Related by context. Frequent words. (Click for all words.) 79 safety tolerability 77 pharmacodynamics 73 pharmacokinetics 69 dose escalation trial 69 label dose escalation 68 pharmacokinetic profile 68 tolerability 68 tolerated dose MTD 67 dose escalation study 66 single ascending dose 65 pharmacodynamic 65 blind placebo controlled 64 blind randomized placebo 64 Phase 2a trial 64 Phase 2b study 64 pharmacokinetic 64 multiple ascending dose 63 placebo controlled 63 Phase Ib 63 investigational oral 63 Phase 1b 63 dosing regimens 62 randomized placebo controlled 62 double blind placebo 62 multicenter randomized double 61 Phase IIa trial 61 randomized double 60 Phase 2a clinical 60 mg BID 60 dose limiting toxicities 60 Phase IIa clinical 60 efficacy 60 immunogenicity 60 randomized #:# 60 blind randomized 59 CYT# 59 Phase IIa 59 dose escalation 59 randomized controlled 58 RG# [001] 58 GRN#L 58 Phase IIb clinical 58 plus ribavirin 58 phase IIb 57 antiviral activity 57 antitumor activity 57 investigational drug 57 Phase 2b clinical 57 Phase 2b trial 57 dose regimen 57 Phase IIb trial 57 HGS ETR1 57 randomized clinical 57 mg dose 57 randomized 57 investigational compound 56 PF # [001] 56 non inferiority 56 docetaxel 56 RDEA# 56 gemcitabine 56 mg/m2 56 monotherapy 56 mixed dyslipidemia 56 Phase IIb 56 Phase 2a 55 antisense drug 55 IMGN# 55 eculizumab 55 orally administered 55 NGX# 55 relapsing remitting multiple sclerosis 55 tolerability profile 55 LEVADEX 55 mitoxantrone 55 randomized Phase 55 randomized controlled clinical 55 administered orally 55 pivotal Phase 55 prospective randomized 55 Secondary endpoints include 55 Phase III clinical 55 bevirimat 54 cytarabine 54 adalimumab 54 pivotal Phase III 54 G CSF 54 FOLFOX 54 ISIS # 54 ofatumumab 54 pegylated interferon 54 AP# [003] 54 receptor antagonist 54 multicenter 54 plasma concentrations 54 mg kg 54 clinical trial 54 active metabolite 54 humanized monoclonal antibody 54 CRx 54 carboplatin