Related by context. All words. (Click for frequent words.) 63 Sustained Virological Response 59 Metastatic breast cancer 59 sustained virologic response 59 Sustained virologic response 58 complete Early Virological 57 telaprevir dosed 57 K ras mutations 56 sustained virological response 56 undetectable HCV RNA 56 Pemetrexed 56 Sustained Virologic Response 56 detectable HCV RNA 56 Venous thromboembolism 55 Renal dysfunction 55 Latent TB 55 Adjuvant therapy 55 Chronic pancreatitis 55 NMIBC 54 gemcitabine carboplatin 54 metastatic hormone refractory 54 stage IIIB 54 modified RECIST criteria 54 serum HBV DNA 54 Inflammatory bowel disease 54 gastrointestinal stromal tumors 54 Lenalidomide 53 achieved sustained virological 53 Anti TNF 53 KRAS wild 53 T#I [002] 53 Omacetaxine 53 ribavirin therapy 53 Hurthle cell 53 relapsed MM 53 dasatinib Sprycel 53 Chronic sinusitis 53 FOLFOX6 53 CCR5 tropic HIV 53 achieve sustained virologic 53 achieved sustained virologic 53 Virulizin ® 53 SVR 53 relapsed refractory multiple myeloma 53 ribavirin RBV 53 transcript De Vries 52 SVR# 52 metastatic malignant melanoma 52 SCr 52 gefitinib Iressa 52 treatment naive genotype 52 HCV genotype 52 Acute sinusitis 52 Non inferiority 52 CIMZIA TM 52 del 5q 52 HCV SPRINT 52 B CLL 52 KRAS status 52 biphosphonates 52 invasive ductal breast cancer 52 Gleevec resistant 52 prodromal phase 52 CR nPR 51 taxane chemotherapy 51 Crohn Disease Activity 51 Fludarabine 51 recurrent NSCLC 51 pegylated interferon alfa 51 imatinib Gleevec 51 CYP#A# substrate 51 Cloretazine 51 FIRMAGON 51 virologic response 51 galiximab 51 peginterferon 51 Chronic bronchitis 51 CIMZIA ™ 51 ritonavir boosted 51 ZACTIMA 51 antiangiogenic therapy 51 refractory NSCLC 51 HER2 positivity 51 EGFR mutation positive 51 Acute myeloid leukemia 50 achieve sustained virological 50 cancer mCRC 50 Uncontrolled hypertension 50 abiraterone acetate 50 Irritable bowel syndrome 50 previously untreated follicular 50 adriamycin 50 RECIST criteria 50 PEG IFN 50 alkylating agents 50 Peginterferon Alfa 2a 50 Glioblastoma multiforme GBM 50 stage IIIb IV 50 interferon therapy 50 chemotherapeutic regimen 50 adjuvant systemic 50 mRCC 50 adalimumab Humira 50 Diffuse Large B 50 XELOX 50 PegIFN 50 histologies 50 peginterferon alfa 2a 50 piperacillin tazobactam 50 Irritable bowel syndrome IBS 50 hepatitis C HCV 50 distinct subtypes 50 Endothelial dysfunction 50 alfa 2a 50 plasma uric acid 50 Postherpetic neuralgia 50 tipranavir ritonavir 50 chronic HCV genotype 50 PegIFN RBV 50 LEUKINE 50 baseline LDH 50 biologic therapy 50 aerodigestive tract 50 Copegus ribavirin 50 serum testosterone 50 pathologic fracture 49 rapid virologic response 49 Elitek 49 oral diclofenac 49 fulvestrant 49 serum HCV RNA 49 infliximab monotherapy 49 progression TTP 49 Solid Tumors criteria 49 EGFR expressing mCRC 49 Prehypertension 49 EGFR expressing 49 DAPT 49 neurologic progression 49 human Chorionic Gonadotropin 49 EGFR TKI 49 Circulating tumor cells 49 Radiofrequency ablation 49 imatinib therapy 49 Malignant glioma 49 Seroconversion 49 ANCHOR trial 49 q8h 49 cytostatic 49 Symptom onset 49 5FU 49 lumiliximab 49 null responders 49 Peg IFN 49 hepatitis C genotype 49 adverse cytogenetics 49 sleeve lobectomy 49 PCa 49 CDAI 49 stage IIIA 