coulometric enantiomorphs inkblot bisection achieved intaglio jsonrpc DGGE Bonferroni dithering tomography Intaglio Buddhabrot technique Bilinear thresholding skinfold isochron Keystroke chemometrics speckle anamorphosis interferometry microscopy Raphson ELISA thermoluminescence MLST Jime decorrelation WKB Warping Reproducibility mentalists noninvasive applied image DLTS