Related by context. All words. (Click for frequent words.) 69 Panzem R 69 SNT MC# 69 PDE4 inhibitor 69 JAK inhibitor 68 incyclinide 68 vascular disrupting agents 68 Darinaparsin 68 Archexin 68 COX Inhibiting Nitric Oxide 68 PI3K/Akt pathway inhibitor 67 YONDELIS 67 metaglidasen 67 Naproxcinod 67 cannabinor 67 IMiDs ® 67 Aganocide ® 67 sodium glucose transporter 67 CCR9 antagonist 67 anticancer compound 67 ularitide 67 oral prodrug 67 CORT # 67 silodosin 67 panitumumab Vectibix 66 LT NS# 66 Aplidin 66 IMiDs R 66 Oracea TM 66 PHX# 66 Aviptadil 66 torezolid phosphate 66 eprotirome 66 midstage clinical 66 Pharmos proprietary 66 R#/MEM # 66 anti inflammatory NSAID 66 Squalamine 66 MTP inhibitor 66 Akt inhibitor 66 YONDELIS R 66 Phenoptin 65 pan HDAC inhibitor 65 PDX pralatrexate 65 Icatibant 65 allosteric modulator 65 forodesine 65 Varespladib 65 JAK inhibitors 65 Cetrorelix 65 Preclinical studies suggest 65 huC# DM4 65 oral picoplatin 65 endothelin receptor antagonists 65 PRT# 65 mertansine 65 Panzem R NCD 65 investigational therapies 65 2 methoxyestradiol 65 liposomal formulation 65 FOLOTYN ® 65 Tyrima 65 PEG SN# 65 Nanobody ® 65 ENMD # 65 alvespimycin 65 Amrubicin 65 highly selective inhibitor 65 Insegia 65 CEQ# 65 RNAi therapeutic targeting PCSK9 65 OMP #M# 65 Ambrisentan 65 SYCREST 65 Proquin XR 64 Aganocide R 64 RGB # 64 Silodosin 64 SinuNase TM 64 MAGE A3 ASCI 64 JAK1 64 Sudhir Agrawal D.Phil 64 LibiGel ® 64 TPI ASM8 64 prostone 64 sodium glucose cotransporter 64 adenosine A2A 64 ATL# [002] 64 intranasal formulation 64 sulfonylhydrazine class 64 selective androgen receptor modulator 64 DPP4 64 nucleoside analog 64 SPRYCEL ® 64 Factor VIIa 64 oral salmon calcitonin 64 GW# [003] 64 orally administered inhibitor 64 Nexavar sorafenib 64 proteasome inhibitor 64 Panzem 64 adipiplon 64 G#DT 64 ALV# 64 MEK inhibitors 64 HuMax CD4 64 Starlix 64 tubulin inhibitor 64 DDP# 64 XL# XL# 64 Exherin TM 64 anti amnesic 64 acyclovir Lauriad R 64 volociximab 64 MEK inhibitor 64 rxRNA 64 entinostat 64 mecamylamine 64 polysaccharide polymer 64 Fx #A 64 Dapagliflozin 64 cathepsin K inhibitor 64 TELINTRA 64 SUTENT ® 64 urocortin 2 64 pradefovir 64 acetonide FA 64 pitavastatin 64 Rebif ® 64 defensin mimetic antibiotic 64 Factor Xa inhibitor 64 immunomodulatory 64 BYETTA exenatide injection 64 sorafenib tablets 64 Dalbavancin 64 Xanafide 64 Tykerb lapatinib 64 Cannabinor 64 Azedra 64 Pivotal Phase III 64 EOquin 64 PXD# 64 AQ4N 64 ruxolitinib 64 diarrhea predominant irritable 64 SAR# [004] 64 dextofisopam 64 therapeutic monoclonal antibody 64 VitiGam TM 64 thalidomide Thalomid 64 dihydrochloride 64 CB2 selective receptor agonist 63 renin inhibitor 63 Pruvel 63 Perforomist ™ Inhalation Solution 63 Exelixis compounds 63 obatoclax 63 Tasimelteon 63 Peginterferon alfa 2b 63 BAY #-# 63 Zorbtive TM 63 Aganocide 63 histone deacetylase HDAC inhibitor 63 XL# XL# XL# XL# 63 Nanobody