49 Genital herpes 49 TMEM density 49 Rapid Virological Response 49 Subarachnoid hemorrhage 49 Chronic cough 49 VFEND 49 relapsed ovarian cancer 49 Topotecan 49 CCyR 49 metastatic CRC 49 myelodysplastic syndromes MDS 49 Free Survival PFS 49 operable pancreatic cancer 49 FOLFIRI 49 Imatinib 49 CHOP chemotherapy 49 APOPTONE 49 virologic response EVR 48 achieving sustained virologic 48 viral kinetics 48 virologic failure 48 ZD# [001] 48 Amrubicin 48 CRp 48 IRESSA 48 immunosuppressant 48 undetectable virus HCV 48 HBeAg seroconversion 48 coinfected patients 48 Meningiomas 48 severe neutropenia 48 interferon ribavirin 48 HBeAg positive 48 metastatic renal cell carcinoma 48 Cognitive impairment 48 Pneumocystis pneumonia PCP 48 interferon beta therapy 48 chemoradiotherapy 48 docetaxel Taxotere ® 48 ACTEMRA TM 48 CK # plasma concentrations 48 Acid reflux disease 48 ACR# responses 48 Habitual snoring 48 CD# expression [002] 48 lymphocytosis 48 -#.# log# 48 locoregional recurrence 48 PegIntron 48 pegylated interferon peg IFN 48 Sleep disordered breathing 48 sorafenib Nexavar 48 ug dose 48 mCRC patients 48 M#V mutation 48 biochemical recurrence 48 fluvastatin 48 virological response 48 Postoperative complications 48 virologic suppression 48 tyrosine kinase inhibitor TKI 48 progressive neurodegenerative disorder 48 chemoresistant 48 Virologic failure 48 IU ml 48 peg interferon 48 Gestational diabetes 48 DAS# [002] 48 Myocardial infarction 48 Shell Lubricants collectively 48 HCV infected 48 peg IFN 48 QTcF 48 tumor histology 48 HBsAg 48 log# reduction 47 K ras mutation 47 Multivariate logistic regression 47 plus COPEGUS 47 glycated hemoglobin HbA1c 47 Neuropathic pain 47 Osteopenia 47 pegylated interferon 47 pegylated interferon alfa 2a 47 nonalcoholic steatohepatitis 47 EBMT criteria 47 Subclinical hypothyroidism 47 atazanavir ritonavir 47 genetic aberrations 47 pegIFN 47 nitazoxanide 47 postdischarge 47 Anal cancer 47 Decompensated 47 chronic HCV 47 liver histology 47 glycated hemoglobin levels 47 angiotensin converting enzyme inhibitor 47 COMBIVIR 47 intra abdominal abscess 47 PSA nadir 47 Procoralan 47 Pegylated Liposomal Doxorubicin 47 Torisel 47 Kaplan Meier curve 47 #mg QD [001] 47 lymphoma CTCL 47 Male hypogonadism 47 treatment naïve genotype 47 asymptomatic metastatic 47 cediranib 47 HCV RESPOND 2 47 Heavy menstrual bleeding 47 Sorafenib 47 neoadjuvant therapy 47 ErbB2 positive 47 Syniverse Technologies NYSE 47 KRAS mutations occur 47 mTOR mammalian target 47 abacavir lamivudine 47 BMS # 47 ischemic cardiomyopathy 47 Partial Response 47 olaparib 47 pituitary adenomas 47 BCG refractory 47 subtrochanteric 47 relapsed SCLC 47 OPTIMIZE 47 PEG interferon 47 bortezomib Velcade R 47 Cetuximab 47 PSVT 47 prostate cancer CRPC 47 XIENCE V PROMUS Stent 47 achieved CCyR 47 adecatumumab 47 Exacerbation 47 Gemcitabine 47 HCV genotype 1 47 radiographic progression 47 Kaplan Meier analysis 47 docetaxel chemotherapy 47 IPSS 47 gemcitabine Gemzar 47 dacarbazine 47 mg kg dose 47 HER2 + 47 Jevtana 46 biochemical relapse 46 Pathological gambling 46 periprocedural MI 46 TNF inhibitor 46 virological failure 46 ULORIC 46 taxane therapy 46 5-FU/LV 46 MabCampath 46 seroconversion 46 Orthorexia 46 HBV DNA 46 composite endpoint 46 chlorambucil 