Related by context. All words. (Click for frequent words.) 61 CFQ R 58 SF #v# 58 Primary endpoints 58 Hepatotoxicity 57 Pharmacodynamic 57 Ocular Surface Disease 57 pharmacodynamic PD 57 Global Impression CGI 57 LUMINATE 56 Main Outcome Measure 56 NIH CPSI 56 YMRS 56 postmarketing adverse 56 UPDRS Part III 56 prospective multicentre 55 Secondary efficacy endpoints 55 subjective sleepiness 55 TQT 55 HEDIS R 55 PANSS Positive 55 Brief Psychiatric 55 subscale scores 55 IntroductionThe 55 PANSS 55 DAS# CRP 55 Outcome Measures 55 HAMD 55 clevidipine 54 VFQ 54 Adverse Event 54 acamprosate calcium 54 ADCS ADL 54 hemodynamic measurements 54 KDOQI 54 atherothrombotic 54 HAQ DI 54 Pharmacodynamics 54 BPS IC 54 Assessment Questionnaire 54 pharmacodynamic parameters 53 EORTC QLQ C# 53 Serious Adverse Event 53 HSCR 53 Echocardiographic 53 Serious Adverse Events 53 inflammatory biomarkers 53 PCWP 53 Ischaemic 53 DQI 53 Crohn Disease Activity 53 clinicopathological 53 PSQI 53 Nocturia 53 UPDRS 53 fosbretabulin 53 EQ 5D 53 Severity Index PASI 53 AST ALT 53 Acute Decompensated Heart Failure 53 STRIDE PD 53 meta regression 53 Severity Index 53 CDAI 53 demonstrated clinically meaningful 52 Neuropsychiatric Inventory NPI 52 Epworth Sleepiness Scale 52 airway hyperresponsiveness 52 ICH GCP 52 Unified Parkinson Disease 52 Insulin Therapy 52 WAIS III 52 HAM D# 52 Current Controlled Trials 52 atherothrombotic disease 52 ADCS CGIC 52 Psoriasis Area 52 Cardiotoxicity 52 MedDRA 52 serologically active patients 52 REMINYL ® 52 Polysomnography 52 GSK# [001] 52 Pharmacokinetic 52 Profile SEP 52 BILAG 52 exploratory endpoints 52 DLQI 52 transcranial Doppler ultrasound 52 BPRS 52 eC SSRS 51 Wakefulness Test 51 convergent validity 51 Multivariate logistic regression 51 Pharmacokinetic PK 51 Scale PANSS 51 UPDRS motor 51 inhaled AAT 51 haematologic 51 EBMT criteria 51 Rating Scale UPDRS 51 pain subscale 51 lipid parameters 51 Negative Symptom Scale 51 demyelinating 51 Adverse Events 51 Secondary endpoints included 51 thorough QT 51 Vapor Intrusion 51 Main Outcome Measures 51 Tumor Response 51 Dysmenorrhea 51 Depression Inventory BDI 51 spirometric 51 Thrombolysis 51 Teriflunomide 51 symptom severity 51 RE LY ® 51 Depression Inventory 51 depressive symptom 51 Randomized Evaluation 51 Aggrenox ® 51 ENGAGE AF TIMI 51 Lp PLA 2 51 CIMZIA ™ 51 QT Prolongation 51 bepotastine besilate nasal spray 51 Orthostatic Hypotension 51 alicaforsen enema 51 Negative Symptoms 51 Severe Asthma 51 Index CDAI 51 Pain Intensity 51 CQI 51 TAXUS ARRIVE 51 MEDMARX 51 SELENA SLEDAI 50 Skin sterol 50 Suboptimal 50 CAPRA 50 Hospitalized Patients 50 ADHD Rating Scale 50 NSABP B 50 Montgomery Åsberg Depression 50 nasal symptom 50 CIBIC + 50 HRCT 50 bivariate analysis 50 Comorbidity 50 prospective nonrandomized 50 Pharmacokinetic parameters 50 Pharmacologic 50 OSDI 50 MS DRGs 50 BEXXAR Therapeutic Regimen 50 Patient Outcomes 50 PLMs 50 Alzheimer Disease Cooperative 50 RenalGuard System TM 50 Modifiable 50 parasitological 50 Functioning GAF 50 Montgomery Asberg Depression 50 Secondary endpoints 50 Depressive Symptomatology 50 Atopic Dermatitis 50 Sleep Disturbance 50 PROactive 50 Electroencephalography 50 