R 63 THR beta agonist 63 Pimavanserin 63 IAP inhibitors 63 NXL# 63 elotuzumab 63 Ganciclovir 63 Virulizin ® 63 ocular formulation 63 OvaRex ® MAb 63 P#X# antagonist 63 Nanobody 63 INCB# [002] 63 Pazopanib 63 Genasense ® oblimersen 63 atacicept 63 deforolimus 63 Immunotherapeutic 63 Cyclooxygenase Inhibiting Nitric Oxide 63 Removab 63 MGCD# [001] 63 receptor tyrosine kinase inhibitor 63 ganetespib 63 Zybrestat 63 hypoxia selective 63 nitric oxide donating 63 antisense inhibitors 63 Luteinizing Hormone Releasing Hormone 63 GTC recombinant human 63 SAR# [002] 63 Cancidas 63 xanthine oxidase inhibitor 63 Sym# 63 lumiliximab 63 hoFH 63 Mipomersen 63 topically applied SEPA 63 RELOVAIR ™ 63 Granulocyte Colony Stimulating Factor 63 rEV# 63 virus HCV protease inhibitor 63 RhuDex ® 63 Proellex TM 63 HGS# 63 #D#C# 63 Initiates Phase III 63 aripiprazole Abilify 63 ATPace TM 63 investigational humanized monoclonal antibody 63 Tß4 63 Loramyc R 63 6R BH4 63 UPLYSO 63 faropenem 63 KRN# 63 TLK# 63 etanercept Enbrel 63 OHR/AVR# 63 IL# PE#QQR 63 HuLuc# 63 Soliris TM eculizumab 63 Guanilib 63 Proxinium TM 63 kidney urologic 63 RezularTM 63 Onconase 63 histone deacetylase HDAC 63 Evoltra ® 63 ZADAXIN ® 63 Linaclotide 63 Behcet uveitis 63 antimitotic 63 outlicensed 63 Muraglitazar 63 Cinryze ™ 63 IV Busulfex 63 Davanat 63 Cleviprex TM clevidipine 63 Solazed TM 63 mGluR5 NAM 63 HuMax EGFr 63 Traficet EN 63 cediranib 63 Novolimus 63 histone deacetylase inhibitor 63 Cloretazine 63 rolapitant 63 #HT# 63 Zavesca r 63 HGS ETR2 63 hereditary deficiency 63 epothilones 63 Marqibo TM 63 selective kinase inhibitor 63 LymphoStat B TM 63 sitaxsentan 63 Actimmune ® 63 rasagiline tablets 63 LEP ETU 63 Personalized Immunotherapy 63 Firazyr 63 phase IIa clinical 63 selective androgen receptor modulators 63 PSN# [002] 63 BNC# 63 mitogen activated ERK kinase 63 protein tyrosine phosphatase 1B 62 histamine dihydrochloride 62 immune modulatory 62 VEGF inhibitors 62 tiapamil 62 SRT# [003] 62 AEGR 62 IMiDs ® compound 62 sorafenib Nexavar 62 regorafenib 62 Genz # 62 Maribavir 62 IMiDs 62 Vectibix panitumumab 62 docetaxel Taxotere R 62 chimeric monoclonal antibody 62 potent antiproliferative 62 HepeX B 62 fenofibric acid 62 Orally administered 62 Anticalins ® 62 Initiates Enrollment 62 hyaluronidase enzyme 62 Civacir 62 Xcytrin R 62 EP #R 62 GLPG# 62 HCV protease inhibitors 62 TKM ApoB 62 Seliciclib 62 MCSP respectively 62 GALNS 62 inhaled formulation 62 Elagolix 62 GPR# agonist 62 Romidepsin 62 Dextofisopam 62 rilonacept 62 teduglutide 62 tolevamer 62 bazedoxifene 62 Gleevec imatinib mesylate 62 docetaxel Taxotere ® 62 neuroprotective properties 62 R sorafenib tablets 62 IAP inhibitor 62 ACAPODENE TM 62 Androxal ® 62 hematological indications 62 liprotamase 62 gallium containing 62 ATD Gel 62 endothelin antagonist 62 Frova ® 62 Vidaza azacitidine 62 XP# XP# 62 Vidaza R 62 EGS# 62 dextromethorphan