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(Click for frequent words.) 77 inhibited tumor 76 inhibit tumor 75 suppresses tumor 74 inhibiting tumor 72 induces apoptosis 71 potently inhibited 68 induce apoptosis 67 c MYC 67 BCL2 67 VEGF vascular endothelial 66 GATA3 66 selectively inhibited 66 potent inducer 66 factor PlGF 66 potent stimulator 66 inhibit metastasis 66 MMP2 66 prostaglandin E2 PGE2 66 antiproliferative activity 66 NKX#.# 65 selectively inhibit 65 TGF beta1 65 upregulates 65 E#F# 65 HepG2 cells 65 antisense inhibition 65 PGE2 65 mediated inhibition 64 MAP kinase 64 alpha#beta# integrin 64 thromboxane A2 64 pro angiogenic 64 mitogenic 64 Overexpression 64 PKC inhibitor 64 monocyte 64 mitogen activated protein 64 inducing apoptosis 64 cathepsins 64 autocrine 64 4E BP1 64 poly ADP ribose polymerase 64 leukemic cell 64 inhibitory effects 64 NFkappaB 64 ERK activation 64 pyruvate kinase 64 potent suppressor 64 TNFα 64 TGF ß1 64 factor NGF 64 cisplatin resistant 64 caspase activation 64 SCD1 64 VEGF induced 64 potently inhibit 64 inhibit viral replication 64 mouse xenograft models 64 β catenin 64 cyclin B1 63 PTP1B 63 radiosensitivity 63 γ secretase 63 neurite outgrowth 63 FasL 63 glucagon receptor 63 pathophysiological effects 63 transthyretin 63 #HT#A 63 TNFa 63 Upregulation 63 fibrogenesis 63 NF kappaB activation 63 oncogenic transformation 63 cyclic AMP cAMP 63 selective modulator 63 apoptosis inducing 63 eNOS 63 MAPK pathway 63 p# activation 63 mGluR2 NAM 63 androgen dependent 63 FOXO3a 63 E selectin 63 transmembrane receptor 63 colorectal tumors 63 TGF β1 63 downregulates 63 oncomodulin 63 EGF receptor 63 fibrin deposition 63 potently inhibits 63 heparanase 63 induced apoptosis 63 CDK4 63 protein tyrosine phosphatase 1B 63 overexpressing 63 FGFR4 63 Flt3 63 neuronal dysfunction 63 LTB4 63 VEGF receptor 63 IL 1ß 63 inhibiting telomerase 63 ERK1 2 63 cathepsin B 63 antiapoptotic 62 COX2 62 gastrin 62 MetAP2 62 Osteopontin 62 PTHrP 62 RANK ligand 62 E cadherin expression 62 anti inflammatory cytokine 62 Vidofludimus 62 TGF beta pathway 62 antimitotic 62 glioma cells 62 hepatoma 62 RAS RAF MEK 62 fatty acid oxidation 62 tumor xenografts 62 lysosomal 62 Androgen receptor 62 p# MAP kinase 62 Akt phosphorylation 62 gamma tocotrienol 62 PI3K/mTOR 62 osteoblast 62 Inosine 62 Eg5 62 leukemic stem cells 62 Akt signaling 62 Topoisomerase II 62 osteoclast formation 62 Angiotensin converting enzyme 62 potent inhibitor 62 apoptotic cell 62 CCR2 62 cyclin E 62 inhibit vascular endothelial 62 CEACAM1 62 Rho kinase 62 cyclic adenosine monophosphate cAMP 62 lowers blood glucose 62 lymphotoxin 62 p#NTR 62 c myc gene 62 effector function 62 lysophosphatidic acid 62 IGF 1R 62 inhibits angiogenesis 62 GSTP1 62 cytoprotective 62 neurotrophic 62 antiangiogenic 62 JAK#/JAK# 62 XL# inhibits 62 androgen independent 62 CB1 receptor 62 PTEN protein 62 HER2 HER2 62 elastase 62 colorectal