triggers apoptosis

Related by string. * trig gered . Triggers . Triggered . triggering . Triggering : triggered landmine blast . triggered flash floods . asthma triggers . allergy triggers . triggered avalanches / Apoptosis : selectively induce apoptosis . induce apoptosis programmed . apoptosis programmed cell . induce apoptosis * ONCONASE triggers apoptosis . triggers apoptosis programmed *

Related by context. All words. (Click for frequent words.) 75 induces apoptosis 74 apoptosis proteins 73 potent inducer 73 downregulates 73 triggers apoptosis programmed 73 phosphorylates 73 Factor Receptor 73 retinoic acid receptor 72 Oncogenic 72 cyclooxygenase COX 72 related apoptosis inducing 72 extracellular signal 72 prostaglandin E2 PGE2 71 Hypoxia Inducible Factor 71 Epithelial 71 phosphatidylinositol 3 71 anionic backbone 71 GRNOPC1 contains 71 ERK1 2 71 mitogen activated protein kinase 71 Interferon gamma 71 selectively inhibited 71 Phosphorylation 71 5 HT2A serotonin 71 Cathepsin B 71 Antigen Specific 71 Protein Kinase C 71 mediated apoptosis 71 serine threonine 71 receptors PPARs 71 Macrophage 70 MAP kinase 70 siRNA binds 70 regulated kinase ERK 70 tensin homolog 70 receptor mediated endocytosis 70 monocyte chemotactic protein 70 lysyl oxidase 70 p# alpha [001] 70 CYP#A# CYP#D# 70 poly ADP ribose polymerase 70 reversible inhibitors 70 inhibit oxidative stress 70 IAP inhibitor 70 PI3K/Akt 70 cyclin dependent kinase inhibitor 70 endoplasmic reticulum stress 70 Fas ligand 70 neutrophil elastase 70 4E BP1 70 TORC2 70 nitric oxide synthase 70 selective inhibition 70 IL #p# 69 acyl CoA 69 potently inhibit 69 HER1 69 dephosphorylation 69 TGF b 69 matrix metalloproteinases MMPs 69 upregulates 69 pRb 69 Proteasome 69 PI3K/Akt pathway 69 cyclic AMP cAMP 69 nitric oxide synthase NOS 69 HER2 HER2 69 peptidic compound 69 Upregulation 69 Extracellular 69 cyclin dependent kinase 69 HepG2 69 Dehydrogenase 69 induce apoptosis 69 c MYC 69 acetylcholinesterase AChE 69 mediated inhibition 69 accumulate preferentially 69 HIF 1a 69 Topoisomerase II 69 mitogen 69 Factor VEGF 69 Epstein Barr Virus EBV 69 potent suppressor 69 inducible nitric oxide synthase 69 undergo apoptosis 69 microtubule dynamics 69 serine threonine kinase 68 Cyclin E 68 potently inhibited 68 PDGFR B 68 68 telomerase reverse transcriptase 68 covalently bound 68 TRAIL induced apoptosis 68 Platelet Derived Growth 68 protein tyrosine phosphatase 1B 68 ERK pathway 68 JAK2 enzyme 68 adenomatous polyposis coli 68 leukocyte adhesion 68 proto oncogene 68 mitogenic 68 adipogenic 68 Modulates 68 mitogen activated protein kinases 68 glucocerebroside primarily 68 fast skeletal troponin 68 NKG2D 68 mitogen activated protein 68 cytochrome c 68 antiproliferative activity 68 dihydrofolate reductase 68 MEK ERK 68 FGFR3 68 Akt signaling 68 catenin 68 E#F# 68 histone deacetylase 68 acetyl CoA 68 induces apoptosis programmed 68 caveolin 1 68 pathophysiological effects 68 Tumor necrosis factor 68 β catenin 68 prostaglandin synthesis 68 protein secreted 68 pDC 68 Angiotensin 68 Endothelial Cells 68 Inhibits 68 constitutively activated 68 peroxidase 68 non porcine pancreatic 68 ErbB4 68 deacetylation 68 myeloid derived 68 FasL 68 Clusterin 68 glucokinase 