46 follicular lymphomas 46 platelet inhibitor 46 nonseminoma 46 Main Outcome Measure 46 VELCADE melphalan 46 Acute pancreatitis 46 DMARD 46 Severe Primary IGFD 46 Cancer AACR NCI 46 cryptogenic 46 octreotide 46 CD4 + CD# 46 APNB 46 myocardial ischaemia 46 mapatumumab 46 resuscitated cardiac arrest 46 neutrophil count 46 CLL SLL 46 seminomas 46 bicalutamide 46 plus dexamethasone 46 pCR 46 CSF biomarkers 46 unprovoked seizures 46 Hypogonadism 46 unresectable stage 46 radical cystectomy 46 neoadjuvant 46 ABC/3TC 46 prospectively defined 46 microtubule targeting 46 tipranavir 46 TDF FTC 46 Aptivus ® 46 Pegasys ® 46 psychology Sigmund Freud 46 certolizumab 46 osteoid 46 deeply ingrained maladaptive 46 ERBB2 46 STELARA 46 Sluzhba 46 clinicopathological features 46 tyrosine kinase inhibitor 46 monoclonal gammopathy 46 histologically 46 symptomatic pulmonary embolism 46 NNRTI resistance 46 periprocedural 46 prior chemotherapy regimens 46 naïve HCV 46 hormone refractory prostate cancer 46 DAS# remission 46 cytogenetic response 46 eplerenone 46 temsirolimus 46 CR CRu 46 mcg albinterferon alfa 2b 46 Boceprevir 46 imatinib mesylate 46 pazopanib 46 Hodgkin lymphoma NHL 46 HER2 negative 46 remission CR 46 untreated multiple myeloma 46 BAY #-# 46 estrogen receptor progesterone receptor 46 Issuances Table 46 genotype 1b 46 pomalidomide 46 annualized relapse 46 chronic hemolysis 46 q#h 46 refractory systemic ALCL 46 adalimumab 46 Thyroid disorders 46 arterial thickening 46 chemotherapy docetaxel 45 dose melphalan 45 relapsed refractory 45 liver metastases 45 enalapril 45 MGUS 45 DOXIL ® 45 cytotoxic chemotherapy 45 mutated KRAS 45 OvaRex MAb 45 peginterferon alfa 2b 45 naive HCV 45 Triapine R 45 vandetanib 45 coinfected 45 indapamide 45 Rapid Virologic Response 45 mCRC 45 FOLPI 45 heavily pretreated 45 Frequent heartburn 45 angiographically 45 mega watt personalities 45 IIIa inhibitors 45 serum ALT 45 seropositive patients 45 Genetic mutation 45 decitabine 45 seliciclib 45 Rheumatic fever 45 HIV RNA 45 radiographic findings 45 ACR# response 45 rituximab refractory 45 neoadjuvant treatment 45 malignant lesion 45 IU mL 45 pegfilgrastim 45 rituximab monotherapy 45 bone metastasis 45 Multikine patented 45 preserved ejection fraction 45 MACCE 45 Chronic Lyme disease 45 INNOVATOR 45 ILLUMINATE 45 Pegasys plus Copegus 45 AMN# [001] 45 Pixantrone 45 #mg QD [002] 45 neurologic impairment 45 asymptomatic carotid stenosis 45 daunorubicin 45 Chronic Myeloid Leukaemia 45 psychiatric comorbidities 45 disease progression TTP 45 #mg BID [001] 45 tenecteplase 45 sunitinib 45 ToGA 45 glomerular filtration 45 radiologically confirmed 45 FDG PET scans 45 azacytidine 45 dose dexamethasone 45 Resistant hypertension 45 virological suppression 45 complete cytogenetic response 45 fludarabine 45 viral etiology 45 baseline HbA1c 45 ivabradine 45 log# IU mL 45 fibrinolytic 45 clodronate 45 FluCAM 45 temozolomide 45 nanomolar potency 45 imatinib mesylate Gleevec 45 untreated CLL 45 HCV RNA 45 Toenail fungus 45 nonfatal MI 45 RGT arm 45 Watchful waiting 45 pegylated interferon ribavirin 45 rebleeding 45 serum PSA 45 Spinal manipulation 44 intravesical 44 Logistic regression 44 binary restenosis 44 rizatriptan 44 Descriptive statistics 44 Myotonic