carcinoma 62 CTGF 62 factor HGF 62 abnormal angiogenesis 62 inhibits VEGF 62 TGF ß 62 antitumor 62 CDK inhibitor 62 5 lipoxygenase 61 leukocyte adhesion 61 tumor suppressor 61 PEDF 61 mTOR inhibitors 61 osteoblast activity 61 collagen degradation 61 thymidylate synthase TS 61 GSK3B 61 ligand TRAIL 61 chemokine receptor 61 eotaxin 61 selective inhibition 61 adipogenic 61 gamma secretase inhibitor 61 colorectal tumor 61 heme oxygenase 61 xenograft tumors 61 MMP9 61 FGFR3 61 mitogen activated protein kinase 61 Factor Receptor 61 inhibiting COX 61 LRP5 61 PDGFR 61 PDGF B 61 activin 61 apoptosis induced 61 isoform selective 61 tryptase 61 prostaglandin synthesis 61 p# alpha [001] 61 aberrantly activated 61 protein CETP 61 hedgehog pathway 61 lipoprotein lipase 61 HuR 61 TGF alpha 61 EGFR receptor 61 ZNF# 61 inducible nitric oxide synthase 61 pro apoptotic 61 receptor inhibitor 61 TXNIP 61 MEK ERK 61 ADAMTS# 61 cyclooxygenase 61 SOCS3 61 microsomal 61 lung fibrosis 61 molecule epidermal 61 ER alpha 61 PPARg 61 HIF 1a 61 VEGFR1 61 inhibits 61 Her-2/neu 61 Myostatin 61 factor EGF 61 ERK signaling 61 mTOR signaling 61 HDAC6 61 IL 1β 61 M1 muscarinic 61 ADAM# 61 Preclinical studies suggest 61 ARF1 61 uPA 61 inhibits protein synthesis 61 potent inhibition 61 erythrocyte 61 pRb 61 HIF 1alpha 61 TMEM#B 61 Src kinase 61 Raf MEK ERK 61 tumor suppressor proteins 61 selectively binds 61 neuro protective 61 Sertoli cell 61 LPS induced 61 p#Kip# 61 phosphatidylinositol 3 61 HER3 61 phosphorylate 61 TNFalpha 61 cardiomyocyte 61 polyamine 61 metabolizing enzyme 61 ovarian carcinoma 61 vascular endothelial 61 MCF7 61 inhibitory effect 61 antiproliferative effects 61 lipid synthesis 61 phosphorylates 61 reversible inhibitor 61 aurora kinase 61 Hedgehog signaling 61 estrogen receptor beta 61 oncoprotein 61 neurturin 61 selective agonist 61 FGFs 61 novel peptide 61 antiproliferative 61 SETDB1 61 ALB # 61 redox active 61 monocytes macrophages 61 PP2A 61 Protein Kinase C 60 Rap1 60 cyclin dependent kinase inhibitor 60 signal transduction inhibitor 60 HER2 neu 60 RKIP 60 muscarinic 60 Wnt signaling pathway 60 endothelial activation 60 Hedgehog pathway 60 CDK5 60 interleukin IL -# 60 Gleevec resistant 60 receptor CXCR4 60 metalloprotease 60 p#INK#a 60 thymic 60 LNCaP cells 60 uPAR 60 factor G CSF 60 upregulated 60 mediated phosphorylation 60 cell motility 60 chimeric monoclonal antibody 60 upregulation 60 PHD2 60 TNF α 60 immune modulator 60 SERMs 60 IGF1R 60 costimulation 60 nicotinic acetylcholine receptor 60 kinase pathway 60 anti CD3 60 keratinocyte 60 renal fibrosis 60 neurotrophic factors 60 Factor VEGF 60 experimental autoimmune encephalomyelitis 60 inhibits bacterial 60 CCR3 60 proto oncogene 60 mammary tumors 60 Clusterin 60 potent anticancer 60 DGAT1 60 novel VDA molecule 60 N Myc 60 RRM1 60 angiogenesis inhibitor 60 gastric carcinogenesis 60 factor beta TGF 60 xenograft models 60 transgene expression 