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(Click for frequent words.) 71 mediated inhibition 71 synthases 69 hematoxylin eosin original 69 tumorigenicity 69 immunostaining 68 ERK1 2 68 organogenesis 68 miRNA expression 68 ERK signaling 68 proteinases 68 metaplasia 68 β1 68 vimentin 68 subcellular localization 68 methyltransferase 68 Upregulation 68 flow cytometric 68 tropomyosin 68 p# MAPK 68 PCR RFLP 67 isotypes 67 matrix metalloproteinases MMPs 67 transcriptional regulation 67 Schematic representation 67 Oncogenic 67 oligomeric 67 Annexin V 67 redox active 67 annexin 67 Fibroblast 67 supernatants 67 Cytochrome 67 HER2 HER3 67 constitutively expressed 67 FGFs 67 Wnts 67 immunoregulatory 67 proteomic analysis 67 glomerular 67 microglial 67 gamete formation 67 matrix metalloproteinases 67 RRM1 67 osteoblastic 66 ligand binding 66 colocalization 66 tetramer 66 ERalpha 66 aberrantly activated 66 phospholipase 66 gastric carcinomas 66 steroidogenesis 66 immunohistochemical analysis 66 covalently bound 66 RNA binding 66 ribonuclease 66 Cyclin E 66 trophoblasts 66 Cathepsin B 66 mononuclear 66 Transcriptome 66 immunocytochemistry 66 lymphoid cells 66 Leydig cell 66 mammalian fatty acid 66 homodimers 66 carcinoembryonic antigen 66 phosphoprotein 66 isoenzyme 66 pharmacological inhibition 66 morphologic 66 ribonucleoprotein 66 CD1d 66 HepG2 cells 66 subcellular 66 substrate specificity 66 cAMP signaling 66 transcriptional regulator 66 aggrecan 66 SDS PAGE 66 VE cadherin 66 airway epithelial 66 immunohistochemical 66 antiapoptotic 66 Extracellular 66 autophagic 66 pleomorphic 66 P2X 66 Histologically 66 orthologs 66 transferrin receptor 66 budding yeast 66 ciliated 66 histone modifications 66 cytidine 66 intermediate filaments 66 DNA intercalator 65 bronchoalveolar lavage 65 serpin 65 Figure 1C 65 Polymorphisms 65 synaptogenesis 65 Estrogen Receptor 65 serine threonine kinase 65 vacuolar 65 mRNA expression 65 metabolomic profiles 65 hematoxylin 65 ligand induced 65 genes differentially expressed 65 monocytes macrophages 65 oocyte maturation 65 lymphangiogenesis 65 adipogenic 65 sequence homology 65 cell adhesion molecule 65 preferentially bind 65 collagenous 65 histologic findings 65 Cytochrome P# 65 pyrimidines 65 cytokine receptor 65 lysates 65 bronchoalveolar 65 vesicle fusion 65 Histone 65 ERK pathway 65 thymidine 65 replicase 65 #S rDNA 65 protein phosphorylation 65 CYP#B# 65 metalloproteinase 65 Histologic 65 axon guidance 65 Smad4 65 JAK STAT 65 cathepsin B 65 transmembrane protein 65 neurite outgrowth 65 downregulates 65 chromatin structure 65 deacetylation 65 Rab5 65 murine model 65 glutamyl 65 RNA polymerases 65 isoenzymes 65 hematopoiesis 65 retinal nerve 65 retinoic acid receptor 65 FGF signaling 65 MDCK cells 65 degranulation 65 phosphate S1P 65 5 hmC 65 glycosyltransferase 65 Monoclonal 65 TIMP 65 striated muscle 65 retinoid X 65 lipoxygenase 65 immunoblotting 65 cyto 65 fibrogenesis 65 N glycan 65 CD# expression [001] 65 Mesenchymal 65 serine protease 65 beta subunit 65 cells overexpressing 65 microsomal 65 tumoral 65 Superoxide 65 Endothelial 65 FGFR3 65 metazoans 65 potent inhibitors 65 protein tyrosine kinase 65 umbilical vein 65 Leydig cells 65 homolog 65 outer membrane proteins 65 cell adhesion molecules 65 branching morphogenesis 64 gastric mucosa 64 proteolytic cleavage 64 phagocytosis 64 endothelial activation 64 Fig. 2B 64 previously undescribed 64 proteoglycan 64 splice variants 64 Histopathologic 64 eccrine 64 proteolytic 64 urothelial 64 N cadherin 64 Nedd4 64 peroxidation 64 