Kaplan Meier method 70 APOE genotype 70 Kaplan Meier analysis 70 sociodemographic factors 70 generalized estimating 70 nonparametric 69 multivariable analyzes 69 MDRD 69 bivariate analyzes 69 HOMA IR 69 Mantel Haenszel 69 Kaplan Meier survival 69 spirometric 69 variance ANOVA 68 proportional hazards 68 confidence intervals CIs 68 Linear regression 68 Subgroup analyzes 68 Bonferroni correction 68 NIHSS score 68 bivariate analysis 68 meta regression 68 Kruskal Wallis test 68 nomogram 67 odds ratios ORs 67 Multivariate analyzes 67 F FDG PET 67 tumor histology 67 Subgroup analysis 67 electrophysiologic 67 MetS 66 intraobserver 66 MDRD equation 66 histopathologic 66 explanatory variables 66 Pearson correlation coefficients 66 generalized linear 66 chi squared 66 covariance ANCOVA 66 etiologic 66 potential confounders 66 prognostic variables 66 Multivariable 66 confounders 66 retrospective cohort 66 allele frequencies 66 prostate cancer CaP 66 ANCOVA 65 intact parathyroid hormone 65 HER2 expression 65 metabolite concentrations 65 confounding variables 65 convergent validity 65 sociodemographic characteristics 65 Kaplan Meier curves 65 Postoperative complications 65 ANOVA 65 multivariable adjusted 65 clinico pathological 65 Kaplan Meier curve 65 regression analyzes 65 immunohistochemical 65 K ras mutations 65 myocardial viability 65 interobserver reliability 65 intima media thickness 65 urodynamic 65 multivariable 65 multivariable regression 65 Bonferroni 64 genetic polymorphisms 64 immunohistochemical analysis 64 prognostic factors 64 VKORC1 64 transvaginal sonography 64 MMSE score 64 clinicopathological 64 QTc prolongation 64 ultrasonographic 64 histopathological 64 residual confounding 64 Histopathologic 64 symptomatic VTE 64 pretest probability 64 sociodemographic 64 NMIBC 64 acetabular fractures 64 HIV tropism 64 linear regression analyzes 64 Histologic 64 echocardiographic 64 biochemical recurrence 64 histologic subtype 64 postintervention 64 colorectal adenoma 64 logistic regressions 64 differential gene expression 64 cortical activation 64 oncologic outcomes 64 mammographic density 63 metabolic parameters 63 unpaired t 63 estimated glomerular filtration 63 genotypic resistance 63 ROC curves 63 transcranial Doppler 63 interobserver 63 transabdominal 63 endometrial carcinoma 63 stratifying patients 63 CIN2 + 63 postoperative complication 63 histological subtype 63 semiquantitative 63 Regression analyzes 63 adenotonsillectomy 63 IPAH 63 prospective multicentre 63 neurocognitive impairment 63 postoperative pulmonary 63 transesophageal echocardiography 63 posttreatment 63 CYP#D# gene 63 nomograms 63 color Doppler sonography 63 correlational 63 Cardiorespiratory fitness 63 serum estradiol 63 hip resurfacing arthroplasty 63 microalbumin 63 prospective multicenter study 63 linear regression analysis 63 angiographically 63 PSADT 63 Meta analyzes 63 transthoracic 63 CYP#D# genotype 63 estimated GFR 63 obstructive coronary artery 63 premorbid 63 glomerular filtration rate 63 autonomic dysfunction 63 neurocognitive function 63 NHANES III 63 physiologic parameters 63 prognostic significance 63 retrospective cohort study 63 nodal metastasis 63 core needle biopsies 63 histopathologic examination 62 covariance 62 Multivariate 62 FDG PET CT 62 rs# [004] 62 D dimer 62 endometrial thickness 62 prostate carcinoma 62 subgroup analyzes 