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(Click for frequent words.) 65 leuprolide acetate 62 Lupron Depot R 62 PROMACTA 61 besifloxacin 61 Lupron Depot 60 Intravitreal 60 weekly subcutaneous injections 60 #mg BID [001] 59 randomized Phase IIb 59 hormone LHRH antagonist 59 pegaptanib 59 GnRH agonist 59 CIMZIA R 59 lanreotide 59 Capesaris 59 OMS# 58 leflunomide 58 sitaxsentan 58 paricalcitol 58 Prosaptide 58 opioid induced bowel dysfunction 58 parecoxib 58 riociguat 58 IMPACT DCM clinical 58 Teriflunomide 58 GLP1 agonist 58 Xelox 57 subconjunctival injection 57 zotarolimus 57 MyVax personalized immunotherapy 57 calcineurin inhibitor 57 octreotide 57 megestrol acetate oral 57 ancrod 57 mitoxantrone plus 57 injected subcutaneously 57 VIRAMUNE 57 tinzaparin 57 octreotide acetate 57 darunavir r 57 verteporfin 57 canakinumab 57 recurrent glioblastoma multiforme 57 analgesic efficacy 57 LPV r 57 divalproex sodium 57 goserelin 57 fosbretabulin 57 valdecoxib 57 Vidaza azacitidine 57 interferon ribavirin 57 Cethrin 57 randomized #:#:# 56 GAMMAGARD 56 forodesine 56 desvenlafaxine succinate 56 anagrelide 56 Budesonide 56 Ceplene/IL-2 56 strontium ranelate 56 ATACAND 56 phase IIIb 56 immunomodulatory therapy 56 CTEPH 56 difluprednate 56 cilengitide 56 urocortin 2 56 cilostazol 56 acetonide FA 56 zalutumumab 56 vidofludimus 56 MAGE A3 ASCI 56 dual endothelin receptor antagonist 56 retropubic 56 GSK# [001] 56 Aclidinium 56 ritonavir boosted lopinavir 56 dexanabinol 56 irbesartan 56 flutamide 56 idraparinux 56 EGRIFTA ™ tesamorelin 56 docetaxel Taxotere ® 56 Pharmacokinetic studies 56 levodopa induced dyskinesia 56 bezafibrate 56 Bifeprunox 56 Losartan 55 Dacogen decitabine 55 noninferior 55 miglustat 55 systemic hypotension 55 alpha blocker 55 Gabapentin GR 55 thienopyridine 55 mg/m2 cohort 55 bleeding pallor 55 fenretinide 55 esophageal candidiasis 55 DURIN TM 55 NP2 Enkephalin 55 dalteparin 55 CIMZIA TM 55 APTIVUS r 55 nitrofurantoin 55 Certolizumab pegol 55 brivaracetam 55 neurologic progression 55 somatostatin analog 55 clevidipine 55 Androxal TM 55 EVIZON TM 55 PROLACRIA 55 AGILECT R 55 #mg dose [003] 55 Aplidin 55 intravenous dosing 55 TELCYTA 55 cysteamine bitartrate 55 β blockers 55 morphometric vertebral fractures 55 DSMB recommended 55 incyclinide 55 subcutaneous ORENCIA 55 mycophenolic acid 55 Tarceva TM 55 Torisel 55 lomitapide 55 platelet inhibitor 55 antiresorptive 55 ritonavir boosted 55 administered subcutaneously 55 injectable formulations 55 Sandostatin LAR 55 squalamine 55 comparator arm 55 NATRECOR R 55 oxymorphone ER 55 intravenous iv 55 rEV# 55 Fibrillex TM 55 Phase Ib study 55 oral methylnaltrexone 55 acute mania 55 TobraDex ® ST 55 senicapoc 55 danazol 55 efalizumab 55 Zavesca ® 55 Zylet 54 dorzolamide 54 EMSAM 54 intensive lipid lowering 54 Cloretazine 54 CA4P 54 DAPT 54 IFN alfa 54 HuMax EGFr 54 cannabinor 54 Luteinizing Hormone Releasing Hormone 54 tocilizumab 54 malignant ascites 54 ORENCIA R 54 MGd 54 rimonabant #mg 54 Toremifene 54 ® lenalidomide 54 dose titration 54 azilsartan medoxomil 54 