Related by context. All words. (Click for frequent words.) 73 homocysteine concentrations 71 plasma folate 71 folate deficiency 70 serum uric acid 70 dietary calcium intake 70 folate concentrations 69 serum phosphate 69 serum vitamin D 69 thyrotropin 69 elevated homocysteine 69 serum urate levels 69 serum homocysteine 69 serum lipid levels 68 atherogenic dyslipidemia 68 plasma homocysteine levels 68 urate levels 68 serum BDNF 68 serum folate 68 Calcium intake 68 transferrin saturation 68 HER2 expression 68 thyrotropin levels 68 albumin excretion 67 plasma homocysteine 67 colorectal adenoma 67 serum estradiol 67 folate intake 67 serum ferritin 67 subclinical hypothyroidism 67 8 OHdG 67 intact parathyroid hormone 67 tHcy 67 urinary oxalate 67 plasma pharmacokinetics 66 nonfasting triglycerides 66 beta carotene supplementation 66 serum IGF 66 vitamin D inadequacy 66 abdominal adiposity 66 subclinical atherosclerosis 66 serum LDL cholesterol 66 dietary folate 66 antioxidant supplementation 66 CVD mortality 66 serum triglycerides 66 hyperhomocysteinemia 65 serum calcium 65 lipid elevations 65 serum parathyroid hormone 65 impaired glucose metabolism 65 adiponectin concentrations 65 fasting glucose levels 65 hydroxyvitamin D levels 65 serum cortisol 65 albumin excretion rate 65 hsCRP levels 65 elevated triglycerides 65 serum PTH 65 extracellular dopamine 65 HOMA IR 65 colorectal adenomas 65 choline intake 65 urinary cadmium 65 folic acid intake 65 subclinical hyperthyroidism 65 #OHD 65 serum testosterone 65 dyslipidaemia 65 elevated CRP 65 dietary sodium 65 plasma lipid 65 N telopeptide 65 serum retinol 65 dietary sodium intake 65 triacylglycerol concentrations 64 serum selenium 64 bioavailable testosterone 64 Inhibin B 64 urinary albumin 64 T2DM 64 Homocysteine 64 urinary excretion 64 SGPT 64 glomerular filtration 64 serum urate 64 gastric cardia 64 antibody titer 64 creatinine ratio 64 hypovitaminosis D 64 androgen deficiency 64 serum concentrations 64 prostate cancer CaP 64 non fasting triglycerides 64 serum leptin 64 polyp recurrence 64 alanine aminotransferase 64 magnesium intake 64 psychiatric morbidity 64 serum PSA 64 gallstone disease 64 plasma triglycerides 64 periprocedural MI 64 uric acid levels 64 prolactin levels 64 troponin T 64 coronary calcification 63 hyperphenylalaninemia HPA due 63 serum calcium levels 63 elevated creatinine 63 serum potassium 63 fructose intake 63 atherothrombotic disease 63 abnormal lipid 63 AST ALT 63 plasma selenium 63 thyroid hormone levels 63 elevated uric acid 63 urinary albumin excretion 63 serum sodium 63 urinary N telopeptide 63 plasma leptin 63 serum CRP 63 fasting insulin 63 urinary calcium 63 histologic subtype 63 neurodevelopmental outcome 63 aminotransferase 63 psychiatric comorbidity 63 secondary hyperparathyroidism 63 methylmalonic acid 63 multivariable analysis 63 IUGR 63 CHD mortality 63 colorectal cancer incidence 63 T1DM 63 lactate dehydrogenase LDH 63 hypercalcaemia 63 selenium intake 63 #OHD levels 63 postmenopausal hormone 63 chromium supplementation 63 overt hypothyroidism 63 serum prostate 63 serum cholesterol 63 hydroxyvitamin D concentrations 63 leukocyte counts 63 elevated ALT 63 Nocturia 63 mg BID dose 63 vitamin D intakes 63 atherosclerotic progression 63 glycosylated hemoglobin HbA1c 63 depressive symptomatology 63 cardio respiratory fitness 63 paricalcitol 63 HGPIN 63 adenoma recurrence 63 Cognitive impairment 63 glycated