quinidine 62 alkylating agent 62 Fibrillex TM 62 Anavex #-# 62 Alzhemed TM 62 aurora kinase 62 Tarceva TM 62 tranilast 62 orally bioavailable 62 Azacitidine 62 PNP inhibitor 62 Anturol ® 62 sodium thiosulfate STS 62 Diamyd R 62 Aflibercept 62 Anidulafungin 62 TG# [003] 62 PSN# [001] 62 Cinquil 62 SARMs 62 insulin sensitizer 62 Tracleer R 62 diabetic neuropathic pain 62 novel immunomodulatory 62 trastuzumab DM1 T DM1 62 Lysteda 62 tanespimycin 62 Sutent sunitinib 62 Aurora Kinase 62 Hsp# Inhibitor 62 XL# anticancer compounds 62 Tumour Vascular Disrupting Agent 62 Pathway Inhibitor 62 methylnaltrexone bromide 62 ISTODAX 62 long acting bronchodilator 62 HQK 62 Cx# [002] 62 Menadione 62 JAK2 inhibitor 62 oxidative stress inducer 62 BRAF inhibitor 62 PGL# 62 A3 adenosine receptor 62 TBC# 62 Recombinant Human 62 Golimumab 62 ESBA# 62 Phase IIb clinical trials 62 gabapentin Neurontin 62 insulin sensitizing 62 Prodarsan ® 62 efaproxiral 62 BAL# [002] 62 Shigamabs ® 62 tezampanel NGX# 62 non nucleoside inhibitor 62 TheraCIM 62 inhaled AAT 62 PrevOnco 62 Raptiva ® 62 ALN PCS 62 novel VDA molecule 62 irinotecan oxaliplatin 62 EcoNail 62 Azedra TM 62 Trandolapril 62 orally bioavailable mimics 62 brivaracetam 62 AEG# 62 EnzymeRx 62 Bayer Onyx 62 generation Hsp# inhibitor 62 Bendamustine 62 rufinamide 62 Trofex TM 62 AMPK activators 62 novel peptide 62 Adenoscan R 62 Taxotere docetaxel 62 ZOLINZA 62 IMA# 62 TRO# 62 TAFA# 62 Initiates Phase II 62 PF # [002] 62 MetroGel 62 Tumor Necrosis Factor 62 CCR5 antagonist 62 Romiplostim 62 Neulasta ® 62 TNF Tumor Necrosis Factor 62 Aplidin R 62 Talabostat 62 MOVIPREP R 62 TLR9 agonist 62 CTAP# Capsules 62 cetuximab Erbitux 62 miconazole Lauriad ® 62 BiovaxID TM 62 lomitapide 62 Pirfenidone 62 adult mesenchymal stem 62 Plicera 62 Noxafil 62 octreotide implant 62 KSP inhibitor 62 Adnectin 62 Gamunex C 62 GPR# agonists 62 AKT inhibitor 62 DAVANAT R 61 PS# [001] 61 metformin sulfonylurea 61 Onalta 61 topical antifungal 61 malignant ascites 61 CDP# 61 deferiprone 61 SPP# Rasilez 61 BrachySil TM 61 Epratuzumab 61 ARIKACE ™ 61 OvaRex R 61 LAB CGRP 61 5 HT2C 61 Zemiva TM 61 targets Galectin receptors 61 Glatiramer acetate 61 Epothilones 61 epigenetic therapies 61 Anturol TM 61 Phase 2a trial 61 Liprotamase 61 antifibrotic 61 bexarotene 61 Aegerion 61 Dasatinib 61 orBec 61 ATL# [001] 61 ISIS # 61 secondary hyperparathyroidism 61 Saforis 61 Zenpep 61 baminercept 61 ABILIFY ® 61 Azathioprine 61 PDE4 inhibitors 61 nucleoside analogs 61 INCB# [003] 61 Amplimexon 61 Aganocide TM 61 oral ridaforolimus 61 immune modulating 61 Eraxis 61 DU #b 61 tipifarnib 61 Neulasta R 61 targeted radiotherapeutic 61 Maxy G# 61 galiximab 61 HuMax 61 Vaprisol 61 LY# [003] 61 ocrelizumab 61 Tolevamer 61 Spiegelmer ® 61 Aclidinium 61 HepDirect 61 bortezomib Velcade 61 RhuDex 61 QRxPharma 61 Saxagliptin 61 Aliskiren 61 ALS #-# 61 Genasense R oblimersen 61 