dystrophy 44 infliximab therapy 44 plasma HCV RNA 44 rhEPO 44 neurocognitive impairment 44 carboplatin paclitaxel 44 imipenem 44 pericardial effusion 44 stress cardiomyopathy 44 placebo dexamethasone 44 #mg BID [002] 44 Nocturia 44 anastrazole 44 logistic regression model 44 Kaplan Meier estimate 44 Aortic dissection 44 neoadjuvant chemotherapy 44 irbesartan 44 nab paclitaxel 44 differential gene expression 44 interferon alfa 2a 44 NSTEMI 44 serum urate 44 Condition Classification 44 CTLs 44 Canker sores 44 spontaneous regression 44 Fludara 44 NRTI 44 radical prostatectomy RP 44 log# copies mL 44 bezafibrate 44 achieved ACR# 44 trabedersen 44 Sarcopenia 44 unresectable 44 metastatic colorectal cancer 44 KRAS mutations 44 Suicidal tendencies 44 EDSS scores 44 anti TNFs 44 multivariate Cox 44 Obstructive sleep apnea OSA 44 cystectomy 44 Screening mammography 44 axitinib 44 NNRTI 44 IIIa inhibitor 44 5 HT2B receptor 44 Operative mortality 44 goserelin 44 Telaprevir 44 DMARDs 44 recurrent unprovoked 44 Median PFS 44 CDAI score 44 AVADO 44 syndromal 44 Excessive daytime sleepiness 44 logistic regression analysis 44 elvitegravir 44 lacunar 44 Gastroesophageal reflux disease 44 standard chemotherapy regimens 44 comorbid anxiety 44 IFN α 44 LPV r 44 multivariate regression analysis 44 affective psychosis 44 multivariate logistic regression 44 topotecan 44 Median survival 44 recurrent GBM 44 Human papillomavirus HPV 44 antidiabetic 44 univariate analyzes 44 interquartile range 44 tipranavir r 44 follicular NHL 44 lamivudine monotherapy 44 subcutaneously administered 44 entecavir 43 Multivariate analysis 43 Non accrual Loans 43 REMICADE monotherapy 43 relapsed CLL 43 Syniverse Technologies SVR 43 BCR ABL mutation 43 Acromegaly 43 Malignant gliomas 43 prodromal 43 ximelagatran 43 pulmonary dysfunction 43 platelet reactivity 43 Tourette syndrome TS 43 Hazard Ratio 43 Mild hypothermia 43 FOLFOX4 43 Waldenstrom Macroglobulinemia 43 log# 43 SUVmax 43 Kivexa 43 femoral fracture 43 tissue oxygen saturation 43 neuropsychological impairment 43 aetiological 43 evaluable patients 43 oblimersen 43 undetectable viral load 43 adnexal mass 43 superior mesenteric artery 43 seroprotection 43 infliximab 43 azacitidine 43 Obstructive sleep apnea 43 histologic findings 43 Urge incontinence 43 plasma renin activity 43 COPAXONE ® 43 RPS1 43 MVax R 43 neurologic dysfunction 43 Tooth brushing 43 dysthymic disorder 43 degarelix 43 cardioembolic stroke 43 Iatrogenic 43 NSTE ACS 43 CsA 43 auto allo 43 Influenza vaccination 43 EGFr 43 covariance 43 tachycardias 43 ARTHRITIS AQUATIC PROGRAM 43 Lupuzor ™ 43 coronary revascularization 43 chemotherapy regimens 43 advanced NSCLC 43 Premature ejaculation 43 mediastinal lymph nodes 43 metastatic HRPC 43 CD8 + lymphocytes 43 Anorexia nervosa 43 Median progression 43 Whole genome sequencing 43 Routine screening 43 Complete Response CR 43 median PFS 43 Shy Drager syndrome 43 imatinib 43 Flu Cy 43 tertiary syphilis 43 gait disturbances 43 Risk premia 43 HCV 43 lenalidomide 43 Hb A1C 43 Y BOCS 42 μmol L 42 neutrophil counts 42 Chronic angina 42 REYATAZ R 42 Enlarged prostate 42 Votrient 42 IL#B 42 lymphoblastoid cell lines 42 Chronic fatigue syndrome 42 virologic 42 perioperative mortality 42 Uveal melanoma 