Cardiorespiratory fitness 50 Common Terminology Criteria 50 apnea hypopnea 50 hepatic enzyme 50 Brief Pain 50 Liraglutide Effect 50 glycosylated hemoglobin HbA1c 50 Beck Anxiety Inventory 50 neuropsychological assessment 50 QOPI 50 Acute Physiology 50 histopathological 50 Erythropoiesis Stimulating Agents ESAs 50 Warfarin Coumadin 50 Negative Syndrome 50 Hypercholesterolemia 50 Diabetic Neuropathy 50 HEDIS ® 50 Demonstrates Sustained 50 Diabetic Foot Ulcer 50 ACCF AHA 50 ACR# ACR# 50 NTx 50 hematological adverse 50 ARCOXIA 50 Interpersonal Psychotherapy 50 ADHD RS 50 Prospective Randomized 50 eNO 50 Patellofemoral 50 bronchial hyperresponsiveness 50 Renal Function 50 Major Adverse Cardiac 50 Enzastaurin 49 Estrogen Receptor 49 Platelet Function 49 prucalopride 49 Appropriateness Criteria 49 HRQL 49 CRQ 49 linear regression analyzes 49 Med eXpert 49 Acute Coronary Syndromes 49 symptom exacerbation 49 erection hardness 49 fasting plasma 49 premorbid 49 Practice Guideline 49 biostatistical analysis 49 Neuropsychiatric Inventory 49 EGS# 49 tissue oxygenation 49 inferential statistics 49 cerebral oximetry 49 Laryngeal Cancer 49 Specification PAS 49 Clinicaltrials.gov 49 MADRS score 49 Risk Stratification 49 MoxDuo IR 49 HCAHPS survey 49 brivaracetam 49 Tiotropium 49 Erectile Function 49 Mutational 49 NIS LL 49 prelicensure 49 prospectively stratified 49 KAPIDEX 49 BSIs 49 Sociodemographic 49 HAZOP 49 Reperfusion 49 Alzheimer Disease Assessment 49 Novarica ACE Ranking 49 SSRI SNRI 49 GPRD 49 pretreatment serum 49 dyspnoea 49 CLIRS 49 bronchopulmonary 49 Disease Activity 49 liver transaminases 49 IKDC 49 serum lipids 49 cardiac repolarization 49 Score IPSS 49 randomized discontinuation 49 Symptom Checklist 49 Meta analyzes 49 RECIST Response Evaluation Criteria 49 Secondary endpoints include 49 Clinician Administered PTSD 49 Headache Disorders 49 serum leptin 49 dose atorvastatin 49 QIDS SR 49 Analyte 49 Randomized Clinical Trials 49 Nesiritide 49 Metabolic Disorder 49 enthesitis 49 semistructured interview 49 Geriatric Depression 49 estimated GFR 49 Erectile Function IIEF 49 Tasigna prolongs 49 Anthropometric 49 CIMZIA TM 49 DAS# [002] 49 Functional Capacity 49 EMBLEM TM 49 Seattle Angina Questionnaire 49 CIMZIA TM certolizumab pegol 49 Postoperative Ileus 49 Medication Adherence 49 albumin excretion rate 49 plasma lipids 49 actigraphy 49 ADAS Cog 49 CIMZIA R 49 subscales 49 ULORIC 49 MSLT 49 mITT population 49 guideline concordant 49 TIMP 1 49 Immunitor 49 myeloproliferative 48 analgesic efficacy 48 Urocortin 2 48 OPTIMIZE 48 Quality Indicators 48 FACIT 48 Clinical Practice Guidelines 48 ICAEL 48 Systemic Sclerosis 48 myocardial revascularization 48 MADRS 48 Coronary CTA 48 BMI z 48 subscores 48 UPDRS scores 48 Hemodynamic 48 Histologic 48 Rotigotine 48 Treatment Outcome 48 serum antibody 48 HbA 1C 48 differential gene expression 48 Randomized Controlled 48 IPSS 48 eprodisate Fibrillex TM 48 Medifacts 48 Oropharyngeal Candidiasis 48 Evaluable 48 GERD symptom 48 NCT# ClinicalTrials.gov 48 Symptom Severity 48 chronic prostatitis chronic 48 Cardiopulmonary bypass 48 pain palliation 48 Androgel R 48 polyarticular 48 clinicopathological features 48 Antiviral