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(Click for frequent words.) 71 indels 70 nucleotide sequence 70 cDNA libraries 70 mRNA molecules 70 somatic mutations 70 mRNA transcripts 70 transgene expression 69 bacterial genomes 69 paralogs 69 heterozygotes 69 missense mutations 69 #S rRNA gene 69 pathogenic mutations 68 ncRNA 68 differential gene expression 68 PrPSc 68 chromosomal aberrations 68 sequence homology 68 differentially expressed genes 68 splice variants 68 nucleotide sequences 68 metabolite concentrations 67 linkage disequilibrium 67 mtDNA mutations 67 microdeletions 67 allele frequencies 67 miRNA expression 67 coexpression 67 #S rRNA 67 NNRTI resistance 66 germline mutations 66 immunohistochemical analysis 66 HbF 66 Supplementary Table 66 phylogenetic analyzes 66 virulence genes 66 blastomeres 66 induced sputum 66 phenotypic variation 66 quasispecies 66 GPx 66 #S rRNA genes 66 proteomes 66 amplicons 66 mutant alleles 65 cDNAs 65 indel 65 genetic loci 65 Alu elements 65 transfected cells 65 aneuploidies 65 genotypic 65 RNA sequences 65 MSH2 65 epistasis 65 untranslated regions 65 fig. S1 65 subcellular compartments 65 gene duplications 65 alternatively spliced 65 intergenic regions 65 splice junctions 65 QTLs 65 orthologous genes 65 helium isotopes 65 Sanger sequencing 65 immunoblotting 65 allele frequency 65 spontaneous mutations 65 eukaryotic genomes 65 nucleated cells 64 segmental duplications 64 spontaneous mutation 64 hamartomas 64 K#N 64 conserved sequences 64 RFLP 64 trophoblast cells 64 Western blotting 64 VNTR 64 PCR amplification 64 allelic 64 fig. S2 64 methylated DNA 64 Plasmodium infection 64 substrate specificity 64 hypermethylated 64 E. faecalis 64 p tau 64 cysteines 64 coding sequences 64 ß amyloid 64 TP# gene 64 MTT assay 64 serum antibodies 64 viral nucleic acids 64 chromosomal rearrangement 64 DNA glycosylase 64 transcriptomes 64 paraffin embedded tissue 64 aneuploid 64 dinucleotide 64 deleterious mutations 64 IgG antibody 64 karyotypes 64 sequenced genomes 64 cellularity 64 HER2 expression 64 Microarray analysis 64 PTPN# 64 primate genomes 64 genomic alterations 64 cytologic 64 renal cell carcinomas 64 CPE delta N 64 inactive X chromosome 64 homozygotes 64 replicase 63 gene rearrangements 63 CD#c 63 Fig. 1D 63 herpesviruses 63 CYP#D# gene 63 PBMCs 63 recombination hotspots 63 unmutated 63 somatic mutation 63 malignant nodules 63 gene expression microarrays 63 glutamate glutamine 63 microarray experiments 63 phenotypic expression 63 RNA extraction 63 heterologous expression 63 parasitaemia 63 p# activation 63 cytochrome b 63 genotypic resistance 63 #S rDNA 63 LRAT 63 cybrid 63 RNA transcripts 63 kilobases 63 outer membrane proteins 63 hierarchical clustering 63 sitosterol 63 proteolytic cleavage 63 monogenic 63 amino acid residues 63 genes differentially expressed 63 soluble proteins 63 de novo mutations 63 Genotypic 63 K ras mutations 63 frameshift mutation 63 heritable variation 63 binding affinities 63 DNA demethylation 63 fluorescence intensity 63 mosaicism 63 BAC clones 63 NR#A# gene 63 interstitial fluid 63 MLH1 63 intergenic 63 chromosomal rearrangements 63 pleural fluid 63 endogenous retroviruses 63 Fig. 3b 63 chimpanzee genomes 63 Genotypes 63 RNA polymerases 63 transcriptomic 63 HLA alleles 63 poly dA 63 transgenic rats 63 TMPRSS2 ERG 63 coding genes 63 intact parathyroid hormone 63 isotypes 63 IgA deficiency 63 logistic regressions 63 orthologs 63 zebrafish genome 63 SUVmax 62 serum homocysteine 62 Cytogenetic 62 mitochondrial genomes 62 homozygote 62 differentially expressed proteins 62 Raman