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(Click for frequent words.) 72 gene polymorphisms 72 PTPN# 72 Polymorphisms 72 rs# [004] 72 mediated inhibition 72 gene polymorphism 72 proto oncogene 71 Dysregulation 71 missense mutations 71 catechol O methyltransferase 71 transcriptional activation 71 allelic variants 70 chromosome #q# [002] 70 constitutively expressed 70 Rap1 70 #q#.# [001] 70 Clusterin 70 ERalpha 70 ERK signaling 70 V#F mutation 70 Upregulation 70 mitogen activated protein kinase 69 upregulates 69 deacetylation 69 mRNA expression 69 ABCB1 69 genetic polymorphism 69 serine protease 69 isoenzyme 69 cell adhesion molecule 69 SMAD4 69 virulence genes 68 hypermethylated 68 HLA DRB1 * 68 genetic loci 68 lymphoid cells 68 phosphatidylinositol 3 68 WNK1 68 missense mutation 68 #p#.# [002] 68 monogenic 68 methylation patterns 68 subcellular localization 68 H#K#me# 68 allelic 68 IL#R 68 MAPK pathway 68 COL#A# 68 serine threonine kinase 68 caveolin 68 metalloprotease 68 synuclein 68 #q# [001] 68 chromosome #q# [001] 67 genetic polymorphisms 67 induced apoptosis 67 phospholipase 67 hypothalamic pituitary 67 quantitative trait loci 67 gastric adenocarcinoma 67 splice variants 67 Polymorphism 67 sequence homology 67 potent inhibition 67 CagA 67 chromosome #q#.# [002] 67 SSc 67 hepatic lipase 67 orthologs 67 Epstein Barr Virus EBV 67 gene rearrangements 67 HepG2 cells 67 miRNA expression 67 decarboxylase 67 tropomyosin 67 nucleolar 67 BRAF V#E 67 ZNF# 67 histone acetylation 67 isoenzymes 67 TTR gene 67 potent inhibitors 67 synthases 67 chromosome #p#.# 67 serine threonine 67 LNCaP cells 67 constitutively active 67 chromosome #p# [002] 67 #q#.# [002] 67 gastric carcinoma 67 chromosome #p# [001] 67 activating mutations 67 RRM1 67 germline mutations 67 ß1 67 HIF 1alpha 66 neurological manifestations 66 #p# [003] 66 steroidogenic 66 Cathepsin B 66 glutamic acid decarboxylase 66 CYP#B# 66 ß catenin 66 β1 66 1alpha 66 transgene expression 66 posttranslational modifications 66 Macrophage 66 prodynorphin 66 methylenetetrahydrofolate reductase 66 CD#b 66 SNP rs# [001] 66 lysine residues 66 5 HTTLPR 66 Oncogenic 66 Brain derived neurotrophic 66 myopathies 66 promoter polymorphism 66 dimeric 66 Cyclin E 66 NR#A# 66 COX2 66 Elevated serum 66 histone deacetylases 66 inducible nitric oxide synthase 66 retinoic acid receptor 66 transcriptional regulation 66 TNFalpha 66 intronic 66 cyclin dependent kinase inhibitor 66 peptide receptor 66 transcriptional regulator 66 microsomal 66 ERBB2 66 ERK1 2 66 methyltransferase 66 rs# [001] 66 clinicopathological 66 astrocytic 66 hydrolase 66 neuronal dysfunction 66 p# activation 66 carboxyl terminal 66 inverse agonist 66 ADPKD 66 proximal tubular 66 phospholipase A2 66 androgen receptor AR 66 isotypes 66 transient receptor 66 Rho GTPases 66 FGFs 66 prolyl 66 FasL 66 ESR1 66 hypermethylation 66 p# MAPK 66 MTHFR 66 hydroxylase 66 Activating mutations 66 homozygotes 66 Smad3 66 cagA 66 proteolytic cleavage 66 polymorphisms 66 monocyte 66 Fas ligand 66 K + ATPase 66 Hypothalamic 66 pathophysiological effects 66 gene locus 66 rs# [002] 66 forkhead 66 Factor VEGF 66 adipogenic 66 uPAR 65 genes differentially expressed 65 chromosome #q#.