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(Click for frequent words.) 72 mitotic 72 metaphase 70 cytokinesis 69 meiosis 69 anaphase 68 chromosome segregation 67 ploidy 66 mitosis 66 kinetochores 66 prophase 66 caspase activation 65 H#K#me# 65 deacetylation 65 centromeres 65 endosomal 65 H#K# [002] 65 beta globin 64 proteolysis 64 genomic instability 64 sister chromatid 64 tyrosine phosphorylation 64 hematopoietic progenitors 64 morphogenesis 64 mitotic spindle 64 DNA replication 64 β catenin 64 nucleolar 64 chromosome condensation 64 X inactivation 63 spermatogenesis 63 ubiquitination 63 BMP signaling 63 cohesin 63 cellular senescence 63 transcriptional regulation 63 LIS1 63 hematopoiesis 63 vesicle fusion 62 actin cytoskeleton 62 germline 62 cytosolic 62 centromeric 62 biogenesis 62 Phosphorylation 62 mitotic progression 62 cyclin B1 62 mitotic spindles 62 synaptogenesis 62 monocyte 62 heterochromatic 62 transactivation 61 RNA polymerases 61 KLF4 61 Rab5 61 membrane fusion 61 centrosome 61 ribosomal DNA 61 melanocyte 61 oligomerization 61 cytoplasmic 61 E3 ubiquitin ligase 61 homologous chromosomes 61 heterochromatin 61 telomeric 61 endonuclease 61 EBNA1 61 transcriptional activation 61 corpus luteum 61 centrosomes 61 Cdc# 61 secretory 61 SUMOylation 61 ribosomal 61 colocalization 61 embryogenesis 61 microglial 61 conformational 61 eukaryotic cell 60 DNMT1 60 p# activation 60 RhoA 60 focal adhesions 60 phosphatase 60 F actin 60 metalloproteinases 60 gastrulation 60 alpha subunit 60 ERK1 2 60 gamete formation 60 autosomes 60 presynaptic 60 cdk5 60 pRb 60 mosaicism 60 oncogenic transformation 60 MyoD 60 MLL gene 60 proapoptotic 60 cell motility 60 cyclins 60 GAPDH 60 polymerases 60 PIP2 60 phosphorylates 60 granule cells 60 beta1 integrin 60 histone H3 60 mesenchymal cell 60 transcriptionally 60 epithelial cell 60 transcriptional repressor 60 ectopic expression 60 tumorigenesis 60 interphase 60 hypothalamic pituitary 60 MAPKs 60 miRNA expression 60 oocyte maturation 60 budding yeast 60 recombination 60 malignant transformation 60 chloroplast 60 constitutively expressed 60 GTPase 60 acinar 60 fibroblast 60 demethylation 60 genes encoding 60 neuroblasts 60 IL 1β 60 autophagic 60 p#Kip# 60 mediated inhibition 60 centrioles 60 pilus 60 chromosomal instability 60 enzymatic activity 60 exocytosis 59 SRY gene 59 downregulated 59 IFN γ 59 E#F# 59 leukemic cell 59 mitogen activated protein kinase 59 histone 59 CEACAM1 59 dimerization 59 interconversion 59 Rap1 59 acetylation 59 proteolytic cleavage 59 Leydig cells 59 HepG2 cells 59 gonadal 59 intronic 59 dimeric 59 constitutively active 59 morphogen 59 genotoxic stress 59 steroidogenesis 59 beta actin 59 substrate specificity 59 BMAL1 59 actin polymerization 59 Prox1 59 mRNA expression 59 telomerase activity 59 catecholamine 59 transcriptional 59 Jhdm2a 59 cyclin 59 evolutionarily conserved 59 chromatin structure 59 MECP2 gene 59 virulence genes 59 transgene expression 59 histone acetylation 59 adherens junctions 59 meiotic recombination 59 ERK2 59 CYP#B# 59 Arp2 3 59 inducible nitric oxide synthase 59 cathepsin B 59 vacuolar 59 suppressor gene 59 GLUT4 59 osteoblast 59 dephosphorylation 59 transferase 59 HIF 1alpha 59 transcriptional silencing 59 mesoderm 59 chromosomal 59 neuroligins 