PICALM

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(Click for frequent words.) 68 Clusterin 67 clusterin 67 PTPN# 66 tumor suppressor protein 66 SNP rs# [001] 65 alpha synuclein gene 65 TCF#L# 65 susceptibility gene 65 TMEM#B 65 VIPR2 65 KIAA# 65 histone deacetylases 64 TCF#L# gene 64 FGFR2 64 #beta HSD1 64 chromosomal regions 64 GSTP1 64 genetic loci 64 FGFR1 64 genetic variants associated 64 rs# [004] 64 GPC5 64 CDKN2A 64 glycolipids 64 autism susceptibility genes 63 BARD1 63 TRAF1 C5 63 sporadic ALS 63 LRP5 63 protein tyrosine phosphatase 63 LRRK2 gene 63 FLT3 63 MAPK pathway 63 Apolipoprotein E 63 epigenetic regulation 63 cell adhesion molecule 63 FGFR3 63 CALHM1 63 chromosome #p# [002] 63 SH#B# 63 K ras mutations 63 PALB2 63 apoE 63 dysbindin 62 Wnt signaling pathway 62 ERBB2 62 MLL2 62 mitogen activated protein kinase 62 chromosome #q# [001] 62 p#INK#a 62 HDACs 62 chromatin structure 62 #q# [001] 62 chemokine receptor 62 ribosomal protein 62 micro RNA 62 promoter methylation 62 H#K# [002] 62 MTHFR 62 homeobox gene 62 susceptibility loci 62 chromosome #q# [002] 62 caveolin 62 pathological hallmark 62 genetic polymorphisms 62 transgenic mouse model 62 LIS1 62 Janus kinase 62 NR#A# 62 rs# [002] 62 Six3 62 retinoid X 62 #p# [003] 61 miRNA expression 61 susceptibility genes 61 glycogen synthase kinase 61 LRAT 61 progressive neurodegenerative disorder 61 TRAIL induced apoptosis 61 DNA methylation patterns 61 Angiotensin converting enzyme 61 apolipoprotein E 61 ABCB1 61 colorectal carcinoma 61 #p# [001] 61 Genetic variants 61 kidney urologic 61 tyrosine phosphorylation 61 ZNF# 61 PTEN gene 61 deacetylase 61 Dysregulation 61 protein tau 61 androgen receptor AR 61 A3 adenosine receptor 61 somatic mutations 61 eotaxin 61 PARP inhibition 61 NKG2D 61 Wwox 61 lipoxygenase 61 PIK3CA 61 FTLD 61 PTEN mutations 61 missense mutations 61 endogenous ligands 61 VKORC1 61 non coding RNA 61 molecular abnormalities 61 IL#R 61 TSC1 61 ERK signaling 61 hepatic lipase 61 APOE e4 61 IKK beta 61 autoantigen 61 APOL1 61 SMAD4 61 downstream effector 61 encodes protein 61 serine protease 61 beta1 integrin 61 LPA gene 61 nephronophthisis 61 genetic locus 60 proto oncogene 60 ADAM# 60 genetic variants 60 KLF4 60 myelofibrosis polycythemia vera 60 protein tyrosine kinase 60 Cathepsin B 60 aMCI precursor 60 phosphorylates 60 ARID1A 60 #S rRNA 60 LRP6 60 gastrointestinal stromal tumors GISTs 60 CHRNA5 60 histone deacetylase 60 endophenotypes 60 apolipoprotein E4 60 hypermethylated 60 TSLP 60 neurofibrillary 60 tumor suppressor gene 60 4E BP1 60 peroxisome proliferator activated 60 methylenetetrahydrofolate reductase 60 Fibroblast Growth Factor Receptor 60 pathophysiological effects 60 ABL1 60 CNTNAP2 60 microRNA molecules 60 PML RARA 60 miR #a [002] 60 receptor tyrosine kinase 60 SORL1 60 synuclein 60 obesity insulin resistance 60 tRNA synthetase 60 Raf MEK ERK 60 resistin 60 FGF2 60 ACE2 60 cell signaling pathways 60 poly ADP ribose polymerase 60 chromosome #p#.