62 clinicopathologic 62 transrectal ultrasound guided 62 anthropometric measurements 62 confounder 62 glycated hemoglobin levels 62 posttest 62 coronary stenosis 62 COMT genotype 62 diabetes mellitus DM 62 sociodemographic variables 62 hyperinsulinemic euglycemic clamp 62 immunohistochemical staining 62 Pearson correlation coefficient 62 deCODE BreastCancer TM 62 carotid IMT 62 sonographic findings 62 urolithiasis 62 Kaplan Meier 62 prospectively defined 62 Liver biopsies 62 psychiatric comorbidity 62 multivariate 62 Secondary efficacy endpoints 62 plasma pharmacokinetics 62 prolonged QT interval 62 transient elastography 62 comorbidity 62 preoperative PSA 62 serum GGT 62 breast carcinoma 62 airway hyperresponsiveness 62 prognostic indicators 62 Regression analysis 62 Symptom severity 62 echocardiographic parameters 62 alexithymia 62 Echocardiographic 62 BRCA2 mutation carriers 62 exploratory endpoints 62 Reynolds Risk Score 62 meta analytic 62 transthoracic echocardiography 62 transrectal ultrasonography 62 airway responsiveness 62 genomewide 62 thyrotropin levels 62 RRM1 62 Glomerular filtration rate 62 glycosylated hemoglobin HbA1c 62 affective psychosis 62 ImmuKnow assay 62 cerebral microbleeds 62 dimensional echocardiography 62 liver transplant recipients 62 chest radiographs 62 proximal femur 62 Interrater reliability 62 hierarchical clustering 62 F FDG uptake 62 anti Mullerian hormone 62 ABCB1 61 multivariate adjustment 61 kidney allograft 61 coronary calcification 61 albumin excretion 61 histologic findings 61 #F FDG PET 61 postoperative mortality 61 System IPSS 61 ASCUS 61 transcranial Doppler ultrasound 61 node metastases 61 familial aggregation 61 inhibin B 61 warfarin dosage 61 fluorodeoxyglucose positron emission tomography 61 histopathologic diagnosis 61 MGUS 61 acetabular fracture 61 FDG PET imaging 61 Kruskal Wallis 61 prespecified secondary 61 orofacial clefts 61 bronchopulmonary dysplasia BPD 61 RT PCR assay 61 pharmacodynamic parameters 61 proband 61 hsCRP levels 61 antidiabetic medication 61 fasting insulin 61 albumin creatinine ratio 61 CVD mortality 61 EUS FNA 61 longitudinal cohort study 61 EQ 5D 61 virological response 61 FDG PET scans 61 haematologic 61 adenoidectomy 61 HRQL 61 MR spectroscopy 61 morphometric vertebral fractures 61 clinicopathological features 61 Doppler echocardiography 61 #q# deletion 61 Logistic regression models 61 renal cysts 61 contrast echocardiography 61 genotypic 61 euthymic patients 61 CC genotype 61 Observational studies 61 glomerular filtration 61 lymph node metastasis 61 randomized controlled trials RCTs 61 exhaled nitric oxide 61 microsatellite instability 61 liver biopsies 61 cTnT 61 perfusion MRI 61 Heavy menstrual bleeding 61 d dimer 61 cystoscopic 61 apolipoproteins 61 urothelial carcinoma 61 Computed tomography 61 CHADS2 61 AST ALT 61 hematological parameters 61 intraclass correlation coefficients 61 Lymph node 61 atypical hyperplasia 61 BMD measurements 61 Wilcoxon rank sum 61 pericardial effusion 61 thyroid hormone levels 61 perioperative complications 61 eNO 61 Child Behavior Checklist 61 STRIDE PD 61 Sensitivity analyzes 61 postoperative atrial fibrillation 61 Tasigna prolongs 61 adnexal mass 61 PCa 61 scintigraphic 61 differentially expressed genes 61 comorbid conditions 61 unmeasured confounders 61 prospective cohort 61 overnight polysomnography 61 