68 matrix metalloproteases 68 proteasome inhibition 68 p# mitogen activated 68 lipoxygenase 68 targets Galectin receptors 68 CFTR cystic fibrosis transmembrane 68 NMDA N 68 factor HGF 68 type plasminogen activator 68 methyl D aspartate 68 Rap1 68 antiapoptotic 67 induce apoptosis programmed 67 BCL2 67 DNA intercalator 67 Inactivation 67 dopamine D2 67 Selective Inhibitor 67 cell adhesion molecule 67 ptau 67 cAMP dependent 67 cytokine signaling 67 BMAL1 67 Angiotensin II 67 MMP2 67 downstream effector 67 IL 1β 67 serine protease 67 targetters 67 cisplatin resistant 67 IGF1R 67 hypoxia inducible factor 67 p# MAPK 67 anaphase promoting complex 67 kinase PI3K 67 constitutive activation 67 E3 ligase 67 ganglioside 67 calcitonin gene related 67 upregulate 67 TRAIL R2 67 SIRT2 67 alpha GAL 67 ectopic expression 67 adenosine diphosphate ADP 67 neuropeptide Y NPY 67 monocytes macrophages 67 Fibroblast 67 Recombinant Human 67 CYT# potent vascular disrupting 67 pyrimidines 67 alpha folate receptor 67 PKC inhibitor 67 Monocyte 67 anti apoptotic 67 mda 7 67 TET2 67 Signaling Pathway 67 phosphatidylinositol 67 NKX#.# 67 receptor tyrosine kinase 67 ErbB1 67 cyclin dependent kinases CDKs 67 MEK1 67 induced apoptosis 67 reversibly inhibits 67 certain protein tyrosine 67 phosphate dehydrogenase 67 retinal ischemia 67 excitatory neurotransmitter glutamate 67 histone deacetylation 67 c MET 67 osteoprotegerin 67 PPARγ 67 adrenoceptor 67 Hepatocytes 67 p# MAP kinase 67 reversible inhibitor 67 DG# compounds targeting 67 ligand TRAIL 67 phospholipase C 67 Eg5 67 Epidermal Growth Factor Receptor 67 gamma amino butyric 67 topoisomerase II 67 somatostatin 67 5 HT1A 67 Nedd4 67 receptor alpha 67 apoptotic cell 67 RAS RAF MEK 67 small molecule activator 67 Overexpression 67 potent inhibition 67 Protein Kinase 67 podocyte 67 androgen receptor AR 67 prostanoid 67 AAG geldanamycin analog 67 kinase pathway 67 oncogenic signaling 67 cathepsins 66 autophagic 66 MAP kinase pathway 66 regulated kinase 66 NFAT 66 5 FU cytotoxic 66 selectively inhibit 66 Tumor Necrosis Factor 66 5 hydroxytryptamine 66 constitutively active 66 cytolytic 66 protein tyrosine kinase 66 cyclic adenosine monophosphate cAMP 66 TNFR 66 TNFalpha 66 TXNIP 66 upregulating 66 myelofibrosis polycythemia vera 66 intracellular proteins 66 underlying vasculopathy 66 apoptotic pathway 66 AnaSpec Introduces 66 Src kinases 66 glyceraldehyde 3 66 Drp1 66 thymidylate synthase TS 66 matrix metalloproteinases 66 aspartyl 66 selectively inhibits 66 peroxisome proliferator activated 66 myocyte enhancer factor 66 mTOR mammalian target 66 Smoothened 66 Kinase Inhibitor 66 constitutively expressed 66 tyrosine kinase receptor 66 Tyrosine Kinase Inhibitor 66 drug monomethyl auristatin 66 MET VEGFR2 66 methyl CpG binding 66 glucocorticoid receptor 66 uroguanylin 66 oligomerization 66 Induces Apoptosis 66 5 HT4 66 acetylcholine receptor 66 enzymatic reactions immunodiagnostics 66 activin 66 thromboxane A2 66 IL6 66 TEL AML1 66 suppresses tumor 66 Homeostasis 66 inhibits protein synthesis 66 metabolism viral replication 66 derived neurotrophic factor 66 Runx2 66 ERK signaling 66 autocrine 66 carbohydrate polymer 66 cell lysis 66 RAS RAF MEK ERK 66 molecule interleukin 