Related by context. All words. (Click for frequent words.) 88 corneal wound 71 angiotensin analog 62 antiangiogenic activity 61 demonstrated antitumor activity 61 kidney urologic 60 leukocyte adhesion 59 myoglobinuria rhabdomyolysis 59 gastrointestinal perforation wound 59 elevated creatinine phosphokinase 59 Tß4 59 MCSP respectively 59 fusion enhancers 59 antitumor efficacy 58 oral prodrug 58 rheumatoid arthritis osteoarthritis ankylosing 58 treat facial wrinkles 58 acetonide FA 58 skeletal metastases 58 elevated creatine phosphokinase 57 gastrointestinal mucositis 57 venous stasis ulcers 57 musculoskeletal tissues 57 TB4 57 dermal wound 57 neurotrophic 57 Bone Morphogenetic Protein 57 LHRH analogues 57 fibrin deposition 57 Budesonide foam crofelemer 57 oral picoplatin 56 TÎ ² 4 56 neointimal hyperplasia 56 rheumatoid arthritis juvenile idiopathic 56 regenerating bone 56 hypervascular tumors 56 GEM OS2 56 MAbs targeting 56 collagen degradation 56 thymosin beta 4 56 vaso occlusive crisis 56 hypertrophic scarring 56 induced tumor regression 56 anti fibrotic 55 topical anti infectives 55 vaginal candidiasis 55 certain protein tyrosine 55 Fibrin MB 55 inhaled iloprost 55 cMET 55 AZX# 55 CVBT #B 55 rheumatoid arthritis psoriatic arthritis 55 Glucocorticoids 55 endotoxemia 55 periodontal tissue 55 osteoinductive 55 experimental autoimmune encephalomyelitis 55 Vascugel R 55 NSAID induced 55 Zemiva TM 55 catheter occlusion 55 Naproxen sodium 55 JAK#/JAK# inhibitor CYT# 55 ophthalmology dermatology 55 fibrotic disease 55 neuropathic pain nerve 55 amino sugar 54 intimal hyperplasia 54 coagulation disorders 54 hypertrophic scars 54 taxane resistant 54 antimitotic 54 gynecologic procedures 54 Pharmos pipeline 54 inducing apoptosis 54 omeprazole widely 54 Tβ4 54 Selzentry Celsentri 54 estramustine 54 factor TNF 54 vasodilatation 54 abnormal angiogenesis 54 hyperalgesia 54 myeloproliferative diseases 54 proteoglycan 54 immune modulation 54 potent vasoconstrictor 54 STAT3 signaling 54 BIOGUARD TM 54 cerebral ischemia 54 severe hypersensitivity reactions 54 Entereg R 54 VEGF inhibitors 54 RoACTEMRA 54 PDGF BB 54 Inhaled nitric oxide 53 targeting refractory relapsing 53 erythropoiesis 53 cardiac tamponade cerebral edema 53 anaphylaxis dyspnea flushing 53 iroxanadine 53 osteogenic 53 omega interferon 53 class mGluR5 inhibitor 53 remyelination 53 novel peptide 53 Exelixis compounds 53 selective inhibition 53 cytoprotective 53 lung cancer NSCLC 53 post surgical adhesions 53 Factor VIIa 53 viral reactivation 53 TRAIL receptor antibodies 53 motor neuron degeneration 53 matrix metalloproteinases 53 serine proteases 53 oncologic diseases 53 pouchitis 53 Darinaparsin 53 ALB # 53 Tasigna prolongs 53 tumor necrosis 53 using Innocoll proprietary 53 deferiprone 53 platelet adhesion 53 lung fibrosis 53 MACD Moving Averages 53 collagen synthesis 53 receptor tyrosine kinase inhibitor 53 ischemia induced 53 cyclooxygenase COX 53 Severe hypersensitivity reactions 53 haematologic 53 stimulates collagen production 53 diagnostic molecular imaging 53 collagen deposition 53 antiinflammatory 53 Beta catenin pathway 53 p# inhibitor 53 cardioprotection 53 riociguat 52 lipid lowering therapies 52 neovascular diseases 52 ERK pathway 52 Hematopoietic 52 intercellular adhesion molecule 52 angiogenic therapy 52 prostatic