carotid atherosclerosis 61 HRCT 61 endometrial hyperplasia 61 sleeve lobectomy 60 β blockers 60 genes CYP#C# 60 BMI z 60 Insulin sensitivity 60 FDG uptake 60 cardioembolic stroke 60 extramedullary 60 atherosclerotic lesion 60 thyrotropin 60 predictor variables 60 T2D 60 HER2 overexpression 60 subclinical hypothyroidism 60 preintervention 60 Brief Psychiatric 60 psychiatric comorbidities 60 HRQOL 60 intraoperative complications 60 subclinical atherosclerosis 60 recursive partitioning 60 CSF biomarkers 60 metaplasia 60 spiral computed tomography 60 sonographically guided 60 KRAS mutation 60 cytologic 60 CYP#C# genotype 60 potential confounding variables 60 Pharmacokinetic parameters 60 pretransplant 60 LVNC 60 anti JCV antibodies 60 advanced neoplasia 60 Index CDAI 60 microalbuminuria 60 transcatheter closure 60 periprocedural 60 LV dysfunction 60 perioperative morbidity 60 DNA methylation patterns 60 aspartate aminotransferase AST 60 histopathologic findings 60 UGT#A# * 60 Skin sterol 60 postoperative AF 60 albumin excretion rate 60 left ventricular diastolic 60 gastric carcinoma 60 abdominal adiposity 60 RE LY trial 60 morphologic 60 retrospective observational study 60 esophageal carcinoma 60 PITX2 60 susceptibility loci 60 retest reliability 60 adenoma recurrence 60 preoperative intraoperative 60 comorbidities 60 methacholine challenge 60 differentiate squamous 60 Neuropsychiatric Inventory NPI 60 DEXA scan 60 laterality 60 hepatic fibrosis 60 HNSCC 60 mRNA expression 60 PSA kinetics 60 nodal metastases 60 virologic responses 60 GABRA2 60 epistasis 60 Response Evaluation Criteria 60 transrectal ultrasound 60 regression coefficient 60 NAMCS 60 preimplantation 60 glaucomatous 60 CTEPH 60 duplex ultrasonography 60 perinatal outcomes 60 hallux valgus 60 preoperatively 60 pharmacokinetics PK 60 acute aortic dissection 60 carotid stenosis 60 GH deficiency 60 thromboembolism 60 Genetic variants 60 FDG PET 60 urodynamic studies 60 FEV ^ sub 60 MTT assay 60 preoperative staging 60 CORE OM 60 regression equations 60 pCR 60 vascular dysfunction 60 chronicity 60 postdischarge 60 pelvic ultrasound 60 cardiac troponin T 60 hepatectomy 60 Logistic regression analyzes 60 hamartomas 60 SNP rs# [002] 60 pairwise comparisons 60 radioimmunoassay 60 Genotypic 60 precursor lesions 60 gadolinium enhanced 60 IGRAs 60 STEP BD 60 sentinel lymph node biopsy 60 anal HPV 60 mucinous 60 tertile 60 serum phosphorous 60 INTERHEART study 60 pelvic lymphadenectomy 60 fFN 60 intraventricular 60 isoprostane 60 neonatal morbidity 60 progesterone receptor PR 60 percutaneous biopsy 60 hepatic lesions 60 psychosocial variables 60 seropositivity 60 ADCS CGIC 60 Doppler sonography 60 plain radiographs 60 abdominal ultrasound 60 interrater reliability 60 EuroSCORE 59 parous women 59 cTnT levels 59 serum biomarkers 59 #q# deletion syndrome 59 Immunohistochemical analysis 59 observational cohort study 59 nonfatal MI 59 rs# [001] 59 Cardiopulmonary bypass 59 TCF#L# gene 59 Depressive symptoms 59 gallstone disease 59 advanced adenoma 59 ventilation perfusion 59 hematopoietic cancers 59 sonographically 59 linear regressions 59 postoperative morbidity 59 thyroglobulin 59 hepatorenal syndrome 59 arterial thickening 59 Framingham Risk Score 59 SLNB 59 hamartoma 59 Sociodemographic 59 cystatin C 59 dopamine receptor gene 59 symptomatic pulmonary embolism 59 FDG-PET/CT 59 cerebral angiography 59 metabolic dysfunction 59 coronary CTA 59 heterotaxy 59 bronchoalveolar lavage 59 nulliparous women 59 serum PTH 59 VCUG 59 hypogonadotropic hypogonadism 59 nonfasting triglyceride levels 59 clomipramine 59 aneurysmal subarachnoid hemorrhage 59 mL/min/#.