# [001] 65 tyrosine phosphorylation 65 proapoptotic 65 susceptibility locus 65 chromosomal rearrangement 65 circadian genes 65 protein tyrosine phosphatase 65 transmembrane protein 65 fig. S4 65 factor HGF 65 Rab5 65 TMEM#B 65 K ras mutations 65 VE cadherin 65 transactivation 65 phosphate S1P 65 microglial 65 paraneoplastic 65 intergenic 65 vimentin 65 PLA2 65 LPS induced 65 aggrecan 65 synthetase 65 LRP5 65 IL 1ß 65 pharmacodynamic biomarkers 65 telomerase reverse transcriptase 65 Peroxisome proliferator activated 65 cotransporter 65 rs# [003] 65 chromosomal aberrations 65 bronchial epithelial cells 65 acetylcholine receptor 65 endothelial activation 65 Overexpression 65 inherited mutations 65 CD# CD# 65 epigenetic modification 65 esterase 65 promoter methylation 65 proteoglycan 65 CDKN2A 65 Genetic variation 65 Leydig cell 65 receptor subtypes 65 cytosolic 65 immunoreactive 65 transduced 65 MAP kinase 65 evolutionarily conserved 65 hydrolases 65 gene encodes 65 XL# inhibits 65 IFN γ 65 lysophosphatidic acid 65 beta subunit 65 PGC 1α 65 downregulation 65 myeloproliferative diseases 65 Trichophyton rubrum 65 immunoblotting 65 SNP rs# [002] 65 IL8 65 nitrotyrosine 65 γ secretase 65 ABCB1 gene 65 PTHrP 65 transcriptional repression 65 Apolipoprotein E 65 phosphoprotein 65 TGF b 65 CD#c 65 cytokine receptor 65 tyrosine kinase receptor 65 BCL2 65 haematopoietic 65 neuronal nitric oxide synthase 65 p#Kip# 65 GABAB receptors 65 ankyrin repeat 65 chemokine receptors 65 PC# cells 65 homologues 65 osteoblastic 65 T#M 65 SLC#A# [001] 65 proinflammatory 65 SNCA 65 endophenotypes 65 cytotoxin 65 cyclin E 65 null mice 65 adenylate cyclase 65 lysosomal 65 antiapoptotic 65 PON1 65 catenin 65 proteolysis 65 MLH1 65 interferon γ 65 Src kinase 65 KLF4 65 tumorigenicity 65 DQB1 * 65 lyase 64 Phenotypic 64 TGF beta1 64 ADAMTS# 64 Leukemias 64 selective modulator 64 Treg cell 64 CpG island 64 renal fibrosis 64 Transcriptional 64 proinflammatory cytokine 64 perilipin 64 interleukin IL -6 64 protein phosphatase 64 genes encoding 64 oligomeric 64 protein encoded 64 homeobox gene 64 sphingolipid 64 hepatocyte growth 64 BMP2 64 adrenoceptor 64 perivascular 64 EF Tu 64 untranslated regions 64 mediated apoptosis 64 CHD7 64 1beta 64 subgenual cingulate 64 MMP# 64 colony stimulating factor 64 carcinoembryonic antigen 64 assay detects 64 hypomethylation 64 pDC 64 AhR 64 clonal expansion 64 Inactivation 64 lymphangiogenesis 64 apo AI 64 dopamine receptor gene 64 PDGFR 64 receptor inhibitor 64 Corynebacterium 64 somatic mutation 64 cardiolipin 64 cathepsin