tissue 52 opioid analgesia 52 ischemia reperfusion 52 ischemia reperfusion injury 52 nucleoside analogs 52 leading oral taxane 52 PASI scores 52 retinal neovascularization 52 beta Estradiol 52 bone grafting procedures 52 photodynamic 52 Mitomycin C 52 immune modulatory 52 Preclinical studies suggest 52 lintuzumab SGN 52 ESBA# 52 vascular disrupting agent 52 NB S# strontium malonate 52 induce angiogenesis 52 vitamin D analogs 52 neointimal 52 PDGFR 52 Myolimus 52 urate lowering 52 budesonide foam 52 Smac mimetics 52 Azixa MPC 52 small molecule activators 52 dissolving blood clots 52 factor PlGF 52 atopic dermatitis AD 52 choroidal neovascularization 52 ocular formulation 52 inhibiting tumor 52 thromboembolic disease 52 Syndrome RLS 52 angiogenesis revascularization 52 microglial activation 52 Akt signaling 52 systemic fungal infections 52 atrial arrhythmias 52 venous ulcers 52 cyclic adenosine monophosphate cAMP 52 CSL Behring therapies 52 tissue fibrosis 52 ocular infections 52 Regenerative Cells 52 immunomodulatory effects 52 MAGE A3 ASCI 52 Apoptone 52 SYN# 52 Angiotensin converting enzyme 52 Xcytrin R 52 multitargeted 52 MEK ERK 52 JUVISTA R Human 52 called punctate keratitis 52 community AABB SmartBrief 52 humanised monoclonal antibody 52 thetreatment 52 Hypotension 52 PDGF B 52 Inosine 52 Platelet Derived Growth 51 PEG SN# 51 Factor VEGF 51 hypoxia activated prodrug 51 huC# DM4 51 prodrugs 51 neurology cardiovascular GIT 51 Vicinium TM 51 preclinical models 51 serine threonine 51 neuro vascular 51 CYT# vascular disrupting 51 hematological toxicity 51 Vascugel ® 51 ALL THINGS ARE POSSIBLE 51 erythema edema 51 cyclooxygenase 2 51 oligomerization 51 ischemic mitral regurgitation 51 proinflammatory cytokines 51 IL 1ß 51 INVEGA ® 51 TGF ß1 51 interleukins 51 lung pancreatic 51 topical antimicrobial 51 cartilage degeneration 51 Prestara 51 excisional 51 thrombus formation 51 prostaglandin D2 51 alvespimycin 51 Pls reject 51 ZFP TF 51 MediGene focuses 51 sodium stibogluconate 51 Histone deacetylase 51 coagulation cascade 51 hepatic fibrosis 51 treatmentof 51 PresbyLens ® 51 Abscesses 51 oncogenic transformation 51 lymph drainage 51 Endothelin 51 PRT# 51 nitric oxide synthase 51 Surgical excision 51 tramiprosate Alzhemed TM 51 commercializes therapeutic products 51 tenascin C 51 neurotrophic factors 51 injectable depot 51 Gastrointestinal Stromal Tumors 51 Additionally Nexavar 51 inhibit angiogenesis 51 Vascugel 51 tau phosphorylation 51 reversing heparin 51 multiple sclerosis rheumatoid arthritis 51 tolerability profiles 51 atherosclerotic renal artery stenosis 51 includes TOLAMBA TM 51 XEN# 51 Oral corticosteroids 51 EGF receptor 51 intra abdominal infections 51 SIRT1 activators 51 ApoA1 51 velafermin 51 tuberculosis TB sepsis 51 telomerase inhibition 51 NF kB pathway 51 DGAT1 inhibitors 51 pro angiogenic 51 fulminant hepatic failure 51 vidofludimus 51 Wound Dressing 51 K ras mutations 51 5 HT6 receptor 51 macular hole 51 pediatric malignancies 51 enhance ApoA 51 PI3 kinase inhibitors 51 neovascularization 51 psoriatic skin 51 Augment Injectable 50 anti secretory 50 bardoxolone methyl 50 ALK inhibitors 50 immune modulator 50 regenerating cartilage 50 neuro protective 50 mTOR inhibitors 50 systemic antifungal 50 EGFr 50 ovarian suppression 50 neovascular 50 ADPKD patients 50 