# m 2 59 hormone receptor status 59 gastric cardia 59 EGFR mutation status 59 Radical prostatectomy 59 neuropsychological assessment 59 immunostaining 59 somatoform disorders 59 methylation patterns 59 surrogate markers 59 dosimetric 59 CHD mortality 59 sonographic examination 59 coinfected patients 59 dyssynchrony 59 fetal malformations 59 lipoprotein levels 59 secondary efficacy endpoint 59 RE LY ® 59 venous thromboembolic disease 59 renal artery stenosis 59 preoperative diagnosis 59 Solid Tumors RECIST 59 colonoscopic 59 BMI waist circumference 59 thrombophilia 59 Hemodynamic 59 statistically nonsignificant 59 definite stent thrombosis 59 Non inferiority 59 histopathological examination 59 advanced adenomas 59 dose proportionality 59 thyroid stimulating hormone TSH 59 renal biopsy 59 atherogenic dyslipidemia 59 DAS# CRP 59 comorbid anxiety 59 late onset hypogonadism 59 serum lipid levels 59 thoracolumbar spine 59 histologic 59 precancerous cervical 59 SYNTAX trial 59 underwent coronary angiography 59 fetal echocardiography 59 BEXXAR Therapeutic Regimen 59 neurodevelopmental outcome 59 gene polymorphisms 59 troponins 59 lymphovascular invasion 59 tertiles 59 MDCT angiography 59 prospective longitudinal 59 Carotid Revascularization Endarterectomy vs. 59 CYP#C# [002] 59 chest radiograph 59 WOMAC pain 59 carotid intima media 59 GSTP1 59 antibody titer 59 urine albumin 59 adiponectin concentrations 59 specific antigen PSA 59 atherothrombotic 59 plasma cortisol 59 biochemical relapse 59 Baseline characteristics 59 subclinical hyperthyroidism 59 APOE e4 59 liver metastasis 59 pre operatively 59 neurophysiologic 59 CYP#C# [001] 59 adverse perinatal 59 postoperative hemorrhage 59 Zevalin consolidation 59 heterozygotes 59 dichotomous variables 59 Main Outcome Measure 59 inflammatory biomarkers 59 locoregional 59 hyperintense lesions 59 morphometric 59 arteriography 59 TRUS 59 posttransplant 59 familial AF 59 polysomnogram 59 S. maltophilia 59 FeNO 59 acetabular dysplasia 59 Severity MSCS score 59 SUVmax 59 pre eclamptic 59 PSA nadir 59 Postoperative 59 serum testosterone 59 bile acid metabolism 59 curative resection 59 miRNA expression 59 vesicoureteral reflux 59 ratio WHR 59 thromboembolic complications 59 familial clustering 59 elevated IOP 59 APACHE II 59 helical CT 59 body fatness 59 Framingham Offspring 59 electroencephalographic 59 radical retropubic prostatectomy 59 NIHSS 59 osteopenic 59 systolic dysfunction 59 SLN biopsy 59 CYP#C# gene 59 corrected QT interval 59 variant rs# 59 LRP5 59 Histological 59 femoral neck fracture 59 haemodynamic 59 varicoceles 59 glycated hemoglobin HbA1c 59 Sentinel Lymph Node Biopsy 59 clinically localized prostate 59 OGTT 59 HIV seroconversion 59 lactate dehydrogenase 59 CT perfusion 59 microsimulation model 59 hemodynamic variables 59 neuropathological 59 liver steatosis 59 DNA methylation markers 59 sensitivity specificity 59 incidentalomas 59 RECIST Response Evaluation Criteria 59 Ebstein anomaly 59 IL#B 59 noncardiac 58 genotype phenotype 58 PCI ExTRACT TIMI 58 polysomnography PSG 58 intracardiac 58 2D 4D