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(Click for frequent words.) 63 cytosolic 62 expressing GFP 61 Fig. 3b 61 heterozygotes 61 transduced 61 Fig. 3c 60 HepG2 cells 60 PTPN# 60 mRNA expression 60 cathepsin B 60 downregulated 60 Supplementary Fig 60 transgene expression 60 null mice 60 mitochondrial respiration 60 ploidy 60 plastid 59 stably expressing 59 leukemic cell 59 stably transfected 59 Peyer patches 59 overexpressing 59 polyamine 59 neurofilament 58 transactivation 58 dephosphorylation 58 splenocytes 58 melanocyte 58 transfected cells 58 transferase 58 cisplatin resistant 58 cyclin E 58 ERK signaling 58 GAPDH 58 C#BL 6 mice 58 LNCaP 58 Rab5 58 budding yeast 58 Overexpression 58 transcriptional repressor 58 unmutated 58 coexpression 58 Kupffer cells 58 globin 58 erythroid 58 CDK4 57 missense mutation 57 micronuclei 57 effector memory 57 autophagic 57 constitutively 57 heterochromatic 57 proteolytic cleavage 57 DNMT1 57 acyltransferase 57 Fig. 1c 57 cytochrome 57 H#K#me# 57 transiently transfected 57 GNAQ 57 hTERT 57 hydrolase 57 Leydig cells 57 ß1 57 cells transfected 57 polyploid 57 homozygotes 57 constitutively active 57 beta subunit 56 N. benthamiana 56 phospho 56 tumorigenicity 56 mosaicism 56 oncogenic transformation 56 induced apoptosis 56 A. thaliana 56 NQO1 56 Fig. 2b 56 trophoblasts 56 circulating endothelial 56 secretory 56 Fig. 2c 56 S. enterica 56 proteinase 56 ERK1 2 56 trophoblast cells 56 LNCaP cells 56 amino terminal 56 constitutively expressed 56 vacuolar 56 wildtype 56 subcellular localization 56 mitotic progression 56 cytochrome b 56 upregulated 56 ectopic expression 56 sphingolipid 56 MDA MB 56 acinar 56 MTT assay 56 uPAR 56 methyltransferase 56 endocytic 56 induces apoptosis 56 vascular endothelial cells 56 1alpha 56 cyclic nucleotide 56 metalloproteinase 56 nucleolar 56 Aâ 56 Foxp3 56 monocyte 56 plastids 56 phagocyte 56 PAX5 55 proapoptotic 55 pyruvate kinase 55 Western blotting 55 immunofluorescence microscopy 55 p#Kip# 55 fig. S4 55 FGFR4 55 proximal tubular 55 E#F# 55 adipogenic 55 Fig. 1A 55 Rap1 55 iNOS 55 chloroplast genome 55 alternatively spliced 55 4E BP1 55 RhoA 55 CD8 + 55 pro apoptotic proteins 55 metalloproteinases 55 leucocytes 55 microvessel density 55 EGFP 55 transgene 55 catenin 55 homodimer 55 phospholipase 55 cytosol 55 cytoplasmic domain 55 proteolytic 55 transferrin receptor 55 matrix metalloproteinases 55 Th1 Th2 55 palladin 55 Fig. 1d 55 p# p# 55 phosphorylate 55 microglial 55 GLI1 55 c MYC 55 Arabidopsis plants 55 telomeric 55 Fig. 2a 55 lysates 55 mitotic 55 phosphorylase 55 pDC 55 transmembrane domains 55 granulocyte 55 hepatoma 55 aminopeptidase 55 CLL cells 55 ubiquitylation 55 Fig. 3a 55 MCF7 55 basophils 55 lung carcinomas 55 Immunohistochemical analysis 55 alveolar epithelial cells 55 beta actin 55 MT1 MMP 55 pRb 55 adipose cells 55 CD3 + 55 caspase activation 55 phosphatidylinositol 55 cyclin 55 isogenic 55 anterior pituitary 55 mitogen activated protein kinase 54 At#g# 54 human ESCs 54 myeloid derived 54 centromeric 54 PrPSc 54 hexose 54 P cadherin 54 phagocytic 54 Fig. 2C 54 thymidine kinase 54 PGCs 54 sequence homology 54 transfected 54 cyclin B1 54 multinucleated 