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(Click for frequent words.) 74 presynaptic 72 catenin 72 Cdc# 72 exocytosis 72 morphogen 71 F actin 71 TrkB 71 transmembrane 71 mitogen activated protein kinase 71 CaM 71 tyrosine phosphorylation 70 PIP2 70 Fig. 1C 70 VE cadherin 70 cytosolic 70 Fig. 1A 70 serine protease 70 Rab5 70 transcriptional activation 69 ERK1 2 69 BMP signaling 69 serine threonine kinase 69 intracellular signaling 69 AMPA receptor 69 coexpression 69 conformational changes 69 cAMP signaling 69 kinase domain 69 muscarinic receptors 69 proteolytic cleavage 69 ACh 69 neuromuscular junction 69 transcriptional regulation 69 modulatory 68 autophagic 68 GTPase 68 alpha subunit 68 Abeta protein 68 NR2B subunit 68 neurite outgrowth 68 iNOS 68 neuronal signaling 68 oligomerization 68 proteolysis 68 polyadenylation 68 MyD# 68 transcriptional repressor 68 MT1 MMP 68 neuronal migration 68 colocalization 68 SIRT2 68 hippocampal 68 RNA polymerase II 68 glutamate receptor 68 beta subunit 68 evolutionarily conserved 68 intronic 68 endonuclease 68 cytokine signaling 68 SOCS3 68 Cyclin D1 68 striatal 68 cytoplasmic domain 68 caveolae 67 Sgk1 67 Supplementary Fig 67 hypothalamic 67 IL 1beta 67 immunoreactive 67 H#K#me# 67 transcriptionally 67 EF Tu 67 Aβ 67 cadherin 67 NMDAR 67 transmembrane protein 67 extracellular signal 67 dimeric 67 orthologs 67 STAT1 67 rostral 67 fig. S1 67 RhoA 67 astrocytic 67 hyperactivation 67 MAPKs 67 intramolecular 67 MAPK 67 centrosome 67 ERK signaling 67 Rac1 67 PDZ domain 67 excitatory 67 IKKß 67 regulated kinase ERK 67 constitutively active 67 phosphorylated 67 Runx2 67 P cadherin 67 microglial 67 ubiquitination 67 GluR1 67 c Src 67 glomerular 67 NMDA receptors 67 hindbrain 67 motoneurons 67 actin binding 67 ligand receptor 67 centromeric 67 hippocampal neurons 67 syntaxin 67 PKC isoforms 67 TIMP 1 67 heterochromatic 67 endocytic 67 serotonergic 67 axon guidance 66 Fas ligand 66 transferase 66 Purkinje cell 66 ubiquitin ligase 66 TAp# 66 osteoblast 66 subcellular localization 66 MAP kinase 66 palytoxin 66 HOTAIR 66 Rap1 66 basolateral 66 non coding RNA 66 IFN γ 66 oligodendrocyte 66 Notch1 66 disulfide bond 66 GAPDH 66 focal adhesions 66 Aß 66 mRNA expression 66 dephosphorylation 66 Fig. 1D 66 JAK STAT 66 neuronal dysfunction 66 synapse formation 66 LDL receptor 66 monocyte 66 calmodulin 66 synaptic 66 COOH terminal 66 Ca2 + 66 ribosomal protein 66 ERK1 66 focal adhesion 66 DISC1 66 LRP6 66 glutamatergic 66 signaling cascade 66 FoxO1 66 p# activation 66 CD#b 66 CEACAM1 66 perivascular 66 3'UTR 66 inferior frontal 66 TNFalpha 66 acetylcholine receptor 66 intron 66 guanosine 66 transmembrane domains 66 Vps# 66 intergenic 66 FKBP# 66 CD1d 66 PTPN# 66 mitochondrial respiration 66 downregulation 66 oligomeric 66 nitrotyrosine 66 BMAL1 66 HIF 1a 66 condensin 66 osteoclast 66 S#A# [002] 66 neuronal differentiation 66 chromatin structure 66 nucleolar 66 DNMT1 66 vesicle fusion 66 IRE1 65 costimulatory 65 semaphorin 65 eNOS 65 antiapoptotic 65 tetramer 65 TGF ß 65 nitric oxide synthase 65 Rab# 65 synaptogenesis 65 cell adhesion molecule 65 GABAergic