Related by context. Frequent words. (Click for all words.) 81 secondary endpoint 80 primary endpoint 76 primary endpoints 76 primary efficacy endpoint 66 demonstrated statistically significant 65 clinical endpoints 64 statistically significant improvement 63 pharmacodynamic 63 non inferiority 60 evaluable 60 statistically significant reduction 59 tolerability 58 clinically meaningful 58 placebo 57 evaluable patients 57 mg dose 57 free survival PFS 57 p = #.# [002] 57 statistical significance 57 placebo p 56 endpoints 56 statistically significant 55 statistically significant differences 55 monotherapy 55 Phase 2b study 55 placebo controlled 55 dosing regimens 55 placebo p = 55 ACTEMRA 55 LEVADEX 54 clinically relevant 54 p = #.# [004] 54 docetaxel 54 etanercept 53 Efficacy 53 certolizumab pegol 53 pharmacokinetic 53 Phase 1b 53 P = .# 53 randomized 52 post hoc 52 p = 52 randomized double 52 reach statistical significance 52 efficacy 52 INCB# [002] 52 sunitinib 52 mg kg 52 prognostic factors 52 pharmacokinetics 52 randomized controlled 52 double blind placebo 52 dyspnea 52 Phase 2a clinical 51 FEV1 51 bortezomib 51 tolerability profile 51 Phase 2b clinical 51 mg doses 51 n = 51 pioglitazone 51 plasma concentrations 51 ADX# 51 safety tolerability 51 budesonide 51 imatinib 50 Phase 2b 50 infliximab 50 Phase IIa clinical 50 AZD# 50 randomized placebo controlled 50 Phase Ib 50 tumor shrinkage 50 hematologic 50 Phase 2a 50 Phase IIa 50 belimumab 50 Phase IIa trial 50 DSMB 50 RCTs 50 antitumor activity 50 Phase IIb clinical 50 ≥ 50 mg/m2 49 HCV RNA 49 gefitinib 49 renal function 49 pegylated interferon 49 Phase IIb 49 trastuzumab 49 randomized clinical trials 49 pharmacokinetic profile 49 allopurinol 49 randomization 49 cethromycin 49 HbA1c 49 unblinded 49 dasatinib 49 randomized clinical 49 sirolimus 49 pharmacologic