PGE2 cyclooxygenase thrombin Puhto inflammatory fibrin clots Palpation response isochromosome hypovolemia SIADH TNF antitrypsin ClCN 0x18 fibrotic SIRS IgE coagulation CXCL12 Irritability interleukins baroreflex viremia Gabucci autoantibodies Bacteremia pneumonic IgM racemosus Pulsus 1QpQpQpe6 granulocytes oxidants IgG1 cytokines