interneurons 65 glial 65 ß catenin 65 ATPase 65 synaptic transmission 65 H#K# [002] 65 X inactivation 65 rRNA 65 ENaC 65 neuroligins 65 cofilin 65 catalytic subunit 65 autocrine 65 Fig. 2b 65 secretory pathway 65 cofactor 65 Dpp 65 mPFC 65 IL 1ß 65 presenilin 65 VEGF receptor 65 Foxp3 65 caveolin 65 γ secretase 65 apoE4 65 noradrenergic 65 midbrain 65 TNF α 65 TGFβ 65 Smad3 65 basal ganglia 65 receptor tyrosine kinase 65 PAK1 65 glutamate receptors 65 adhesion molecule 65 posterior cingulate 65 podocyte 65 downstream effector 65 chromosome #q# [002] 65 phagocytosis 65 calcineurin 65 paralogs 65 ouabain 65 mitotic spindle 65 sGC 65 homodimers 65 activin 65 Immunohistochemical analysis 65 receptor activation 65 secretory 65 tubulin 65 myofibroblasts 65 vascular endothelial cells 65 axonal 65 receptor molecule 65 GABAergic neurons 65 TGF β 65 caudate 65 S nitrosylation 65 phosphorylates 65 M1 muscarinic 65 transgenic mice expressing 65 fig. S2 65 NMDA receptor 65 TNFR 65 p#Kip# 65 amyloid β 65 endoplasmic reticulum ER 65 noncoding 65 ligand binding 65 apoE 65 cell adhesion molecules 65 GABAergic 65 proximal tubule 65 dimerization 65 paxillin 65 CaMKII 65 phosphoprotein 65 cytochrome 65 MEK1 65 cingulate 65 GABA receptor 64 cortical neurons 64 ABCA1 64 dopaminergic neurons 64 glycosyltransferase 64 Wnt signaling 64 p# MAPK 64 GABAA receptors 64 cytokine receptors 64 mediated inhibition 64 COL#A# 64 potent inhibition 64 cyclin 64 anterior pituitary 64 SUMOylation 64 fibrillar 64 tumor suppressor protein 64 EGFP 64 cysteine residues 64 cytoskeletal 64 H#K# [001] 64 γ 64 cathepsin B 64 tRNA synthetase 64 mitogenic 64 catecholamine 64 neuronal plasticity 64 MyoD 64 protein tyrosine phosphatase 64 RNA polymerases 64 prefrontal cortical 64 proapoptotic 64 Fig. 3b 64 E3 ubiquitin ligase 64 biogenesis 64 apoptotic 64 cAMP 64 pyrimidine 64 medial prefrontal 64 eIF4E 64 histone acetylation 64 histone modifications 64 secretase 64 Phosphorylation 64 neurofilament 64 receptor gene 64 synaptic vesicles 64 proline rich 64 hypothalamic pituitary 64 c Myb 64 autoregulation 64 β 64 extracellular 64 adipogenic 64 uracil 64 hydroxylation 64 pyramidal neurons 64 immunoreactivity 64 NKG2D 64 CpG 64 caspase activation 64 NR#A# 64 Cathepsin B 64 TRPV3 64 cilium 64 nAChR 64 structural rearrangements 64 Aâ 64 TRPV4 64 MAPK pathway 64 Fig. 3a 64 efferent 64 dorsolateral 64 melanocyte 64 dopaminergic 64 NKT cell 64 mitotic progression 64 β catenin 64 dinucleotide 64 proteolytic 64 FGF signaling 64 Nod1 64 Notch signaling 64 pDCs 64 adherens junctions 64 NR2B 64 ERK pathway 64 postsynaptic neuron 64 Kv#.# 64 E cadherin 64 orthologous 64 nucleolin 64 JNK1 64 tumor suppressor p# 64 5 HT1A 64 apical 64 KLF4 64 TRPV1 receptors 64 Purkinje cells 64 FGFs 64 amino terminal 64 phosphatidylinositol 64 FasL 64 #ß 64 isoenzymes 64 oxidative phosphorylation 64 cdk5 64 tyrosine hydroxylase 64 tropomyosin 64 beta adrenergic receptors 64 homodimer 64 cypin 64 subcellular 64 morphogenesis 64 perirhinal cortex 64 calpain 64 ribosomal proteins 64 mediated apoptosis 64 gamma oscillations 64 Hedgehog signaling 64 telomeric 64 ERK2 64 TrkA 64 cytoplasmic 64 histone 64 junctional 64 TSC1 64 IL #p# 64 chromosome condensation 64 SCD1 64 ephrin 64 p#/CBP 64 aggrecan 64 anterior cingulate 64 GLUT4 64 proteoglycan 64 Fig. 3B 64 inflammatory cytokine 64 osteoblast differentiation 64 isoforms 64 KIAA# 64 circadian clock genes 64 pDC 64 Fig. 2C 64 osteocalcin 64 homologues 64 Kir#.