alkylating agent 54 QLT# 54 Adenoma Prevention 54 retinal vein occlusion induced 54 mycophenolate mofetil 54 multidose 54 EGFR TKI 54 PROCHYMAL 54 ACTILON 54 everolimus eluting stents 54 brimonidine 54 choroidal vasculopathy 54 clazosentan 54 tafamidis 54 PEARL SC 54 mesilate 54 Dabigatran etexilate 54 LHRH agonist 54 NLX P# 54 subcutaneous methylnaltrexone 54 EMPHASIS HF trial 54 corticosteroid dexamethasone 54 Spheramine 54 TAXOTERE R 54 Aptivus ® 54 Raptiva efalizumab 54 antithrombotic therapy 54 rhTSH 54 label dose titration 54 menadione 54 phase IIb clinical 54 RLAI 54 EDARBI 54 Anti VEGF 54 Helicobacter pylori eradication 54 aerosolized KL4 surfactant 54 placebo controlled clinical 54 bevasiranib 54 NV1FGF 54 ARIKACE 54 systemic corticosteroid 54 administered intradermally 54 opiate antagonist 54 Ophena 54 OMS#HP 54 vastus lateralis 54 thalidomide dexamethasone 54 colorectal cancer liver metastases 54 ADAGIO study 54 mecasermin 54 Proellex TM 54 REOPRO 54 mecamylamine 54 Cloretazine R VNP#M 54 EVIZON ™ 54 headache nasopharyngitis 53 BAY #-# 53 unresectable HCC 53 Megace 53 intravenous bisphosphonates 53 Traficet EN 53 RSD# oral 53 clomipramine 53 deferoxamine 53 sitagliptin metformin 53 Dacogen injection 53 oxcarbazepine 53 nonoperative treatment 53 intra articular injection 53 PF # [002] 53 beta blocker therapy 53 nimodipine 53 TBC# 53 Aggrastat ® tirofiban hydrochloride 53 adalimumab 53 volociximab 53 metastatic malignant 53 Alphagan P 53 methylnaltrexone 53 bowel resection 53 Prestara 53 intranasal formulation 53 evaluating Prochymal 53 Degarelix 53 reteplase 53 RezularTM 53 subcutaneously administered 53 continuous intravenous infusion 53 selective A2A adenosine receptor 53 samalizumab 53 OZURDEX ® 53 ATL# [002] 53 androgen suppression 53 megestrol acetate 53 teriparatide 53 Atrasentan 53 VELCADE melphalan 53 corticosteroid therapy 53 ELONVA 53 non splenectomized 53 iSONEP 53 antifibrinolytic 53 Femara letrozole 53 Plasmin 53 ACZ# 53 bicalutamide 53 SRT# [003] 53 cefdinir 53 omecamtiv mecarbil 53 tipranavir 53 medroxyprogesterone acetate 53 tamsulosin 53 rDNA origin 53 sargramostim 53 PRISTIQ 53 ONTAK 53 Tacrolimus 53 BYSTOLIC 53 dose escalation phase 53 sevelamer carbonate 53 Kamada AAT 53 bone marrow reticulin deposition 53 Saforis 53 TELINTRA 53 ALVESCO HFA 53 TRIZIVIR 53 sirolimus eluting stents 53 ORENCIA ® 53 intravascular hemolysis 53 vandetanib 53 Granulocyte Colony Stimulating Factor 53 prospectively stratified 53 atorvastatin #mg 53 Acute Ischemic Stroke 53 Teriparatide 53 Vorapaxar 53 Vascular Wrap 53 eplerenone 53 multicenter Phase II 53 prospective nonrandomized 53 serotonin norepinephrine reuptake inhibitor 53 Aflibercept 53 potentiation 53 coadministration 53 pharmacodynamic PD 53 Tavocept 53 Raptiva ® 53 BRINAVESS 53 GRN# 52 oral anticoagulant therapy 52 rhIGF-I/rhIGFBP-3 52 visilizumab 52 CIMZIA TM certolizumab pegol 52 GnRH agonists 52 LATUDA 52 relapsing remitting MS RRMS 52 lumiliximab 52 topically administered 52 ara C 52 sub maximal 52 prazosin 52 CBLC# 52 Afatinib 52 epoprostenol 52 Oral