42 refractory follicular lymphoma 42 ponatinib 42 Hypertrophic cardiomyopathy 42 Compulsive hoarding 42 talabostat 42 Mild cognitive impairment 42 YERVOY 42 Multidrug resistant TB 42 optic neuropathy 42 Kaplan Meier estimates 42 allogeneic SCT 42 dosimetric 42 Backup Kevin Kolb 42 underlying pathophysiology 42 metastatic lesions 42 prior antiangiogenic therapy 42 LRRK2 mutation 42 lamivudine 42 nodular partial response 42 bendamustine 42 tumor regressions 42 COPAXONE 42 evaluable subjects 42 Clot busting 42 Fluzone Intradermal vaccine 42 nilotinib 42 any liveauctioneers.comlive auction 42 fatty infiltration 42 cytotoxic agents 42 IFN alfa 42 rugged CompactPCI 42 autoimmune pancreatitis 42 APTIVUS R 42 heavily pretreated patients 42 dasatinib 42 CRu 42 APOE genotype 42 inherited neurological disorder 42 bronchopulmonary dysplasia 42 Overactive bladder 42 plus ribavirin 42 GBM tumors 42 Pricing Supplement 42 HLA DR2 42 oversulfated version 42 telbivudine 42 Linear regression 42 exfoliative glaucoma 42 Peg riba 42 oral allopurinol 42 leukocyte count 42 orofacial pain 42 plasma concentrations 42 Protelos 42 chronic hepatitis C 42 mitoxantrone 42 imetelstat 42 CML 42 oxaliplatin 42 dose cohorts 42 endoscopic remission 42 Vertebral fractures 42 Syniverse Holdings 42 poststroke 42 decreasing accounts receivable 42 Febrile seizures 42 olmesartan 42 Reasonable suspicion 42 chronic lymphocytic leukemia CLL 42 Oncophage 42 diastolic velocity 42 African Sleeping Sickness 42 experienced virologic failure 41 Rick Badie column 41 Pixuvri 41 vertebral fracture 41 Urinary tract infections 41 cyclophosphamide FC 41 lumbar disc disease 41 SCH # 41 CD4 + cell 41 Skin lesions 41 continuously abstinent 41 circadian genes 41 equianalgesic dose 41 Morbid obesity 41 comorbid disorders 41 psychiatric comorbidity 41 Yeast infections 41 VICTRELIS 41 Takotsubo cardiomyopathy 41 copies mL 41 Figure 1A 41 CYP#C# * 41 Severe hypoglycemia 41 atherothrombotic 41 Genentech Biogen 41 survivin 41 Nasal congestion 41 EGFR mutation 41 mg subcutaneous 41 conditional logistic regression 41 logistic regression models 41 chronic Lyme 41 Cerebral palsy involves 41 QRS width 41 Anomalous radioactivity 41 diagnosed multiple myeloma 41 Capitalised terms 41 § #-#.# [001] 41 Xcytrin 41 Podloso 41 TAXUS Stent 41 complete cytogenetic 41 insulin glargine 41 occult metastases 41 plus methotrexate 41 dose cytarabine 41 defibrotide 41 circulating EPCs 41 CPOP R 41 ZOMIG Nasal Spray 41 Industry Classification Benchmark ICB 41 intersexuality 41 free survival PFS 41 sUA 41 complete remissions 41 endophenotypes 41 honeymooner quarantined 41 ACR# [002] 41 TMC# [001] 41 multicentre randomized 41 Neuroticism 41 etoposide 41 disease progression 41 REYATAZ r 41 Triassic sequence 41 monotherapy 41 Male pattern baldness 41 familial aggregation 41 CVP chemotherapy 41 Aplastic anemia 41 tirofiban 41 syncopal 41 PLX# 41 amrubicin 41 lamivudine refractory patients 41 marketed EGFR 41 levosimendan 41 tau protein tangles 41 HbA1C 41 Difficulty swallowing 41 belimumab 41 Calorie restriction 41 clinicopathological 41 Target Lesion Revascularization TLR 41 diaphysis 41 Sinowal 41 sCD# 41 lateral sclerosis ALS 41 True thicknesses 41 G CSF 41 proband 41 iclaprim 41 5 FU 40 familial