spectra 62 isoenzyme 62 GSTT1 62 mitochondrial DNA mtDNA 62 promoter methylation 62 posttranslational modifications 62 prion strains 62 S. enterica 62 MGUS 62 Immunohistochemical analysis 62 TMPRSS2 ERG fusion 62 Arabidopsis genome 62 mammalian genomes 62 transgenic mice expressing 62 fluoroquinolone resistance 62 RT qPCR 62 β1 62 gene amplification 62 MRSA isolates 62 immunostaining 62 mitochondrial proteins 62 hemagglutinin gene 62 mRNA expression 62 chromatogram 62 HLA DRB1 62 M. genitalium 62 cytological 62 Bonferroni correction 62 glycolytic 62 conditional logistic regression 62 C. neoformans 62 PCR assay 62 fig. S4 62 FDG uptake 62 BRAF protein 62 recombinants 62 serum PTH 62 replicon 62 proteomic analysis 62 cTnT 62 haplotypes 62 peritoneal fluid 62 B. cereus 62 amino acid sequences 62 scintigraphic 62 microsatellite instability 62 Trichophyton rubrum 62 etiologic 62 lactate dehydrogenase 62 prion infection 62 analyte 62 immunofluorescence microscopy 62 lymphoblastoid cell lines 62 gDNA 62 mutant worms 62 hepatocellular carcinomas 62 PER2 62 gametocytes 62 ncRNAs 62 OGG1 62 ORFs 62 Telomere length 62 antimicrobial susceptibility 62 Amino acid 62 globin genes 62 protein isoforms 62 5 hmC 62 pseudogenes 62 ChIP chip 62 yeast genome 62 mean ± SEM 62 microRNA molecules 62 methylation markers 62 PCR amplified 62 seminomas 62 uracil 62 H#K#me# 62 amino acid substitutions 62 equimolar 62 quantitative trait loci 62 PFGE 62 explants 62 histopathologic examination 62 M. pneumoniae 62 enolase 62 microarray gene expression 62 GSTM1 62 cis regulatory 62 hepatic enzymes 62 tumor biopsies 62 histone modifications 62 cell lysates 62 chromatograms 62 BDNF protein 62 single celled yeast 62 C. jejuni 62 karyotyping 62 bronchial epithelial cells 62 thermodynamic stability 62 D#N 62 renal cysts 62 CFU ml 62 viral genomes 62 polyploid 62 ribosomal DNA 62 deacetylation 62 Fas ligand 62 transcriptional profiling 62 noncoding RNAs 62 immunohistochemical 62 stably transfected 61 exonuclease 61 telomere lengths 61 chromosomal mutations 61 synthetic analogues 61 Leydig cells 61 CDK4 61 rDNA 61 KCNH2 61 ventricular myocardium 61 CGG repeats 61 bisulfite sequencing 61 N acetyltransferase 61 mammographic density 61 micronuclei 61 carcinoids 61 ± SEM 61 hepatoma 61 cellular prion protein 61 JILA scientists 61 pairwise comparisons 61 TP# mutations 61 serum biomarkers 61 site directed mutagenesis 61 #q#.# [002] 61 enteroviral 61 thyroglobulin 61 gastric adenocarcinoma 61 ZFN modified cells 61 epigenetic alterations 61 micrometastasis 61 ChIP Seq 61 noncoding 61 multiple logistic regression 61 protein tyrosine phosphatase 61 serum lipid 61 phenotypic traits 61 SMAD4 61 metabolomic profiles 61 coding exons 61 nitrotyrosine 61 Arabidopsis genes 61 evolvability 61 Haplotype 61 siRNA knockdown 61 S nitrosylation 61 genomic loci 61 chest radiographs 61 quantitative PCR 61 miRNA genes 61 serum IgG 61 homodimer 61 follicular fluid 61 GenBank accession 61 osteosarcomas 61 glycosylated 61 H#Y 61 epithelial tumors 61 osteoblastic 61 N. gonorrhoeae 61 CD# expression [001] 61 TET2 61 chimp genomes 61 plastids 61 colorectal polyp 61 amino acid substitution 61 lysate 61 somites 61 urine cytology 61 Fig. 2b 61 HER2 overexpression 61 pyrimidine 61 thymidine kinase 61 abnormal prions 61 allelic variants 61 CYP #D# 61 monozygotic twins 61 MDRD 61 microdeletion 61 mesotheliomas 61 L. pneumophila 61 thyrotropin 61 colocalization 61 APOC3 61 agarose gel electrophoresis 61 kilobase 61 randomized controlled trials RCTs 61 seropositivity 61 LRP5 61 mammalian tissues 61 intracranial hemorrhage ICH 