corticosteroids 52 Vernakalant 52 Glypromate 52 glatiramer acetate injection 52 BRIM2 52 CLARITY study 52 fondaparinux 52 plasmid encoding 52 hydrocodone polistirex 52 safinamide 52 bicifadine 52 hereditary deficiency 52 YONDELIS 52 BrachySil TM 52 Mylotarg 52 clopidogrel Plavix 52 GW# [003] 52 medically refractory 52 lavage 52 COPAXONE 52 MULTAQ 52 carboplatin paclitaxel 52 TDF FTC 52 RhuDex ® 52 mesalamine granules 52 pain palliation 52 ocrelizumab 52 fistula closure 52 SinuNase TM 52 PDE4 inhibitors 52 ularitide 52 TASKi3 52 anti androgen 52 Tysabri natalizumab 52 Dose escalation 52 dopamine partial agonist 52 Fibrin Pad 52 PASI scores 52 ximelagatran 52 lapatinib Tykerb 52 EOquin TM 52 tranexamic acid 52 chemoradiation therapy 52 CYPHER Stent 52 phase Ib 52 inhaled treprostinil 52 midstage clinical 52 edifoligide 52 rindopepimut 52 CK # administered 52 Myelodysplastic Syndrome MDS 52 octreotide implant 52 figitumumab 52 Zemplar Capsules 52 TOVIAZ 52 vernakalant hydrochloride 52 abatacept 52 periocular 52 BRIM3 52 BETAS 52 piperacillin tazobactam 52 dabigatran etexilate 52 Thal Dex 52 solanezumab 52 Phase IIIb clinical 52 multicenter randomized controlled 52 TH# [003] 52 Multidetector CT MDCT 52 Alfimeprase 52 DU #b 52 Fenretinide 52 CEQ# 52 5mg dose 52 cariprazine 52 ibandronate 52 cis retinoic acid 52 #mg/day [002] 52 Indomethacin 52 phase IIa clinical 52 Subgroup analysis 52 daily subcutaneous injections 52 SYMMETRY trial 52 lenalidomide dexamethasone 52 oral ridaforolimus 52 pharmacodynamic profile 52 STRIDE PD 52 CCyR 52 PDE4 inhibitor 52 Crizotinib 52 SinuNase 52 cerebrovascular events 52 urate lowering 52 Specifid 52 hour bronchodilation 52 BENICAR HCT 52 Cimzia TM 52 gamma secretase inhibitor 52 bronchodilation 52 EmbraceAC 52 androgen ablation 52 Phase IIB 52 bortezomib Velcade 52 Microplasmin 52 LEP ETU 52 Zyclara 52 Hyalgan 52 GEM OS1 52 diclofenac sodium 52 Cand5 52 FRAGMIN 52 Amphinex ® 52 BANZEL 52 nabilone 52 callus formation 52 glatiramer 52 olaparib 52 oral talactoferrin 52 sunitinib Sutent 52 SPRYCEL ® 52 postoperative chemotherapy 52 nalbuphine ER 52 antiandrogen 51 Amrubicin 51 posttraumatic arthritis 51 KIACTA ™ 51 PEGylated Fab fragment 51 fluocinolone acetonide 51 valvulopathy 51 EXPAREL TM 51 cortical stimulation 51 inotropic 51 Pemetrexed 51 Octreolin 51 tasisulam 51 Phase IIb clinical trials 51 receptor tyrosine kinase inhibitor 51 multicenter randomized placebo controlled 51 phase III isavuconazole 51 PD LID 51 IAP inhibitor 51 Phase IIb III 51 Diamyd r vaccine 51 luteinizing hormone releasing 51 calcium antagonist 51 ziprasidone 51 interferon beta 1b 51 adjuvant radiotherapy 51 selective androgen receptor modulator 51 Increlex R 51 Melphalan 51 severe exacerbations 51 vinflunine 51 GHRH 51 celecoxib Celebrex 51 tegaserod 51 PhG alpha 1 51 avosentan 51 postprocedure 51 beta 1a 51 Alvesco R 51 humanised monoclonal antibody 51 anticholinergics 51 β blocker 51 unfractionated heparin 51 generation purine nucleoside 51 CGRP 51 SomatoKine 51 Uricase PEG 51 liver transaminases 51 Sutent sunitinib 