59 Fig. 3b 59 synaptic vesicle 59 overactivation 59 germinal center 59 Hedgehog signaling 59 ERK signaling 59 SOX9 59 methyltransferase 59 Hcrt 59 neurite outgrowth 59 insulin signaling pathway 59 epithelial 59 ERK1 59 orthologs 59 catenin 59 CHD7 59 NKT cell 59 keratinocyte 59 homodimers 59 MAPK 58 carboxyl terminal 58 cytoskeletal 58 c MYC 58 ubiquitylation 58 polycystin 58 tumorigenicity 58 E3 ligase 58 zygotic 58 rDNA 58 postsynaptic 58 fig. S1 58 neuroepithelial cells 58 ribosomal proteins 58 caveolin 58 c Src 58 actin binding 58 lymphoid 58 neural crest 58 Rac1 58 NFAT 58 gamma H2AX 58 trophoblast 58 peroxisome 58 cyclin E 58 epigenetic silencing 58 Sox9 58 E cadherin 58 thymocytes 58 coactivators 58 polyadenylation 58 methylation 58 Drosha 58 FGFR2 58 organogenesis 58 translationally 58 radial glia 58 DNA demethylation 58 haploid 58 anaphase promoting complex 58 Id1 58 androgen receptor AR 58 uracil 58 Wnt signaling 58 motoneurons 58 T#M 58 mRNA 58 osteogenic differentiation 58 beta subunit 58 neuronal migration 58 tropomyosin 58 genomic imprinting 58 EF Tu 58 heterologous expression 58 CPEB 58 endocytic 58 hypermethylation 58 malignant phenotype 58 eIF2 58 β1 58 thymocyte 58 DSBs 58 mTOR signaling 58 chaperone proteins 58 conformational changes 58 proteolytic 58 protein phosphorylation 58 amyloidogenic 58 RNA polymerase II 58 lysophosphatidic acid 58 hepatocyte 58 KCNE2 58 synthases 58 TFIIH 58 tissue homeostasis 58 genetic recombination 58 monocytes macrophages 58 p# MAPK 58 VE cadherin 58 proto oncogene 58 phagocytosis 58 TGF b 58 phosphorylation 58 autocrine 58 histone methylation 58 hyperactivation 58 beta globin gene 58 chromatin remodeling 58 homologous recombination 58 serine protease 58 tetramer 58 #q#.# [002] 58 microdeletion 58 synthetase 58 ovulatory 58 nucleosome 58 Chromosomal 58 induced apoptosis 58 H#K# methylation 58 isoenzyme 58 histone modifications 58 glycosylation 58 MLH1 57 estrogen receptor alpha 57 NAD + 57 osteoblastic 57 isoenzymes 57 nucleolar dominance 57 phenotype 57 MT1 MMP 57 pDC 57 peroxisomes 57 membrane proximal 57 IKKa 57 COOH terminal 57 ERK activation 57 constitutively 57 Vpr 57 extracellular signal 57 mRNA decay 57 ligase 57 synapsis 57 STAT1 57 dinucleotide 57 gene rearrangements 57 neoplastic transformation 57 DNA methylation 57 cAMP 57 Sertoli cell 57 mammary cells 57 structural rearrangements 57 epigenetic modification 57 Xenopus laevis 57 #BP# 57 LKB1 57 CXCL# 57 tumor suppressor protein 57 secretory pathway 57 FKBP# 57 FGFR3 57 T lymphocyte 57 BMP4 57 aromatase 57 isoforms 57 metabolic enzymes 57 synapse formation 57 PGCs 57 leukocyte adhesion 57 Golgi apparatus 57 neural progenitor 57 allelic 57 heterozygotes 57 downregulation 57 cadherin 57 Nup# 57 phenotypic expression 57 6S RNA 57 germline cells 57 RNAP 57 MMP# 57 alternative splicing 57 hTERT 57 kinetochore 57 c Myb 57 ligand receptor 57 plastid 57 E cadherin expression 57 kinase pathway 57 umbilical vein 57 mitotic checkpoint 57 Vps# 57 CD1d 57 metabolizing enzymes 57 posttranslational modification 57 ß1 57 centromere 57 rRNA 57 neuronal differentiation 57 PcG proteins 57 adipogenic 57 MDM2 57 TAp# 57 cytokine receptor 57 IL 1ß 57 neuromuscular junction 57 translocations 57 adenylate cyclase 57 mesenchyme 57 Supplementary