# 60 GPC3 60 MTHFR gene 60 GATA3 60 STAT4 60 MYH9 gene 60 Monocyte 60 gene variants 60 PON1 60 #q#.# [001] 60 Genetic variations 60 causative genes 60 histone methylation 60 epigenetic modification 60 TGFBR1 * 6A 60 CYT# potent vascular disrupting 60 regulates gene expression 60 eIF 4E 60 chromosomal rearrangement 60 CagA 60 Alpha synuclein 60 Smad3 60 methylated DNA 60 somatic mutation 59 HER2 receptor 59 apoE4 59 neuroligins 59 single nucleotide polymorphism 59 RUNX3 59 ALDH2 59 chromosome #p# [001] 59 ORMDL3 59 CDH1 59 protein kinases 59 selective inhibition 59 APOE gene 59 neuropsychiatric diseases 59 germline mutations 59 miRNA genes 59 histone deacetylation 59 tyrosine kinases 59 DNA methyltransferases 59 activate SIRT1 59 MEK ERK 59 focal adhesion kinase FAK 59 PDGFR 59 thyrotropin 59 KIF6 gene 59 phospholipase A2 59 neurofibrillary tangles 59 progranulin 59 histone modification 59 VEGF receptor 59 rs# [001] 59 serine threonine kinase 59 neuronal dysfunction 59 Protein Kinase C 59 tyrosine kinase receptor 59 TTR amyloidosis 59 CCR1 59 NS5A 59 NPM1 59 p# MAPK 59 KRAS oncogene 59 epigenetic alterations 59 IDH1 59 p# activation 59 Neuregulin 1 59 retinoic acid receptor 59 neuropeptide Y NPY 59 mGluR2 NAM 59 monogenic 59 JAK2 mutation 59 casein kinase 59 Smac mimetics 59 transthyretin TTR 59 c MET 59 PKC enzyme 59 PDE#A 59 CHD7 59 leukocyte adhesion 59 Lp PLA 2 59 #q#.# [002] 59 bcl 2 59 podocyte 59 inactivating mutations 59 NKX#.# 59 transmembrane receptor 59 genes encoding 59 galectin 59 molecular mechanisms underlying 59 DQB1 * 59 rs# [003] 59 HLA DRB1 59 gene locus 59 beta amyloid peptide 59 5 hydroxymethylcytosine 59 Transcription factors 59 59 MDM2 59 NFAT 59 histone modifications 59 Akt3 59 chromosome #q#.# [001] 59 superoxide dismutase 59 MLH1 59 CCR5 delta# 59 Activating mutations 59 apoptotic pathway 59 R#W [002] 59 nicotinic receptor 59 cholesterol metabolism 59 IFRD1 59 tumor suppressive 59 E#F# 59 Aurora kinase 59 NOD2 59 causative gene 59 carcinoembryonic antigen 59 transgenic mouse models 59 protein kinase C 59 homodimers 59 myeloproliferative neoplasms 58 genomewide 58 Smurf1 58 p#/CBP 58 TOMM# 58 gastric carcinogenesis 58 ncRNA 58 D aspartic acid 58 novel VDA molecule 58 protein fragment 58 SLC#A# [001] 58 LKB1 58 oncoprotein 58 Overexpression 58 polymorphisms 58 COL#A# 58 FUS1 58 FOXP3 58 p# INK4a 58 vimentin 58 PI3 kinase 58 cellular pathways 58 catechol O methyltransferase 58 IDH1 mutation 58 MnSOD 58 microRNA expression 58 causal variants 58 protein CETP 58 hypomethylation 58 SLITRK1 58 BCR ABL 58 PI3K/mTOR 58 biologic pathways 58 Shortened telomeres 58 58 ubiquitin ligase 58 COX2 58 pathogenic mechanisms 58 CaM kinase II 58 ADAMTS# 58 ATG#L# 58 cyclin E 58 pathological hallmarks 58 DISC1 58 PPARγ 58 prostate