Activity 48 empirically validated 48 MERLIN TIMI 48 IRLS 48 Cimzia TM 48 Somnolence 48 Clinical Practice Guideline 48 number NCT# ClinicalTrials.gov 48 bivariate 48 Myocardial Perfusion 48 ActiveStrategy Enterprise 48 RE LY trial 48 esophageal manometry 48 Solid Tumors 48 MiDAS 48 TLR antagonist 48 hematological parameters 48 HOMA IR 48 Myocardial Ischemia 48 ADAS cog 48 SMRP 48 pulmonary exacerbations 48 clinico pathological 48 Exelixis XL# 48 CRp 48 IIEF 48 dose Iluvien 48 ANCOVA 48 Status Scale EDSS 48 syndromic 48 APEX AMI trial 48 Thrombotic 48 Index FSFI 48 sterile compounding 48 biologic DMARD 48 β blockers 48 SYNTAX 48 cardiometabolic syndrome 48 B2A 48 CORE OM 48 somatostatin analog 48 clinically meaningful improvement 48 Zestra R 48 tipranavir r 48 SAEs 48 GAMMAGARD 48 Myocardial Infarction TIMI 48 Pearson correlation coefficient 48 ATL/TV# 48 CAHPS 48 RxNorm 48 Low Incidence 48 Bioavailability 48 EuroSCORE 48 overnight polysomnography 48 Pulmonary Arterial Hypertension 48 TNSS 48 prespecified secondary 48 Aplidin R 48 Hypertriglyceridemia 48 CME CE 48 riociguat 48 tapentadol ER 48 Left Ventricular 48 serum GGT 48 events ADEs 48 Adult Cardiac Surgery 48 Carotid Endarterectomy 48 Common Toxicity Criteria 48 Septic Shock 48 NSQIP 48 Plaque Psoriasis 48 MS DRG 48 Thorough QT 48 WOMAC scores 48 Myocardial 48 ADEs 48 Assessment Scale 48 WOMAC pain 48 Fibromyalgia Impact Questionnaire 48 serum bicarbonate 48 NCCN guidelines 48 neurocognitive functioning 48 CEUS 48 Recommended Practices 48 Notified Bodies 48 IL 1ß 48 ACC NCDR 48 GW# [003] 48 Clinical Efficacy 48 Mean Symptom Complex 48 RISPERDAL ® 48 Polymorphism 48 beta 1a 47 J Immunol 47 Neuropsychological 47 clinical pharmacology studies 47 SIMPADICO 47 autonomic dysfunction 47 ug dose 47 Fibromyalgia syndrome 47 RAPTIVA 47 Differential Diagnosis 47 Otelixizumab 47 IPAH 47 DAS# scores 47 NeuroStar TMS Therapy 47 atherogenic dyslipidemia 47 clinically meaningful improvements 47 Atomoxetine 47 clinically relevant 47 SYN# 47 Quantifiable 47 Subscale 47 AZILECT R 47 Elitek 47 OLYMPIA registry 47 PRIALT 47 Clinical Outcome 47 Symptom severity 47 QualityMetric 47 Continual Improvement 47 mg BID dose 47 RhuDex 47 Quotient TM 47 COMT genotype 47 AAO HNS 47 Ischemic 47 ANTEGREN 47 Cognitive Dysfunction 47 comorbid anxiety 47 achieved statistical significance 47 NNT = 47 IVIVC 47 tumor lysis syndrome 47 Percutaneous Coronary Interventions 47 NIHSS 47 Complications Trial 47 induced sputum 47 dyslipidaemia 47 INFERGEN 47 serum bilirubin 47 multivariate logistic regression 47 Angiox ® 47 Ambulatory Blood Pressure 47 FDG PET imaging 47 Guideline Update 47 ischemic cardiovascular 47 CIBIC plus 47 HORIZONS AMI trial 47 Degarelix 47 pathophysiologic 47 CTEPH 47 atherosclerotic cardiovascular 47 Transthyretin 47 Stress Induced 47 Rating Scale MADRS 47 serum ALT 47 Functional Assessment 47 bivariate analyzes 47 CT urography 47 VerifyNow P#Y# Test 47 UA NSTEMI 47 aspartate aminotransferase AST 47 VAPRISOL 47 Iron Overload 47 covariate 47 psychosocial variables 47 escitalopram Lexapro 47 NYHA functional class 47 cognitive affective 47 DSM IV diagnoses 47 Sibutramine Cardiovascular Outcomes 47 AtherOx 47 Diseases