ADAMTS# 64 Jhdm2a 64 steroidogenic 64 Western blotting 64 annexin V 64 potent inducer 64 lipoprotein metabolism 64 proto oncogene 64 syngeneic 64 bronchial epithelial cells 64 transiently transfected 64 RT qPCR 64 F actin 64 situ hybridisation 64 γ secretase 64 MMP# 64 N acetyl 64 amine oxidase 64 PGC 1α 64 hypothalamic pituitary 64 neural stem 64 apoE 64 spectrin 64 immunofluorescence 64 malignant prostate 64 intracellular signaling 64 antiproliferative effects 64 morphometric 64 ankyrin repeat 64 alveolar epithelial cells 64 regulated kinase ERK 64 Immunohistochemical staining 64 osteogenic 64 kinase inhibition 64 Inactivation 64 cotransporter 64 hamartomas 64 Stromal 64 virulence genes 64 Phosphorylation 64 immunoreactivity 64 guanosine 64 proteinase 64 cytokeratin 64 S. pombe 64 colon carcinoma 64 thymidylate synthase TS 64 ncRNA 64 seminal vesicle 64 Secretase 64 serine threonine 64 evolutionarily conserved 64 scanning microscopy 64 metazoan 64 polynucleotide 64 Peroxisome proliferator activated 64 hematopoietic progenitor cells 64 transgenic mouse models 64 extramedullary 64 synaptotagmin 64 mitochondrial DNA mtDNA 64 DNA adducts 64 beta1 integrin 64 metalloproteinases 64 proteolysis 64 colorectal carcinoma 64 fig. S4 64 choroidal 64 Epithelial 64 prostate carcinoma 64 biochemical assays 64 IgG4 64 elastase 64 ABL1 64 morphogenesis 64 cyclic adenosine monophosphate cAMP 64 epithelial barrier 64 colorectal adenocarcinoma 64 DNA methyltransferases 64 cellular organelles 64 hyperplastic 64 uracil 64 phenotypic expression 64 Xenopus laevis 64 MAP kinase 64 proximal tubule 64 Figure 2C 64 dinucleotide 64 metastatic lymph nodes 64 adventitia 64 myogenic 64 BMAL1 64 ultrastructural 64 Sertoli cell 64 Histological 64 leiomyoma 64 neural crest 64 coiled coil 64 mucinous 64 keratinocyte 64 Macrophage 64 Androgen receptor 64 lysate 64 astrocytic 64 mitogen activated protein kinase 64 peroxidase 64 HLA DQ2 64 Endometrial 64 homogenates 63 mimetics 63 siRNA knockdown 63 metabolizing enzyme 63 posttranslational modification 63 neoplastic 63 GRP# 63 immunofluorescence microscopy 63 NKG2D 63 HER2 HER2 63 Cytotoxic T 63 Skeletal muscle 63 Clusterin 63 prognostic significance 63 motoneurons 63 subcellular compartments 63 mechanotransduction 63 mitochondrial metabolism 63 chondrocyte 63 cytoplasmic domain 63 epithelia 63 chemoattractant 63 florbetaben 63 transferase 63 cyclic peptide 63 amyloid fibrils 63 secretory pathway 63 homeobox gene 63 constitutively active 63 TIMP 1 63 MT1 MMP 63 haematopoietic 63 luminal surface 63 ortholog 63 fluorescently tagged 63 E cadherin expression 63 RANTES 63 corneal endothelium 63 oligomerization 63 occludin 63 acinar 63 pyrophosphate 63 phorbol 63 Supplementary Fig 63 epithelial cells lining 63 Smad3 63 gene polymorphisms 63 transcriptomic 63 intracellular bacteria 63 splenocytes 63 myocyte 63 electron microscopic 63 cDNA microarray 63 transcriptional activation 63 ectopic expression 63 tenascin 63 ß catenin 63 Situ Hybridization 63 cathepsins 63 transgenic mice expressing 63 CD# expression [002] 63 neuronal differentiation 63 cultured rat 63 deoxy 63 DNase 63 somatostatin receptor 63 gastric carcinoma 63 PCA3 gene 63 chromatin modifications 63 lysine residues 63 fig. S1 63 hepatoma 63 Rap1 63 synovial 63 C1q 63 cells transfected 63 xenobiotic 63 Protease 63 dimeric 63 cyclic nucleotide 63 monocytic 63 transcriptional repressor 63 post translational modifications 63 acyl CoA 63 histone acetylation 63 androgen receptor AR 63 Tie2 63 cell nuclei 63 somatostatin receptors 63 macromolecule 