fibrotic 50 bioactive glass 50 cannabinor 50 pain palliation 50 RAS RAF MEK 50 γδ T cells 50 microvascular endothelial cells 50 VDAs 50 airway hyper responsiveness 50 E2F Decoy 50 experimentally induced 50 arterial thrombosis 50 oxypurinol 50 Acne Rosacea 50 parkinsonian symptoms 50 myofibroblasts 50 mimetics 50 TAK #MR 50 fibrotic diseases 50 Virulizin ® 50 keloid scars 50 mitogen 50 CA4P 50 receptor inhibitor 50 degranulation 50 Candida infection 50 allantoin 50 evaluating Prochymal 50 NFκB 50 intestinal epithelium 50 Archexin 50 drug ISA# 50 cell transplantation 50 mediated inhibition 50 calcium hydroxyapatite 50 relieve muscle spasms 50 LEUKINE 50 Q#IR 50 potent inhibitors 50 Tarceva TM 50 nitric oxide synthase NOS 50 Ganetespib 50 vivo coagulation 50 JAK#/JAK# 50 acne rosacea 50 Tissue Factor 50 axonal degeneration 50 granulation tissue formation 50 MEK inhibitors 50 swelling stiffness 50 Salicylic acid 50 p# activation 50 keratinocyte migration 50 imexon 50 anticancer activity 50 potent inducer 50 fibrillin 50 prostanoid 50 psoriasis eczema 50 ERK1 2 50 percutaneous tibial nerve 50 NKG2D 50 Prostacyclin 50 ischemic tissues 50 immuno modulatory 50 HER signaling pathway 50 preclinically 50 Anidulafungin 50 MP4OX 50 anti angiogenic agents 50 Th2 cytokines 50 mucociliary clearance 50 liver fibrosis 50 generation URAT1 inhibitor 50 TNF blocker therapy 50 enzyme cofactor 50 allergic inflammation 50 tumorigenicity 50 severe dermatologic toxicities 50 AT1 receptor 50 Topical NSAIDs 50 calcitonin 50 investigating Serdaxin 50 Chrysalin 50 ADAMTS# 50 elastase 50 PPARgamma 50 TGF beta signaling 50 motesanib 49 gemifloxacin 49 blood clot dissolving 49 vascular endothelial 49 osteoconductive 49 autoimmune uveitis 49 complement Coblation within 49 chondral 49 website jabil.com 49 dermal wounds 49 ZACTIMA 49 vascularization 49 lymphomas leukemias 49 neuronal dysfunction 49 cathepsins 49 dephosphorylation 49 intravenous bisphosphonates 49 hyaluronan HA 49 direct thrombin inhibitors 49 venous reflux 49 hyperkeratotic 49 hereditary deficiency 49 infarcted myocardium 49 demethylation 49 interstitium 49 SIRT1 protein 49 enzymatic pathways 49 PEAK PlasmaBlade 49 eculizumab therapy 49 osteoclast activity 49 Zysolin TM 49 Zemplar Capsules 49 ischemic ulcers 49 Reversible Posterior Leukoencephalopathy Syndrome 49 endothelin receptor 49 bone sarcomas 49 cediranib 49 posttranslational modification 49 bone morphogenetic protein 49 neovascularisation 49 chemopreventive agent 49 NAGS deficiency 49 DFUs 49 urocortin 2 49 ciliary neurotrophic factor 49 gastric pancreatic 49 photodamaged skin 49 azelaic acid 49 hyperoxia 49 ZYBRESTAT fosbretabulin 49 Salicylic Acid 49 fibrotic disorders 49 AutoloGel System 49 organogenesis 49 acupuncture biofeedback 49 LLLT 49 γ secretase 49 Arnica Montana 49 fibrinolysis 49 romidepsin 49 diaper dermatitis 49 cognitive impairment associated 49 Colloidal silver 49 resorptive 49 6R BH4 49 basic fibroblast 49 inflamed tissues 49 keratinocyte 49 hypersensitivity reactions eg anaphylaxis 49 chiropractic manipulation 49 inhibiting enzymes 49 phase IIb study 49 squalamine 49 tarsal tunnel 49 Silodosin 49 vascular inflammation 49 plasma kallikrein 49 lenalidomide dexamethasone 49 Tumour Vascular Disrupting Agent 49 HGS ETR2 49 spinal manipulative 49 Elevated PSA 49 immunomodulation 