54 valine 54 actin polymerization 54 ribosomal protein 54 proximal tubule 54 proteins encoded 54 caveolin 54 synaptogenesis 54 thaliana 54 proteolysis 54 eosinophil 54 GLUT4 54 fucose 54 actin binding 54 eukaryotic cell 54 Supplementary Table 54 3'UTR 54 LRP6 54 basolateral 54 cells overexpressing 54 HepG2 54 embryonal carcinoma 54 neural progenitor 54 lymphoid cells 54 transgenic mice expressing 54 inducible 54 GTPase 54 phosphorylated 54 miR #a [001] 54 antigenic epitopes 54 glucokinase 54 MDCK cells 54 MLH1 54 cyclooxygenase 54 globin gene 54 Fas ligand 54 COL#A# 54 DU# [002] 54 megakaryocytes 54 cellular prion protein 54 mRNA encoding 54 MDR1 54 virulence genes 54 acetyl CoA 54 Jhdm2a 54 retrotransposon 54 MyoD 54 HPV# E7 specific 54 mutant p# 54 miR# 54 HFE gene 54 ERK2 54 paracellular 54 caveolae 54 phosphoprotein 54 homozygosity 54 PcG proteins 54 Sp1 54 cytoplasmic 54 ubiquitination 54 Notch1 54 ^ sup #m 54 IFNg 54 downregulation 54 Fig. 2B 54 p# activation 54 phagocytes 54 caveolin 1 54 mitochondrial gene 54 ß catenin 54 extracellular domain 54 aneuploid 54 PEPCK 54 palytoxin 54 cerevisiae 54 esterase 54 erythrocytes 54 dynamin 54 transcriptional activation 54 mice lacking 54 Fig. 1C 54 transmembrane receptor 54 carboxylase 54 effector T 54 neurite outgrowth 54 CXCL# 54 p# MAPK 54 Upregulation 53 Supplemental Figure 53 laminin 53 syntaxin 53 RNase H 53 coding genes 53 SMase 53 Jurkat cells 53 S. cerevisiae 53 SOCS3 53 Rho GTPases 53 HER2 neu 53 polypeptide 53 glyceraldehyde 3 53 DSBs 53 FGF signaling 53 Macrophage 53 NFkappaB 53 enterocytes 53 bronchial epithelial cells 53 isomerase 53 kinase gene 53 cofilin 53 globin genes 53 tubule 53 oxidative phosphorylation 53 murine 53 tumor suppressor proteins 53 vesicle fusion 53 Bcl2 53 Cdc# 53 mononuclear 53 β catenin 53 suppresses tumor 53 MMP9 53 heme oxygenase 1 53 Activating mutations 53 glutamyl 53 metalloprotease 53 proline rich 53 biogenesis 53 secretase 53 MAPK pathway 53 adipocyte 53 transcriptional activity 53 TGF ß1 53 Fig. 1B 53 hippocampal neurons 53 PC3 cells 53 c fos 53 suppressor gene 53 osteoblast 53 histone H3 53 trophoblast 53 chromosome segregation 53 c myc 53 CD8 cells 53 substrate specificity 53 MAP kinase 53 proto oncogene 53 superoxide dismutase 53 genes encoding 53 PP2A 53 NFκB 53 cytokine receptor 53 fibroblast 53 integrin expression 53 granulocytes 53 uncoupling protein 53 protein tyrosine kinase 53 reductase 53 lacZ 53 MDSCs 53 chondrocyte 53 Fig. 4b 53 beta1 integrin 53 cytolytic activity 53 synthase 53 cells 53 proteasomes 53 polymorphonuclear 53 acetyltransferase 53 Xenopus 53 prostaglandin E2 PGE2 53 intestinal epithelial cells 53 microRNA molecule 53 enolase 53 insulin signaling pathway 53 embryonic tissues 53 serpin 53 p# mutation 53 intronic 53 CHD5 53 serine protease 53 meiotic 53 synuclein 53 hematopoetic stem cells 53 colorectal tumor 53 mRNA transcripts 53 neuroblastoma cells 53 CCL# 53 PDGFR 53 CYP#B# 53 P. patens 53 ATP synthase 53 secretory pathway 53 RNA polymerases 53 sister chromatid 53 TGF beta1 53 constitutively activated 53 induce apoptosis 53 BCL2 53 ALDH 53 RKIP 53 thioredoxin 53 CEACAM1 53 fig. S3 53 potent inducer 53 mitogenic 