# 64 neuronal activity 64 orbitofrontal cortex OFC 64 tau protein 64 cytosol 64 oocyte maturation 63 IL 1β 63 #β HSD1 63 NAc 63 transgene expression 63 monomeric 63 spermatogenesis 63 Fig. 1b 63 PC# cells 63 vacuolar 63 adrenocortical 63 N methyl 63 β amyloid 63 occludin 63 chemokine receptor 63 mRNA encoding 63 TGF b 63 paracrine 63 Fig. 2B 63 ubiquitylation 63 deacetylation 63 TNF receptors 63 uPAR 63 constitutively 63 Htt 63 WNK1 63 ERK activation 63 primary visual cortex 63 ciliary 63 ectopic expression 63 anti apoptotic 63 PER2 63 microglial activation 63 caveolin 1 63 mTORC1 63 mRNA 63 site directed mutagenesis 63 cyclin B1 63 Eg5 63 CPEB 63 Androgen receptor 63 upregulation 63 Fig. 4B 63 RNA binding 63 urothelial 63 chemoattractant 63 Sp1 63 cytokine secretion 63 E#F# 63 serotonin receptor 63 histone methylation 63 PKC delta 63 Runx1 63 neuronal cell 63 GlcNAc 63 superoxide dismutase 63 NF κB 63 depolarization 63 adenylate cyclase 63 TGF beta pathway 63 vimentin 63 BCL2 63 homologs 63 PPARg 63 ganglioside 63 metaphase 63 mTOR signaling 63 lymphangiogenesis 63 acetylation 63 acinar 63 heterodimer 63 tyrosine residues 63 cyclins 63 isoleucine 63 thalamic 63 Polycomb 63 ectodomain 63 untranslated regions 63 angular gyrus 63 EBNA1 63 nAChRs 63 noncoding RNA 63 P2X 63 glycosylated 63 oscillatory 63 HPA axis 63 chondrocyte 63 FOXO3a 63 TGF beta1 63 MCF7 cells 63 CaM kinase II 63 Wnt pathway 63 CDH# 63 PAX5 63 pRb 63 Skp2 63 afferent 63 hormone secretion 63 KLF# 63 FGF2 63 transmembrane domain 63 pro angiogenic 63 evolutionary conserved 63 Nampt 63 hypometabolism 63 MMP9 63 cortical regions 63 Lyn kinase 63 striatal dopamine 63 phospho 63 Fig. 2a 63 innervation 63 cotransporter 63 cyclic AMP cAMP 63 Hcrt 63 protein kinase C 63 enzymatic activity 63 PTHrP 63 spectrin 63 multiprotein complex 63 β1 63 RAS RAF MEK 63 sphingolipid 63 BMP4 63 thioredoxin 63 lysophosphatidic acid 63 miR# 63 mesoderm 63 ciliated 63 eotaxin 63 oncoprotein 63 NFkappaB 63 fronto 63 vWF 63 downregulated 63 histone H4 63 tubule 63 PDGFR 63 membrane fusion 63 Arp2 3 63 proinflammatory cytokine 63 Fig. 1B 63 astrocyte 63 C1q 63 inhibitory 63 Rb#/p# 63 AMPA receptors 63 acyl CoA 63 Dysregulation 63 epithelia 63 mononuclear 63 gene p# 63 N cadherin 63 isotype 63 myosin II 63 phosphatidylinositol 3 63 BMP receptor 63 amino acid residues 63 Notch receptor 63 homolog 63 Nedd4 63 coiled coil 63 cis regulatory 63 granule cells 63 osteoblastic 63 hypothalamic pituitary adrenal axis 63 dopamine signaling 63 TGF β1 63 subcortical 63 downstream effectors 63 beta globin 63 PHD2 63 alanine 62 PTH secretion 62 neurotransmitter receptor 62 gene inactivation 62 amygdala neurons 62 synuclein 62 substrate specificity 62 carboxyl terminal 62 fig. S4 62 CCL# 62 methyltransferase 62 