49 neurocognitive deficits 49 menadione 49 Aldara Cream 49 studies evaluating satraplatin 49 immunomodulatory 49 nalbuphine ER 49 PlGF 49 Prolactin 49 Pseudomonas aeruginosa infections 49 Soliris therapy 49 collagen crosslinking 49 molecular biomarkers 49 Evoltra ® 49 regenerate cartilage 49 matrix metalloproteinases MMPs 49 sensory nerve fibers 49 autophagic 49 erythropoietic 49 GRN# 49 PROCHYMAL 49 cartilage regeneration 49 activin 48 discogenic pain 48 potentiation 48 molecular imaging radiopharmaceuticals 48 BrachySil 48 anti EGFR antibody 48 vivo 48 Imiquimod 48 signaling cascades 48 antiangiogenic agents 48 occlusive 48 Plasmin 48 corneal epithelial 48 Topical treatments 48 cell adhesion molecules 48 About MIGENIX MIGENIX 48 NP2 Enkephalin 48 c MET 48 Pirfenidone 48 LPA1 receptor 48 M1 macrophages 48 humoral immunity 48 vascular permeability 48 facials chemical peels 48 hydroxy acids 48 Altrazeal R 48 noninfectious uveitis 48 PRP injections 48 antiresorptive 48 bone morphogenic protein 48 dosing frequency 48 transgenically produced product 48 circulating endothelial cells 48 Spider veins 48 DispersinB 48 neurite outgrowth 48 Fast Track designations 48 pleiotropic 48 TGF ß 48 TNF blocking 48 axonal regeneration 48 anabolic hormone 48 myocardial reperfusion 48 locoregional recurrence 48 axonal damage 48 oncomodulin 48 benfotiamine 48 berberine 48 hemorrhage arterial thromboembolic 48 TransVax 48 wound healing 48 chemotherapeutic treatments 48 MGN# 48 Eltrombopag 48 collagens 48 topically applied 48 insulin sensitizing 48 VEGF receptor 48 lung epithelium 48 GSK3B 48 immune modulators 48 pharmacological approaches 48 hypocalcaemia 48 gamma amino butyric 48 glucose uptake 48 topical retinoids 48 guanylate cyclase C 48 factor EGF 48 inhaled anesthetics 48 heavily pretreated 48 homeopathy acupuncture 48 sphingosine kinase 48 haematological malignancies 48 volociximab 48 Th1 type 48 Shows Efficacy 48 neuroinflammatory 48 contractile muscle 48 galiximab 48 plasminogen activators 48 diabetic ulcer 48 EETs 48 novel peptides 48 BEMA TM LA 48 mGluR5 NAM 48 renal fibrosis 48 OTCBB URGP specialty 48 hematological tumors 48 atherogenesis 48 collagen fillers 48 Behcet uveitis 48 Tasimelteon 48 prostaglandin synthesis 48 Applied Therapeutics ENT 48 Zoraxel 48 diabetic retinopathy DR 48 Propionibacterium acnes 48 stem cell engraftment 48 neural muscular skeletal 48 TBC# 48 Clot busting 48 FGFs 48 GED aPC 48 follicular Non Hodgkin 48 Fresher barometers however 48 Adhesion Barrier 48 airway hydration 48 inhibits protein synthesis 48 bone morphogenetic proteins 48 intradermal delivery 48 Afatinib 48 EGFR pathway 48 cytotoxic effects 48 vasodilation 48 neurotoxic protein 48 Cortisone injections 48 Pagoclone 48 tanespimycin 48 TXNIP 48 endoluminal 48 biochemical abnormalities 48 wound exudate 48 ARIKACE ™ 48 Trofex TM 48 clinical trials SGN 48 ganetespib 48 anti angiogenic agent 48 collagenase 48 Squalamine 48 analgesic effects 48 OrCel ® 48 intestinal absorption 48 OXi# 48 Calcium phosphate 48 midstage clinical trials 48 applied topically 48 AMPK activators 48 scintigraphic 48 platelet activation 48 antiangiogenic drugs 48 juvenile chondrocytes 48 Slightly Overbought 48 pigment epithelium derived 48 intravenous cyclophosphamide 48 dermaPACE TM 48 peptide hormone 48 COX enzymes 48 peroxidation 