Androxal TM 61 candidate deforolimus 61 Denufosol 61 CB2 selective 61 pharmacodynamic properties 61 FVIIa 61 phase IIb trial 61 multiple myeloma MM 61 favorable pharmacokinetic profile 61 microtubule inhibitor 61 acyclovir Lauriad ® 61 HCV polymerase 61 CA4P 61 multitargeted 61 Bremelanotide 61 buccal spray 61 Huntexil 61 selective S#P# receptor agonist 61 oxypurinol 61 Difimicin 61 BZL# 61 cetuximab Erbitux ® 61 mTOR inhibitors 61 droxidopa 61 TRAIL receptor antibodies 61 antifibrinolytic 61 trospium 61 CCX# 61 SIRT1 activators 61 Interferon alpha 61 CYT# potent vascular disrupting 61 DCVax R 61 eltrombopag 61 Sebivo 61 TLR antagonists 61 trastuzumab emtansine T DM1 61 ARRY # 61 telomerase therapeutic 61 ZK EPO 61 mTOR kinase 61 Friedreich Ataxia FRDA 61 Intravenous Human 61 Zemplar Capsules 61 THALOMID 61 topical formulations 61 ELND-#/AZD-# 61 CR# vcMMAE 61 drug ISA# 61 Presents Preclinical 61 DPP4 inhibitor 61 Pafuramidine 61 Evoltra 61 MOZOBIL 61 TÎ ² 4 61 DPX Survivac 61 amrubicin 61 compound INCB# 61 canakinumab 61 Soriatane 61 OMNARIS HFA 61 VitiGam 61 chemotherapy induced neutropenia 61 reslizumab 61 Raptiva R 61 Soliris eculizumab 61 Carfilzomib 61 Ventavis 61 forodesine hydrochloride 61 Triolex 61 sargramostim 61 Omacetaxine 61 HDL Mimetic Peptide 61 mTOR mammalian target 61 fostamatinib 61 PEGylated anti 61 Kepivance 61 selective adenosine 61 Adentri 61 ganaxolone 61 sodium Injection 61 Velac 61 ceftazidime 61 Tredaptive 61 JAK2 inhibitors 61 tafamidis 61 Zolinza 61 delafloxacin 61 humanised monoclonal antibody 61 Leukine ® 61 ADP receptor antagonist 61 PLK1 SNALP 61 novel prodrug 61 CINQUIL 61 Onalta ™ 61 Cerashield 61 interferon gamma 1b 61 MORAb 61 BEMA TM LA 61 Rigel R# 61 Vidofludimus 61 serotonin synthesis 61 antiproliferative effects 61 peptibody 61 Kuvan sapropterin dihydrochloride 61 INS# [001] 61 IMC #B 61 Campath ® 61 AAG geldanamycin analog 61 PORxin TM 61 Triapine R 61 novel histone deacetylase 61 beta 1a 61 antidiabetic 61 cysteamine bitartrate 61 SinuNase ™ 61 Velcade bortezomib 61 MGd 61 #ME# 61 GSK# [002] 61 compound PMX # 61 erlotinib Tarceva ® 61 Cellegesic 61 MNTX 61 active moiety 61 antiangiogenesis 61 small molecule defensin 61 AZILECT ® 61 MYLOTARG 61 erythropoietic 61 biologic therapeutics 61 AMD# [003] 61 PANVAC VF 61 Solazed 61 riociguat 61 glatiramer 61 Oral NKTR 61 HMG CoA reductase inhibitors 61 Ophena TM 61 pharmacokinetic PK study 61 Sporanox 61 vidofludimus 61 myeloproliferative diseases 61 INCB# [001] 61 COLAZAL R 61 iobenguane 61 Cand5 61 topical ophthalmic 61 Argatroban 61 Antiangiogenic 61 Initiate Phase 61 Pertuzumab 61 VA# [002] 61 alvimopan 61 hepatotoxic 61 RNA antagonists 61 CINTREDEKIN BESUDOTOX 61 OXIGON TM 61 candesartan cilexetil 61 favorable pharmacokinetic 61 phase III isavuconazole 61 colesevelam HCl 61 filgrastim 61 CB1 antagonists 61 Atiprimod 61 Ozarelix 61 enzastaurin 61 Kineret ® 61 Reports