60 adrenoceptor 60 mesenchymal cell 60 overactivation 60 PDGF receptor 60 autophagic 60 immunomodulatory effects 60 Darapladib 60 MDM2 60 syngeneic 60 Î ² 60 anti proliferative 60 tyrosine hydroxylase 60 androgen hormone 60 osteoprotegerin 60 phosphate S1P 60 Notch1 60 FAAH 60 p# Shc 60 metalloproteinase 60 histone deacetylases 60 Dysregulation 60 induced angiogenesis 60 EGFr 60 OGG1 60 upregulate 60 PI3K/Akt pathway 60 aromatase enzyme 60 soluble tumor necrosis 60 protein tyrosine kinase 60 apelin 60 DHFR 60 vidofludimus 60 receptor blocker 60 caveolin 1 60 neointimal 60 S6K 60 ERa 60 selective inhibitor 60 antiangiogenesis 60 prostate tumor 60 Ets2 60 miR #b [002] 60 mammary tumor 60 myocyte 60 PIK3CA 60 selectively inhibits 60 osteoclast 60 TGF β 60 triggers apoptosis 60 UCP2 60 paxillin 60 pharmacological inhibition 60 CatB 60 proteinase 60 chemopreventive agent 60 IGF1 60 RANK Ligand 60 inverse agonist 60 antimetastatic 60 mTOR mammalian target 60 AT1R 60 STK# [002] 60 hedgehog signaling 60 selective kinase inhibitor 60 diagnostic biomarker 60 potent inhibitors 60 isotypes 60 1alpha 60 CXCL# 60 5 HT2A serotonin 60 Treg cell 60 monocyte chemoattractant protein 60 heme oxygenase 1 60 ERK pathway 60 IL6 60 selective agonists 60 mineralocorticoid receptor 60 anti angiogenic agent 60 factor CTGF 60 kidney urologic 60 LPA1 60 tumorigenicity 60 RAS RAF MEK ERK 60 PARP1 60 endothelial nitric oxide synthase 60 ENMD # 60 Th1 type 60 tumor angiogenesis 60 Raf kinase 60 RUNX3 60 myoepithelial cells 60 HIF 1α 60 gastric carcinoma 60 selectively inhibiting 60 gene polymorphism 60 FGF receptor 60 SIRT2 60 Akt activation 60 triggers apoptosis programmed 60 PIGF 60 nAChR 60 miR #a [001] 60 JAK2 enzyme 60 c MET 60 tumor vascularization 60 Angiotensin 60 GLI1 60 TRAIL induced apoptosis 60 AGTR1 60 cyclooxygenase 2 60 HIV reverse transcriptase 59 EZH2 59 NF kappaB 59 thyroid hormone receptor 59 mediated apoptosis 59 tumor vasculature 59 chondrocyte 59 ectopic expression 59 neuroblastoma cells 59 serotonin uptake 59 matrix metalloproteinases 59 liver metastasis 59 growth hormone secretion 59 FKBP# 59 GSK3 59 mutant KRAS 59 alveolar epithelial cells 59 tumorigenesis 59 hypoxia inducible factor 59 proteoglycan 59 serine protease 59 MT1 MMP 59 prostaglandin D2 59 PKC# 59 IFN gamma 59 insulin sensitizing 59 lipoxygenase 59 Tumour Vascular Disrupting Agent 59 pDCs 59 vascular endothelial cells 59 Kinoid 59 intracellular uptake 59 Akt1 59 PLA2 59 IFNg 59 TGF beta 59 small molecule tyrosine 59 lymphoid organs 59 frataxin 59 antibody mediated 59 CYT# potent vascular disrupting 59 amyloid β 59 beta1 integrin 59 lymphangiogenesis 59 glucocorticoid receptor 59 CCR1 59 recombinant erythropoietin 59 VEGFR2 59 activated microglia 59 leukotriene pathway 59 HER2/neu 59 regulated kinase ERK 59 HCV replication 59 apoptotic pathway 59 PDGF alpha receptor 59 accumulate preferentially 59 S/GSK# 59 sphingosine 1 