ratio 58 overt hypothyroidism 58 aortic annulus 58 monozygotic 58 prostate cancer PCa 58 nonvertebral fracture 58 depressive symptomatology 58 metaanalysis 58 genetic loci 58 chromosomal aberrations 58 T2DM 58 HRQoL 58 radical cystectomy 58 axial length 58 creatinine clearance CrCl 58 serum BDNF 58 transcriptional profiling 58 SSc 58 androgen suppression 58 vasogenic edema 58 serum IGF 58 perimenopausal women 58 aldosterone antagonist 58 Lp PLA 2 58 ductal breast cancer 58 hepatocellular carcinomas 58 postoperative infections 58 aortic regurgitation 58 pancreatic adenocarcinoma 58 T1DM 58 oophorectomy 58 digital rectal examination 58 waist circumference WC 58 ADAS cog 58 recurrent venous thromboembolism 58 malignant polyps 58 postmenopausal hormone 58 hemorrhagic complications 58 hyperplastic 58 aortic atherosclerosis 58 Randomized trials 58 intima media thickness IMT 58 Visual Analogue Scale VAS 58 pharmacokinetic PK 58 Pathologic 58 calculated creatinine clearance 58 Diseases Ninth 58 varicocele 58 epithelial ovarian cancer 58 chlamydial infection 58 perinatal complications 58 pharmacodynamic effects 58 antidiabetic medications 58 linear regression 58 perioperatively 58 NRF2 gene 58 TMPRSS2 ERG fusion 58 adnexal masses 58 postprocedure 58 Primary endpoints 58 pathologic examination 58 longitudinal observational study 58 creatinine ratio 58 KRAS status 58 LV ejection fraction 58 nondiabetic patients 58 breast cancer subtypes 58 bronchial hyperresponsiveness 58 telomere lengths 58 co receptor tropism 58 computed tomography CT scan 58 ICD implantation 58 recurrent VTE 58 BRAF V#E mutation 58 lethal arrhythmias 58 Tumor Response 58 coronary arteriography 58 CP CPPS 58 metabolic syndrome MetS 58 ischemic lesions 58 thyroid nodule 58 fundus photography 58 ductal carcinomas 58 coronary endothelial 58 pathologic diagnosis 58 prognostic markers 58 baseline FEV 58 potentially confounding variables 58 carotid plaque 58 BMI percentile 58 cervicitis 58 retrospectively analyzed 58 APOC3 58 statistically significant correlations 58 peripartum 58 ADPKD 58 fraternal twin pairs 58 undergoing coronary angiography 58 Inhibin B 58 Estrogen Receptor 58 aortic stiffness 58 rs# [002] 58 transgene expression 58 TNM staging 58 bone scintigraphy 58 Rating Scale BPRS 58 cTnI 58 detrusor overactivity 58 cerebral perfusion 58 apolipoprotein E4 58 methylenetetrahydrofolate reductase 58 ^ sup #m 58 micrometastasis 58 serum concentrations 58 anterior temporal 58 pulmonary artery banding 58 QIDS SR 58 urethral stricture 58 Immunohistochemical 58 abnormal cytology 58 genomic alterations 58 leiomyoma 58 vitro experiments 58 karyotypes 58 induced sputum 58 TURBT 58 serum testosterone levels 58 RVOT 58 GAMMAGARD 58 inferential statistics 58 postoperative delirium 58 Cytogenetic 58 actigraphy 58 proliferative retinopathy 58 pyridostigmine 58 Hb A1C 58 pyelonephritis 58 adrenalectomy 58 ER CHOP 58 microscopic hematuria 58 platelet reactivity 58 HER2 amplification 58 Main Outcome Measures 58 estrogen receptor ER 58 serum cotinine 58 adjuvant systemic 58 % CI #.#-#.