Preclinical Data 61 eniluracil 61 tramiprosate 61 prokinetic agent 61 HGS ETR1 mapatumumab 61 molecular imaging radiopharmaceutical 61 Vascugel 61 siRNAs targeting 61 ORENCIA R 61 CYC# 61 Microplasmin 61 Receives Orphan Drug Designation 61 novel anticancer 61 ALN TTR# 61 prescribed proton pump 61 bosutinib 61 HCV protease inhibitor 60 octreotide acetate 60 DAVANAT ® 60 Arcalyst 60 Meets Primary Endpoint 60 Yondelis ® 60 Targretin 60 Ophthotech 60 radezolid 60 LAF# 60 SILENOR TM 60 IV APAP 60 TH# [003] 60 oral gallium 60 carbohydrate polymer 60 HoFH 60 Nabi HB R 60 VDAs 60 ProLindac TM 60 RH1 60 Fludara ® 60 CD# antibody [001] 60 preclinical efficacy 60 DAVANAT 60 Vandetanib 60 Initiate Clinical Trial 60 Zerenex 60 EndoTAG 60 Octreolin 60 Inhalation Aerosol 60 RNAi therapeutic targeting 60 USL# 60 Zenvia ™ 60 Cethrin R 60 AzaSite Plus 60 TRPV1 agonist 60 oxaliplatin Eloxatin 60 TLR8 agonist 60 RLY# 60 AVN# [001] 60 MYDICAR ® 60 R roscovitine 60 dasatinib Sprycel 60 eosinophilic asthma 60 nonclinical studies 60 Ceflatonin 60 Inhalation Solution 60 radiotherapeutic 60 hormone LHRH antagonist 60 refractory chronic lymphocytic 60 Arranon 60 Pharmos pipeline 60 Aurora kinase 60 Pyridorin 60 Initiates Clinical 60 PEG PAL 60 calcitonin 60 Ereska 60 PPAR gamma agonists 60 Enzastaurin 60 generation purine nucleoside 60 Erbitux cetuximab 60 R Saizen R 60 Epanova 60 Curaxin 60 Gaboxadol 60 Hsp# inhibitor 60 NP2 Enkephalin 60 teriflunomide 60 GRN# 60 BiTE 60 PREOS 60 PROVIGIL 60 Darapladib 60 VAPRISOL 60 Aryplase 60 GKAs 60 Kahalalide F 60 Ceplene TM 60 mesylate 60 Perifosine 60 Kuvan R 60 tasimelteon 60 Fodosine 60 Troxatyl 60 rNAPc2 60 HuMax CD# 60 IMiD 60 renin inhibitors 60 lintuzumab SGN 60 fosbretabulin 60 FASLODEX 60 VALSTAR 60 Annamycin 60 amifostine 60 Nexavar ® 60 novel emulsion formulation 60 targeted antifolate 60 Presents Preclinical Data 60 DNA intercalator 60 adenosine injection 60 Zemplar 60 Fibrillex 60 fibrotic disease 60 nalbuphine ER 60 alpha interferons 60 neuronal nicotinic receptors NNRs 60 Gelclair 60 Panzem ® 60 Xyrem ® 60 tezampanel 60 PI3K/mTOR 60 Serostim ® 60 prucalopride 60 REGN# 60 IMPDH inhibitor 60 SGLT inhibitors 60 Prodarsan R 60 Cardio Vascu Grow 60 faropenem medoxomil 60 CCR2 60 Ixabepilone 60 TLR9 agonists 60 Sanvar R 60 Opterone R 60 omacetaxine mepesuccinate 60 vosaroxin 60 #HT#A 60 Zysolin TM 60 Aurora kinase inhibitor 60 valtorcitabine 60 Alocrest 60 Dual Opioid TM 60 Catena ® 60 rhIGF-I/rhIGFBP-3 60 vinorelbine tartrate 60 Emezine 60 LymphoStat B belimumab 60 Bazedoxifene 60 SILENOR 60 proteasome inhibitors 60 candidate epratuzumab 60 novel antifolate 60 Cloretazine R 60 Urocidin 60 OMP #R# 60 humanized monoclonal antibodies 60 Radezolid 60 Xolegel 60 Navelbine ® 60 Phase 2b Clinical Trial 60 5 HT2C serotonin 60 Posiphen TM 60 Trizytek 60 oncolytic virus therapies 60 antiarrhythmic 60 Fluconazole 60 ospemifene 60 