66 polysaccharide polymer 66 heme oxygenase 1 66 DLX5 66 5 lipoxygenase 66 toxic amyloid beta 66 cortisol synthesis 66 beta actin 66 sphingomyelin 66 5 HT1A receptor 66 aryl hydrocarbon receptor 66 EGF receptor 66 regulates gene expression 66 cytokine receptor 66 BRAF kinase 66 Monoclonal 66 Cytotoxic T 66 topoisomerase II inhibitor 66 MAP kinases 66 Receptor Antagonist 66 potent cytotoxic 66 hip osteonecrosis avascular 66 naturally occurring molecule 66 heme oxygenase 66 cyclin B1 66 CDK5 66 converting enzyme 66 HER pathway 66 Secretase 66 66 naturally occurring neuroprotective 66 NF KappaB 66 5 HT2A inverse 66 cytochrome P 66 aldose reductase 66 Hematopoietic 66 Signal transduction 66 transferase 66 neurite outgrowth 66 γ secretase 66 TGF alpha 66 Th1 type 66 covalently linked 66 SMase 66 gamma H2AX 66 homodimers 66 NFκB 66 NFkappaB 66 MAPK 66 inverse agonist 66 Anthrax Toxin 66 attach auristatin 66 3 carbinol 66 PDGFR 66 Angiotensin Converting Enzyme 66 M1 muscarinic 66 mesenchymal transition 66 uracil 65 proapoptotic 65 tryptase 65 interleukin IL -# 65 protein CETP 65 Dystrophin 65 mitochondrial depolarization 65 folate analogue metabolic 65 histone methyltransferase 65 CDK inhibitor 65 RAS MAPK pathway 65 Glucocorticoid 65 mediated phosphorylation 65 PI3K Akt 65 TGFß 65 PKC isoforms 65 selective antagonist 65 Vpr 65 phosphoprotein 65 2A receptor agonist 65 carcinoids originate 65 inhibit angiogenesis 65 RUNX3 65 Wnt beta catenin 65 Hedgehog signaling 65 Inhibitory 65 Eg5 kinesin motor 65 focal adhesion kinase FAK 65 XL# inhibits 65 E2F 65 peroxisome 65 glycosyltransferase 65 S6K 65 chondrocyte 65 INH naturally occurring 65 transthyretin TTR 65 hyperphosphorylation 65 Oxidative 65 Mutational 65 Progenitor Cells 65 nicotinamide adenine dinucleotide 65 Epidermal Growth Factor 65 Introgen ADVEXIN 65 inhibit vascular endothelial 65 PECAM 65 sulfonylhydrazine class 65 IFN g 65 PDGF alpha receptor 65 Transcription Factor 65 metalloproteinase 65 Angiotensin converting enzyme 65 PAR1 65 Alu RNA 65 ATRA IV 65 Apoptosis 65 Aurora Kinase 65 Tubulin 65 conductance regulator 65 Mesenchymal 65 LDLR 65 vesicular monoamine transporter 65 oxidase 65 Notch receptor 65 LRP5 65 Vascular Endothelial Growth 65 isoprenoid 65 dehydrogenase 65 specific lectin receptors 65 STAT3 signaling 65 calcium calmodulin dependent 65 cyclin dependent kinase CDK 65 monophosphate 65 adipokine 65 thyroid hormone receptor 65 misfolds 65 isoenzyme 65 inhibiting enzymes 65 oncoprotein 65 adipogenesis 65 V#F mutation 65 LRP6 65 SMN1 65 Antithrombin 65 fibrin deposition 65 intercellular adhesion molecule 65 histone deacetylases 65 Cx# [001] 65 succinate dehydrogenase 65 cyclooxygenase 65 nicotinic acetylcholine receptor 65 Tie2 65 receptors EGFR 65 lysophosphatidic acid 65 tumor suppressor protein 65 phosphate S1P 65 Endothelial 65 histone acetyltransferase 65 RNase L 65 acetylcholinesterase 65 transcriptional activation 65 Adenoviral 65 GAPDH 65 Histone deacetylase 65 osteoblast 65 Bone Morphogenetic Protein 65 FGFs 65 factor receptor EGFr 65 urate oxidase 65 VEGFR1 65 peptide CGRP 65 transcriptional repressor 65 naturally occurring amino acid 65 microsomal 65 decreased matrix metalloproteinase 65 JAK STAT 65 