ICD 47 ACUITY 47 somatic symptoms 47 Cronbach alpha 47 PANSS total 47 Ashworth Scale 47 multivariate analyzes 47 prospective observational cohort 47 Hamilton Rating Scale 47 oxycodone CR 47 Prognostic Value 47 HADS 47 Multivariable 47 dosimetric 47 physiologic parameters 47 acute mania 47 CTQ 47 antipsychotic prescribing 47 HRQoL 47 electrophysiologic 47 Adverse Event Reporting 47 airflow limitation 47 metabolite concentrations 47 Implementation Guides 47 6MWD 47 Cystic Fibrosis Questionnaire Revised 47 sociodemographic factors 47 glycoprotein IIb IIIa inhibitor 47 SGRQ 47 toxicologic 47 ß blockers 47 Chronic Obstructive Lung 47 NUEDEXTA 47 interrater 47 ISMP 47 Clinical Guideline 47 NDA resubmission 47 function subscale 47 Demonstrated Significant 47 ST Segment Elevation 47 Hematocrit 47 Dyspnea 47 Interrater reliability 47 Pearson correlation coefficients 47 intestinal permeability 47 Score DAS# 47 multivariate Cox 47 multivariable analysis 47 Acute Coronary Syndromes ACS 47 interobserver 47 rs# [004] 47 Alkaline Phosphatase 47 Kidney Function 47 Pharmacoeconomic 47 antithrombotics 47 Score DAS 47 rilonacept 47 venous thromboembolic disease 47 Sensorimotor 47 Visensia 47 Pelvic Organ Prolapse 47 Quantitation 47 Descriptive statistics 47 EURIDIS 47 prospective randomized multicenter 47 Prognostic Factors 47 electroencephalographic 47 Multiple logistic regression 47 Non Inferiority 47 WOMAC 47 Eur Urol 47 Antitumor 47 CAHPS ® 47 NYHA 47 Clinical Evaluation 47 Visual Analogue Scale VAS 47 Disease Severity 47 Heart Rate Variability 47 HSSP 47 multicenter prospective 47 myocardial infarctions MIs 46 Microalbuminuria 46 left ventricular diastolic 46 platelet aggregation inhibitors 46 posttreatment 46 YONDELIS 46 intrathecal baclofen 46 Lewy bodies DLB 46 OZURDEX 46 preadmission 46 patientswith 46 Hepatic 46 angiographically 46 Generally Accepted 46 Radiographic 46 TNM staging 46 GWTG 46 aurora kinase 46 Wireless Temperature Monitoring 46 Archexin 46 Natalizumab 46 QoL 46 HRQOL 46 neurocognitive function 46 Homeostasis 46 Female Sexual Function 46 conditional logistic regression 46 MAXALT 46 Patient Satisfaction Survey 46 Exhaled Nitric Oxide 46 Formative Assessment 46 multicentre randomized 46 Cinacalcet HCl 46 Histopathological 46 Physical Component 46 paroxetine Seroxat 46 secondary efficacy endpoint 46 Reproducibility 46 Outcomes Study 46 Clintrace 46 HCPCS 46 symptomatic DVT 46 Vimpat R 46 HEDIS 46 hyperhomocysteinemia 46 dose escalation phase 46 cardiac autonomic 46 subscore 46 Depressive Symptoms 46 Evaluation Tool 46 Actively participates 46 PROactive Study 46 ANOVA 46 MDRD 46 Surviving Sepsis Campaign 46 vasomotor 46 serum homocysteine 46 Albuminuria 46 mean ± SEM 46 Heterogeneity 46 oral triptans 46 posttest 46 NIHSS score 46 icatibant 46 dexamethasone suppression 46 carotid IMT 46 Impact Questionnaire 46 SWOG 46 sustained ventricular tachycardia 46 Zolpimist ™ 46 meta analytic 46 spectrophotometric 46 Late Breaker 46 antineoplastic 46 mapping geochemical sampling 46 HoFH 46 TASKi3 46 multivariate regression analysis 46 Renal Anemia 46 interrater reliability 46 logistic regression analyzes 46 Multiple linear regression 46 Neurocognitive 