B 64 alveolar epithelial cells 64 amyloidogenic 64 NKG2D 64 Fibroblast 64 neoplastic 64 cis regulatory 64 Protein Kinase C 64 orthologous 64 transgenic mice expressing 64 N methyl 64 eicosanoid 64 immunoreactivity 64 cytoplasmic domain 64 AT1R 64 histone modifications 64 hepatoma 64 homodimers 64 phenotypic expression 64 differential gene expression 64 PKC isoforms 64 mesangial 64 amino terminal 64 hyperplastic 64 biochemical abnormalities 64 glutamatergic 64 Protein kinase 64 Wnt signaling pathway 64 prostaglandin E 64 hyperinsulinemia 64 TMPRSS2 ERG fusion 64 TGF ß 64 lipoprotein metabolism 64 protein tyrosine kinase 64 synaptogenesis 64 somatostatin 64 mTOR mammalian target 64 E#F# 64 aberrantly activated 64 #β estradiol 64 plasma lipid 64 estrone 64 mycobacterial 64 cytokeratin 64 colorectal carcinoma 64 cytopathic 64 HLA DRB1 64 HDAC3 64 ^ sup ^ 64 ectopic expression 64 neurite outgrowth 64 glomerular 64 At#g# 64 essential thrombocythemia 64 Akt activation 64 previously uncharacterized 64 receptor gene 64 adrenocortical 64 #p#.# [001] 64 transiently transfected 64 beta amyloid peptide 64 cyclooxygenase COX 64 Factor Receptor 64 P cadherin 64 cyclin dependent kinase 64 kDa protein 64 microcephalin 64 dopamine D2 64 lymphocytic 64 VEGF receptor 64 MSH2 64 glycosyltransferase 64 murine leukemia virus 64 monocytic 64 isomerase 64 HLA DQ2 64 neurexins 64 HBx 64 acetyltransferase 64 KIAA# 64 underlying pathophysiology 64 maternally inherited 64 protein phosphorylation 64 tetramer 63 receptor tyrosine kinase 63 steroidogenesis 63 3'UTR 63 p tau 63 retinol binding protein 63 Aromatase 63 splenocytes 63 metaplasia 63 synovial cells 63 mineralocorticoid 63 SLC#A# [002] 63 overactivation 63 differentially expressed genes 63 cytochrome b 63 eNOS 63 constitutive activation 63 etiologic 63 protein kinase C 63 airway hyperresponsiveness 63 ultrastructural 63 phospho 63 chemokine receptor 63 amino acid substitutions 63 colorectal adenocarcinoma 63 thyrotropin 63 fibrogenesis 63 tumoral 63 TRPV4 63 vasopressin receptor 63 TNF α 63 polyadenylation 63 somatostatin receptor 63 FKBP# 63 L. pneumophila 63 apoE 63 LIS1 63 miR #a [001] 63 calcium calmodulin dependent 63 adipokines 63 pulvinar 63 MDR1 63 tumor suppressor protein 63 gliosis 63 #HT#A 63 major histocompatibility complex 63 replicase 63 homozygosity 63 coexpression 63 autosomal recessive 63 inhibitory effects 63 c fos 63 alternatively spliced 63 IL 1β 63 PAX5 63 Prognostic factors 63 transferase 63 ribosomal protein 63 thyroid carcinoma 63 homologue 63 inactivating mutations 63 MECP2 gene 63 operon 63 clade B 63 autophagic 63 transcriptional repressor 63 Oxidative damage 63 kinase domain 63 carboxy terminal 63 neurofilament 63 catechol O methyltransferase COMT 63 polyamine 63 SGPT 63 secreted protein 63 activin 63 IgG4 63 proline rich 63 Subtype 63 CCR5 delta# 63 apoE4 63 predisposing factor 63 