51 protease inhibitor PI 51 Febuxostat 51 Kivexa 51 APTIVUS 51 Panzem R NCD 51 Perflutren Lipid Microsphere Injectable 51 LHRH agonists 51 eluting stent 51 Viread Emtriva 51 ZACTIMA 51 antiangiogenic therapy 51 MS relapses 51 pharmacokinetic PK study 51 imatinib therapy 51 MIST II 51 adjuvant cisplatin 51 hip resurfacing arthroplasty 51 TLK# 51 Cloretazine VNP#M 51 Ocrelizumab 51 AZOR 51 prospective randomized multicenter 51 Pyridorin 51 bevacizumab Avastin ® 51 hepatic toxicity 51 KADIAN ® 51 oral anticoagulation 51 moderate hepatic impairment 51 CHAMPION PCI 51 phenelzine 51 Bezielle 51 decompressive surgery 51 solifenacin 51 DEB# 51 Celecoxib 51 liposomal formulation 51 AERx 51 Pivotal Phase III 51 cabergoline 51 candesartan 51 Mipomersen 51 alvespimycin 51 inotropes 51 Tolvaptan 51 double blinded placebo 51 VESIcare 51 lamotrigine 51 TAXUS Stent 51 taribavirin 51 inhibitor RG# 51 RISPERDAL ® 51 symptomatic hypotension 51 coagulation parameters 51 GENASIS clinical 51 d4T stavudine Zerit 51 MERLIN TIMI 51 meniscectomy 51 Forodesine HCl 51 #:# randomization 51 acute peripheral arterial 51 ipratropium bromide 51 VPRIV 51 Neupogen ® 51 Proxinium TM 51 SNT MC# 51 anastrozole 51 Retisert TM 51 pegylated liposomal doxorubicin 51 Canvaxin 51 fostamatinib 51 MIRAPEX ER 51 eptifibatide 51 Phase Ib IIa 51 atazanavir 51 HuMax CD4 51 ILUVIEN ® 51 PHPT 51 Targretin capsules 51 multiple myeloma MM 51 AChE inhibitors 51 H2 antagonists 51 Lucentis ranibizumab Genentech 51 Eculizumab 51 ABILIFY ® 51 SIMPADICO 51 NUCYNTA ® 51 antiandrogens 51 Cefprozil 51 CALGB # [002] 51 ARIMIDEX 51 intra arterial 51 Phase Ib clinical 51 postinjury 51 Bevasiranib 51 KRN# 51 glycoprotein IIb IIIa inhibitor 50 Lumiracoxib 50 AERx ® 50 COPAXONE R glatiramer acetate 50 elevated transaminases 50 alpha#beta# integrin 50 UVIDEM 50 AERx iDMS 50 IMPACT DCM trial 50 RhuDex R 50 PPAR agonist 50 orally administered synthetic retinoid 50 romidepsin 50 Gliadel Wafer 50 mg FV 50 VIIBRYD 50 bevacizumab Avastin 50 raloxifene Evista 50 Avastin bevacizumab 50 Crestor rosuvastatin 50 Sym# 50 Phase #b/#a 50 Candesartan 50 Xinlay 50 hepatic metabolism 50 adrenocorticotropic hormone ACTH 50 Vascugel 50 idiopathic thrombocytopenic purpura ITP 50 integrin inhibitor 50 Temsirolimus 50 rolofylline 50 Ataluren 50 cerivastatin 50 IPLEX 50 elotuzumab 50 POSIDUR TM 50 reslizumab 50 electrical cardioversion 50 Phase #b/#a trial 50 pentostatin 50 primary humoral immunodeficiency 50 ankle arthrodesis 50 bupropion SR 50 dual orexin receptor 50 darunavir ritonavir 50 Genentech Rituxan 50 Phase 2b study 50 droperidol 50 subacromial 50 macular edema secondary 50 undergone splenectomy 50 Tasigna prolongs 50 intraventricular 50 trastuzumab Herceptin R 50 Clolar ® 50 NeuroSTAT ® 50 Zevalin R Ibritumomab 50 amifostine 50 SUTENT ® 50 coxibs 50 prospective multicenter randomized 50 Keppra ® injection 50 glargine 50 Desmoteplase 50 occlusion PAO 50 FOLFOX chemotherapy 50 proton pump inhibitor PPI 50 budesonide foam 50 oxaliplatin injection 50 confirmatory Phase III 50 risedronate 50 lansoprazole 