# [006] 58 anthropometric measures 58 radioligand 58 aminotransferase levels 58 SGRQ 58 IgG antibody 58 multivariate statistical 58 Prehypertension 58 chorioamnionitis 58 diffusion tensor 58 Unified Parkinson Disease 58 symptom exacerbation 58 carotid plaques 58 NNT = 58 incomplete revascularization 58 creatinine clearance 58 corneal topography 58 preoperative 58 subscores 58 predictive validity 58 affective psychoses 58 Rh factor 58 ertapenem 58 Abdominal ultrasound 58 rCBF 58 SpCO 58 computed tomographic scans 58 RT qPCR 58 nonobese 58 RQ PCR 58 Endothelial dysfunction 58 KRAS mutation status 58 demographic variables 58 apparent diffusion coefficient 58 Cronbach alpha 58 afterload 58 pharmacodynamic PD 58 impaired insulin secretion 58 TRUS biopsy 58 Thrombolysis 58 obstructive coronary 58 prospectively stratified 58 anovulation 58 anthropometry 58 IKDC 58 Bacterial vaginosis 58 Hazard Ratio HR 58 ECG abnormalities 58 Preoperative 58 BRCA gene mutation 58 fetal chromosomal 58 HAQ DI 58 serum leptin 58 diastolic pressures 58 aneuploidy screening 58 malignant lesions 58 hematological relapse 58 #.#ng/ml 58 orthologous genes 58 SNP rs# [001] 58 ECLS 58 pharmacodynamic markers 58 aortic calcification 58 axillary lymph nodes 58 seminal vesicle invasion 58 tumorigenicity 58 Preoperatively 58 Flow cytometry 58 basal bolus regimen 58 PIB PET 58 Alzheimer Disease Assessment 58 nonpharmacologic 58 Cystatin C 58 NHAMCS 58 5 HTTLPR 58 sonographic diagnosis 58 FGFR2 gene 58 tipranavir ritonavir 58 angiographic outcomes 58 reflux esophagitis 58 unfavorable prognostic 58 statistical significance p 58 IgA deficiency 58 aminotransferases 58 neuropathologic 58 sonographic appearance 58 invasive carcinoma 58 impaired endothelial 58 hypercalciuria 58 leiomyomas 58 trials RCTs 58 MSH2 57 upper endoscopy 57 oral glucose tolerance 57 Complication rates 57 ELBW infants 57 urine cytology 57 LNG IUS 57 Secondary endpoints 57 inotropic agents 57 silent myocardial ischemia 57 C#Y 57 gestational diabetes mellitus 57 subtrochanteric 57 intra abdominal abscess 57 Glomerular Filtration Rate 57 endometrial biopsy 57 statistically significant correlation 57 hip BMD 57 plasma creatinine 57 carotid bruit 57 Doppler ultrasonography 57 parous 57 androgen deprivation 57 PITX2 methylation 57 fluorescein angiography 57 Radiographs 57 fetuin 57 computed tomographic 57 penetrance 57 immunoblotting 57 polygenic 57 serum PSA 57 monozygotic twin 57 intraventricular hemorrhage 57 COL#A# 57 microarray experiments 57 serum bilirubin 57 nonmelanoma skin cancers 57 normotensive 57 microvessel 57 relapsed MM 57 clinically meaningful improvement 57 HbA 1c levels 57 Socio demographic 57 ConclusionThis 57 % CI #.#-#.# [004] 57 Recurrence Score 57 DAS# [002] 57 nodal dissection 57 mutated K ras 57 syndromic 57 parasitaemia 57 ultrastructural 57 confidence interval #.#-#.# 57 digital subtraction angiography 57 diastolic velocity 57 ß blockers 57 Pharmacodynamic 57 quantitative EEG 57 pT3 57 invasive prenatal 57 Comorbidity 57 BioMAP ® 57 pretargeting 57 PCNSL 57 K#N 57 radical prostatectomy RP 57 tumor subtype 57 coronary catheterization 57 CIN3 57 logit 57 pulmonary angiography 57 recurrent miscarriage 57 homozygote 57 Eur Urol 57 vertebral fracture 57 thoracoscopic lobectomy 57 pharmacokinetic parameters 57 chromosomal rearrangement 57 APOL1 57 esophageal reflux 57 conventional coronary angiography 57 operable breast cancer 57 handgrip strength 57 monoclonal gammopathy 57 mammographically 57 thyroid nodules 57 GnRH agonists 57 lung epithelium 57 serum cortisol 57 coronary artery stenosis 57 KRAS mutations

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