carcinogenesis 58 microRNAs miRNAs 58 osteocalcin 58 perilipin 58 MSH2 58 myeloproliferative disorders 58 NKX2 58 MAP#K# 58 matrix metalloproteinase 58 FGFs 58 previously uncharacterized 58 WDR# 58 ACh 58 allelic variants 58 IRAK1 58 5 HTTLPR 58 FMR1 gene 58 phosphatidylinositol 3 58 transcriptional regulation 58 MECP2 gene 58 splice variants 58 microdeletion 58 C#Y 58 defensin 58 rRNA 58 autoantigens 58 c Myb 58 SLC#A# [002] 58 soluble CD# ligand 58 prognostic markers 58 gene polymorphism 58 alpha glucans 58 Kinases 58 apolipoprotein B 58 JAK2 enzyme 58 GPx 58 MAP kinase pathway 58 inhibitory receptor 58 muscular dystrophies 58 Oxidative damage 58 HMGA2 58 mRNA encoding 58 inverse agonist 58 TLR9 agonists 58 WT1 58 Phosphorylation 58 receptor kinase 58 IDH mutations 58 micro RNAs 58 Hedgehog pathway 58 Upregulation 58 Hypoxia Inducible Factor 58 hypoxia inducible factor 58 GSTT1 58 myeloproliferative diseases 58 breast cancer subtypes 58 CDK4 58 TP# gene 58 UsiRNAs 58 ubiquitinated 58 FOXO 58 proteins encoded 58 TERT 58 LDL receptor 58 HER1 58 HFE gene 58 FGFR2 gene 58 inherited mutations 58 IRF6 58 costimulatory 58 RhuDex ™ 58 gene APOE 58 noncoding RNA 58 tumor antigen 58 cathepsins 58 sortilin 58 mutated genes 58 BRAF V#E 58 Wnt beta catenin 58 mitochondrial dysfunction 58 TNFalpha 58 mRNA expression 58 ApoE 58 mda 7 58 CYP#C# [002] 58 molecular biomarkers 58 RAF kinase VEGFR 58 ErbB1 58 FGFR 58 cyclin dependent kinases 58 abnormal p# 57 INF2 57 HLA DQ2 57 susceptibility locus 57 PPAR γ 57 mGluR5 antagonist 57 sPLA2 57 regulating gene expression 57 lipid metabolism 57 underlying vasculopathy 57 vitamin D receptor 57 G#S [002] 57 5 HT2A serotonin 57 receptor molecule 57 uPAR 57 beta catenin 57 adipokines 57 signaling molecule 57 lymphangiogenesis 57 apolipoprotein E APOE 57 SH2 B 57 Single Nucleotide Polymorphisms SNPs 57 RNAi therapeutic targeting 57 oncogenesis 57 HGPS 57 diagnostic biomarker 57 selective antagonists 57 IL #R 57 molecular subtypes 57 histone deacetylase inhibitors 57 methylation patterns 57 STAT3 signaling 57 serotonin receptor 57 tau protein 57 familial pancreatic cancer 57 SOD1 57 Tumor Necrosis Factor 57 Cdc7 57 neuroendocrine 57 gene fusions 57 glucocorticoid receptor GR 57 epigenetic silencing 57 familial ALS 57 NFkB 57 evolutionary conserved 57 CD# ligand 57 chromatin immunoprecipitation ChIP 57 NPHP 57 TCF4 57 IGFBP2 57 gene loci 57 chronic myeloid 57 Dr. Pasinetti 57 melanocyte stimulating hormone 57 GRP# 57 drug metabolizing enzymes 57 effector function 57 virulence genes 57 gene polymorphisms 57 PPARg 57 receptors PPARs 57 PDGF receptor 57 HuLuc# 57 ESR1 57 HMGCR 57 causative mutations 57 sarcosine 57 hypermethylation 57 urocortin 57 deacetylation 57 genetic determinants 57 Prox1 57 histone acetylation 57 Hutchinson Gilford progeria 57 bile acid metabolism 57 LRRK2 57 ErbB3 57 matrix metalloproteinases MMPs 57 missense mutation 57 receptor antagonism 57 Eg5 57 gene APOE4 57 ADPKD 57 #p#.