hemoglobin HbA1c 63 inhibin B 62 nephrotoxicity 62 cTnT levels 62 carotid plaque 62 HbA 1c 62 neurodevelopmental outcomes 62 autonomic dysfunction 62 μg L 62 euthyroid 62 triglyceride concentrations 62 diabetes mellitus DM 62 blood phenylalanine Phe 62 chlamydial infection 62 atherosclerotic vascular disease 62 Cystatin C 62 rs# [002] 62 antiandrogens 62 apolipoprotein B 62 serum creatinine levels 62 tHcy concentrations 62 Homocysteine levels 62 Insulin sensitivity 62 Serum calcium 62 serum bilirubin 62 Folate deficiency 62 HIV HCV coinfected 62 Helicobacter pylori infection 62 dietary intakes 62 nitrotyrosine 62 oxcarbazepine 62 triacylglycerol 62 elevated triglyceride levels 62 adiponectin levels 62 corticosteroid dose 62 serum albumin 62 iodine intake 62 hemoglobin concentration 62 Hb A1C 62 μmol L 62 lipoprotein Lp 62 Hyperlipidemia 62 TT genotype 62 recurrent venous thromboembolism 62 dose Iluvien 62 chronic periodontitis 62 hsCRP 62 nonalcoholic steatohepatitis NASH 62 LDL cholesterol concentrations 62 hypercalciuria 62 β blockers 62 haematologic 62 density lipoprotein cholesterol HDL 62 Lp PLA 2 62 platelet reactivity 62 scintigraphic 62 stone formers 62 poor metabolizers 62 hemoglobin concentrations 62 premenstrual syndrome PMS 62 fetuin 62 Drospirenone 62 euthymic 62 carotid IMT 62 atypical ductal hyperplasia 62 malondialdehyde 62 Elevated serum 62 Proteinuria 62 myeloperoxidase 62 alanine aminotransferase ALT 62 advanced adenoma 62 iPTH 62 calcium intakes 62 protein excretion 62 neutrophil counts 61 fructose intolerance 61 Prehypertension 61 plasma cortisol 61 myocardial ischaemia 61 elevated LDH 61 serum phosphate levels 61 aminotransferase levels 61 ABCB1 61 phytoestrogen intake 61 colorectal neoplasia 61 postoperative AF 61 plasma lipids 61 HbA1C 61 PHPT 61 arterial thickening 61 atherogenic 61 c reactive protein 61 metabolic syndrome MetS 61 differential gene expression 61 tumor histology 61 elevated IOP 61 calcium excretion 61 lactate dehydrogenase 61 highest quintile 61 subsyndromal 61 mRNA expression 61 SHBG levels 61 aminotransferase ALT 61 phylloquinone 61 C Reactive Protein 61 HbA 1c levels 61 antihypertensive therapy 61 HbA1C levels 61 STRIDE PD 61 serum glucose 61 nonfasting triglyceride levels 61 medication nonadherence 61 trans palmitoleate 61 shorter telomere length 61 myocardial fibrosis 61 MetS 61 antiphospholipid antibodies 61 Skin sterol 61 amino acid homocysteine 61 urinary BPA 61 metabolite concentrations 61 pressure natriuresis 61 dietary intake 61 rCBF 61 Heavy menstrual bleeding 61 CLA supplementation 61 HeFH 61 Creatinine 61 urinary iodine 61 visceral adiposity 61 urine albumin 61 oesophageal adenocarcinoma 61 CC genotype 61 elevated LDL cholesterol 61 isoflavone intake 61 nonvertebral fracture 61 urinary tract symptoms LUTS 61 Hypercholesterolemia 61 B7 H3 61 prolonged QT interval 61 thyroid dysfunction 61 adrenal function 61 NQO1 61 salivary flow 61 lignan intake 61 ß carotene 61 tocopherol 61 carotid stenosis 61 DHEA supplementation 61 hydroxy vitamin D 61 gastric carcinoma 61 chronic prostatitis 61 microvascular complications 61 exhaled nitric oxide 61 penetrance 61 CP CPPS 61 aspartate aminotransferase AST 61 Endothelial dysfunction 61 lowest tertile 61 rs# [001] 61 blood Phe levels 61 inadequate calcium intake 61 tertiles 61 urolithiasis 61 Adenomas 61 serum ALT 61 inflammatory biomarkers 61 Androgen 61 alkaline phosphatase 61 lymphocyte