63 retinal ischemia 63 Dehydrogenase 63 dorsal root ganglion 63 Neurotrophic Factor 63 functional polymorphism 63 E#F# 63 confocal laser scanning 63 carboxyl terminal 63 protein conformation 63 posttranslational modifications 63 coexpression 63 vaginalis 63 lung epithelial cells 63 epithelial cell 63 Histone deacetylase 63 MAPK pathway 63 cytokine receptors 63 thrombin receptor 63 enolase 63 assay detects 63 radiosensitivity 63 ectodomain 63 Cx# [001] 63 GPI anchored 63 neural progenitor 63 FGFR1 63 heterologous expression 63 COL#A# 63 palmitate 63 Peyer patches 63 Elevated serum 63 bronchoalveolar lavage BAL 63 At#g# 63 melanocyte 63 stably transfected 63 Clinical Relevance 63 proapoptotic 63 chromosome condensation 63 matrix metalloproteases 63 non coding RNA 63 DNA glycosylase 63 tumor suppressor PTEN 63 upregulates 63 protein electrophoresis 63 PTPN# 63 Prox1 63 peroxisome 63 homologue 63 glutamine synthetase 63 proton pump 63 glycan structures 63 Morphological 63 #S subunit 63 Monocytes 63 macrophage infiltration 63 eicosanoid 63 Amino acid 63 hnRNP 63 vascularisation 63 kDa protein 63 bone morphogenic protein 63 kinase pathway 63 nucleases 63 protein tyrosine 63 Confocal microscopy 63 p# mitogen activated 63 thrombospondin 63 proline rich 63 ERK1 63 neoplastic cells 63 ploidy 63 gene rearrangements 63 insertional 63 NOD mouse 63 monomeric 63 methylation patterns 63 mRNA sequences 63 1beta 63 Oxidase 63 prolyl 63 Hematopoietic 63 PON1 63 pylori 63 protein secreted 63 ribosomal protein 63 micronuclei 63 hepato 63 CEACAM1 63 acyltransferase 63 bioluminescence imaging 63 ryanodine receptor 63 immunofluorescent 63 AhR 63 reaction PCR 63 anterior pituitary 63 tryptase 63 epidermal cells 63 lactate dehydrogenase 63 isolated perfused 63 fibrosarcoma 63 Src kinase 63 multigene 63 peroxisomal 63 ^ sup #m 63 triphosphate 63 uPAR 63 CCL# 63 cardiac myocytes 63 Dopaminergic 63 tRNA synthetase 63 OCT4 62 Aromatase 62 pharmacodynamic biomarkers 62 cytokines IL 62 SOCS3 62 chloroplast genome 62 histopathological 62 Fas ligand 62 subcellular structures 62 pyrimidine 62 bone morphogenetic proteins BMPs 62 Phylogenetic analysis 62 intramolecular 62 MMP2 62 site directed mutagenesis 62 proximal tubular 62 phosphatases 62 H#K#me# 62 biogenesis 62 histopathologic examination 62 homologues 62 ependymal 62 Conjugated 62 perivascular 62 MTT assay 62 type plasminogen activator 62 FDG uptake 62 cyclase 62 acetylcholine receptor 62 PPARg 62 LNCaP cells 62 polycystin 62 Mutational 62 pro angiogenic 62 PC# cells 62 ribosomal proteins 62 Jurkat cells 62 Thermus thermophilus 62 acyclic 62 PPARγ 62 T2 weighted images 62 Nod1 62 HLA G 62 PDGFR 62 endonuclease 62 molecular pathogenesis 62 Caenorhabditis 62 hemoglobins 62 Eukaryotic 62 hematopoietic progenitors 62 TGF beta1 62 kinase domain 62 Fig. 1D 62 IGF1R 62 motor neuron degeneration 62 mineralocorticoid receptor 62 pulmonary metastases 62 Huntingtin 62 histone H3 62 cell lysate 62 Histological examination 62 metalloprotease 62 clinicopathological 62 jejunal 62 leukocyte recruitment 62 epigenetically 62 NSCLC tumors 62 Crystallographic 62 miR #a [001] 62 Trichophyton rubrum 62 myofibroblasts 62 mass spectrometric 62 thymidine kinase 62 null mice 62 myofibroblast 62 desmin 62 transduced 62 stilbene 62 multiplex assay 62 62 M1 muscarinic 62 serine proteases 62 Phenotypic 62 nucleolar 62 activin 62 eukaryotic cell 62 Immunohistochemical 62 Antigen Specific 62 rRNA 62 intercellular adhesion molecule 62 quinone 62 stereochemistry 62 tyrosine phosphorylation 62 radiolabeled 62 interleukin 