methyltransferase 65 Raf kinase 65 selectively binds 65 DNA methyltransferase inhibitors 65 SCD1 65 5' monophosphate 65 FUS1 65 cell adhesion molecules 65 cytotoxic T lymphocyte 65 elastase 65 metalloproteases 65 Stromal 65 pancreatic islet beta 65 guanylate cyclase C 65 Alfacell proprietary ribonuclease 65 dioxygenase 65 cytokines IL 65 glial cell 65 plasmid encoding 65 overactivation 65 killer NK 65 stem cell pluripotency 65 FKBP# 65 D aspartic acid 65 Factor NGF 65 RANK Ligand 65 Polymorphisms 65 TIR1 65 complement inhibitor eculizumab 65 Shows Promise Against 65 Cdc7 65 beta. 65 synaptogenesis 65 opioid peptides 65 NF kappaB 65 Aromatase 65 granzyme B 65 lipoprotein lipase 65 HCV protease 65 vWF 65 fibril formation 65 Rab5 65 SGLT2 65 enzyme AMPK 65 Integrin 65 1beta 65 VE cadherin 65 oncogenic transformation 65 tetramer 65 apoptosis programmed cell 65 Smad3 65 coiled coil domain 65 Mg Usa 65 CK # selectively 65 NQO1 65 STAT1 65 NF kappaB activation 65 NOTCH1 65 Tumor Suppressor 65 regulating gene expression 65 neurofibromin 64 glial derived neurotrophic 64 IL 1beta 64 Jagged1 64 ubiquitination 64 VEGF receptor 64 avidin 64 hypermethylated 64 histone acetylation 64 plasmacytoid dendritic cells 64 potent vasoconstrictor 64 thrombin receptor 64 receptor kinase 64 thioredoxin reductase 64 PML RARA 64 Soluble CD# 64 hydroxylase 64 triphosphate 64 HIF biology 64 glycolipid 64 Akt activation 64 coagulation cascade 64 DNA methyltransferases 64 siRNA Delivery 64 GABAA receptors 64 alpha TNFa 64 activin receptor type 64 iNOS 64 HER2 ErbB2 64 vinca alkaloid 64 melanocyte stimulating hormone 64 downregulation 64 Vascular endothelial growth 64 pharmacological inhibition 64 catecholamine 64 survival motor neuron 64 IKK beta 64 Nkx#.# 64 Cytochrome P# 64 c Src 64 highly selective inhibitor 64 alpha subunit 64 targeted radiotherapeutic 64 basophils 64 Dysregulation 64 signal transduction inhibitor 64 cyclin dependent kinases 64 microglial 64 Nampt 64 glucocerebrosidase 64 apoptosis induced 64 kidney urologic 64 phosphoinositide 64 prostaglandin D2 64 vimentin 64 Ad5FGF 4 64 hematopoietic progenitors 64 homeobox 64 TNF Tumor Necrosis Factor 64 dipeptide 64 GNAQ 64 l lysine 64 ONCONASE triggers apoptosis 64 focal adhesion kinase 64 casein kinase 64 ubiquitinated 64 intracellular signaling 64 fibrogenesis 64 decarboxylase 64 GATA3 64 lipoprotein lipase LPL 64 #T# L1 64 B lymphocyte stimulator 64 RhoA 64 xanthine 64 mGluR2 NAM 64 Receptor Agonist 64 ankyrin repeat 64 HepG2 cells 64 factor receptor FGFR 64 NF κB 64 phosphorylate 64 encodes protein 64 Vidaza ® 64 #beta HSD1 64 RAF kinase 64 kinase PI3K Akt pathway 64 Oncogenes 64 Î ² 64 cyclin E 64 CD#L 64 pancreatic colon 64 hepatic lipase 64 exocrine 64 N acetylgalactosamine 64 reductase 64 dasatinib Sprycel ® 64 mTOR signaling 64 Cyclin Dependent 64 Abl 64 orally administered inhibitor 64 selectively activates 64 N methyl 64 platform HDL Mimetic 64 acinar 64 anterior pituitary 64 receptor activator 64 FGFR1 64 intracellular accumulation 64 Polymerase 64 pro apoptotic 64 inflammatory cytokines TNF 64 Inappropriate activation 64 Transcriptional 64 posttranslational modification 64 Cyclooxygenase 2 64 NFkB 64 Pruvel TM 64 pralatrexate injection folate