61 immunological responses 61 IgG4 61 advanced neoplasia 61 gene deletions 61 insertional mutagenesis 61 Xenopus embryos 61 rotaviruses 61 phosphorylated tau 61 erythrocytes 61 X. laevis 61 atherosclerotic lesion 61 sputum specimens 61 Liver biopsies 61 SDS PAGE 61 sCJD 61 Phylogenetic analysis 61 C. albicans 61 Immune responses 61 nanomolar 61 metabolic parameters 61 Immunohistochemical staining 61 immunodominant 61 oxidized lipids 61 oligonucleotide probes 61 mutant allele 61 constitutively expressed 61 aneuploidy 61 heterozygosity 61 PCR RFLP 61 NRTI resistance 61 DNMT1 61 BCR ABL mutations 61 ROC curves 61 immunofluorescent 61 tryptase 61 antibody antigen 61 T2 lesions 61 mutated K ras 61 vertebrate genomes 61 gene rearrangement 61 missense 61 Lp PLA 2 61 lysine residues 61 d dimer 61 circulating lymphocytes 61 exome 61 biochemical marker 61 reproducible measurements 61 bronchoalveolar lavage fluid 61 microcephalin 61 nucleases 61 ginsenosides 61 mitochondrial metabolism 61 neutrophil counts 61 germline mutation 61 epidermidis 61 immunoreactivity 61 genomic deletions 61 viral isolates 61 regression equations 61 tumorigenicity 60 penetrance 60 immunoblot 60 subcellular localization 60 subtilis 60 qRT PCR 60 chromosome translocations 60 Proteobacteria 60 busulfan 60 Clusterin 60 non coding RNA 60 HCV replication 60 gene loci 60 ESBLs 60 physicochemical properties 60 homozygosity 60 UGT#A# * 60 Hsp# [001] 60 breast carcinomas 60 logistic regression model 60 histone acetylation 60 homologous genes 60 ultrastructural 60 enzyme inhibition 60 karyotype 60 logistic regression analyzes 60 clade B 60 Candida species 60 stoichiometry 60 electrophysiologic 60 MEFs 60 bacterial isolates 60 cytopathic 60 hyperplastic 60 Infectivity 60 microglial 60 tissue biopsies 60 HIV tropism 60 microwell plate 60 fig. S6 60 hydroxyproline 60 BubR1 60 DLC1 60 #ß 60 C1q 60 MC1R gene 60 carotid plaque 60 causal variants 60 RNA ribonucleic acid 60 genetic polymorphisms 60 HLA B# 60 #q# deletion 60 DGGE 60 lipoprotein cholesterol 60 Salmonella enterica 60 metabolome 60 ovarian hormones 60 mutational 60 Bacteroides 60 telomeric 60 humoral responses 60 Supplementary Fig 60 S. maltophilia 60 lung adenocarcinomas 60 cytosine methylation 60 CYP#D# 60 Fig. 1c 60 CLA isomers 60 CD4 ^ sup 60 mitochondrial DNA mutations 60 capsular polysaccharide 60 Postoperative complications 60 Leydig cell 60 serological tests 60 mitochondrial gene 60 DNA methylation patterns 60 biochemical assays 60 directed mutagenesis 60 insertions deletions 60 pathogenic bacterium 60 G6PD 60 NFTs 60 PCR primers 60 RQ PCR 60 apolipoproteins 60 thioredoxin 60 immunized mice 60 organism genome 60 virologic responses 60 leiomyoma 60 aneuploid cells 60 echogenicity 60 multinucleated 60 lysates 60 synaptic proteins 60 endonuclease 60 HCV replicon 60 inhibin 60 KLF4 60 μmol L 60 Trypanosoma brucei 60 sarcosine 60 granzyme B 60 transfection efficiency 60 amyloidogenic 60 variant allele 60 MLL2 60 tyrosine phosphorylation 60 TPMT 60 ALK mutations 60 HRCT 60 extracellular proteins 60 methylation patterns 60 Gram stain 60 totipotent 60 HBsAg 60 microarray datasets 60 hepatic enzyme 60 KRAS oncogene 60 microsatellite markers 60 troponin T 60 MTHFR gene 60 colonic mucosa 60 IGFBP 60 pDC 60 genetic alterations 60 antibody titer 60 hexose 60 Solexa sequencing 60 cDNA synthesis 60 plasma lipid 60 metaplasia 60 CAG repeats 60 succinate dehydrogenase 60 nucleic acid sequence 60 telomere DNA 60 chlamydial 60 previously uncharacterized 60 CCL#L# 60 TRIM5 60 Drosophila genome 60 electrophysiological recordings 60 aminotransferases 