59 cytokine interleukin 59 immunotoxin 59 downregulated 59 glucose homeostasis 59 immunoregulatory 59 erythropoiesis 59 Histone deacetylase 59 demonstrated antitumor activity 59 serotonin reuptake 59 DNMT1 59 dephosphorylation 59 secretory pathway 59 intracellular accumulation 59 Angiotensin II 59 neuronal apoptosis 59 mitogen 59 RANKL 59 Pathway Inhibitor 59 myofibroblast 59 acetylcholine receptor 59 Abeta# 59 tenascin C 59 angiotensin receptor 59 iNOS 59 acetylcholinesterase 59 ErbB2 59 podocyte 59 superoxide dismutase 59 enzymatic activity 59 Wnt signaling 59 myeloid derived 59 osteoprotegerin OPG 59 VEGF 59 MUC1 * 59 NK1R 59 STAT3 59 nitric oxide synthase 59 hydrolase 59 c myc 59 detoxification enzymes 59 glomerular 59 Aβ 59 Lyn kinase 59 neuroinflammatory 59 synovial cells 59 chimeric antibody 59 CXCL5 59 histone deacetylase HDAC 59 DG# compounds targeting 59 chemopreventive 59 constitutively activated 59 neurofibrillary 59 fibrotic disease 59 prostaglandin E2 59 enzyme inhibitor 59 interferon γ 59 endothelial nitric oxide 59 CD# expression [001] 59 regulates gene expression 59 Th2 cytokines 59 Lodamin 59 erythropoietic 59 irreversible inhibitor 59 P cadherin 59 isoenzyme 59 SSc 59 amyloid plaque formation 59 antigenic epitopes 59 murine 59 neuronal cell 59 Shp2 59 PDGF BB 59 constitutively expressed 59 immune modulating 59 clonogenic 59 plasminogen activator 59 FGFR1 59 protein tyrosine kinases 59 SGLT2 59 PPARγ 59 orexin receptors 59 cytokines chemokines 59 tumor suppressor gene 59 NQO1 59 cytokine IL 59 lung epithelial 59 PI3 kinase 59 antitumor effects 59 neuroprotectant 59 SMN1 59 neurotrophin 59 glucokinase 59 related apoptosis inducing 59 EGFR pathway 59 renin angiotensin system 59 CTLA4 59 receptor PPAR 59 alkylating agent 59 p# deficient 59 acetylcholinesterase AChE 59 Ii protein 59 SERCA2a 59 p# MAPK 59 dose dependently 59 cardiac fibroblasts 59 eicosanoid 59 IFN γ 59 mice overexpressing 59 tubulin polymerization 59 capillary endothelial cells 59 TGF b 59 anti angiogenic 59 triphosphate 59 xenograft 59 overactivated 59 antiangiogenic agent 59 LDL receptor 59 prostate carcinoma 59 tumor suppressor protein 59 ornithine decarboxylase 59 Tumor necrosis factor 59 Cyclin E 59 C5aR 59 cyclin dependent kinase 59 cytotoxic T lymphocyte 59 UCP1 59 neuroprotective properties 59 mTORC1 59 agonist induced 59 1beta 59 PI3K/AKT 59 PSN# [002] 59 leukocyte recruitment 59 EGFR mutant 59 downstream effectors 59 cardiac myocytes 59 AKT inhibitor 59 secretase 59 PLK1 59 cyclooxygenase COX 59 utrophin 59 pegylated liposomal doxorubicin 59 NADPH oxidase 59 vascular inflammation 59 lipid accumulation 59 inhibit angiogenesis 59 pancreatic islet 59 platelet adhesion 59 thrombopoietin TPO 59 HDAC 59 palladin 59 neointimal hyperplasia 59 HDAC2 59 VEGFb 59 atherogenesis 59 S#K# 59 PDE7B 59 chemoresistance 59 overexpression 59 Immunohistochemical analysis 59 peptide hormone 59 monocyte chemotactic