# [001] 57 CYP# [002] 57 PCA3 gene 57 narcolepsy cataplexy 57 Genetic variation 57 monocyte chemoattractant protein 57 potently inhibit 57 γ secretase 57 humanin 57 Epstein Barr Virus EBV 57 PTP1B 57 UCP2 57 coding genes 57 JAK2 57 ThermoDox ® clinical 57 ERK1 2 57 IGF2 57 plasma kallikrein 57 miR #b [002] 57 PAR1 57 cytomegalovirus CMV 57 gene expression patterns 57 metalloprotease 57 Factor Receptor 57 previously undescribed 57 Syk 57 HER2 HER3 57 mRNA transcripts 57 AKT1 57 MIF protein 57 molecular pathway 57 microdeletions 57 APOE4 57 protein tyrosine phosphatase 1B 57 prolyl 57 protein encoded 57 Dr. Bezprozvanny 57 E selectin 57 Li Fraumeni 57 paxillin 57 phosphorylated tau 57 SORL1 gene 57 Alzheimer disease cognitive impairment 57 SIRT3 57 cystatin C 57 YKL 57 Darapladib 57 Welsh Bohmer 57 multiple sclerosis psoriasis 57 KLF# 57 RhuDex R 57 promoter hypermethylation 57 HER3 57 G Protein Coupled 57 proapoptotic 57 Polymorphisms 57 Amyloid plaques 57 HIF 1alpha 57 nucleotide variations 57 chitinase 57 TTR gene 57 haplotype 57 IKZF1 57 HAAH 57 dopamine D4 receptor 57 IDH2 57 SHANK3 57 ApoE gene 57 miRNAs 57 FBPase 57 ANGPTL4 57 RECAF TM 57 nestin 57 noncoding RNAs 57 Abeta# 57 adipokine 57 JAK inhibitors 57 MC1R 57 Telomere shortening 57 major histocompatibility complex 57 TEL AML1 57 JAK3 57 SNP rs# [002] 57 Htt 57 c MYC 57 MMP# 57 hereditary predisposition 57 induce apoptosis 57 metabolic enzymes 57 progressive neurodegenerative 57 cytokeratin 57 functional polymorphism 57 chromosomal aberrations 57 certain protein tyrosine 57 CCR2 57 activin 57 CCR3 57 mediated apoptosis 57 kinase pathway 57 inosine 57 DLC1 57 immunoregulation 57 ptau 57 posttranslational modifications 57 PDGFR B 57 V#F mutation 57 ALN TTR 57 isoenzymes 57 neuropathologic 57 clade B 57 epigenetic mechanisms 57 Brd4 57 AhR 57 Macrophage 56 deCODE AF TM 56 beta amyloid peptides 56 ALK mutations 56 MicroRNA 56 PKCi 56 tau protein tangles 56 BRAF mutation 56 autosomal dominant disorder 56 activating mutation 56 induces apoptosis 56 genetic polymorphism 56 metabolizing enzyme 56 tumorigenesis 56 ERK pathway 56 HDAC inhibitors 56 glutathione peroxidase 56 axon guidance 56 Amyloid beta protein 56 STK# [002] 56 ChIP seq 56 number variation CNV 56 metalloproteinase 56 caveolin 1 56 RNase L 56 epigenetic changes 56 TLR3 56 SIRT1 gene 56 protein tyrosine phosphatases 56 essential thrombocythemia 56 SCD1 56 antisense inhibitors 56 miRNA molecules 56 immunohistochemical staining 56 IL 1Ra 56 SNPs 56 engineered RAP peptides 56 HDAC2 56 neuropathic pain metabolic diseases 56 folate metabolism 56 T2D 56 penetrance 56 metabolic abnormalities 56 HDAC inhibition 56 HER2 neu 56 MGUS 56 HSF1 56 MAPT 56 1 diabetes T1D 56 microRNA miR 56 IL 1β 56 neuropilin 56 HG PIN 56 FoxO1 56 RRM1 56 esophageal squamous cell carcinoma 