intercellular signaling 62 granzyme B 62 costimulation 62 amyloid peptide 62 phosphoinositide 62 nociceptive 62 gamma secretase 62 PI3K Akt 62 PrP 62 ESR1 62 myofibroblast 62 ERBB2 62 E3 ligase 62 Smad4 62 inducible 62 polyglutamine 62 Sonic hedgehog 62 leucine zipper 62 transduced 62 phosphatase 62 encodes protein 62 BRAF protein 62 CXCR2 62 fusiform gyrus 62 triacylglycerol 62 histone H3 62 matrix metalloproteinases 62 D2 receptor 62 actin polymerization 62 overactivation 62 messenger ribonucleic acid 62 Hh 62 TERT 62 heterozygotes 62 retinoid X 62 neuropeptides 62 CHD5 62 PDZ domains 62 HIF 1α 62 cytidine 62 proto oncogene 62 PIP3 62 dorsomedial 62 lateral orbitofrontal cortex 62 LKB1 62 3' UTR 62 ligand induced 62 ABCB1 62 somatosensory cortex 62 GRP# 62 PP2A 62 Fig. 4a 62 MnSOD 62 RUNX3 62 fig. S3 62 neurone 62 FGF# 62 entorhinal cortex 62 ADAMTS# 62 ADAM# 62 protein tau 62 protein fragment 62 polypeptide chain 62 mRNA decay 62 neuropeptide Y 62 polypeptide 62 BDNF gene 62 meiotic recombination 62 LDLR 62 glucose transporter 62 baroreceptor 62 EGF receptor 62 receptor subunit 62 heterodimers 62 adrenoceptor 62 DNA demethylation 62 amyloid deposits 62 hematopoiesis 62 transactivation 62 antibody antigen 62 dynamin 62 receptor subtypes 62 Amino acid 62 MMP2 62 CYP#E# 62 cyclin dependent kinase 62 Wnts 62 miRNA expression 62 tyrosine 62 cytoskeletal protein 62 cytochrome P# 62 erythroid 62 antigen binding 62 fascin 62 5 hydroxytryptamine 62 Src kinase 62 cortical activation 62 calcium homeostasis 62 glucocorticoid receptor 62 dynactin 62 thymocyte 62 alternatively spliced 62 heme oxygenase 62 histone protein 62 protein encoded 62 operon 62 tau phosphorylation 62 1alpha 62 serine threonine 62 Upregulation 62 HBx 62 AT1R 62 TACI 62 polyamine 62 osteoclast formation 62 Akt 62 Fig. 3A 62 downregulate 62 p# NTR 62 arcuate nucleus 62 mRNA transcripts 62 glutamate signaling 62 NFAT 62 receptor kinase 62 muscarinic 62 HepG2 cells 62 steroidogenic 62 lysosomal 62 CXCL# 62 LIS1 62 huntingtin 62 intracellular 62 prostaglandin E2 PGE2 62 contractile 62 PGC 1α 62 kappa opioid receptors 62 antiparallel 62 dentate gyrus 62 Fig. 1c 62 major histocompatibility complex 62 focal adhesion kinase FAK 62 phospholipase C 62 anaphase promoting complex 62 TXNIP 62 phospholipase D 62 beta amyloid peptide 62 XBP1 62 actin cytoskeleton 62 c fos 62 chromatin remodeling 62 erythrocytes 62 1α 62 #S proteasome 62 null mice 62 mice lacking 62 clusterin 62 upregulates 62 phospholipid 62 vascular endothelial 62 posttranslational modification 62 carcinoembryonic antigen 62 Rho GTPases 62 proinflammatory 62 TRAF6 62 ncRNA 62 calcium ion 62 SOD2 62 metalloproteases 62 SH2 domain 62 P gp 62 endogenous ligand 62 SOX9 62 transcriptional machinery 62 adipogenesis 62 rostral anterior cingulate cortex 62 androgen receptor AR 62 NAADP 62 HtrA2 62 Golgi apparatus 62 NHEJ 62 CagA 62 transcriptional regulators 62 prokaryotic 62 flavin 62 gene locus 62 neuronal 62 c MET 62 Microtubule 62 PcG 62 matrix metalloproteinase 62 ß amyloid 62 trimers 62 extracellular calcium 62 accumbens 62 quinone 62 dioxygenase 62 messenger molecule 