analogue 64 hydrolases 64 ChR2 64 gamma aminobutyric acid 64 serine proteases 64 MT1 MMP 64 Anti Tumor 64 lymphotoxin 64 Ovitrelle R Serostim 64 PDGF receptor 64 irreversible inhibitor 64 eIF4E 64 Fibrinogen 64 c myc gene 64 Ribavirin causes 64 synthetases 64 proteolysis 64 myogenesis 64 NS5B polymerase 64 Immunomodulatory 64 cystic fibrosis transmembrane 64 ERK phosphorylation 64 super oxide dismutase 64 ZFN TM 64 inhibits plasma kallikrein 64 endosomal release 64 Ras MAPK pathway 64 sphingolipid 64 antisense inhibition 64 Enzastaurin 64 neuronal dysfunction 64 Dendritic Cells 64 pyrimidine 64 agonistic human 64 Cdc# 64 lysosomal 64 cytoplasmic domain 64 lymphangiogenesis 64 catalytic subunit 64 GABAergic 64 lytic 64 prolyl 64 lipopolysaccharide 64 Integrase 64 ERalpha 64 alpha#beta# integrin 64 induced angiogenesis 64 NOD2 64 EGFR signaling 64 substrates inhibitors 64 LPS induced 64 Synthase 64 Phenylalanine 64 Protein kinase 64 p# deficient 64 Fibroblast Growth Factor 64 nicotinamide 64 deoxy 64 PHD2 64 carboxyl terminal 64 Yap1 64 Endothelin 64 cystic fibrosis transmembrane conductance 64 Estrogen Receptor 64 Skeletal Muscle 64 calcium calmodulin 64 regulator CFTR gene 64 transcriptional regulation 64 superoxide dismutase 64 OMP #R# 64 acid GABA 64 5 HT2A receptor 64 TP Xeloda 64 Monocytes 64 nutlin 3a 64 Rho GTPases 64 oligodendrocyte progenitor cells 64 SETDB1 64 immunotoxin 64 PLA2 64 PPAR alpha 64 Prolactin 64 factor PlGF 64 cholecystokinin CCK 64 PPARgamma 64 Situ Hybridization 64 excitotoxic 64 retinoid X 64 gluconeogenesis 64 bispecific 64 tubulin polymerization 64 macrophage migration inhibitory 64 KLF2 64 pancreatic endocrine 64 p# subunit 64 DHFR 64 R Saizen R 64 adenylate cyclase 64 Integrins 64 Beta Amyloid 64 CD# CD# 64 neurotrophic 64 cultured neurons 64 IL 1Ra 64 alkylating 64 Src kinase 64 MMAE 64 Phospholipase 64 aurora kinase 64 PKC alpha 64 secretase 64 cyclooxygenase 2 64 mesenchymal cell 64 TGF beta pathway 64 Ph + acute lymphoblastic 64 adhesion molecule EpCAM expressing 64 leukotriene pathway 64 lipocalin 64 chemokine receptor 64 glutamyl 64 triiodothyronine 64 cryopyrin 64 FGFR4 64 beta subunit 64 mitotic kinesin 64 1alpha 63 transgenic mice expressing 63 lyase 63 mevalonate 63 TGF ß 63 erlotinib Tarceva ® 63 Neuropeptide Y 63 Pathway Inhibitor 63 ß catenin 63 intestinal epithelium 63 PI3 Kinase 63 2 methoxyestradiol 63 thrombopoietin TPO natural 63 potent stimulator 63 agent VDA 63 TLR7 agonist 63 Janus kinase 63 protein kinase C 63 histone demethylase 63 activate p# 63 extracellular domain 63 hepatoma 63 CCL# 63 Attenuates 63 Lymphocytic 63 acyl coenzyme 63 IL 1ß 63 coronary vasodilation 63 metaphase 63 anti inflammatory cytokine 63 pyruvate kinase 63 neuronal apoptosis 63 5alpha reductase 63 prostate secretory 63 aberrantly activated 63 diphosphate 63 angiogenic responses 63 viral protease 63 targeted diseased tissues 63 selective modulator 63 Tumour Vascular Disrupting Agent 63 Six3 63 cholesterol homeostasis 63 phosphoinositide 3 63 antibody mediated 63 keratinocyte 63 novel cardiac myosin 63 oxidative phosphorylation 63 synthetase 63 macrophage migration 63 hormone secreted 63 D aspartate 63 Hypertrophy 63 investigational humanized monoclonal