Fig 57 caveolin 1 57 CD#b 57 transcriptional repression 57 uPAR 57 apoptotic cell 57 intron 57 S nitrosylation 57 caveolae 57 intestinal epithelium 57 functional polymorphism 57 epigenetic alterations 57 mitotic catastrophe 57 lymphocyte 57 intracellular compartments 57 protein tyrosine kinase 57 condensin 57 RNA binding 57 matrix metalloproteinase 57 Notch signaling 57 JAK STAT 57 RUNX3 57 amino terminal 57 Fig. 2a 57 ubiquitin proteasome 57 cytochrome c oxidase 57 osteoclast 57 JNK1 57 cell adhesion molecules 57 Foxp3 57 myofibroblasts 57 mRNAs 57 transcription elongation 57 subcellular 57 mitochondrial respiration 57 Smad3 57 missense mutation 57 cis regulatory 57 synuclein 57 ligand binding 57 Clusterin 57 speciation 57 FGF signaling 57 BubR1 57 EGFP 57 noncoding RNA 57 SMAD4 57 rostral 57 Tumor suppressor genes 57 ESCRT 57 receptor mediated endocytosis 57 MDSCs 57 ß catenin 57 lysosomal 57 Dpp 57 eukaryotic cells 57 homolog 56 Cyclin E 56 proteinases 56 adipocyte 56 immunoreactivity 56 oligodendrocyte 56 promoter methylation 56 PAX5 56 basolateral 56 matrix metalloproteinases MMPs 56 globin genes 56 cardiac fibroblasts 56 GABAB receptors 56 intramolecular 56 short hairpin RNA 56 transmembrane 56 TNFalpha 56 cells transfected 56 DNA polymerases 56 matrix metalloproteinases 56 Fig. 1A 56 effector molecules 56 locomotor activity 56 Th2 56 AMACR 56 conceptus 56 Overexpression 56 mammary stem cells 56 V#F mutation 56 polyamine 56 astrocytic 56 Pol IV 56 erythrocyte 56 polypeptides 56 transcriptional regulator 56 fig. S4 56 orthologous 56 RNA polymerase 56 menin 56 Sp1 56 apoptosis pathway 56 pDCs 56 polyglutamine 56 upregulates 56 granzyme B 56 lymphoid organs 56 kinase domain 56 COL#A# 56 HIV reverse transcriptase 56 dedifferentiation 56 intestinal epithelial cells 56 immunoreactive 56 paxillin 56 CTCF 56 protein p# 56 dynamin 56 germ cells 56 sister chromatids 56 ErbB4 56 cellular prion protein 56 aminopeptidase 56 Ca2 + 56 Peyer patches 56 Skp2 56 TIMP 56 SMN1 56 H#K# [001] 56 DNA methyltransferase 56 integrin expression 56 Cyclin D1 56 primordial germ cells 56 paracrine 56 oxidative phosphorylation 56 intercellular communication 56 piRNAs 56 tumoral 56 ATPase 56 FasL 56 transmembrane receptor 56 trophoblasts 56 oncoprotein 56 At#g# 56 lysine residues 56 chromatin modification 56 glutamate receptors 56 cofilin 56 X chromosome inactivation 56 cAMP signaling 56 mechanotransduction 56 adipogenesis 56 regulated kinase ERK 56 microtubule dynamics 56 replicative 56 overexpressing cells 56 lymphoid cells 56 epidermal cells 56 TORC2 56 IFN gamma 56 C. albicans 56 ectoderm 56 serine threonine kinase 56 apoptotic 56 siRNA mediated 56 RT qPCR 56 thyrotropin 56 cytoplasmic domain 56 mesenchymal 56 spectrin 56 1beta 56 splice variants 56 trophoblast cells 56 cardiomyocyte 56 hypomethylation 56 proinflammatory mediators 56 hypermethylated 56 transcriptional activity 56 unmethylated 56 palmitoylation 56 agonist induced 56 immunostaining 56 TRIM# 56 subcellular compartments 56 Kir#.