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(Click for frequent words.) 69 differentially regulated 67 constitutively expressed 65 mRNA expression 64 orthologs 64 H#K#me# 64 upregulated 63 promoter methylation 63 TMPRSS2 ERG 63 differentially expressed genes 62 intronic 62 downregulated 62 constitutively active 62 V#F mutation 61 genes encoding 61 transfected 61 heterozygotes 61 immunostaining 61 orthologous 61 COL#A# 61 transduced 61 follicular fluid 61 transgene expression 61 rs# [004] 61 μg ml 60 hypermethylated 60 DRD2 60 splice variants 60 intergenic 60 hypermethylation 60 overexpressing 60 Genotypes 60 inhibin B 60 SNP rs# [001] 60 hepatocellular carcinomas 60 μmol L 60 isoforms 60 lactate dehydrogenase 60 genomic loci 60 IgG antibody 59 HGPIN 59 SNP rs# [002] 59 NPM1 mutations 59 HER2 expression 59 lyase 59 carboxylase 59 UGT#A# * 59 alternatively spliced 59 tryptase 59 Cathepsin B 59 Supplementary Fig 59 HepG2 cells 59 IGFBP 59 germline mutations 59 splenocytes 59 CagA 59 sequence homology 59 rs# [001] 59 proinflammatory mediators 59 mRNA transcripts 59 ERBB2 59 RRM1 59 PTPN# 59 CYP#A# [002] 59 mitogen activated protein kinase 59 genotyped 59 homozygotes 59 Upregulation 59 miRNA expression 59 TMPRSS2 ERG fusion 58 missense mutations 58 ERalpha 58 nutlin 3a 58 CDKN2A 58 TIMP 1 58 #S rRNA 58 GSTP1 58 TNFalpha 58 AMACR 58 PBMCs 58 DNMT1 58 K ras mutations 58 Immunohistochemical staining 58 fig. S1 58 BRAF V#E 58 coexpression 58 Clusterin 58 rRNA 58 immunoreactivity 58 serum concentrations 58 WT1 58 HLA DQ2 58 transcriptional regulation 58 pg mL 58 ABCB1 58 rs# [003] 57 univariate analysis 57 subcellular localization 57 protein isoforms 57 missense mutation 57 somatostatin 57 lysine residues 57 Wwox 57 μM 57 overexpressed 57 genes differentially expressed 57 miR #a [001] 57 bronchial epithelial cells 57 Histone 57 immunoglobulin G 57 MTHFR 57 coding genes 57 #ß 57 p# activation 57 gene polymorphisms 57 EAAT2 57 seropositivity 57 57 pg ml 57 K ras 57 iNOS 57 gene locus 57 IL #p# 57 Jhdm2a 57 methylation patterns 57 inducible nitric oxide synthase 57 CCR5 delta# 57 miRNA genes 57 virulence genes 57 transiently transfected 57 C#BL 6 mice 57 KLF4 57 cells transfected 57 variant alleles 57 kDa protein 57 FLT3 57 coding sequences 57 TIMP 57 VCAM 1 57 transfected cells 57 normoxic 57 immunohistochemical analysis 57 ribosomal proteins 57 glucuronide 57 nanomolar 57 S#A# [002] 57 myo inositol 57 multivariate analyzes 57 GSTT1 57 carcinoembryonic antigen 57 3'UTR 57 situ hybridization 57 mutated K ras 57 cytosolic 57 cisplatin resistant 57 RNA binding 57 serine threonine 57 EphB4 57 GlcNAc 57 gene expression profiles 57 carboxyl terminal 56 MLH1 56 allelic 56 lymphovascular invasion 56 HER2 neu 56 unmethylated 56 K#R [002] 56 activating mutations 56 CpG 56 EGFP 56 RASSF1A 56 lymphoid cells 56 IL#B 56 histologic 56 chromosomal regions 56 clinicopathological 56 tumorigenicity 56 inherited mutations 56 PIK3CA 56 CD3 + 56 cytokeratin 56 circadian genes 56 orthologous genes 56 immunoblotting 56 hydroxylase 56 tocopherol 56 Foxp3 56 DLC1 56 genotypic 56 IFN gamma 56 fasting plasma 56 adrenocortical 56 cyclooxygenase COX 56 papillary renal cell carcinoma 56 erythrocytes 56 valine 56 cyclin E 56 #beta 56 nonexposed 56 Western blotting 56 Fig. 1A 56 Leydig cells 56 glycated 56 nM 56 statistically