50 Certolizumab 50 ADVANCE PD 50 valopicitabine NM# 50 intradiscal 50 dose escalation clinical 50 CYP#D# inhibitor 50 LB# [003] 50 HGS ETR2 50 LOVENOX R 50 concomitant AEDs 50 factor Xa inhibitor 50 Fablyn 50 double blinded randomized 50 sunitinib malate 50 vinorelbine tartrate 50 selective A1 adenosine 50 overt nephropathy 50 indibulin 50 blinded randomized 50 evaluating CK # 50 epoetin alpha 50 Cleviprex TM clevidipine 50 COREG 50 FROVA 50 Besivance ™ besifloxacin ophthalmic 50 albiglutide 50 rosiglitazone maleate 50 iniparib 50 IMPACT DCM 50 Anturol TM 50 Itopride 50 EMBEDA TM 50 biologic DMARD 50 phase IIb III 50 treat benign prostatic 50 intra articular injections 50 catheter occlusion 50 oral antidiabetic agents 50 nadroparin 50 pregabalin 50 PFO closure 50 Adjunctive 50 Q#IR 50 5 fluorouracil leucovorin 50 HYLENEX recombinant 50 ACOMPLIA R 50 ZYBRESTAT fosbretabulin 50 placebo controlled randomized 50 acyclovir Lauriad R 50 CRMD# 50 bile acid sequestrant 50 Peginterferon alfa 2b 50 conjugated estrogen 50 Gemzar gemcitabine 50 ATL# [001] 50 d4T 50 insulin detemir 50 synthetic retinoid 50 ACTIVE W 50 oral bisphosphonate 50 Fulvestrant 50 novel oral anticoagulant 50 Elitek 50 noninfectious uveitis 50 pantoprazole 50 hemodynamic variables 50 Xanafide 50 LT NS# 50 Eli Lilly Cymbalta 50 Aeroquin 50 zoledronic acid Zometa 50 ocular itching 50 Ovidrel 50 mapatumumab 50 treatment naive genotype 50 WBPA 50 VNP#M 50 Octreotide 50 ischemia induced 50 CIMZIA ™ 50 CINTREDEKIN BESUDOTOX 50 antioxidant supplementation 50 BAL# [002] 50 Prolacria 50 GRNVAC1 50 cancer neuroendocrine tumor 50 oxypurinol 50 Tredaptive 50 OvaRex ® MAb 50 Atacand 50 clot busting therapy 50 Parathyroid hormone 50 lesional 50 biliary tract cancer 50 Convivia TM 50 symptomatic neurogenic orthostatic hypotension 50 dexrazoxane 50 FASLODEX 50 amrubicin 50 GORE TAG Device 50 tolevamer 50 ganciclovir 50 Hedgehog agonist 50 saphenous vein grafts 50 venous stasis 50 HCV RESPOND 2 50 INFeD 50 Bankart lesion 50 FOR FURTHER INFORMATION ABOUT 50 steroid refractory ulcerative 50 ATL/TV# 50 Vitaxin 50 Augment Injectable 50 de novo kidney transplant 50 Ecallantide 50 reserpine 49 small molecule Hedgehog 49 Kahalalide F 49 PROCRIT 49 CAELYX 49 myoblast therapy 49 Inhalation Aerosol 49 Vfend 49 HeartMate XVE 49 achieving PASI 49 FSAD 49 Raptiva R 49 vasoactive 49 ABSORB trial 49 HCl capsules 49 Resten NG 49 nab paclitaxel 49 MoxDuo 49 antiarrhythmic drug 49 Squalamine 49 C2L 49 COZAAR 49 Alequel ™ 49 axonal damage 49 pegylated recombinant 49 XL# SAR# 49 UPLYSO 49 stated Michelle Berrey 49 Paxil paroxetine 49 Angiox R 49 alfa 2a 49 NSCL cancer 49 Phase #/#a 49 metastatic colorectal carcinoma 49 Novolimus 49 Soliris eculizumab 49 subtalar 49 Byetta exenatide 49 angiotensin receptor 49 PPAR gamma agonist 49 metastatic RCC 49 AOD# [002] 49 investigational monoclonal antibody 49 metastatic CRC 49 Sibutramine Cardiovascular Outcomes 49 MEVACOR 49 INSPIRE Trial Phase III 49 oral beclomethasone dipropionate 49 alemtuzumab Campath 49 virologic failure 49 anti muscarinic 49 