1beta 62 Htt 62 cyclooxygenase COX 62 Immunohistochemical analysis 62 covalently bonded 62 Integrins 62 polyamine 62 GLUT4 62 protein biosynthesis 62 cisplatin resistant 62 HepG2 62 hydrolases 62 vascular endothelial 62 metaphase 62 5 hydroxymethylcytosine 62 peptide receptor 62 bone marrow stromal cells 62 HIF 1α 62 lacrimal gland 62 enzymatic pathways 62 myo inositol 62 Figure 1A 62 Biosynthesis 62 mediated apoptosis 62 survivin expression 62 amino acid residue 62 adrenoceptor 62 TNFalpha 62 clonal expansion 62 Osteopontin 62 Electron microscopy 62 transcriptional activity 62 cyclooxygenase 2 62 Phenylalanine 62 mitogen activated protein kinases 62 sclerosing 62 cysteine proteases 62 epithelial tissues 62 ciliates 62 matrix metalloproteinase 62 cytochrome oxidase 62 phosphorylates 62 thermodynamic stability 62 murine models 62 immuno modulatory 62 gp# protein [002] 62 mycobacterial 62 CCR9 62 SIRT2 62 gene inactivation 62 ,#,# [002] 62 vascular endothelial cells 62 BMP4 62 hedgehog signaling pathway 62 Prevotella 62 myopathies 62 poly ADP ribose polymerase 62 ligand receptor 62 ERBB2 62 adducts 62 ß amyloid 62 cellularity 62 immunohistochemical staining 62 neuroligins 62 #T# L1 62 intercellular signaling 62 fibrin deposition 62 surgically resected 62 microRNA expression 62 Prenatal diagnosis 62 62 c MYC 62 pleiotropic effects 62 hypointense 62 telomere maintenance 62 RNA splicing 62 tubule 62 cuticular 62 clonogenic 62 gut microbiota 62 chick embryos 62 noncoding RNAs 62 nucleotide sequences 62 pleiotropic 62 viral pathogenesis 62 beta. 62 DGAT1 62 Tyrosine 62 pDC 62 plastid 62 fascin 62 TRPV4 62 choroid plexus 62 orthologous 62 membrane lipids 62 cultured neurons 62 scavenger receptor 62 lyase 62 cell lysates 62 prostaglandin synthesis 62 heterodimers 62 Fibroblasts 62 homodimer 62 centromeric 62 synthetase 62 Overexpression 62 VSV G 62 HER2 receptor 62 histone code 62 microglial activation 62 Eg5 62 prostate epithelial cells 62 IL #p# 62 tumor infiltrating lymphocytes 62 tumor suppressor protein 62 oxidases 62 multiprotein complex 62 BRAF V#E 62 beta actin 62 n cofilin 62 missense mutations 62 Fig. 1b 62 zebrafish larvae 62 bone morphogenetic proteins 62 Plasminogen 61 FISH fluorescence 61 H#K# [002] 61 hypermethylated 61 pathophysiological 61 CagA 61 podocytes 61 1alpha 61 gene encodes 61 paxillin 61 cathepsin 61 lipid vesicles 61 homeobox 61 junctional 61 membrane receptors 61 gene amplification 61 myc 61 endonucleases 61 conformational changes 61 demethylase 61 retinal pigment epithelium 61 Transcriptional 61 mitochondrial gene 61 HepDirect prodrug 61 ligase 61 alpha subunit 61 Schwann cell 61 diphosphate 61 Mycobacterium smegmatis 61 LRP6 61 effector molecules 61 P. gingivalis 61 neuronal dysfunction 61 KLF4 61 PARP1 61 mesangial 61 HCV replication 61 microstructural 61 anaphase promoting complex 61 Flt3 61 mesothelial cells 61 submucosal 61 EF Tu 61 dioxygenase 61 myometrium 61 coding genes 61 Mutagenesis 61 sphingolipid 61 synovial tissue 61 druggable target 61 autoradiography 61 Transcription Factor 61 neovascularization 61 BMP signaling 61 circular dichroism 61 esterase 61 RQ PCR 61 fluorescently labeled 61 fibril formation 61 ventricular myocardium 61 transcriptional regulators 61 etiologic 61 4E BP1 61 acid phosphatase 61 chromatid 61 adrenocortical 61 calcitonin gene related 61 glucose transporter 61 Cytoplasmic 61 molecular determinants 61 melanocytic 61 gene polymorphism 61 de novo synthesis 61 caveolae 61 olfactory epithelium 61 heterochromatic 61 eosin 61 catenin 61 engineered RAP peptides 