protein 59 Thyroid hormone 59 CDDO Im 59 Nampt 59 PECAM 1 59 induce apoptosis programmed 59 S#A# [002] 59 mutant huntingtin protein 59 CD#b 59 experimentally induced 59 mutated p# 59 THR beta agonist 59 act synergistically 59 pancreatic prostate 59 Fas ligand 58 colon carcinoma 58 glioblastoma cells 58 CTLA 4 58 Syk 58 Tie2 58 potent antitumor activity 58 muscarinic receptors 58 inhibit platelet aggregation 58 ActRIIB 58 NFkB 58 SGK1 58 IFN g 58 Fibroblast Growth Factor 58 receptor tyrosine kinase inhibitor 58 LPA1 receptor 58 microRNA miR 58 hormonally sensitive 58 aldose reductase 58 CCR9 58 intratumoral injection 58 NKG2D 58 inhibit replication 58 TLE3 58 thymidylate synthase 58 lactate dehydrogenase 58 receptor gamma 58 FGFR2 58 glutamyl 58 anti apoptotic proteins 58 huntingtin gene 58 extracellular signal 58 #ME# 58 platelet activation 58 adipogenesis 58 vascular disrupting agent 58 IAP inhibitor 58 GPR# [002] 58 PKCi 58 polymorphonuclear leukocytes 58 intestinal mucosal 58 chemokine SDF 1 58 metaglidasen 58 PC# cells 58 CD#c 58 Smad3 58 somatostatin 58 dopamine transporter 58 Angiolix 58 vimentin 58 pleiotropic 58 receptor CD# 58 oxysterols 58 PEGPH# 58 proapoptotic 58 thrombin receptor 58 hematopoietic progenitors 58 tyrosine kinase 58 specific lectin receptors 58 Janus kinase 58 PAR1 58 c Src 58 investigational humanized monoclonal antibody 58 pDC 58 gastrointestinal stromal tumors GISTs 58 S#P# 58 KRAS oncogene 58 suppressor cells 58 diphosphate 58 ß catenin 58 EGFR signaling 58 beta endorphin 58 plasma kallikrein 58 pharmacological chaperone 58 tumor metastasis 58 thyrotropin 58 IGFBP 3 58 FOXO1 58 prolongs survival 58 Tumor Necrosis Factor 58 breast cancer metastasis 58 Tissue Factor 58 apoptosis programmed cell 58 cortisol synthesis 58 SIRT3 58 tumor stroma 58 Treg cells 58 glycogen synthase 58 castrate resistant 58 GPC3 58 Pim kinases 58 endothelin receptor 58 glioblastoma tumor 58 CB2 receptor 58 toxic amyloid beta 58 microglial activation 58 constitutively active 58 alpha#beta# 58 IL 1beta 58 naturally occurring molecule 58 umbilical vein 58 IGFBP2 58 CRACC 58 RANTES 58 CHD5 58 PTPN# 58 chemotherapeutic drug 58 AT1 receptor 58 serine threonine kinase 58 Monocyte 58 vWF 58 Phosphorylation 58 CXCR4 receptor 58 anticancer activity 58 small molecule agonists 58 PGC 1α 58 CYP#B# 58 anti atherogenic 58 leukotriene 58 neuroprotective effects 58 androgen receptor AR 58 Oncogenic 58 C. pneumoniae 58 Oxidative damage 58 lysyl oxidase 58 androgen receptor 58 antiangiogenic activity 58 Bcr Abl 58 inhibiting 58 axonal degeneration 58 antiestrogen 58 intestinal epithelium 58 mTOR 58 Cyclooxygenase 2 58 cytoplasmic domain 58 mice lacking 58 Fc receptors 58 HDAC3 58 TrkB 58 inhibiting enzymes 58 HDACi 58 Factor VIIa 58 spermidine 58 paracrine 58 ACh 58 PI3K Akt 58 beta subunit 58 CCL# 58 intimal hyperplasia 58 plasma leptin 58 TNFR 58 synthetase 58 suppressor gene 58 HB EGF 58 