62 phosphorylation 62 conformational 62 glucokinase 62 catabolism 62 intracellular proteins 62 6S RNA 62 POMC neurons 62 excitatory neurons 62 cell adhesion 62 ERK phosphorylation 62 transmembrane receptor 62 Alternative splicing 62 acetyltransferase 62 intercellular communication 62 synaptotagmin 62 MDR1 62 interconversion 61 cyclic nucleotide 61 bradykinin 61 chromatin modification 61 lipoprotein lipase 61 HIF 1alpha 61 periaqueductal gray 61 JNK activation 61 tumor suppressive 61 SLC#A# [002] 61 cells transfected 61 5' triphosphate 61 CA1 61 GNAQ 61 eIF2 61 protein conformation 61 Clusterin 61 Hh pathway 61 histidine 61 lipoxygenase 61 Jhdm2a 61 endogenous ligands 61 CD#c 61 N Myc 61 Cyclin E 61 vasodilatory 61 leukemic cell 61 endoplasmic reticulum 61 demyelination 61 inducible nitric oxide synthase 61 peptidase 61 Prox1 61 binding affinities 61 proNGF 61 alveolar macrophages 61 DARPP 61 temporoparietal junction 61 retinal neurons 61 ATP hydrolysis 61 insular cortex 61 alpha synuclein protein 61 voltage gated 61 lyase 61 basal forebrain 61 cerebellar 61 Mcl 1 61 GSK 3ß 61 raphe 61 monoamines 61 DNA methylation patterns 61 FGFR3 61 MAP kinase pathway 61 neuroligin 61 isoenzyme 61 redox sensitive 61 mRNA translation 61 MALAT1 61 μM 61 molecular signaling pathway 61 tumorigenicity 61 #q#.# [002] 61 oxidase 61 superior temporal gyrus 61 p# p# 61 Macrophage 61 CTGF 61 protein tyrosine kinase 61 serine 61 cytochrome c 61 phosphatases 61 regulates gene expression 61 hypothalamic pituitary adrenal HPA 61 interneurons 61 PU.1 61 translationally 61 Figure 2C 61 sortilin 61 electroencephalographic 61 Ser# 61 genetic loci 61 renal fibrosis 61 isoform 61 dysbindin 61 DLC1 61 Fig. 1a 61 CHI#L# 61 STIM1 61 decarboxylase 61 SOD1 61 c Fos 61 transcriptional regulator 61 Dopaminergic 61 SVZ 61 IFN gamma 61 hypoperfusion 61 chemokine 61 TET2 61 c MYC 61 transferrin receptor 61 porphyrin 61 lateral hypothalamus 61 Wnt beta catenin 61 T2 weighted images 61 protein phosphatase 61 forebrain 61 membrane protein 61 neuronal synapses 61 glycosylation 61 methyl D aspartate 61 Brain derived neurotrophic 61 ribosomal 61 HMG CoA reductase 61 Fc receptor 61 EGFr 61 mitotic spindles 61 4E BP1 61 nNOS 61 oligomer 61 cyclin D1 61 intracellular signal transduction 61 #S rRNA 61 #BP# 61 aminobutyric acid 61 CGRP 61 cell motility 61 K + ATPase 61 HDAC3 61 ventrolateral 61 MAP kinases 61 c myc 61 T lymphocyte 61 rs# [004] 61 EZH2 61 potassium ion 61 GPR# [002] 61 alpha secretase 61 excitatory synapses 61 HCV replication 61 erythrocyte 61 adenosine receptors 61 amyloid beta peptides 61 KaiC 61 neurotransmission 61 endogenous cannabinoids 61 regulated kinase 61 E cadherin expression 61 61 synaptic vesicle 61 kainate 61 myo inositol 61 integrins 61 dendritic spines 61 ß2 61 dystroglycan 61 vitamin D receptor VDR 61 demethylation 61 mesenchyme 61 radial glia 61 S#K# 61 angiotensinogen 61 D aspartate 61 cytokinesis 61 miR #a [001] 61 transcription elongation 61 centromere 61 vesicle trafficking 61 rCBF 61 cytoplasmic tail 61 somatosensory 61 parietal cortex 61 cystic fibrosis transmembrane conductance 61 cortical