fallopian tube cancers 49 tricuspid regurgitation 49 AMEVIVE 49 ulnar styloid 49 arthrography 49 CIPN 49 nonsteroidal 49 SERMs 49 Zyban bupropion 49 Alequel 49 MAXY alpha 49 vasodilatation 49 warfarin therapy 49 Zerenex 49 induced macular edema 49 peginterferon 49 TRISENOX ® 49 recurrent herpes labialis 49 Tibolone 49 cholinesterase inhibitor 49 oral antidiabetes 49 XIENCE V Everolimus Eluting 49 prostanoid 49 multicenter prospective 49 TAXUS V 49 Prexige lumiracoxib 49 cetuximab Erbitux 49 lorvotuzumab mertansine 49 pharmacokinetics PK 49 N acetyl cysteine 49 keloid scarring 49 Iloperidone 49 pioglitazone 49 SANVAR 49 HGS ETR1 mapatumumab 49 celgosivir 49 E1 INT TM 49 Medidur FA 49 MICARDIS ® 49 viral kinetic 49 EFFEXOR XR 49 Lofexidine 49 chronic thromboembolic pulmonary 49 intravenous AAT 49 trastuzumab DM1 T DM1 49 clopidogrel therapy 49 Dual Opioid 49 Zenvia ™ 49 laquinimod 49 abacavir containing 49 XIENCE V stent 49 Phase Ib IIa clinical 49 Avandia Actos 49 cobiprostone 49 AQ4N 49 EndoTAGTM 1 49 recurrent malignant glioma 49 pravastatin 49 Aurexis 49 Aptivus 49 paclitaxel carboplatin 49 EVICEL 49 fluoropyrimidine 49 Phase 2b kidney transplant 49 orally disintegrating 49 generation antisense inhibitor 49 radicular pain 49 tumor necrosis 49 ZYBRESTAT 49 nucleotide analog 49 GEM OS2 49 CYT# potent vascular disrupting 49 anticoagulant warfarin 49 arzoxifene 49 Erbitux cetuximab 49 inhibit platelet function 49 poststroke depression 49 NovoSeven ® 49 Safinamide 49 Abbokinase 49 MIVI III 49 carbidopa levodopa 49 subcutaneous formulation 49 aspirin clopidogrel 49 FVIIa 49 venlafaxine Effexor 49 regorafenib 49 thrombolytic agent 49 medroxyprogesterone 49 Veramyst 49 asymptomatic hyperuricemia 49 Mirapexin 49 Paraplatin 49 preclinical efficacy 49 Lixivaptan 49 collagenase 49 LymphoStat B TM 49 pyrimidine nucleoside analog 49 PrevOnco 49 hepatic encephalopathy HE 49 JAK3 inhibitor 49 interferon gamma 1b 49 Dosa suffers 49 CYP#A# inhibitors 49 Phase III Pivotal 49 ELACYT 49 Percutaneous Transluminal Coronary Angioplasty 49 huN# DM1 49 NUCYNTA R 49 serum biomarker 49 dose escalation Phase 49 Zirgan 49 Edoxaban 49 distal radial fracture 49 FOLFIRI chemotherapy 49 Amicar 49 bevacizumab 49 Catena ® 49 reboxetine 49 intraarticular 49 dronedarone 49 uremic pruritus 49 antidepressants fluoxetine 49 LCP Tacro TM 49 TAXUS Element Paclitaxel Eluting 49 duloxetine 49 Retisert 49 proprietary transdermal patch 49 DuraSite R 49 prospective randomized 49 AQUAVAN R 49 gefitinib Iressa 49 PFO migraine 49 inhaled budesonide 49 Pivotal Clinical Trial 49 AVANDIA 49 Nuvion 49 treat chronic sinusitis 49 glitazone 49 IFN α 49 selective antagonist 49 fatty infiltration 49 prospective multicenter 49 Diabetic Macular Edema DME 49 Chemophase 49 Itraconazole 49 LEUKINE 49 ddI 49 Leukine ® 49 cefprozil 49 PrevOnco ™ 49 vasodilatory 49 Fluconazole 49 hematological toxicity 49 Triapine R 49 Phase III metastatic melanoma 49 nimesulide 49 release cysteamine bitartrate 49 assessing T DM1 49 INTELENCE 48 postmenopausal estrogen 48 antibody MAb 48 opioid analgesia