differentially regulated 63 Supplementary Fig 63 polycystin 63 chemoattractant 63 TCF#L# gene 63 epigenetic alterations 63 regulated kinase 63 interleukin IL -# 63 ultrastructure 63 TIMP 63 phosphatases 63 ABL1 63 KCNQ1 63 protein conformation 63 DNMT1 63 immunoregulatory 63 DNA methyltransferase 63 Genotypes 63 de novo mutations 63 GSTP1 63 Cryptococcus neoformans 63 #S rRNA 63 induces apoptosis 63 Phosphorylation 63 extracellular signal 63 HER2 HER3 63 granulomatous 63 transcriptional activity 63 microdeletion 63 myeloid 63 dephosphorylation 63 guanosine 63 c KIT 63 DNA methylation patterns 63 NS5B 63 epithelia 63 5 HT1A receptor 63 peroxidase 63 cells transfected 63 thioredoxin 63 CYP#A# gene 63 circadian clock genes 63 proteinases 63 potent inducer 63 myeloproliferative 63 isoform 63 homolog 63 extramedullary 63 polymorphism 63 phosphorylase 63 microglial activation 63 immunodominant 63 mitogen activated protein kinases 63 cell adhesion molecules 63 NFAT 63 dinucleotide 63 autosomal dominant disorder 63 JNK1 63 Fc receptor 63 JAK2 enzyme 63 Microarray analysis 63 periventricular 63 Skeletal muscle 63 gastric carcinomas 63 protein secreted 63 COMT 63 myeloperoxidase 63 kallikrein 63 ornithine decarboxylase 63 subcellular compartments 63 Jhdm2a 63 histone acetyltransferase 63 HLA DR4 immune 63 protein tyrosine 63 noncoding RNAs 63 GSTT1 63 SIRT2 63 IGFBP2 63 Extracellular 63 H#K# [002] 63 UGT#B# 63 Supplementary Table 63 pro angiogenic 63 PON1 gene 63 #p# [001] 63 proteinase 63 syngeneic 63 glutamyl 63 ribosomal DNA 63 Immunohistochemical staining 63 downregulates 63 unmethylated 63 TCF#L# 63 phosphorylates 63 membrane proximal 63 encodes protein 63 hamartomas 63 basolateral 63 proximal tubule 63 Alternative splicing 63 receptor gamma 63 P2X 63 hyperactivation 63 Cytotoxic T 63 antiphospholipid antibodies 63 aminotransferase 63 p# Shc 63 ERK1 63 Flt3 63 LPA1 receptor 63 CYP#A# [002] 62 CpG islands 62 TRAF1 62 epithelial tumors 62 aspartate 62 superfamily 62 pathogenic mutations 62 neural stem 62 IL #p# 62 tryptase 62 VHL gene 62 cyclooxygenase 2 62 HLA DR4 62 neural progenitor 62 cytochrome 62 chromosome condensation 62 aldehyde dehydrogenase 62 Estrogen receptor 62 hypothalamic pituitary adrenal axis 62 FGFR2 62 nicotinic receptor 62 mRNA transcripts 62 previously undescribed 62 melanocyte 62 FGFR3 62 glycolipid 62 cAMP signaling 62 histone methylation 62 TOP2A gene 62 Sjögren syndrome 62 downstream effectors 62 Vascular endothelial growth 62 prostate carcinoma 62 mononuclear 62 chromosome #q 62 62 Apc 62 PBMCs 62 acyl CoA 62 CYP #D# 62 selective antagonists 62 alpha synuclein protein 62 #S rRNA gene 62 pathological hallmark 62 FLT3 62 aminopeptidase 62 Hedgehog signaling 62 miRNA genes 62 #S rRNA genes 62 Estrogen Receptor 62 LRP6 62 immunofluorescence microscopy 62 guanine nucleotide exchange 62 HER2 HER2 62 PCA3 gene 62 CYP#C# [002] 62 