46 Hepatitis C Genotype 46 indications contraindications 46 advanced hepatocellular carcinoma 46 International Prostate Symptom 46 Rating Scale BPRS 46 CIPN 46 metabolic parameters 46 ROTARIX 46 EMPHASIS HF 46 FDG-PET/CT 46 Shows Efficacy 46 psychopathological symptoms 46 immunohistochemical 46 Visual Analog Scale 46 genetic polymorphisms 46 XSPA 46 Functioning Scale 46 nonsignificant 46 Psychometric 46 Postoperative complications 46 DOXIL 46 crizotinib PF # 46 Gastrointestinal Disorders 46 angiotensin II receptor blockers 46 VKORC1 46 Xyrem ® 46 Pemphigus 46 baminercept 46 Shows Promise Against 46 ZACTIMA 46 symptomatic intracranial hemorrhage 46 Glycemic Control 46 urine albumin 46 dose cohort 46 IOP lowering 46 transthoracic echocardiography 46 CIBIC Plus 46 Thomson Reuters MarketScan 46 #dhTxB# 46 Logistic regression 46 baseline FEV 46 Miconazole 46 CALGB 46 physiological nutritional 46 liver histology 46 Percutaneous Coronary Intervention 46 Generalised Anxiety Disorder 46 Health Assessment Questionnaire 46 neuropathologic 46 IMPACT DCM 46 semiquantitative 46 Guidance Document 46 SSRI citalopram 46 E2B 46 Subgroup analyzes 46 Anxiety Depression 46 Multivariate analysis 46 serum cotinine 46 Surgical Mesh 46 Enhesa 46 Vertebral Fractures 46 Acute MI 46 Novel Compound 46 UPLYSO 46 AZOR 46 phosphorylated tau 46 atherosclerotic renal artery stenosis 46 Spinal Manipulation 46 prognostic variables 46 etiologic 46 DAS# remission 46 Heritability 46 Amplicor 46 NHAMCS 46 longitudinal cohort study 46 Histological 46 Digit Symbol Substitution 46 PLMS 46 ER CHOP 46 multivariable analyzes 46 Polyp Prevention Trial 46 T2DM 46 Etanercept 46 IRLS score 46 Xalatan R 46 salivary cortisol 46 HealthGate 46 Repeatable Battery 46 prospectively defined 46 erythropoietic 46 NVLAP 46 skin sterol 46 Interstitial Cystitis 46 IHE profiles 46 florbetaben 46 Confirmatory 46 urodynamic parameters 46 KRAS gene mutations 46 MediServe 46 preoperative intraoperative 46 GLP GMP 46 diabetes mellitus DM 46 HYCAMTIN 46 oral diclofenac 46 Muscarinic 46 Vectra DA 46 OSAHS 46 Hemodialysis Patients 46 Prehypertension 46 CAMMS# 46 EchoCRT 46 observational cohort study 45 decrements 45 CNS LS 45 Physical Exams 45 gastroduodenal 45 LV ejection fraction 45 constipation OIC 45 Epitopes 45 logistic regression analysis 45 Study Shows Benefits 45 neurocognitive deficits 45 TWGs 45 Symptom 45 CPT coding 45 enterococcal 45 multivariate statistical 45 Intramuscular 45 IMV ServiceTrak 45 Abnormal Involuntary Movement 45 ICD Registry 45 midkine 45 Therapeutic Arthritis 45 Autologous Stem Cell Transplantation 45 APACHE II 45 Cystatin C 45 Severity MSCS score 45 syncopal 45 Ambulatory EHR ensures 45 Fatty Liver 45 ACTOS ® 45 Lower Limb 45 System AERS 45 PD2i ® 45 waist circumference WC 45 GIK infusion 45 rhITF 45 aminotransferase 45 bispectral index BIS 45 Ejection Fraction 45 STEMIs 45 transrectal ultrasound guided 45 Significantly Improved 45 TQT studies 45 rhinoconjunctivitis 45 periprocedural MI 45 platelet reactivity 45 Glypromate 45 State Examination MMSE 45 NDTI 45 abdominal adiposity 45 ACRIN 45 Hemoglobin A1c 45 Acute Coronary Syndrome 45 CSF Assurance 45 Rating Scale IRLS 45 treat NNT 