48 vascular reactivity 48 Vaginal bleeding 47 sensory axons 47 electrostimulation 47 phototoxicity 47 While Ambrilia anticipates 47 fatty acid oxidation 47 samalizumab 47 Prolotherapy 47 Homspera 47 alveolar epithelial cells 47 nonclinical studies 47 thrombolytic agents 47 RhuDex R 47 BioSilicon 47 acute HAE attacks 47 incyclinide 47 proteasome inhibitor 47 vasodilatory 47 immune modulating 47 Bracketed figures 47 zileuton 47 TOCOSOL Camptothecin 47 wound debridement 47 Minimally invasive surgery 47 nerve degeneration 47 inhibiting viral replication 47 RGB # 47 g3 nutrition beverage 47 redox sensitive 47 peripheral artery 47 Interferon beta 47 acupuncture acupressure 47 immuno inflammatory 47 S/GSK# 47 myeloproliferative neoplasms MPNs 47 anti leukemic 47 inflammatory cytokine 47 cholecystokinin CCK 47 BCL2 47 DXL# 47 inhalation anthrax infection 47 acinar 47 PEMF 47 acupuncture aromatherapy 47 fuse vertebrae 47 neural degeneration 47 dystrophic 47 biphosphonates 47 Neurotrophic factors 47 therapeutic regimens 47 resorbable 47 mTOR inhibition 47 dermatological disorders 47 hemostatic agents 47 Catena ® 47 dimebon latrepirdine 47 TGF beta1 47 MEK1 47 Fibroblast Growth Factor Receptor 47 Cellegesic 47 venous leg 47 cardiac fibrosis 47 leukocyte recruitment 47 rifalazil 47 transcytosis 47 Prodarsan 47 nicotinic acetylcholine receptor 47 Hedgehog signaling 47 nausea vomiting rash 47 armyworm outbreaks 47 Zybrestat 47 novel trazodone formulation 47 glycosaminoglycans 47 acupuncture meditation 47 imatinib resistance 47 overlapping toxicities 47 S Aktiengesellschaft FSE 47 include GALNS N 47 Arteriovenous 47 vessel dilation 47 upregulation 47 Pazopanib 47 cetuximab Erbitux 47 Disease Modifying 47 remitting Multiple Sclerosis 47 Colon polyps 47 venous stasis 47 Mitral valve repair 47 canagliflozin 47 cyclin dependent kinases 47 dopamine neuron 47 Vitaxin 47 axon regeneration 47 thymic carcinoma 47 chronic periodontitis 47 QT interval prolongation 47 TNFa 47 rALLy 47 insert titanium rod 47 cytokine receptor 47 cranio sacral therapy 47 NSABP C 47 Tavocept 47 adipiplon 47 oral hyoscyamine spray 47 TELCYTA 47 AVI antisense 47 topical creams 47 HCV replication 47 JAK#/JAK# inhibitor 47 cell receptor TCR 47 periorbital 47 Antioxidant supplements 47 meniscal repair 47 Altrazeal TM 47 vasodilators 47 protein tumor necrosis 47 Photodynamic therapy 47 debriding 47 Torsades de Pointes 47 GGF2 47 anticancer therapy 47 Steroid injections 47 lymphotoxin 47 RSD# oral 47 dysfunction Zada 47 CB2 receptor 47 Balloon sinuplasty 47 Resten NG 47 VEGF inhibition 47 pyrimethamine 47 SURFAXIN r 47 immunoregulation 47 Retinoic Acid 47 therapeutic armamentarium 47 Carfilzomib 47 Ceflatonin 47 Cimzia TM 47 tenascin 47 Microtubule 47 Hyperbaric Oxygen Therapy HBOT 47 oxybutynin gel 47 LJ# [002] 47 STN DBS 46 Barrett esophagus BE 46 demyelination 46 esophageal inflammation 46 tissue oxygenation 46 fibrogenesis 46 cell lysis 46 PyroCarbon 46 triglyceride lowering 46 EGFR mutation positive 46 Wnts 46 vascular dysfunction 46 ocular inflammatory 46 AVI ESPRIT technology 46 Phase #/#a trial 46 topical microbicides 46 Triolex 46 pazopanib 46 neuroinflammation 46 hematological indications 46 allergic airway inflammation 46 topical formulations 46 EVICEL 46 Chronic inflammation 46 Zyclara Cream 46 neuroprotection 46 