60 prion gene 60 GSTP1 60 estrogen metabolites 60 carbonate globules 60 FDG PET imaging 60 papillomas 60 amplicon 60 cisplatin resistant 60 N glycan 60 recursive partitioning 60 phenotypic characteristics 60 colorectal tumor 60 T. vaginalis 60 rRNA 60 μg ml 60 inhibin B 60 hypericin 60 contigs 60 cell lysate 60 Platelet counts 60 intronic 60 neutralizing antibody responses 60 abnormal prion protein 60 FUS1 60 hemoglobins 60 Cathepsin B 60 CYP#C# [002] 60 p# mutations 60 tetramers 60 miRs 60 DNA rearrangements 60 matrix interferences 60 genetic aberrations 60 isotype 60 GAGs 60 F FDG PET 60 PCR reactions 60 PALB2 60 cDNA microarray 60 Transcriptome 60 mycobacterial 60 fungal genomes 60 orthologous 60 valine 60 TT genotype 60 oocyst 60 6S RNA 60 polycystin 60 eotaxin 60 lincRNA 60 body louse genome 60 comparative genomic analysis 60 TCF#L# gene 60 interobserver 60 thrombospondin 60 β amyloid 60 SLNB 60 agarose gel 60 immunoreactive 60 epigenetic modifications 60 prostanoid 60 silico prediction 60 leucocyte 60 segmental duplication 60 alkaline phosphatase ALP 60 AST ALT 60 kDa protein 60 sentinel nodes 60 variant alleles 60 WNK1 60 DSBs 60 aneuploidy screening 60 hyperactivation 60 C#T [002] 60 annexin V 60 RRM1 60 thyroid hormone levels 60 eosinophil count 60 statistical correlations 60 nutlin 3a 59 cell lysis 59 coronary stenosis 59 ploidy 59 peripheral blood mononuclear 59 sialic acids 59 nephron 59 hypermethylation 59 morphologic 59 PTEN gene 59 synuclein 59 HMGA2 59 Figure 1A 59 commensal bacteria 59 astrocytic 59 unicellular organisms 59 A. gambiae 59 nucleotide bases 59 phagocytic cells 59 #BP# 59 COL#A# 59 Multivariate analysis 59 precursor lesions 59 colorectal neoplasia 59 urease 59 chloroplast genome 59 meta analytic 59 Serologic 59 umbilical vein 59 proteolysis 59 resistant mutants 59 histopathological 59 linkage disequilibrium LD 59 chromosome aberrations 59 hypoperfusion 59 short hairpin RNAs 59 mutations 59 pilocytic astrocytomas 59 PGCs 59 leucocytes 59 immature dendritic cells 59 MIC# [001] 59 immunochemical 59 genomic DNA 59 haematopoietic 59 axonal degeneration 59 modifier genes 59 SAXS 59 bronchoalveolar lavage 59 semiquantitative 59 Aspergillus nidulans 59 K ras gene 59 genes BRCA1 59 UGT#A# 59 MC4R gene 59 TBARS 59 monophyletic 59 Pearson correlation coefficients 59 impedance measurements 59 diffusivity 59 supernatant 59 alpha synuclein protein 59 polyploidy 59 GIST tumors 59 gene polymorphisms 59 hTERT 59 SGPT 59 rs# [004] 59 mesothelin 59 airway responsiveness 59 brain lesions 59 proton MR spectroscopy 59 Prochlorococcus 59 multiplex assay 59 Or#b 59 hydroxylation 59 cardiac troponin T 59 X inactivation 59 Fig. 1E 59 FMR1 59 HAR1 59 plastid 59 HepG2 cells 59 allergenic proteins 59 FUS protein 59 obligate intracellular 59 shRNAs 59 microdose 59 gliosis 59 liver metastasis 59 precancerous adenomas 59 epigenetic markers 59 Trichinella 59 epigenetic changes 59 At#g# 59 Nucleic acid 59 cDNA library 59 T. pallidum 59 Enterobacter 59 dermatophytes 59 histologic subtype 59 phylogenetic analysis 59 JAK2 mutation 59 splice variant 59 prostate carcinoma 59 supernatants 59 pathologic examination 59 Calcium absorption 59 lipoprotein associated phospholipase 59 C#Y 59 RASSF1A 59 ε 59 metastatic lesions 59 nonvaccine 59 chromosome #q# [001] 59 miRNA expression profiles 59 pulp metallic 59 culturing methods 59 intracellular pH 59 chromosomal alterations 59 chemiluminescence 59 demethylase 59 phylogenetically 59 antigenicity 59 Kaplan Meier curve 59 Enterobacter cloacae 59 motor neuron degeneration 59 histologic examination 59 procaspase 