counts 61 echocardiographic parameters 61 heterozygotes 61 serum insulin 61 eosinophil count 61 sUA 61 anovulatory infertility 61 prostate carcinogenesis 61 serum bicarbonate 61 #q# deletion syndrome 61 sitosterol 61 hemoglobin A1c HbA1c 61 serum TSH 61 fasting plasma glucose FPG 61 HER2 overexpression 61 elevated LDL 61 chloride secretion 61 HDL Cholesterol 61 folate vitamin B 61 VaD 60 serotonin synthesis 60 liver enzymes ALT 60 cerebral oxygenation 60 Vitamin D supplementation 60 density lipoprotein cholesterol 60 BMI z 60 arterial calcification 60 nanograms milliliter 60 aspartate aminotransferase 60 endogenous estrogen 60 serum triglyceride 60 Subgroup analyzes 60 tic severity 60 hematopoietic cancers 60 Albuminuria 60 MMSE scores 60 K DOQI 60 serum IgE 60 umol L 60 serum lipids 60 circulating EPCs 60 univariate analyzes 60 serum lipid 60 vitamin K1 60 Nonalcoholic Fatty Liver Disease 60 deferiprone 60 atrophic gastritis 60 Depressive symptoms 60 IDDM 60 Prostate Specific Antigen PSA 60 antigen PSA levels 60 Dietary intake 60 hip BMD 60 VLBW 60 IL 1ß 60 GH deficiency 60 SCr 60 KIF6 carriers 60 Epidemiologic studies 60 ADPKD 60 Ischemic 60 left ventricular diastolic 60 Prostate specific antigen 60 intestinal permeability 60 body fatness 60 prenatal exposures 60 aminotransferases 60 inhibin 60 H. pylori eradication 60 transaminase levels 60 mIU L 60 elevated serum creatinine 60 specific antigen PSA 60 myopathy rhabdomyolysis 60 hematological parameters 60 plasma adiponectin 60 baseline HbA1c 60 OSAHS 60 AAT deficiency 60 thiazides 60 morphological abnormalities 60 platelet activation 60 nmol l 60 hypercholesterolaemia 60 blood glucose concentrations 60 histological subtype 60 ALT AST 60 node metastases 60 glomerular filtration rate 60 glycemia 60 cTnI 60 glycated hemoglobin levels 60 folate folic acid 60 hemoglobin Hb 60 G6PD 60 colorectal cancer CRC 60 NIDDM 60 extrapyramidal symptoms 60 attain statistical significance 60 dopamine D2 receptor 60 SGOT 60 carotid artery intima media 60 thiopurine 60 MSMB 60 lipid lowering agents 60 hereditary hemochromatosis 60 hepatic steatosis 60 bacterial prostatitis 60 SGRQ 60 cholinergic tone 60 vitamin B# deficiency 60 alpha defensins 60 μg dL 60 haemorrhagic stroke 60 Hcy 60 mammographic density 60 IGFBP 3 60 G allele 60 myo inositol 60 glycated hemoglobin 60 thyroid carcinoma 60 malondialdehyde MDA 60 PSADT 60 cystatin C 60 PSA nadir 60 enterolactone 60 lumbar spine BMD 60 BLLs 60 congenital toxoplasmosis 60 seropositivity 60 BMPR2 60 IPAH 60 FeNO 60 intraocular pressure IOP 60 serum sodium levels 60 triiodothyronine 60 reduce serum phosphate 60 tertile 60 cardiac troponin T 60 tryptase 60 spontaneous preterm delivery 60 serum testosterone levels 60 autoantibody levels 60 hyperinsulinemia 60 intracranial hemorrhage ICH 60 Triglyceride 60 hepatic cirrhosis 60 affective psychosis 60 postoperative delirium 60 GSTT1 60 adrenal suppression 60 cortisol secretion 60 albuminuria 60 folic acid supplementation 60 SERCA2a 60 paraoxonase 60 #.