# 56 Androgen receptor 56 membrane protein 56 intracellular signaling 56 HepG2 56 vimentin 56 fluorescence intensity 56 RRM1 56 regulates gene expression 56 demethylase 56 lymphangiogenesis 56 Oncogenic 56 PTPN# 56 overexpressing 56 D. melanogaster 56 subcellular localization 56 processive 56 steroidogenic 56 #S rRNA 56 activin 56 LDL receptor 56 TACI 56 IRAK1 56 mitochondrial 56 dimer 56 MAP kinases 56 protein synthesis 56 mRNA encoding 56 NR#A# 56 MyD# 56 autoregulation 56 nucleotide 56 Oct4 56 transcriptionally active 56 1alpha 56 homologs 56 Cx# [001] 56 proline rich 56 cellular metabolism 56 IRE1 56 hormone secretion 56 tau phosphorylation 56 epithelial barrier 56 clonal expansion 56 sequence homology 56 HtrA2 56 glycolytic 56 tRNA 56 GLUT1 56 Vpu 56 Fig. 2b 56 PP2A 56 GPR# [002] 56 microglial activation 56 FGFs 56 MAP kinase 56 receptor tyrosine kinase 56 Alu elements 56 MAPK pathway 56 PTH secretion 56 RNA synthesis 56 DLX5 56 epigenetic modifications 56 hyperactivated 56 fatty acid synthesis 56 ENaC 56 neuronal dysfunction 56 1α 56 inhibin B 55 axonal 55 ependymal cells 55 renal fibrosis 55 protein tyrosine phosphatase 55 3'UTR 55 cytoplasmic tail 55 N cadherin 55 Mammalian 55 oligomer 55 Cathepsin B 55 ESR1 55 mice lacking 55 EZH2 55 phosphatases 55 Nampt 55 antigen binding 55 constitutively activated 55 NF κB 55 germline mutations 55 chromatin condensation 55 anterior pituitary 55 chondrocyte 55 upregulation 55 ubiquitin ligase 55 lyase 55 ERalpha 55 cathepsins 55 leukocyte 55 Chk1 55 Rb#/p# 55 glomerular 55 non coding RNA 55 Aβ 55 adhesion molecule 55 synaptic transmission 55 Mitotic 55 Pten 55 neural stem cell 55 gene transcription 55 S. cerevisiae 55 glutamate receptor 55 prostaglandin E2 PGE2 55 transmembrane protein 55 c myc 55 RAD# [001] 55 overexpression 55 mutant allele 55 hammerhead ribozyme 55 fibrillin 1 55 actin myosin 55 embryonic tissues 55 γ 55 granulosa cell 55 mevalonate 55 dynein 55 Germline 55 iNOS 55 Cre recombinase 55 Hh pathway 55 BMP receptor 55 PGE2 55 transfected cells 55 endocytosis 55 eukaryotic 55 histone H4 55 Src kinase 55 eIF4E 55 GLI1 55 amino acid residue 55 Cytochrome 55 Aß 55 chemotactic 55 oligomeric 55 sRNA 55 biosynthetic pathway 55 GABAA receptors 55 SGK1 55 β 55 histone deacetylation 55 nodulation 55 TGF ß1 55 proximal tubule 55 Rho GTPases 55 ribosomal protein 55 lymphocyte activation 55 potent inducer 55 Wnts 55 vascular endothelial cells 55 erythropoiesis 55 NKX#.# 55 pyruvate kinase 55 axon guidance 55 HAR1 55 NHEJ 55 chromosomal rearrangements 55 retinoic acid receptor 55 ephrin 55 primordial follicles 55 neurogenesis 55 leukocyte recruitment 55 apoptotic cells 55 E selectin 55 lactate dehydrogenase 55 actin dynamics 55 intracellular proteins 55 MMP2 55 signaling cascade 55 cysteine residues 55 humoral 55 protein secretion 55 ligand induced 55 occludin 55 granulocyte 55 ciliated 55 neutrophil 55 epigenetically 55 diploid 55 stem cell pluripotency 55 tumor suppressor PTEN 55 Htt 55 ribonucleic acids 55 PrP 55 phosphoinositide 55 integrin activation 55 oncogenic 55 histone H3 lysine 55 rRNA genes 55 mediated apoptosis 55 eNOS 55 forkhead 55 paralogs 55 alternatively spliced 55 cofactors 55 acrosome reaction 55 Runx2 55 transduced 55 E1A 55 receptor kinase 55 mitogen activated protein kinases 55 gene inactivation 55 MLL2 55 mRNA degradation 55 translocates 55 FGF2 55 progenitor cell 55 intergenic 55 erythroid 55 Macrophage 55 MAP kinase pathway 55 pyrimidine 55 phosphatidylinositol 55 TGFbeta 55 nAChR 55 cytochrome c 55 TMPRSS2 ERG fusion 55 homozygosity 