significant correlations 56 microglial 56 IL 1beta 56 Plasma concentrations 56 At#g# 56 functional polymorphism 56 phosphorylated 56 Rho GTPases 56 locomotor activity 56 anterior pituitary 56 chromosome #q# [001] 56 ERK signaling 56 normal karyotype 56 methylated DNA 56 homozygous 56 rs# [002] 56 transcriptomic 56 DLX5 56 intron 56 susceptibility loci 56 ectopic expression 56 intergenic regions 56 lipoxygenase 56 MAPK pathway 56 allelic variants 56 ESR1 56 heterologous expression 56 supernatants 56 amplicons 56 loci 56 pyrimidine 56 TT genotype 56 Serum concentrations 56 inactivating mutations 56 cultured neurons 56 CYP# [002] 55 heterozygote 55 quantitative RT PCR 55 qRT PCR 55 TP# mutations 55 PTHrP 55 HLA DRB1 * 55 serum albumin 55 elastase 55 Drosha 55 inbred strains 55 transferase 55 MSH2 55 plastids 55 histological subtype 55 acetylated 55 proto oncogene 55 homologues 55 ZNF# 55 tyrosine phosphorylation 55 histologies 55 underwent surgical resection 55 beta subunit 55 kaempferol 55 mice lacking 55 PON1 55 cytochrome b 55 IL 1β 55 non coding RNA 55 HOTAIR 55 CXCL# 55 gastric carcinoma 55 bone marrow stromal cells 55 human chorionic gonadotropin hCG 55 operon 55 pT3 55 distantly related species 55 striatal 55 phylogenetic analyzes 55 variant allele 55 PcG proteins 55 1α 55 gene rearrangements 55 JAK2 V#F 55 synthases 55 eotaxin 55 alkaline phosphatase 55 histone H3 55 transmembrane 55 5alpha reductase 55 downregulation 55 heterozygosity 55 somatic mutation 55 Alu elements 55 CD#c 55 acetylation 55 HER2 amplification 55 hydroxyphenyl 55 microRNA expression 55 phosphorylates 55 cDNAs 55 deacetylation 55 enolase 55 KRAS mutations 55 FLT3 ITD 55 dephosphorylation 55 plasma lipid 55 breast carcinoma 55 CHD7 55 C. albicans 55 polyamine 55 ERK1 2 55 hepatoma 55 carcinoids 55 genotypes 55 glycosylated 55 p# MAPK 55 BRAF mutations 55 adenylate cyclase 55 #p# [003] 55 3' UTR 55 Histologic 55 metabolite concentrations 55 mucinous 55 Figure 2C 55 adrenal cortex 55 polymorphisms 55 immunoreactive 55 perilipin 55 STAT1 55 TSC1 55 dehydrogenase 55 cell adhesion molecule 55 L. pneumophila 55 outer membrane proteins 55 urothelial 55 cytochrome 55 chloroplast genome 55 -#.# ± [002] 55 S. enterica 55 alkaline phosphatase ALP 55 serine protease 55 polyadenylation 55 CDK4 55 heterozygous 55 somatic mutations 55 survivin 55 paralogs 55 E. faecalis 55 astrocytic 55 transcriptional activation 55 mycobacterial 55 mononuclear cells 55 quantitative PCR 55 monocyte chemotactic protein 54 QTLs 54 Cytotoxic T 54 pmol L 54 esterase 54 indels 54 mRNA 54 microarray experiments 54 activin 54 Polymorphisms 54 undetectable HBV DNA 54 basal cell nevus syndrome 54 immunofluorescence 54 null mice 54 microdeletion 54 BRAF protein 54 miR #b [002] 54 seminomas 54 CYP#C# [002] 54 histone modifications 54 noncoding RNA 54 assay detects 54 epithelial tumors 54 isogenic 54 C#Y 54 hippocampal neurons 54 TMEM#B 54 glutamic acid decarboxylase 54 overexpressing cells 54 #p#.