#mmol L [002] 60 somatic symptoms 60 naturally occurring estrogen 60 neurologic impairment 60 HRQOL 60 recurrent UTI 60 carcinoembryonic antigen 60 Univariate analysis 60 comorbid depression 60 #,# DCB 60 androgenic hormones 60 iron supplementation 60 Heritability 60 PTH secretion 60 G6PD deficiency 60 PASI scores 60 soluble CD# ligand 60 multivariable adjusted 60 inducible nitric oxide synthase 60 myocardial necrosis 60 highest tertile 60 affective psychoses 60 multivariate adjustment 60 gastric adenocarcinoma 60 serum magnesium 59 hypogonadal 59 mesangial 59 hormone therapy HT 59 antiandrogen 59 testicular germ cell 59 femoral neck BMD 59 sFlt 1 59 serum thyroglobulin 59 hyperammonemia 59 amyloid β 59 Viral load 59 E selectin 59 relapsed MM 59 Vitamin D insufficiency 59 nondiabetic patients 59 PGDH 59 coronary artery calcification 59 mean serum phosphorus 59 isoprostane 59 hepatic fibrosis 59 LV dysfunction 59 gestational diabetes mellitus GDM 59 recurrent tonsillitis 59 Serum creatinine 59 prevalences 59 socioeconomic gradient 59 insulin resistance syndrome 59 microvessel density 59 Prostatitis 59 Nilotinib 59 maternal serum 59 gene polymorphism 59 virological response 59 elevated fasting glucose 59 thyroid stimulating hormone 59 homocysteine levels 59 thromboembolic disease 59 psychiatric comorbidities 59 Cotinine 59 oral bisphosphonate 59 HbA 1C 59 ovarian hormones 59 socioeconomic status SES 59 serum aminotransferase levels 59 Osteopenia 59 cobalamin 59 Thiazolidinediones 59 β blocker 59 antidepressant efficacy 59 RBP4 59 PCA3 scores 59 vitamin D insufficiency 59 platelet inhibition 59 lipid parameters 59 EFFEXOR XR 59 BENICAR HCT 59 Myocardial infarction 59 neurocognitive impairment 59 psychosocial functioning 59 Apolipoprotein B 59 polyunsaturated fatty acids PUFAs 59 TMP SMX 59 APOE genotype 59 bilirubin levels 59 NNRTI resistance 59 cardiovascular mortality 59 selenium supplementation 59 allele frequencies 59 cerebral infarction 59 pulmonary exacerbations 59 SRBD 59 mL/min/#.# m 2 59 neuropsychological impairment 59 foveal thickness 59 cerebral microbleeds 59 hypertensives 59 interindividual variability 59 CIN3 59 Fasting blood glucose 59 isolated systolic hypertension 59 transgene expression 59 pCR 59 lupus anticoagulant 59 Cardiorespiratory fitness 59 Testosterone deficiency 59 APOE e4 59 leptin concentrations 59 HMG CoA reductase inhibitors 59 prolactin elevation 59 diastolic blood pressures 59 phosphorylated tau 59 prepubertal 59 creatine kinase 59 elevated cortisol 59 antioxidant intake 59 clomipramine 59 facial clefts 59 logistic regression analyzes 59 apolipoprotein A1 59 prognostic indicators 59 Levels Linked 59 diastolic BP 59 lymphocyte activation 59 nonvertebral fractures 59 PUFA intake 59 salivary cortisol 59 Symptom severity 59 ALT elevation 59 intelligence quotient IQ 59 Hepatotoxicity 59 HbF 59 clinically insignificant 59 Cholinesterase Inhibitors 59 intima media thickness IMT 59 somatoform disorders 59 Renal dysfunction 59 leiomyomas 59 polycystic ovary syndrome PCOS 59 leukocyte count 59 normotensive 59 hyperprolactinemia 59 LDL Cholesterol 59 acromegalic patients 59 alkalosis 59 Prolactin 59 ibandronate 59 hormone therapy estrogen 59 glycosylated hemoglobin levels 59 PAOD 59 endothelial activation 59 Atomoxetine 59 estrogen metabolites 59 EpCAM expression 59 lactose maldigestion 59 Cardiovascular Risk 59 LRP5 59 asymptomatic carotid stenosis 59 Socioeconomic status 59 exhaled NO 59 serum lactate 59 etiologic 59 Valproate 59 HbA1c levels 59 disease NAFLD 59 tibolone 59 chronic prostatitis chronic 59 urinary cortisol 59 paroxetine sertraline 59 fructose diet 59 plasma creatinine 59 retinol binding protein 59 hematologic parameters 59 fatty acid intake 59 antitumor effect 59 hENT1 59 thiazide diuretics 59 PIGF 59 testosterone supplementation 59 neurocognitive