55 Phylogenetic analysis 55 KIAA# 55 nucleolin 55 DNA recombination 55 hnRNP 55 histone methyltransferase 55 cell adhesion molecule 55 selfing 55 microsomal 55 mRNA transcripts 55 protein Mcl 1 55 spindle fibers 55 junctional 55 guanosine 55 Amino acid 55 coreceptor 55 AMPA receptor 55 dehydrogenase 55 importin 55 induced neuronal 55 genetic loci 55 cell adhesion 55 coexpression 55 γ secretase 55 ribosomal genes 55 epithelia 55 posttranslational 55 cell lysis 55 esterase 55 TRPV4 55 RNA transcription 55 BDNF gene 55 circadian clock genes 55 cholesterol homeostasis 55 protein conformation 55 chromosomal deletions 55 downregulating 55 telomere shortening 55 repolarization 55 Fig. 1a 55 MCF7 55 supernatants 55 homodimer 55 SVZ 55 SOD2 55 ribonucleoprotein 55 cyclic adenosine monophosphate cAMP 55 isomerase 55 replicase 55 coding genes 55 chromosome #q# [002] 55 Synuclein 55 myeloid 55 DNA adducts 55 heterozygosity 55 polymerase 55 DNA methyltransferases 55 integrin receptor 55 p# p# 55 neuronal cell 55 Math1 55 RKIP 54 CD8 + 54 microRNAs miRNAs 54 stem cell differentiation 54 tRNA genes 54 Western blotting 54 polyploid 54 NFκB 54 palladin 54 extramedullary 54 protein biosynthesis 54 ERBB2 54 mutant alleles 54 coiled coil 54 transcriptional regulators 54 Rho kinase 54 CDK5 54 #ß 54 ACh 54 peptide receptor 54 cyclin dependent kinase 54 Wnt1 54 inducible 54 cyclic nucleotide 54 mitochondrial gene 54 PIP3 54 Monocyte 54 TNFR 54 cofactor 54 tumor suppressor p# 54 transdifferentiation 54 hypervariable 54 Inactivation 54 Fig. 1E 54 serotonin transporters 54 quantitative trait loci 54 M1 muscarinic 54 GlcNAc 54 RANKL 54 adhesion proteins 54 murine 54 germline stem cells 54 transiently transfected 54 Notch1 54 synthase 54 miR #b [001] 54 methylation patterns 54 frameshift 54 fatty acid oxidation 54 dependent protein kinase 54 Hsp# [001] 54 misfolding 54 missense mutations 54 Fig. 1C 54 hippocampal neurons 54 antiproliferative activity 54 SOCS3 54 homology 54 acetylcholine receptor 54 signaling pathways 54 polypeptide chain 54 PCR amplified 54 cyclooxygenase COX 54 ovarian hormones 54 beta catenin 54 kinase gene 54 tumorigenic 54 p#NTR 54 adrenocortical 54 lamin 54 Th1 cells 54 receptor activation 54 receptor gene 54 KaiC 54 serine threonine 54 isotypes 54 suppresses tumor 54 humoral immunity 54 Fc receptor 54 hematopoetic stem cells 54 branching morphogenesis 54 mutagenesis 54 endogenous 54 serine 54 BRAF protein 54 myosin 54 histone modification 54 cytokines IL 54 aneuploid 54 triggers apoptosis 54 PDGFR 54 renal cysts 54 ubiquitinated 54 microtubule 54 Leydig cell 54 methylenetetrahydrofolate reductase 54 thymic 54 tumor suppressor gene 54 intercellular signaling 54 G6PD 54 placental tissues 54 trinucleotide 54 Immunohistochemical analysis 54 intestinal mucosa 54 HSCs 54 endonucleases 54 sphingolipid 54 posttranslational modifications 54 chromosomal translocation 54 effector function 54 antigen receptor 54 hair follicle stem cells 54 dsDNA 54 neural progenitor cells 54 Inappropriate activation 54 autosomal 54 striatal 54 ras gene 54 organismal 54 myometrial 54 erythrocytes 54 wildtype 54 Sonic hedgehog 54 NF kappaB 54 LRAT 54 desmosomes 54 potent inhibitors 54 globin 54 P cadherin 54 eotaxin 54 proteoglycan 54 Dysregulation 54 eicosanoid