antibody 63 ubiquitin ligase 63 transiently transfected 63 novel chimeric natriuretic 63 Intracellular 63 GLI1 63 peroxisomal 63 adrenal cortex 63 sulfatase 63 enkephalin 63 tryptophan hydroxylase 63 Arp2 3 63 tau phosphorylation 63 immune modulator 63 Histone 63 corticotrophin releasing factor 63 oxidative stress inflammation 63 PPAR peroxisome proliferator activated 63 genotoxic stress 63 PI 3K 63 kinase domain 63 Abeta protein 63 IGFBP2 63 Novel Oral 63 ErbB receptors 63 cyclic GMP 63 potent topoisomerase II 63 EphB2 63 phospholipase A2 63 combines paclitaxel 63 integrin alpha 63 costimulatory 63 transactivation 63 potent inhibitor 63 apoptosis inducing 63 glutamic acid decarboxylase GAD 63 ATP Adenosine 63 adipocyte 63 D aspartate NMDA receptor 63 receptor CXCR4 63 CYP#A# substrate 63 Cyclin D1 63 HER1 HER2 63 receptor partial agonist 63 PARP1 63 HDAC enzymes 63 corticotropin releasing factor 63 Tyrosine 63 P glycoprotein 63 activated protein kinase 63 MAPKs 63 PDGF B 63 monocyte chemoattractant protein 63 prostaglandin E 63 regulator CFTR protein 63 dependent protein kinase 63 transmembrane receptor 63 ornithine decarboxylase 63 polyamine 63 vesicular stomatitis virus 63 receptor subtype 63 Myeloid 63 copper zinc superoxide 63 Mucosal 63 Skp2 63 SUMOylation 63 novel VDA molecule 63 microsomal triglyceride transfer 63 cytochrome p# 63 NS#/#A protease 63 triiodothyronine T3 63 M1 macrophages 63 apoptotic 63 vitro pharmacology 63 interferon pathway 63 interleukin 1beta 63 CRTC2 63 HIF 1alpha 63 Flt3 63 Rho kinase 63 P#Y# [001] 63 receptor mediated 63 Apoptotic 63 Pegylated 63 presynaptic 63 potent inhibitors 63 CD# expressing 63 drug metabolizing enzyme 63 hydroxyphenyl 63 LPA1 receptor 63 mineralocorticoid receptor 63 DNA adducts 63 peptide receptor 63 targeted antifolate 63 Kinases 63 paxillin 63 Glucocorticoids 63 Transdrug R 63 cyclase 63 small molecule glucokinase 63 P selectin 63 glutamic acid decarboxylase 63 SGLT1 63 IRS1 63 integrin receptor 63 Reductase 63 soluble tumor necrosis 63 Leukocyte 63 kappa B 63 acyltransferase 63 sphingosine 1 63 microtubule associated 63 MDM2 63 mitotic catastrophe 63 FLT3 63 epithelial cells lining 63 melanocyte 63 peroxidation 63 TNF Alpha 63 Neuronal 63 peroxynitrite 63 proprietary polysaccharide 63 DNA Methylation 63 mitochondrial respiration 63 Leukotrienes 63 ornithine 63 actin polymerization 63 covalently bonded 63 chronic eosinophilic leukemia 63 autoreactive B 63 β cells 63 Raf MEK ERK 63 Levels Linked 63 humanized therapeutic 63 Receptor Antagonists 63 EGFR receptor 63 colorectal carcinoma 63 HIF 1α 63 proximal tubule 63 syngeneic 63 E selectin 63 guanylate cyclase type 63 ubiquitylation 63 beta amyloid peptide 63 immunostimulatory 63 eNOS 63 intracellular pathway 63 detoxify harmful 63 chemoattractant 63 Gamma secretase 63 Bruton tyrosine kinase 63 Treg cell 63 Fibroblast Growth Factor Receptor 63 glucagon receptor 63 human airway epithelial 63 thyrotropin 63 antiproliferative effects 63 tropomyosin 63 Androgen Receptor 63 ERK5 63 prostaglandin E2 63 RNA binding 63 intermediate filaments 63 steroidogenesis 63 abnormal lymphocytes 63 downregulating 63 pleiotropic 63 Sphingosine 1

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