52 VSV G 52 receptor tyrosine kinase 52 Cyclin D1 52 regulated kinase ERK 52 S1P ^ sub 52 hnRNP 52 orthologs 52 CD4 + T lymphocytes 52 thymidine 52 exocytosis 52 VEGFR1 52 Inappropriate activation 52 thymosin 52 PIP2 52 MEFs 52 capillary endothelial cells 52 GlcNAc 52 granule cells 52 IKKß 52 dimerization 52 mutant alleles 52 cell adhesion molecule 52 activin 52 explants 52 ciliates 52 suppressor cells 52 PrP 52 bcl 2 52 MyD# 52 E3 ligase 52 endosomal 52 SMN1 52 midgut 52 Xenopus laevis 52 breast epithelial cells 52 3' UTR 52 homozygote 52 cadherin 52 p# mutations 52 diffusible 52 orthologous genes 52 Kir#.# 52 carcinoembryonic antigen 52 transcriptional coactivator 52 downregulate 52 endometrial cells 52 matrix metalloproteinase 52 FGFR3 52 SVZ 52 transient transfection 52 chloroplast 52 adrenoceptor 52 lymphoid 52 protein tyrosine phosphatase 52 RUNX3 52 aneuploid cells 52 T lymphocyte 52 BRAF protein 52 TAp# 52 glycosylase 52 cis regulatory 52 phosphate dehydrogenase 52 Phosphorylation 52 actinin 52 apoptotic cells 52 brown adipose tissue 52 thymidylate synthase TS 52 Catenin 52 mycoides 52 FGF2 52 retroviral vector 52 mammary cells 52 perivascular 52 autoreactive B 52 neoplastic cells 52 dioxygenase 52 Mice deficient 52 nephron 52 ribonuclease 52 functional polymorphism 52 lung fibroblasts 52 quinone 52 monocytic 52 Treg cells 52 operon 52 EphB4 52 TGF ß 52 receptor kinase 52 prion gene 52 Fig. 3A 52 bone marrow stromal cells 52 Cytochrome 52 VEGF receptor 52 ATPase 52 ERK1 52 ERK pathway 52 #β HSD1 52 CD# + [001] 52 somatostatin 52 autoreactive 52 Nup# 52 ras gene 52 menin 52 mutant KRAS 52 inner mitochondrial membrane 52 phagocytosis 52 MnSOD 52 transmembrane protein 52 cytoplasmic tail 52 vacuole 52 hematopoietic progenitor cells 52 beta tubulin 52 phosphatase 52 K ras gene 52 lymphoid tissue 52 B Raf 52 mediated phosphorylation 52 FKBP# 52 protein secreted 52 PrPC 51 Cytotoxic T 51 FOXO3a 51 apo AI 51 synthases 51 phosphorylates 51 cytochrome c 51 epigenetic silencing 51 H#K# [002] 51 senescent cells 51 Agrobacterium 51 endonuclease 51 phenotype 51 S#A# [002] 51 germinal center 51 mouse ESCs 51 Eq. 51 H2AX 51 homodimers 51 isoleucine 51 eNOS 51 SOD1 protein 51 homeobox 51 Genetic variation 51 Oncogenic 51 cytoskeletal 51 miR #a [002] 51 Drosha 51 clade C 51 Sertoli cell 51 cytotoxicity assays 51 p#NTR 51 mRNA molecules 51 antiproliferative activity 51 skin fibroblasts 51 phosphorylated tau 51 acetylation 51 #S proteasome 51 glycosylated 51 erythropoiesis 51 N cadherin 51 cytokine secretion 51 androgen receptor AR 51 WT1 51 Drp1 51 HOTAIR 51 paxillin 51 syngeneic 51 gene encodes 51 presynaptic 51 cyclins 51 humoral responses 51 EGF receptor 51 hematopoietic progenitors 51 cyclic AMP cAMP 51 mutant proteins 51 Ectopic expression 51 cytokine interleukin 51 Drosophila embryos 51 evolutionarily conserved 51 rDNA 51 Htt 51 keratinocyte 51 neural crest 51 HIF 1a 51 P selectin 51 oligosaccharide 51 NFATc1 51 cysteine protease 51 pT3 51 mycobacterial 51 eukaryotic cells 51 CaM 51 BMAL1 51 FABP 51 trypanosome 51 p# deficient 51 phosphorylation 51 tumor infiltrating lymphocytes 51 Lymphocytes 51 cytokinesis 51 short hairpin RNAs 51 peroxisome 