myeloperoxidase 58 EETs 58 SPINK1 58 M1 macrophages 58 Preclinical studies 58 pan HDAC inhibitor 58 messenger ribonucleic acid 58 TORC2 58 glucocerebroside primarily 58 cyclin D1 58 nitrotyrosine 58 TAp# 58 induced cytotoxicity 58 Selective inhibition 58 proinflammatory cytokines 58 CA4P 58 Akt 58 FUS1 58 Macrophage 58 Id1 58 PKC beta 58 peroxidase 58 mGluR5 antagonist 58 Htt 58 monocyte macrophage 58 Wnt#b 58 activate p# 58 Hedgehog signaling pathway 58 TET2 58 GSTT1 58 oncogenic signaling 58 aP2 58 isoenzymes 58 alpha MSH 58 colon tumors 58 melanocyte 58 osteopontin 58 estrogen receptors 58 ciliary neurotrophic factor 58 clusterin 58 E3 ubiquitin ligase 58 Hypoxia Inducible Factor 58 Y2 receptor 58 potent inducers 58 targeted antifolate 58 antitumor efficacy 58 Cx# [001] 58 serotonin receptor 58 factor receptor 58 SIRT1 gene 58 neuropeptide Y NPY 58 DNA intercalator 58 HuLuc# 58 A3 adenosine receptor 58 cytokines interleukin 58 MUC1 58 ovarian pancreatic 58 transactivation 58 NKT cells 58 HSP# inhibitor 58 Akt pathway associated 58 receptor antagonism 58 cyclophilin D 58 factor receptor EGFr 58 PON1 58 IGF IR 58 basophils 58 lipoic acid 58 costimulatory 58 melatonin receptor 58 Soy isoflavones 58 MAPK 58 thyroid carcinoma 58 anaplastic lymphoma kinase 58 PlGF 58 orthotopic 58 protein kinase C 58 lymphoid cells 58 orally administered inhibitor 58 cells overexpressing 58 cyclin dependent kinases CDKs 58 intestinal mucosa 58 tumor antigen 58 CagA 58 intratumoral 58 glycogen synthase kinase 58 CCR9 antagonist 58 tumor suppressive 58 extracellular domain 58 kinase inhibition 58 Smurf1 58 Bcl xL 58 VEGF protein 58 Hh pathway 58 K ras mutations 58 vascular disrupting 58 nucleoside analog 58 TGFβ 58 lowering blood glucose 58 Smac mimetics 58 Six3 58 tumor metastases 58 Valproic acid 58 lymphoid tumors 58 necrotic core 58 orally bioavailable 58 hormone angiotensin 58 toxic beta amyloid 58 hepatic lipase 58 TNF blocker therapy 58 antisense inhibitors 58 estrogen metabolism 58 pro inflammatory cytokine 58 angiogenic 58 immunoreactivity 58 leptin receptor 58 constitutive activation 58 BACE1 58 58 tumor cells 58 nicotinamide 57 ErbB4 57 humanised antibody 57 potentiating 57 potent antiproliferative 57 adenomatous polyposis coli 57 NKT cell 57 ERK5 57 apoptotic 57 NF kB pathway 57 coronary artery atherosclerosis 57 EGFR protein 57 miR #a [002] 57 ENaC 57 oral prodrug 57 procollagen 57 delta isoform 57 pleiotrophin 57 fibroblast 57 dihydrofolate reductase 57 intercellular adhesion molecule 57 phosphorylated tau 57 antioxidant enzyme 57 resistin 57 osteoclast activity 57 EGFR tyrosine kinase inhibitor 57 thalidomide Thalomid 57 ceramide 57 neural progenitor 57 murine model 57 AAG geldanamycin analog 57 KLF4 57 γδ T cells 57 BMP signaling 57 TRAIL R2 57 LDLR 57 5HT 57 LHRH receptor positive 57 MTP inhibitor 57 hepatocellular 57 oncogenesis 57 PEGylated 57 amyloid ß 57 anti fibrotic 57 inhibitor