# [002] 54 wildtype 54 matrix metalloproteinases 54 differential gene expression 54 HDAC2 54 Aβ 54 lymph node metastasis 54 DQB1 * 54 fig. S4 54 cortical neurons 54 homodimers 54 promoter hypermethylation 54 MAPK 54 transcriptomes 54 estrogen receptor ER 54 metabolizing enzymes 54 IL 1ß 54 cTnI 54 bronchoalveolar lavage fluid 54 NFKBIA 54 CYP#B# 54 heterodimers 54 unmutated 54 frameshift mutation 54 thyrotropin 54 Genotypic 54 A. thaliana 54 GABRA2 54 Leukemias 54 activating mutation 54 methylated 54 HIF 1a 54 gene expression 54 SLC#A# [002] 54 μg L 54 transgenic mice expressing 54 hydrolase 54 GSTM1 54 metabolomic profiles 54 untranslated regions 54 #S rRNA gene 54 RCAN1 54 c MYC 54 prostate cancer CaP 54 triacylglycerol 54 mRNAs 54 LDL receptor 54 constitutively 54 P. gingivalis 54 multivariable analysis 54 Metabolites 54 SGPT 54 siRNA knockdown 54 interleukins 54 PAK1 54 nmol l 54 gene polymorphism 54 homogenates 54 receptor gene 54 acetyl CoA 54 plasma pharmacokinetics 54 PI3K Akt 54 Fig. 3b 54 immunofluorescence microscopy 54 XL# inhibits 54 phosphatases 54 FGFR2 54 histone H4 54 hypothalamic 54 isotypes 54 etiologic 54 #q# [001] 54 DNA methyltransferases 54 IGF binding 54 cytokine receptor 54 Elevated serum 54 hydrolases 54 #S rDNA 54 cell lysates 54 proteolytic cleavage 54 oxidative metabolism 54 phosphatidylinositol 54 sarcosine 54 arginine vasopressin 54 polymorphonuclear 54 melanocyte 54 colorectal tumor 54 sarcomatoid 54 kinase domain 54 hepatic lipase 54 HIF 1α 54 eukaryotic 54 acylated 54 histopathologic 54 biochemical relapse 54 caveolae 54 VNTR 54 glomerular 54 ng ml 54 amino terminal 54 intestinal epithelial cells 54 heritable traits 54 histologic subtype 54 P cadherin 54 CC genotype 54 APOL1 54 endometrioid 54 4E BP1 54 Jurkat cells 54 Amino acid 54 BMP2 54 SCN5A 54 phospho 54 cotransporter 53 coding exons 53 Dysregulation 53 ribosomal RNA rRNA 53 MicroRNA 53 metabolizing enzyme 53 Ki# 53 colon carcinoma 53 c Fos 53 FGFs 53 WNK1 53 advanced adenomas 53 cis regulatory 53 extracellular 53 eNOS 53 phenotypes 53 receptor kinase 53 prostate adenocarcinoma 53 chemotactic 53 overexpression 53 GenBank accession 53 protein encoded 53 synuclein 53 S. cerevisiae 53 adenocarcinomas 53 beta1 integrin 53 tumoral 53 colorectal adenocarcinoma 53 quantitative trait loci 53 UTRs 53 PCa 53 Kupffer cells 53 receptor gamma 53 dinucleotide 53 colorectal carcinoma 53 P. patens 53 chromosome #q# [002] 53 downregulate 53 lymphocytic 53 HLA DR 53 androgen receptor AR 53 Pgp 53 cDNA libraries 53 miRNAs 53 beta actin 53 subfamilies 53 nucleotide sequences 53 alanine aminotransferase 53 arachidonic acid AA 53 IgE antibody 53 RNA polymerases 53 causal variants 53 prostate carcinoma 53 ptau 53 prolyl 53 posttreatment 53 Lp PLA 2 53 Monocytes 53 T rubrum 53 trophoblast cells 53 catenin 53 EGFR gene 53 circadian clock genes 53 nodal metastasis 53 chromosome #p#.# 53 homozygosity 53 gene expression patterns 53 malondialdehyde 53 gene amplification 53 TAp# 53 mutant alleles 53 nonmetastatic 53 SSc 53 RhoA 53 BRCA1 BRCA2 53 immunodominant 53 PCR assay 53 chitinase 53 MGUS 53 Fig. 2A 53 nucleotide substitutions 53 p# mutation 53 intact parathyroid hormone 53 preferentially bind 53 anti HBs 53 PAX5 53 morphogen 53 dehydroepiandrosterone sulfate 53 transcriptional repressor 53 PGC 1α 53 operons 53 pT2 53 Fig. 1b 53 ploidy 53 parous women 53 arabinose 53 receptor binding 53 epigenetic modification 53 telomere lengths 53 p# mutations 53 chromosomal aberrations 53 hemagglutinin H 53 Homozygous 53 noncoding RNAs 53 C. jejuni 53 ultrastructural 53 ciliated 53 multiple logistic regression 53 CD# + [001] 53 homologous 53 reverse transcriptase polymerase chain 53 