indolent NHL 46 VNP#M 46 ularitide 46 DACH platinum 46 CR# vcMMAE 46 erythropoietin receptor 46 Platelet Rich Plasma 46 PLX cells 46 Clinical Efficacy 46 oxidative metabolism 46 mucus glands 46 pharmacological chaperone 46 taxane refractory 46 haemostatic 46 endothelial activation 46 ENTEREG ® 46 PROSTVAC ® 46 apoptotic pathway 46 immune reconstitution 46 Dr. Kauvar 46 glycosaminoglycan 46 myocyte 46 tumor malignancies 46 chondrocyte 46 myocardial tissue 46 superoxide anion 46 prostacyclins 46 Mohs micrographic surgery 46 Optiquel ™ 46 ostarine 46 hydrolytic 46 debrided 46 CRu 46 surgically induced 46 ligaments tendons 46 tetrahydrobiopterin 46 recombinant interferon 46 growth hormone secretion 46 immunotherapeutic approaches 46 N chlorinated antimicrobial 46 hedgehog pathway 46 lung metastasis 46 VA# [002] 46 ragweed allergy immunotherapeutic 46 rBChE 46 TransVax ™ 46 pharmacodynamic markers 46 chronic venous insufficiency 46 HQK 46 statistically significant correlations 46 PI3K inhibitors 46 lipoic acid 46 lytic 46 PRIMO CABG 46 novel oral anticoagulant 46 ANAVEX #-# [001] 46 viral polymerase 46 tumor metastasis 46 PDE# inhibitors 46 injectable antithrombotics 46 Curaxins 46 Onalta ™ 46 factor VIIa 46 bone morphogenetic proteins BMPs 46 inflammation thrombosis oncology 46 osteoblast 46 isavuconazole 46 Optic nerve 46 Dr. Sosne 46 tezampanel 46 XL# XL# XL# XL# 46 intestinal mucosa 46 metalloproteinases 46 unsightly veins 46 NEUMUNE 46 gut mucosa 46 RH1 46 mucus secretion 46 cis RA 46 acadesine 46 Prodarsan ® 46 release MMAE 46 undergo hyperbaric oxygen 46 Telintra 46 antiviral antibacterial 46 decompressive 46 potent activator 46 apremilast 46 WITH GOD 46 cobalt molybdenum 46 pharmacological treatments 46 muscular dystrophies 46 targets VEGFR EGFR 46 joints tendons 46 Haemacure fibrin sealant 46 CML CP 46 Elastin 46 cefixime 46 vasodilator 46 lumiliximab 46 rosacea acne 46 resolvins 46 briakinumab 46 perampanel 46 CYP#A# inhibitors 46 osteoblast differentiation 46 ischemic diseases 46 meningeal 46 elacytarabine 46 epithelial tissues 46 osteo 46 photoaged skin 46 vaginal lidocaine 46 SNT MC# 46 IFN β 46 prokinetic 46 extracellular matrix ECM 46 TGF Beta 46 Anti Factor VIII 46 ventricular remodeling 46 ERK signaling 46 antineoplastic 46 uPA 46 nattokinase 46 diabetic peripheral neuropathy 46 IGF IR 46 microbicidal 46 muco adhesive 46 beta lactamases 46 resorption 46 telomerase activator 46 hematologic cancers 46 acupuncture Reiki 46 antibody mediated 46 dural 45 Thrombotic events 45 tamponade 45 crystalized chemicals 45 cholesterol biosynthesis 45 Thyroid hormone 45 decubitus ulcers 45 #D#C# 45 Altrazeal 45 selectively inhibiting 45 Retinoids 45 POSIDUR TM 45 pomalidomide 45 PS# DARA 45 refractory acute myeloid 45 www.soliris.net 45 MKC# PP 45 angiogenic 45 cardiovascular ischemic 45 Restanza demonstrated 45 non selective NSAIDs 45 Ranges EUR USD 45 phase IIb trial 45 REP# 45 amino acid metabolism 45 CDP# 45 cartilage defect 45 rindopepimut 45 pathophysiological processes 45 oncology indications 45 iron chelators 45 Adhibit 45 Fanconi syndrome 45 intraocular 45 Lu AA# 45 functional mitral regurgitation 45 p# inhibitors 45 homeopathics 45 investigational therapies 45 atelectasis 45 topically applied gel 45 compound INCB# 45 oral mucosa 45 vascular occlusion 45 opioid antagonists