progesterone receptor PR 62 GABRA2 62 transgenic mouse models 62 murine model 62 TSC1 62 Xenopus laevis 62 receptor subtype 62 apoptosis pathways 62 prostaglandin synthesis 62 constitutively 62 E3 ubiquitin ligase 62 IMPDH 62 TMPRSS2 ERG 62 calcium homeostasis 62 phenotype 62 MYH9 gene 62 RNA polymerases 62 β catenin 62 progressive neurodegenerative disorder 62 downregulating 62 NAT2 62 leukotriene B4 62 Oxidative 62 NFκB 62 gene loci 62 miRNAs miR 62 lymphoid 62 dysregulated 62 estrogen receptor beta 62 IL #R 62 H#K# [001] 62 neuroinflammatory 62 transmembrane receptor 62 nNOS 62 mGluR 62 noradrenergic 62 RANTES 62 NMDAR 62 Phylogenetic analysis 62 dysgenesis 62 heterozygotes 62 vacuolar 62 dorsal root ganglion 62 familial clustering 62 glycolipids 62 peroxisome 62 4E BP1 62 dimerization 62 chromosomal regions 62 rs# rs# 62 overexpressing 62 HLA DR 62 penetrance 62 myocyte 62 FUS1 62 PAR1 62 genetic determinants 62 striatal 62 thyroid peroxidase 62 ribonucleoprotein 62 prognostic marker 62 selective agonists 62 EGFR HER2 62 Plasmodium vivax 62 HIF 1a 62 missense 62 fibrotic disease 62 IgA deficiency 62 tyrosine hydroxylase 62 beta globin gene 62 beta actin 62 Saccharomyces 62 paraganglioma 62 substrate specificity 62 extracellular domain 62 insertional 62 lymphoblastoid cell lines 62 upregulation 62 variant rs# 62 Modulates 62 regulated kinase ERK 62 dependent protein kinase 62 CEACAM1 62 mutant allele 62 HER2 expression 62 TRPV1 receptors 62 β cell 62 hepatocellular carcinomas 62 somatic mutations 62 SOD2 62 hypogonadotropic hypogonadism 62 retinal ischemia 62 S. enterica 62 selective inhibition 62 rRNA 62 MMP2 62 glycosylated 62 osteoprotegerin 62 enteropathy 62 transmembrane 62 hypothalamus pituitary 62 cathepsins 62 c myc gene 62 oligomerization 62 polynucleotide 62 heterozygosity 62 CREBBP 62 polymicrobial 62 NADPH oxidase 62 alpha7 62 microdeletions 62 myelofibrosis polycythemia vera 62 hypervariable 62 hyperhomocysteinemia 62 diphosphate 62 cisplatin resistant 62 glutamatergic neurons 62 IgG1 62 Htt 62 Cadherin 62 selectively inhibited 62 IGF IR 62 p# mitogen activated 62 C#BL/#J 62 DLX5 62 VKORC1 62 genotoxic stress 62 biologic pathway 62 neural crest 62 motor neuron degeneration 62 arrhythmogenic 62 LDL receptor 62 kinase pathway 62 Western blotting 62 effector function 62 prothrombotic 62 Kir#.# 62 agonist induced 62 phenothiazines 62 melatonin receptor 62 #q# [002] 62 hypoperfusion 62 pyrimidines 62 CYP#A# CYP#D# 62 PKC inhibitor 62 evolutionary conserved 62 adrenal cortex 62 thrombospondin 62 superior temporal gyrus 62 CHI#L# 62 μ opioid receptor 62 TrkA 62 PPARg 62 intercellular adhesion molecule 62 cyclin dependent kinases 62 M1 muscarinic 62 OPRM1 62 lactate dehydrogenase LDH 62 Prevotella 62 thymidine kinase 62 serum leptin 62 multinucleated 62 glucocorticoid receptors 62 HDAC enzymes 62 outer membrane proteins 62 umbilical vein 