61 SNP rs# [001] 61 #S rRNA 61 p# Shc 61 bFGF 61 Hepatocytes 61 ribonucleotide 61 isomerase 61 oxidase 61 proton magnetic resonance 61 astrocyte cells 61 beta tubulin 61 cardiolipin 61 antigenic epitopes 61 adipokines 61 PDZ domains 61 radioligand 61 cell lysis 61 squamous carcinoma 61 Tr DNA 61 PKC isoforms 61 differentially expressed genes 61 epigenetic modifications 61 Microtubule 61 collagens 61 histone modification 61 seminal vesicles 61 abnormal angiogenesis 61 Activating mutations 61 T#M 61 differentially regulated 61 intrahepatic 61 DNA methylation patterns 61 mechanistic studies 61 malignant lymphomas 61 Drosophila embryos 61 microRNA miR 61 ssDNA 61 HDACi 61 apical membrane 61 glycolipid 61 bacterial genomes 61 epigenetic modification 61 cell organelles 61 MDR1 61 TGF alpha 61 isoprenoid 61 GFP fluorescence 61 cytochrome c 61 eIF2 61 pathologic diagnosis 61 flavin 61 protein fragment 61 histone H3 lysine 61 hydrolytic 61 N Myc 61 lymphoid organs 61 mitochondrial respiration 61 tonsillar 61 exocytosis 61 intermediate filament 61 glycolytic 61 translationally 61 urate oxidase 61 phospholipid membranes 61 receptor activator 61 polymorphonuclear 61 glycopeptide 61 avidin 61 basophils 61 mouse mammary 61 protease enzyme 61 thymosin beta 4 61 antibody antigen 61 osteoblast differentiation 61 KRAS oncogene 61 Intracellular 61 epithelial tumors 61 carboxy terminal 61 inducible nitric oxide synthase 61 #S rRNA gene 61 Fig. 1A 61 cadherin 61 FUS1 61 chemosensitivity 61 5 methylcytosine 61 p# p# 61 reverse transcriptase polymerase chain 61 papillomas 61 aminotransferase 61 metabolite concentrations 61 XL# inhibits 61 Protein Expression 61 E. faecalis 61 thyroid carcinoma 61 Fig. 1C 61 receptor inhibitor 61 CB2 receptor 61 enzymology 61 micrograph 61 histopathological examination 61 LIS1 61 beta globin gene 61 retinal pigment epithelial cells 61 oligomer 61 differential gene expression 61 cytoprotective 61 ubiquitylation 61 transmembrane proteins 61 cryo electron microscopy 61 multinucleated 61 transcriptome sequencing 61 nitric oxide synthase 61 agonist induced 61 neuromuscular junction 61 intracellular proteins 61 hepatobiliary 61 primary hyperparathyroidism 61 factor HGF 61 cationic lipid 61 multinucleated giant cells 61 Histopathological 61 γδ T cells 61 androgen dependent 61 EGF receptor 61 mammalian tissues 61 oxidative metabolism 61 S nitrosylation 61 ciliary 61 exocrine 61 nuclease 61 Hypothalamic 61 microtubule dynamics 61 NOD SCID mice 61 X ray crystallographic 61 ChR2 61 defensin 61 AMACR 61 efferent 61 morphometrics 61 Nicotinic 61 TGF ß 61 receptor ligand 61 quantitative trait loci 61 epididymal 61 aminopeptidase 61 quantitative RT PCR 61 liposomes containing 61 selectin 61 Lymphocytes 61 immunomodulation 61 thioredoxin 61 gut mucosa 61 TUNEL 61 ß1 61 gadolinium enhanced 61 amyloidogenic 61 cofactors 61 protein glycosylation 61 Runx2 61 crystallin 61 beta lactamases 61 qRT PCR 61 EP4 61 E3 ligase 61 binding affinities 61 C#BL 6 mice 61 metabolizing enzymes 61 adipose derived 61 neuronal signaling 61 Vps# 61 chromatin modification 61 agarose gel electrophoresis 61 fronto 61 pancreatic endocrine 61 breast cancer subtypes 61 stably expressing 61 TMEM#B 61 forkhead 61 maternally inherited 61 NR#A# 61 gastric adenocarcinoma 61 splenic 61 chromatin remodeling complex 61 monocyte 61 neuro endocrine 61 anti CD3 61 mesenchyme 61 Quantitative RT PCR 61 anterograde 61 insulin signaling pathways 61 transabdominal 61 immunoreactive 61 presynaptic 61 Sgk1

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