maribavir 60 synthetic siRNA 60 selective modulator 60 inhibitor rofecoxib 60 inhalation powder 60 ONCONASE R 60 compound perifosine 60 darinaparsin ZIO 60 Intravenous CP 60 Pegloticase 60 PREOS R 60 Abiraterone acetate 60 Pyridorin TM 60 indibulin 60 telomerase inhibitor drug 60 evaluating satraplatin 60 brivanib 60 vinca alkaloid 60 ICA # 60 factor TNF 60 elvucitabine 60 anticancer therapeutics 60 anti secretory 60 ELIQUIS 60 Zavesca R 60 Orapred ODT 60 glucokinase activator 60 Itraconazole 60 ALN HPN 60 antitumor effect 60 Methylnaltrexone 60 Orencia abatacept 60 Tesmilifene 60 NB S# strontium malonate 60 proprietary polysaccharide 60 oral candidiasis 60 TRISENOX ® 60 epothilone 60 Chemokine 60 immuno modulatory 60 CaPre TM 60 Quinamed 60 CRF1 receptor antagonist 60 Bezielle 60 HDAC Inhibitor 60 OMNARIS Nasal Spray 60 azelastine 60 QuatRx 60 JAK#/JAK# inhibitor 60 HeFH 60 phase IIb III 60 Aceon 60 levocetirizine 60 JAK#/JAK# inhibitor CYT# 60 apoptosis inducer 60 PhosLo 60 Potelligent Technology 60 Myocet 60 Phase 2b clinical trials 60 pregabalin Lyrica 60 paclitaxel Taxol ® 60 Phase #b/#a clinical 60 anti angiogenic agents 60 antiepileptics 60 MAXY VII 60 ® pioglitazone HCl 60 Bystolic nebivolol 60 bardoxolone 60 Chemophase 60 Serdaxin ® 60 davalintide 60 PEGPH# 60 nitric oxide donating prostaglandin 60 Hycamtin 60 including eniluracil ADH 60 calcineurin inhibitors 60 AMEVIVE 60 Veregen TM 60 lesinurad 60 Actemra tocilizumab 60 SYN# 60 Elisabeth Lindner CEO 60 tramiprosate Alzhemed TM 60 estrogen receptor modulators 60 Ophena 60 PKC# 60 ACOMPLIA R 60 myelofibrosis polycythemia vera 60 acadesine 60 ipratropium bromide 60 acitretin 60 benign prostatic hypertrophy BPH 60 delivers fluocinolone acetonide FA 60 Triapine 60 Tezampanel 60 DNA RNA Medicines 60 Entereg R 60 pegylated interferons 60 Linjeta TM 60 next generation URAT1 60 ThermoDox R 60 orally disintegrating 60 Olmesartan 60 sapacitabine CYC# 60 cleavable linker 60 alefacept 60 Cloretazine R VNP#M 60 MAXY G# 60 lapatinib Tykerb 60 uricase 60 albiglutide 60 Sphingosine 1 60 PRTX 60 PROCRIT ® 60 ALGRX 60 Cephalon Oncology 60 INTEGRILIN 60 MEK inhibitor RDEA# 60 Rhucin R 60 Carvedilol 60 pharmacokinetic properties 60 HCV RNA polymerase 60 kallikrein 60 selective agonists 60 dipeptidyl peptidase 4 60 Rescula 60 oral nucleoside analogue 60 compound AEZS 60 FOR FURTHER INFORMATION ABOUT 60 squalamine 60 Ixempra 60 SERMs 60 anti atherothrombotic 60 immunological diseases 60 rhThrombin 60 Exherin 60 Symadex 60 Cathepsin S 60 demonstrated antitumor activity 60 Abbokinase 60 VivaGel ™ 60 fluoropyrimidine 60 histone deacetylase HDAC inhibitors 60 Achieves Primary Endpoint 60 Temsirolimus 60 trastuzumab DM1 60 generic enoxaparin 60 Actonel ® 60 non alcoholic steatohepatitis 60 cutaneous T 60 LNP formulations 60 RDEA# 60 hyperphenylalaninemia HPA due 60 Roche Xeloda 60 selective estrogen receptor modulator