pancreatic cancer 40 Varicose vein 40 hypomanic episode 40 NIHSS score 40 Hb levels 40 anastrozole 40 CLI summarizes information 40 unruptured aneurysm 40 TNF inhibitors 40 Peritoneal mesothelioma 40 tofacitinib 40 Taxotere ® 40 Multiple logistic regression 40 CCL# 40 methotrexate MTX 40 angiotensin converting enzyme ACE 40 boceprevir 40 mg BID 40 rituximab 40 Rasilez Tekturna 40 Informed consent 40 NSCLC 40 ASA# 40 ofatumumab 40 Calcium intake 40 ribavirin 40 clinically insignificant 40 Lapatinib 40 glargine 40 acetabular fracture 40 LEXIVA r 40 tumor shrinkage 40 anterograde 40 hypercoagulable 40 Lt. Col. Pavel Ryaguzov 40 relapsers 40 EDNOS 40 leukemic cells 40 neuro degenerative disorders 40 depressive symptomatology 40 Male infertility 40 Rotavirus infection 40 prior relapsers 40 logistic regressions 40 Act PDUFA guidelines 40 randomized #:#:# 40 Chickenpox vaccine 40 Smallpox vaccine 40 IRLS score 40 Lactose intolerance 40 peginterferon alfa 2a #KD 40 interventricular septum 40 § #-#.# [003] 40 Chronic insomnia 40 Irregular heartbeat 40 USC #d 40 IFN Beta 40 schizophreniform disorder 40 receiving VICTRELIS 40 A1c levels 40 proximal colon 40 Timed Walk 40 lopinavir r 40 secondary endpoint 40 Subsection b 40 LMWH 40 Mental retardation 40 overnight polysomnography 40 anti TNF 40 surgical ventricular 40 mathematical Jeopardy 40 genotype 40 § #.#.# [001] 40 XIENCE V stent 40 Fecal incontinence 40 Posttraumatic stress disorder PTSD 40 Hebrew word shoah 40 comparator PI r 40 dissociative symptoms 40 Inhaled anthrax 40 Virtual colonoscopy 40 lopinavir 40 adefovir 40 severe psoriasis 40 Undiscovered Resources 40 carboplatin 40 radiographically 40 perifosine 40 Hip dysplasia 40 XIFAXAN rifaximin 40 Sexual arousal 40 iodixanol 40 ISEL 40 cabazitaxel 40 sorafenib 40 angiographic restenosis 39 Brain plasticity 39 cerebral atrophy 39 Barrett esophagus occurs 39 ultra rapid metabolizer 39 thyroid deficiency 39 www.dictionary.com 39 Westport Wiscasset 39 viral suppression 39 Vidaza 39 morphologic characteristics 39 lumbar spine BMD 39 Visual acuity 39 Spinal fractures 39 bacterial antibiotic resistance 39 % EXCLUDING FUEL 39 covariate 39 Skripal 39 Sexual intercourse 39 serum parathyroid hormone 39 Pelvic organ prolapse 39 candesartan 39 DSM IV diagnosis 39 interferon 39 stepwise logistic regression 39 follicular lymphoma 39 Velcade 39 unsecured PHI 39 reintervention 39 sub syndromal 39 lipoprotein profile 39 SITC code 39 echogenic foci 39 viral load 39 Acid reflux 39 ECLS 39 Chronic homelessness 39 polygenic 39 pharmacodynamic 39 lapatinib 39 bivariate 39 Kraepelin 39 nonarteritic anterior ischemic optic 39 Permitted Holders 39 interferon beta 39 fragility fracture 39 explanatory variables 39 Oleg Gordievsky 39 atorvastatin #mg 39 trastuzumab 39 NJAC #:#-#.# 39 Penile cancer 39 acronym FSB 39 copies ml 39 HbA1c levels 39 Heartworm disease 39 Okla. Stat 39 Encarta Dictionary 39 Urinary incontinence 39 FRMs 39 relapsed Hodgkin lymphoma 39 Bonferroni correction 39 Assumption Deterrence Act 39 zalutumumab 39 Variable Rates 39 darunavir ritonavir 39 plus MTX 39 target lesion revascularizations 39 methylation patterns 39 Nasal allergies 39 undergoing CABG 39 NIH CPSI 39 odanacatib 39 hypertrophic cardiomyopathy HCM 39 LEXIVA