immunized mice 53 generalized vitiligo 53 caveolin 1 53 neuroligins 53 allele frequencies 53 Immunohistochemistry 53 fructosamine 53 cAMP 53 E selectin 53 genetic loci 53 trophoblast 53 chromatin structure 53 cathepsin B 53 ncRNAs 53 equimolar 53 MEFs 53 Fig. 2a 53 isoenzyme 53 TTR gene 53 HNSCC 53 LRAT 53 indel 53 surgically resected 53 creatine kinase 53 transcriptionally 53 methyltransferase 53 APOC3 53 uracil 53 monocyte chemoattractant protein 53 pancreatic adenocarcinoma 53 interleukin 1ß 53 IFN g 53 MLL gene 53 proteomes 53 steroidogenic 53 evolutionarily conserved 53 vimentin 53 metabolites 53 hierarchical clustering 53 linkage disequilibrium 53 tHcy 53 Corynebacterium 53 sphingolipid 53 C#BL 6 53 STAT4 53 B7 H3 53 Immunohistochemical 53 proteins encoded 53 gene expression microarrays 53 receptor subtypes 53 colocalization 53 HLA DR4 immune 53 prepubertal 53 transmembrane domains 53 covalently bound 53 MIF protein 53 distant metastasis 53 synaptogenesis 53 genetic polymorphisms 53 peroxidase 53 metabolic enzymes 53 MDM2 53 apolipoprotein B 53 invasive carcinomas 53 Immunoglobulin E 53 GLUT4 53 clusterin 53 alpha synuclein protein 53 phenotypic variation 53 sRNAs 52 potent inhibitors 52 μ opioid receptor 52 #q#.# [001] 52 BMAL1 52 pRb 52 short hairpin RNAs 52 E cadherin 52 HLA DRB1 52 statistically significant correlation 52 cells μL 52 mutated p# 52 STK# [002] 52 genomic alterations 52 mRNA molecules 52 RNA sequences 52 ± SEM 52 VIPR2 52 de novo synthesis 52 peripheral blood mononuclear 52 Microarray analysis 52 replicon 52 CpG island 52 gene encodes 52 elevated creatinine 52 FGFR4 52 nucleated cells 52 IgE antibodies 52 protein tyrosine phosphatase 52 histopathological 52 induced sputum 52 RQ PCR 52 ERK pathway 52 LRP5 52 Leydig cell 52 CD# CD# 52 uPAR 52 serum estradiol 52 mutationally activated 52 signaling pathways 52 humanized mice 52 exocytosis 52 estrogen receptor alpha 52 rCBF 52 TYMS 52 hepatic enzyme 52 HLA antigens 52 Heterozygous 52 YKL 52 gene deletions 52 lymphoblasts 52 methylenetetrahydrofolate reductase 52 paternally inherited 52 transgenic rats 52 hematological parameters 52 nAChR 52 Supplementary Table 52 antiphospholipid antibodies 52 serine threonine kinase 52 micronuclei 52 GPx 52 H#K# [001] 52 Rab5 52 Xenopus 52 polyploid 52 Alkaline Phosphatase 52 noncoding 52 heparanase 52 KIAA# 52 CYP# [001] 52 GPC5 52 phosphorylated tau 52 alternative splicing 52 MT1 MMP 52 aspartate 52 alanine aminotransferase ALT 52 RUNX3 52 microsatellite markers 52 Xenopus laevis 52 nucleolar 52 Genetic variation 52 homologs 52 IGFBP 3 52 S. pombe 52 serum antibody 52 GAPDH 52 Aspergillus nidulans 52 pharmacodynamic PD 52 endonuclease 52 normotensive 52 ALK mutations 52 histologic subtypes 52 HipA 52 E#F# 52 bile acid 52 inhibitory effects 52 immunohistochemical 52 splice junctions 52 phospholipase 52 osteoblast 52 prodynorphin 52 HMGA2 52 transcriptional regulator 52 hypothalamic pituitary 52 SIRT2 52 trophoblasts 52 Gram stain 52 SLC#A# [001] 52 histone acetylation 52 SNCA 52 bFGF 52 HBeAg 52 mutant allele 52 centromeric 52 chloroplast 52 TOP2A 52 IL#R 52 AST ALT 52 IKKß 52 dose dependently 52 ubiquitinated 52 microdeletions 52 FDG uptake 52 familial pancreatic cancer 52 susceptibility locus 52 nonobese 52 dopamine transporter gene 52 cyclic AMP cAMP 52 clade B 52 RT qPCR 52 Fig. 1a 52 thyroglobulin 52 advanced adenoma 52 adduct 52 1ß 52 missense 52 Histological 52 stably transfected 52 breast cancer subtypes 52 Prevotella 52 plasma adiponectin 52 odorant receptor 52 PTH secretion 52 epigenetic alterations 52 Cx# [001] 52 lipocalin 52 diphosphate 52 #q#.