51 constitutive expression 51 cardiac myocytes 51 MDMX 51 DNA adducts 51 transcriptional regulation 51 intestinal epithelium 51 Vps# 51 telomerase RNA 51 Syt II 51 hematopoetic 51 metaphase 51 inhibitory activity 51 triphosphate 51 Src kinase 51 amyloid peptides 51 kinase pathway 51 #p# [003] 51 synthetase 51 ß 51 lysosomal 51 Akt 51 dependent protein kinase 51 colony stimulating factor 51 osteoclast 51 ChR2 51 Nanog 51 methylenetetrahydrofolate reductase 51 nucleoli 51 lyase 51 NOD SCID mice 51 Dictyostelium discoideum 51 meiotic recombination 51 C#Y 51 Cre recombinase 51 coactivators 51 histone modification 51 replicon 51 forkhead 51 Gly 51 antiapoptotic 51 thymocytes 51 vesicular stomatitis virus 51 homolog 51 luciferase reporter 51 prokaryote 51 V#E 51 SWI SNF 51 DLC1 51 Fig. 1b 51 glutathione S transferase 51 lysosomal enzyme 51 siderophore 51 tumorigenic 51 DMT1 51 E3 ubiquitin ligase 51 TGF β 51 Myb 51 catalase 51 hydroxylation 51 Fig. 2A 51 neurotrophin 51 epithelia 50 gamma H2AX 50 MSH2 50 cell progenitors 50 Bmal1 50 Wnt protein 50 LRAT 50 intracellular 50 NKX#.# 50 rRNA 50 kinase domain 50 Saccharomyces cerevisiae 50 leukocyte 50 p# [001] 50 MAPK 50 centromeres 50 Frizzled 50 defensin 50 E cadherin 50 beta galactosidase 50 SUVmax 50 tyrosine phosphorylation 50 coding sequences 50 serine threonine kinase 50 mesenchymal cell 50 replicase 50 apoE 50 receptor signaling 50 genotoxic stress 50 mitochondrial 50 flagellar 50 anaphase promoting complex 50 ncRNAs 50 TGF alpha 50 PGE2 50 epidermal cells 50 endocytic pathway 50 glutamine synthetase 50 cyanobacterial 50 Vpr 50 nucleotide substitution 50 gene polymorphism 50 metazoan 50 transferrin receptors 50 lectin 50 neural progenitor cells 50 mutant allele 50 Rb#/p# 50 overexpression 50 SIRT6 50 Androgen receptor 50 pilus 50 #T# L1 50 malignant transformation 50 paraventricular nucleus 50 glioma cells 50 JAK STAT 50 apolipoprotein 50 mouse embryonic fibroblasts 50 HCT# 50 miRNAs miR 50 hepatocyte 50 vacuoles 50 mitogen activated protein kinases 50 glioblastoma cells 50 leukemic stem cells 50 nucleotide excision repair 50 D. melanogaster 50 HIF 1alpha 50 cytotoxic T lymphocytes 50 APOC3 50 XBP1 50 prostate epithelial cells 50 EGFR protein 50 LDL receptor 50 pancreatic endocrine 50 proinsulin 50 muscarinic 50 bax 50 germline mutation 50 RNA synthesis 50 EphA2 50 Purkinje cell 50 TMEM#B 50 enzymatic activity 50 Mitotic 50 FLT3 kinase 50 eIF4E 50 nucleolin 50 hydroxylase 50 catechol O methyltransferase 50 isoforms 50 mouse neural stem 50 glucose transporter 50 dendritic 50 acetylcholine receptors 50 neurite 50 RASSF1A 50 synaptic vesicles 50 myocyte 50 splice variants 50 telomerase activity 50 acetylcholine receptor 50 adipocytes fat 50 Hsp# [001] 50 endothelial nitric oxide synthase 50 neural stem 50 cytopathic 50 TEL AML1 50 neural cells 50 infected macrophages 50 JNK1 50 cell adhesion molecules 50 dermal papilla 50 transfection efficiency 50 mRNAs 50 lymphoid organs 50 mediated inflammatory 50 HEK# 50 endosome 50 EBNA1 50 focal adhesion kinase FAK 50 HERV 50 thymocyte 50 myc 50 S#K# 50 Bcl 50 totipotent 50 EGFRvIII 50 ribosomal RNA 50 alveolar macrophages 50 mtDNA mutations 50 P gp 