deficits 59 fasting plasma 59 trans palmitoleic acid 59 SUVmax 59 hemoglobin A1c levels 59 lymphocyte count 59 symptomatic VTE 59 Lp PLA2 59 PDE7B 59 hyperglycaemia 59 antipsychotic prescribing 59 serum triglyceride levels 59 Aortic stenosis 59 glucose insulin 59 SHBG 59 urinary tract symptoms 59 NHANES III 59 intracerebral haemorrhage 59 parous women 59 reticulocytes 59 complete cytogenetic response 59 bronchopulmonary dysplasia BPD 59 pmol L 59 WOMAC pain 59 hepatic enzyme 59 Hb A1c 59 neurosensory 58 systolic BP 58 HDL2 58 dysglycemia 58 Fracture Risk 58 #.#ng/ml 58 ACh 58 neurocognitive function 58 serum biomarkers 58 dietary DHA 58 AGHD 58 intravesical therapy 58 bronchial hyperresponsiveness 58 #ß 58 convergent validity 58 prenatal multivitamin 58 grade cervical intraepithelial 58 airway hyperresponsiveness 58 Teriparatide 58 mineral density 58 vascular reactivity 58 Selective serotonin reuptake inhibitors 58 MDRD 58 supine hypertension 58 postmenopausal estrogen 58 primary hyperparathyroidism 58 proteinuria 58 CORE OM 58 Cognitive Impairment 58 serum GGT 58 residual confounding 58 ACEIs 58 NAT2 58 Ki# 58 aged ≥ 58 nondemented 58 #F FDG PET 58 Recommended Dietary Allowance 58 salmeterol fluticasone propionate 58 systolic dysfunction 58 p# activation 58 undetectable viral 58 serous ovarian cancer 58 fasting triglycerides 58 orofacial clefts 58 Telomere length 58 lipoprotein levels 58 Clusterin 58 cytologic 58 androgen depletion 58 KDOQI 58 CIN2 + 58 psychosocial variables 58 NYHA functional class 58 neurocognitive functioning 58 Suicidal ideation 58 euthymic patients 58 symptomatic intracranial hemorrhage 58 invasive ductal 58 erection hardness 58 esophageal squamous cell carcinoma 58 Non inferiority 58 mmHg diastolic 58 cervicitis 58 fetal malformations 58 RBC folate 58 moderate renal impairment 58 distal colon cancer 58 affective disorders 58 HNSCC 58 PUFA 58 resected pancreatic cancer 58 gestational diabetes mellitus 58 LHRH agonists 58 metabolic acidosis 58 plasma renin activity 58 ursodeoxycholic acid 58 coronary stenosis 58 cranial irradiation 58 dietary nitrate 58 nitrofurantoin 58 interleukin IL -6 58 sitaxsentan 58 interobserver 58 BMI percentiles 58 thyroid stimulating hormone TSH 58 radiosensitivity 58 hypoperfusion 58 gestational hypertension 58 STEP BD 58 arterial oxygen saturation 58 anovulation 58 cardioprotective effects 58 subclinical 58 thiazide 58 NHANES #-# 58 thromboxane A2 58 trans fat intake 58 fructosamine 58 immunoreactivity 58 ULORIC 58 blood Phe 58 cardiovascular morbidity 58 eculizumab therapy 58 GSTM1 58 ALT elevations 58 monogenic 58 lumbar spine bone 58 Fasting plasma glucose 58 nocturnal hypoglycaemia 58 plasminogen activator inhibitor 58 #/#mmHg 58 endometrial hyperplasia 58 antiarrhythmic 58 Chronic Heart Failure 58 endogenous hormones 58 cardiac autonomic 58 cystatin 58 postprandial glycemia 58 clinicopathological 58 dehydroepiandrosterone sulfate 58 perioperative mortality 58 bezafibrate 58 transaminases 58 titrated glipizide 58 dose ionizing radiation 58 Serum concentrations 58 flutamide 58 onset diabetes mellitus 58 lipid lowering therapy 58 Estradiol 58 mean ± SEM 58 vasodilatation 58 TSNA 58 intermittent hypoxia 58 attention-deficit/hyperactivity disorder ADHD 58 preserved ejection fraction 58 heparanase 58 cTnT 58 subchronic 58 hepatocellular carcinomas 58 Endothelial function 58 multiple logistic regression 58 osteopenic 58 meta