45 Endothelial dysfunction 45 NextGen Inpatient Clinicals 45 PITX2 methylation 45 CSBM 45 Functional Outcomes 45 tipranavir ritonavir 45 Hyperparathyroidism 45 depressive symptomatology 45 International Prognostic Scoring 45 BEXXAR 45 Prolongs Survival 45 Kaplan Meier estimates 45 recombinant soluble 45 IBDQ 45 Atopic 45 Clinical Documentation 45 Electronic Submission 45 serum parathyroid hormone 45 myocardial viability 45 F FDG PET 45 Hematological 45 ESHO 45 AIR CF1 45 semistructured interviews 45 cerebral glucose metabolism 45 Diamyd Medical Diamyd 45 Controlled Trial 45 Suicidality 45 PJTG 45 Assessment Methodology 45 Virologic Response 45 plasma renin activity 45 Global Impression 45 CDAI score 45 IEC #-# [001] 45 Geosphere 45 Comorbidities 45 Photometric 45 mild hepatic impairment 45 postintervention 45 Solid Tumours 45 Opioid Use 45 Prioritized 45 UACR 45 C Reactive Protein 45 clinicopathologic 45 ADDM 45 Nascobal Nasal Spray 45 HSCT 45 MIVI TRUST 45 HCAHPS 45 logistic regression models 45 Mammographic 45 MBHO 45 EQUIP OB 45 RhuDex ® 45 urodynamic 45 serum retinol 45 Bipolar Disorders 45 Coronary artery bypass grafting 45 Coronary Artery Calcium 45 Ranolazine 45 InviroSNAP 45 arterial oxygen saturation 45 electrocardiographic 45 CSAMT MT 45 OQ 45 serum aminotransferase levels 45 trough FEV1 45 International Statistical Classification 45 hematologic adverse 45 teriflunomide 45 efalizumab 45 EMBEDA TM 45 REALITY Trial 45 Distress Scale 45 glucose insulin 45 EFNS 45 Retinal Vein Occlusion 45 Cholinesterase Inhibitors 45 tardive dyskinesia TD 45 hyperacute 45 statistical significance p 45 Quetiapine 45 affective psychosis 45 CPT code 45 Infarct 45 retrospective cohort 45 urinary N telopeptide 45 Patient Reported Outcome 45 Cardiovascular Risk 45 NWEA MAP 45 intraclass correlation coefficients 45 ICAAC IDSA 45 Healthy Behaviors 45 Cancer Genetic Markers 45 multivariable logistic regression 45 diabetic dyslipidemia 45 histopathologic 45 SAS# Type 45 intima media thickness IMT 45 localized prostate 45 trials RCTs 45 serotonin reuptake inhibition 45 hepatic lesions 45 Child Behavior Checklist 45 Scale Revised 45 apnea hypopnea index 45 pretest probability 45 Ionizing Radiation 45 Score TOS 45 macrolide antibiotic 45 paroxetine sertraline 45 psychiatric comorbidities 45 scintigraphic 45 Temperature Humidity 45 Lipid Lowering 45 Dacogen injection 45 NADP 45 Hazard Perception 45 Somatic 45 Adalimumab 45 univariate analyzes 45 Metametrix 45 PrimeSUITE 45 Hypertrophy 45 Clin J 45 Acute Treatment 45 glaucomatous 45 adjuvant systemic 45 PARP Inhibitor 45 ® Integration CMMI 45 Detrol Detrol LA 45 Medi Span ® 45 GWTG Stroke 45 Stable Angina 45 Radianse Reveal 45 pulse amplitude 45 anticoagulant warfarin 45 chronic thromboembolic pulmonary 45 ezetimibe simvastatin 45 NCCN Drugs 45 Intervention Trial 45 pairwise comparisons 45 CCPM 45 ALSFRS R 45 Subgroup Analysis 45 psychometric properties 45 Timed Walk 45 Logistic regression analyzes 45 mesilate 45 dorzolamide 45 Perioperative 45 Depression Scale 45 Univariate 45 Susceptibility Testing 45 Proteinuria 45 glucocorticoid induced 45 Randomized Controlled Trials 45 PRESEPT 45 urothelial 45 psychophysiological