50 MMP2 50 prostate tumor 50 #S rRNA 50 lymphocyte 50 TGF b 50 receptor gene 50 myeloid 50 HbF levels 50 TNFα 50 HLA DRB1 * 50 glycogen synthase kinase 50 cysteines 50 eotaxin 50 dermal papilla cells 50 cardiomyocyte 50 undifferentiated hESCs 50 μ opioid receptor 50 cytidine 50 adhesion proteins 50 differential gene expression 50 HDAC6 50 outer membrane proteins 50 ciliated 50 ErbB4 50 defensins 50 KRAS gene 50 telomere dysfunction 50 TGF β1 50 GSTM1 50 hyperactivated 50 HOXB# 50 Tie2 50 MC4R gene 50 JNK activation 50 NF1 gene 50 Akt1 50 receptor activation 50 NF κB 50 ribonucleoprotein 50 lung epithelial cells 50 ribosomal 50 pmol 50 leukaemic 50 C#BL 6 50 agarose gel electrophoresis 50 nestin 50 uPA 50 Cx# [001] 50 retroviral 50 decarboxylase 49 mesothelin 49 Plk1 49 oncoprotein 49 SGK1 49 yeast Saccharomyces cerevisiae 49 amino acid substitutions 49 myofibroblast 49 PTP1B 49 TRAIL induced apoptosis 49 antitrypsin 49 costimulatory 49 BRAF V#E 49 ER alpha 49 pancreatic islet 49 fluorescently tagged 49 interneurons 49 aT cell 49 plant Arabidopsis thaliana 49 miR #b [001] 49 mesenchymal cells 49 PAK1 49 metalloproteases 49 gut mucosa 49 polypeptides 49 PIP3 49 nodulation 49 #S rRNA gene 49 macrophage 49 outcrossing 49 adhesion molecule 49 PDE#A 49 CD#b 49 monocytes macrophages 49 intracellular proteins 49 autoregulation 49 rs# [004] 49 polynucleotides 49 Reductase 49 GTP hydrolysis 49 FGFs 49 organogenesis 49 FUS1 49 leptin receptor 49 histone H3 lysine 49 myeloid lineage 49 FLT3 49 #S rDNA 49 receptor CD# 49 nicotinic receptor 49 polyploidy 49 bispecific 49 endosomes 49 untranslated regions 49 SUMOylation 49 Rac1 49 intergenic 49 TOR pathway 49 ribosomal DNA 49 ± SEM 49 regulates gene expression 49 3' 49 serine 49 pseudogenes 49 estrogen receptor alpha 49 coreceptor 49 oncoproteins 49 Brain derived neurotrophic 49 tumor suppressor PTEN 49 GluR1 49 acinar cells 49 subcellular 49 PPARg 49 ATF2 49 apical membrane 49 retinal neurons 49 IGF2 49 effector molecules 49 myofibroblasts 49 lymphoblasts 49 endocytosis 49 Id1 49 focal adhesions 49 activated macrophages 49 Histone 49 Dysregulation 49 ubiquitin ligase 49 epithelial cells lining 49 eukaryotic 49 upregulation 49 specific CD8 + 49 tropomyosin 49 endostatin 49 LXRs 49 tubulin 49 embryoid bodies 49 Rho GTPase 49 inhibitory receptor 49 intron 49 cyclin dependent kinase inhibitor 49 pancreatic islet beta 49 mononuclear cells 49 cytokine signaling 49 procaspase 3 49 neuroblasts 49 beta catenin 49 somites 49 microtubule associated 49 dinucleotide 49 glycosyltransferase 49 histone modifications 49 cellulase 49 protein myosin 49 MLL gene 49 isoenzymes 49 cell epitopes 49 IGF1 49 protein kinase 49 terminally differentiated 49 recycling endosomes 49 anaphase 49 F FLT 49 cell receptor TCR 49 parasitaemia 49 B lymphocyte 49 myelination 49 Golgi apparatus 49 PKM2 49 protein isoforms 49 interphase 49 nucleolus 49 Dpp 49 cathepsins 49 HCV replication 49 tumor suppressor 49 meristem 49 LKB1 49 kinesin motor 49 myocytes 49 short hairpin RNA 49 junctional adhesion molecule 49 prion protein PrP 49 apoptotic 49 homologue 49 cytoskeletal protein 49 podocytes 49 CD# + [002] 49 piRNAs 49 E cadherin expression