regression 58 isoenzyme 58 immunotoxicity 58 alexithymia 58 ghrelin concentrations 58 cardiovascular calcification 58 Atherosclerotic 58 basal cell nevus syndrome 58 μg liter 58 postmenopausal hormone replacement 58 arachidonic acid AA 58 dietary choline 58 prostatic hyperplasia 58 GnRH agonists 58 adrenomedullin 58 colorectal neoplasms 58 dosing frequency 58 thrombocytopenic 58 sociodemographic characteristics 58 plasma triglyceride levels 58 schizophreniform disorder 58 hepatic glucose production 58 KCNH2 58 PCNSL 58 MULTAQ 58 IOP lowering 58 HIV seropositive 58 extrapyramidal symptoms EPS 58 obstructive coronary artery 58 mcg dL 58 Histopathologic 58 hepatorenal syndrome 58 ß amyloid 58 bacteriuria 58 unmeasured confounding 58 serum markers 58 hepatic enzymes 58 cardiac repolarization 58 emotional lability 58 strontium ranelate 58 DHEAS 58 Suicidality 58 amyloid deposition 58 VLDL cholesterol 58 glomerular 58 renoprotective 58 density lipoprotein HDL cholesterol 58 glycaemia 58 Calorie intake 58 apoC III 58 IgG4 58 FDG uptake 58 breast endometrial 58 esophageal adenocarcinoma 58 circulating IGF 58 DHA supplementation 58 clinico pathological 58 serum HBV DNA 58 lipid lowering medications 58 comorbid anxiety 58 MYH9 gene 58 folate supplementation 58 vaginal progesterone gel 58 B vitamin supplementation 58 circulating estrogens 58 B vitamin folate 58 gene polymorphisms 58 impaired cognition 58 phthalate exposure 58 Histologic 58 erythrocyte sedimentation rate 58 perioperative morbidity 58 Darapladib 58 perimenopausal women 58 dysmenorrhoea 58 sodium intakes 58 pharmacokinetic interactions 58 endoxifen 58 Androgen deprivation therapy 58 Vitamin B# deficiency 58 systemic corticosteroid 58 dual endothelin receptor antagonist 58 CD# expression [001] 58 neonatal morbidity 58 elevated bilirubin 58 intima media thickness 58 EoE 58 lobular involution 58 Natalizumab 58 Benign Prostatic Hyperplasia 58 carotid plaques 58 de novo mutations 58 NP CRNs 58 idiopathic Parkinson disease 58 dyslipidemic 58 transaminase elevations 58 irregular menstrual cycles 58 silibinin 58 SSc 58 microglial 58 dose dependently 58 postoperative mortality 58 thyroglobulin 58 CYP#D# 58 CANCIDAS 58 nonfatal MI 58 neurodevelopmental impairment 58 N acetylaspartate 58 advanced adenomas 58 angiotensin converting enzyme 58 Lovaza ® 58 folic acid supplement 58 immunostimulatory effects 58 colorectal polyp 58 nicotine metabolite 58 nutrient intakes 58 #mg/day [001] 58 atypical hyperplasia 58 selective modulator 58 multivariate analyzes 58 metabolic disturbances 58 arterial stiffening 58 depressive symptom 58 estrone 58 leptin deficient mice 58 prednisone prednisolone 58 invasive lobular 58 Invasive Breast Cancer 58 carotid atherosclerosis 58 β carotene 58 airway hyper responsiveness 58 airway responsiveness 58 angiotensin receptor blockers ARBs 58 zinc supplementation 58 CYP#D# inhibitor 58 β amyloid 58 Plasma concentrations 58 tryptophan depletion 58 prostate abnormalities 58 atorvastatin #mg 58 elevated prolactin 58 mcg dl 58 deep venous thromboses 58 Subgroup analysis 58 urine NGAL 58 PBDE chemicals 58 hematologic toxicity 58 pharmacologic treatments 58 sodium valproate 58 rs# [004] 58 HDL C 58 Hypotension 58 liver histology 58 postoperative morbidity 57 dose atorvastatin 57 microalbuminuria 57 PNH patients 57 Hemoglobin A1c 57 phthalate metabolites 57 hippocampal volume 57 premorbid 57 familial aggregation 57 A1c levels