62 metalloproteinase 62 adipocyte 62 N acetyl 62 glucose transporter 62 β2 62 TRAF1 C5 62 neurokinin 62 Inhibitory 62 Tie2 62 tumor suppressor PTEN 62 ribosomal proteins 62 Histone 62 3' UTR 62 mosaicism 62 gene MECP2 62 nucleoli 62 potently inhibited 62 Hashimoto thyroiditis 62 lung carcinomas 62 Genotypic 62 Cytochrome P# 62 poly ADP ribose polymerase 62 5q 61 Leydig cells 61 excitotoxic 61 IL 1beta 61 RNase L 61 lymphocyte activation 61 ataxias 61 TIMP 1 61 basophils 61 5 HT6 receptor 61 underlying vasculopathy 61 Prefrontal 61 replicon 61 erythroid 61 fibrocytes 61 cytokine receptors 61 intestinal microflora 61 CDH1 61 intracellular protein 61 acinar 61 NFkB 61 idiopathic myelofibrosis 61 RUNX3 61 endogenous ligands 61 SMN1 61 Caenorhabditis 61 DRB1 * 61 HLA DR2 61 RNA binding 61 pleiotropic 61 virulence determinants 61 anaphase promoting complex 61 fig. S1 61 Dopaminergic 61 oxysterols 61 HIF 1α 61 apolipoprotein E 61 O methyltransferase 61 GABAA receptors 61 prostate epithelial cells 61 leiomyomas 61 neuroligins 61 polymorphonuclear 61 endothelial nitric oxide synthase 61 downregulated 61 hematoxylin 61 deacetylase 61 IGFBP 61 FoxP3 61 rCBF 61 alleles 61 NQO1 61 chromatin modifications 61 leptin receptor 61 C#T [002] 61 airway epithelial 61 Janus kinase 61 chondrocyte 61 JAK STAT 61 HOTAIR 61 Mycobacterium smegmatis 61 osteoblast 61 MMP9 61 receptor kinase 61 A. thaliana 61 posterior cingulate 61 soluble fms 61 C1q 61 prognostic biomarker 61 prefrontal cortical 61 annexin V 61 apolipoproteins 61 osteogenic 61 CC genotype 61 cytokines IL 61 eIF4E 61 Androgen 61 dysregulation 61 acyltransferase 61 Escherichia coli Klebsiella pneumoniae 61 STK# [002] 61 PI3K Akt 61 peptidase 61 Akt signaling 61 Genetic variations 61 chromatin structure 61 synovial fibroblasts 61 CD1d 61 RIP1 61 matrix metalloproteinase 61 TGF ß1 61 CHEK2 61 leiomyoma 61 acetylated 61 breast carcinoma 61 malignant phenotype 61 breast carcinomas 61 papillary renal cell carcinoma 61 KCNH2 61 intron 61 TP# mutations 61 secretory 61 lesional 61 peroxisome proliferator activated 61 alpha subunit 61 autoantigen 61 TRPV3 61 alkaline phosphatase 61 C. trachomatis 61 meiotic recombination 61 inflammatory cytokine 61 alpha2 61 susceptibility gene 61 myc 61 vascular endothelial 61 cellular prion protein 61 urocortin 61 antiproliferative effects 61 hippocampal neurons 61 hypometabolism 61 ortholog 61 Leukotrienes 61 mutated K ras 61 5 HT1A 61 paralogs 61 Endothelial dysfunction 61 myeloproliferative neoplasms 61 retinoid X 61 SMase 61 FMR1 61 serpin 61 VNTR 61 cyclic peptide 61 p# INK4a 61 beta amyloid peptides 61 cyclic nucleotide 61 Autoantibodies 61 TOP2A 61 DNA demethylation 61 Alleles 61 oxidase 61 immune dysregulation 61 KRAS oncogene 61 Synuclein 61 APOA5 61 PALB2 61 secretory pathway 61 γ 61 peripheral blood mononuclear 61 urate oxidase 61 hepatocellular 61 BARD1 61 myo inositol