Related by context. Frequent words. (Click for all words.) 72 hyperinsulinemia 71 proinflammatory 70 dysregulated 70 demyelination 70 Aß 70 synaptic transmission 69 glutamate receptors 69 mitochondrial dysfunction 69 catecholamine 69 HPA axis 69 neurodegeneration 69 pathophysiological 69 neurofibrillary tangles 69 amyloid deposits 69 cyclooxygenase 2 69 dopaminergic 69 downregulation 68 neuroendocrine 68 dopaminergic neurons 68 glucose homeostasis 68 dysregulation 68 cholinergic 68 superoxide dismutase 68 proinflammatory cytokines 68 protein kinase C 68 metabolic abnormalities 68 transgenic mouse model 68 molecular mechanisms underlying 68 proteolysis 68 behavioral abnormalities 68 malignant transformation 68 neurotransmission 68 neurodegenerative disorder 67 upregulation 67 remyelination 67 neuronal cell 67 lung fibrosis 67 synaptic plasticity 67 muscular dystrophies 67 transcriptional regulation 67 hypothalamic 67 neurotransmitter glutamate 67 Oxidative stress 66 tau protein 66 myelination 66 cerebellar 66 neuroprotective effects 66 induce apoptosis 66 vascular inflammation 66 apoE 66 induced apoptosis 66 anti apoptotic 66 GPR# [002] 66 brain lesions 66 platelet activation 66 Wnt signaling 66 IL 1beta 65 neuronal 65 monocyte 65 carbohydrate metabolism 65 presynaptic 65 neuropathological 65 Neuronal 65 mRNA expression 65 developmental abnormalities 65 induces apoptosis 65 eNOS 65 NMDA receptors 65 chronicity 65 fatty acid metabolism 65 overactivity 65 CTGF 65 Aβ 65 neovascularization 65 neuropsychiatric disorders 65 partial agonist 65 inflammatory mediators 65 cellular pathways 65 neurogenic 65 axonal 65 serotonin receptor 65 serotonergic 64 pro apoptotic 64 Notch signaling 64 Overexpression 64 osteopontin 64 degenerative disorders 64 glial 64 dimerization 64 serotonin transporter 64 parkinsonism 64 cognitive deficits 64 peripheral tissues 64 ubiquitination 64 protein misfolding 64 metabolic acidosis 64 cognitive dysfunction 64 anti fibrotic 64 progranulin 64 evolutionarily conserved 64 enzymatic activity