3 59 metabolizing enzymes 59 microRNA expression 59 albumin excretion 59 lymphoid tissues 59 Genetic mutations 59 putative biomarkers 59 genomewide association studies 59 anterior pituitary 59 etiologic agent 59 UV wavelengths 59 fetal malformations 59 Treg cell 59 isoprostane 59 photon fluorescence 59 silibinin 59 neutralizing antibody 59 GAPDH 59 peptide antigens 59 assay detects 59 Univariate 59 morphological characteristics 59 ELISpot 59 vivax 59 coagulase negative staphylococci 59 FGFs 59 histological examination 59 Bulk density 59 GLUT1 59 hippocampal cells 59 QTc prolongation 59 variograms 59 serum HBV DNA 59 autosomal 59 methyltransferases 59 hemagglutination 59 PSADT 59 serum HCV RNA 59 eukaryote 59 Activating mutations 59 Multivariate logistic regression 59 multivariate analyzes 59 physiologic parameters 59 Mycoplasma pneumoniae 59 IDH1 mutation 59 PSA nadir 59 maternally inherited 59 EUS FNA 59 Prox1 59 amino acid sequence 59 bacteria Escherichia coli 59 CD4 + CD# 59 multiple linear regression 59 troponins 59 Corynebacterium 59 RCAN1 59 S. Typhimurium 59 -# mV [001] 59 porcine circovirus type 59 dengue serotype 59 histopathologic 59 intraoperative complications 59 fasting plasma insulin 59 histological subtype 59 clinico pathological 59 Fig. 2A 59 Confocal microscopy 59 fructosamine 59 TOP2A gene 59 genes CYP#C# 59 GBM tumors 59 ABCB1 59 endonucleases 59 Prevotella 59 amyloid plaque formation 59 rifamycins 59 abnormal proteins 59 NRF2 gene 59 pharmacodynamic markers 59 Kruskal Wallis test 59 genotyping arrays 59 MAPCs 59 enzymatic pathways 59 imprinted genes 59 clades 59 unmethylated 59 chromosomal instability 59 immunoglobulin G 59 Leptospira 59 serologically 59 Skeletal muscle 59 abnormal chromosomes 59 m z 59 proline rich 59 FGFR2 59 chromosomal anomalies 59 lymphocyte counts 59 Replikin Count 59 germline 59 carcinoembryonic antigen 59 spirometric 59 proviral DNA 59 genomewide 59 rumen fermentation 59 acyl CoA 59 unmethylated DNA 59 proinflammatory mediators 59 t# c# CLA 59 UTRs 59 Alanine 59 nanohorns 59 SNP rs# [002] 59 ^ sup #m 59 Alternative splicing 59 MMP# 59 P. putida 59 resonance frequencies 59 EAAT2 59 absorption spectra 59 uncharacterized genes 59 molecular scissors 59 osteochondromas 59 KRAS mutations 59 serum aminotransferase levels 59 H#N# isolates 59 cellulases 59 chromatin immunoprecipitation 59 aminotransferase 59 plasma pharmacokinetics 59 SOCS3 59 glycosylation pattern 59 M. anisopliae 59 confidence intervals CIs 59 STAT4 59 CHD7 59 bcl 2 59 extracolonic findings 59 TNFalpha 59 virological response 59 maize genome 59 isoforms 59 gadolinium enhanced 59 Genetic variation 59 mammographically 59 guanylate 59 genes encode 59 murine models 59 Nedd4 59 microglial activation 59 conventional angiography 59 gel electrophoresis 59 positional cloning 59 normal karyotype 59 db db mice 59 vesicle fusion 59 TSC1 59 chromosomal DNA 59 protein encoded 59 HSPCs 59 explanatory variables 58 RefSeq 58 cytotoxicity assays 58 VEGFR1 58 colorectal adenoma 58 PARP inhibition 58 quantitative PCR qPCR 58 CYP# [001] 58 peptide sequences 58 DNA deoxyribonucleic acid 58 inflammatory biomarkers 58 distinct lineages 58 enterolactone 58 cystatin C 58 HPV genotypes 58 vitro experiments 58 bivariate 58 Dicer enzyme 58 exons 58 polypoid lesions 58 pneumococci 58 serologic testing 58 metazoan 58 homogenates 58 transcriptomics 58 SNe Ia 58 intraobserver 58 coagulation proteins 58 nucleotide substitution 58 figs. 58 KIAA# 58 IgG1 58 uniparental 58 genetic variants associated 58 trophoblasts 58 dizygotic twins 58 fetal chromosomal 58 Fig. 2a 58 Fig. 2B