# [002] 52 renal cell carcinomas 52 DNA methylation patterns 52 proinflammatory 52 PrPSc 52 highest tertile 52 spermatogonia 52 PKM2 52 IgA deficiency 52 antibodies bind 52 stably expressing 52 DEAR1 52 MAPKs 52 MRSA isolates 52 5 HTTLPR 52 fluconazole resistant 52 oligomeric 52 lung fibroblasts 52 subtyped 52 aromatase 52 N acetyltransferase 52 HIV uninfected 52 induce apoptosis 52 Fibroblast 52 acyl CoA 52 non mutated KRAS 52 Phylogenetic analysis 52 c fos 52 single nucleotide polymorphism 52 immunotoxin 52 endometrial ovarian 52 amino acid residue 52 paraffin embedded 52 enzyme inhibition 52 #q# [002] 52 histopathologic examination 52 c Myb 52 pyrimidines 52 Tg mice 52 defensin 52 invasive lobular 52 paraventricular nucleus 52 endothelial activation 52 lacZ 52 upregulates 52 transcriptome 52 ortholog 52 SMAD4 52 adipose cells 52 hormone secretion 52 airway hyper responsiveness 52 cellular organelles 52 HER2 homodimer levels 52 archaeal 52 TP# gene 52 GLI1 52 benzimidazole 52 spontaneous mutations 52 PER2 52 RANTES 52 male Sprague Dawley 52 lung ovary 52 biotinylated 52 troponin T 52 haematologic 52 Aß 52 multivariate Cox 52 5 HT2A serotonin 51 serum ALT 51 β amyloid 51 proteolysis 51 lupus anticoagulant 51 clinically meaningful differences 51 reaction RT PCR 51 Cytogenetic 51 prostatic adenocarcinoma 51 affinity purified 51 statistically significant differences 51 LHRH receptor positive 51 hamartomas 51 matrix metalloproteinase 51 TCF#L# 51 System IPSS 51 isoprenoid 51 prion strains 51 dehydrogenases 51 HFE gene 51 SPINK1 51 CDX2 51 B. fragilis 51 APOE e4 51 baseline LDH 51 thymosin 51 osteoblastic 51 microsomal 51 serotonin receptor 51 penetrance 51 urothelial carcinoma 51 Estrogen Receptor 51 Pseudomonas syringae 51 CHI#L# 51 quantitative polymerase chain 51 PDGFRA 51 familial aggregation 51 situ LCIS 51 probands 51 homodimer 51 seronegative 51 reticulocytes 51 cystatin C 51 guanosine 51 embryonal carcinoma 51 allogeneic transplant 51 T2 weighted images 51 polyamines 51 maternally inherited 51 glycolipids 51 relapsed MM 51 ribosomal protein 51 transcriptional profiles 51 retinoid X 51 advanced neoplasia 51 glycolytic 51 regulates gene expression 51 HER2 HER3 51 mosaicism 51 transcriptional 51 airway responsiveness 51 autophagic 51 #q# deletion 51 EGFR protein 51 #p# [001] 51 eicosanoid 51 dsRNA 51 T1c 51 cultured hippocampal neurons 51 IDH1 mutation 51 folate metabolism 51 mycobacteria 51 syngeneic 51 plasma leptin 51 K ras gene 51 histone modification 51 NS5B 51 trisomic 51 conserved sequences 51 IPAH 51 intraperitoneally 51 MAP kinase 51 dopamine D2 receptor 51 EBNA1 51 MIC# [001] 51 EGFR mutations 51 subcellular compartments 51 VKORC1 51 Peyer patches 51 tumor histology 51 miRNA 51 FLT3 mutations 51 androgen receptor gene 51 SHBG levels 51 CDH1 51 nucleotide sequence 51 resistin 51 mammalian tissues 51 PCR RFLP 51 homozygote 51 umbilical vein 51 MYH9 gene 51 proteomic analysis 51 thioredoxin 51 lung carcinomas 51 TGF β 51 heavily pretreated 51 motile 51 NSCLC tumors 51 cyclic nucleotide 51 serum PTH