56 immunotoxin 56 TNF receptors 56 CHD5 56 maternally inherited 56 Nonalcoholic fatty liver 56 CTNNB1 56 dysregulation 56 #q# deletion 56 RASSF1A 56 ependymomas 56 transcriptional activation 56 MAPK 56 pharmacodynamic biomarkers 56 HOTAIR 56 quantitative trait loci 56 PHD2 56 lysophosphatidic acid LPA 56 breast cancer metastasis 56 activated microglia 56 orally administered inhibitor 56 VLDL cholesterol 56 SOD1 gene 56 Epidermal Growth Factor 56 phosphate S1P 56 S#A# [002] 56 TNFAIP3 56 novel peptides 56 methylation markers 56 β amyloid 56 potent inhibition 56 pDCs 56 SCN5A 56 post transcriptional 56 HDL2 56 telomere dysfunction 56 RIP1 kinase 56 PI3K 56 TLR8 56 DLX5 56 CISH 56 protein p# 56 HBx 56 amyloidogenic 56 HER signaling pathway 56 RNA splicing 56 gene rearrangements 56 KRAS mutations 56 alpha synuclein protein 56 HDAC 56 Ets2 56 carbohydrate metabolism 56 IL 1ß 56 molecular markers 56 NPM1 mutations 56 amino acid substitutions 56 Parkinson disease Alzheimer disease 56 genomic variants 56 Epidermal Growth Factor Receptor 56 TXNIP 56 miR #a [001] 56 TLR4 56 RAS MAPK pathway 56 PI3K Akt 56 melatonin receptor 56 prognostic marker 56 SNPs pronounced snips 56 parkin gene 56 EGFR signaling 56 autoantibody 56 beta secretase inhibitors 56 PDGF alpha receptor 56 Cyclin E 56 TrkB 56 Signaling Pathway 56 NPM1 mutation 56 Hedgehog signaling pathway 56 SGK1 56 spinocerebellar ataxia 56 HbF 56 progranulin mutations 56 HLA DR 56 potent inhibitor 56 MSMB 56 Epstein Barr virus EBV 56 downregulation 56 human leukocyte antigen 56 Fas ligand 56 cyclic AMP cAMP 56 gastric carcinoma 56 thioredoxin 56 PTP 1B 56 lipoprotein metabolism 56 adhesion molecule 56 amyloid beta plaques 56 Hypertriglyceridemia 56 T#M 56 tumor suppressor 56 NS4B 56 B7 H3 56 airway remodeling 56 APOE genotype 56 CC genotype 56 clinicopathological 56 5q 56 RNA sequences 56 Foxp3 56 peptide antigens 56 virulence determinants 56 fatty acid synthase 56 modifier genes 56 CEACAM1 56 MEF2A 56 mTOR mammalian target 56 adipogenic 56 loci 56 p# alpha [001] 56 SNCA 56 kinase inhibition 56 fronto temporal dementia 56 testicular germ cell 56 BRAF gene 56 Genetic predisposition 56 subclinical atherosclerosis 56 genetic biomarkers 56 Wnts 56 alpha#beta# 56 molecular biomarker 56 leukotriene pathway 56 HLA genes 56 NMDA N 56 JAK2 gene 56 amyloid peptide 56 MEK1 56 evolutionarily conserved 56 dopamine transporter 56 Haptoglobin 56 tRNA synthetases 56 CD#L 56 Alzheimer disease vascular dementia 56 monocytic 56 HMMR 56 biomarker identification 56 variant rs# 56 CENP E 56 TGF beta pathway 56 MTHFD1L gene 56 Hp2 2 56 Notch receptor 56 alpha7 NNR 56 motor neuron degeneration 56 mitochondrial gene 56 generalized vitiligo 56 familial clustering 56 huntingtin gene 56 mitochondrial metabolism 56 5 lipoxygenase 56 Rap1 56 oxysterols 56 mGluRs 56 GRNCM1 56 autoantibodies 56 immunodeficiencies 56 neuropsychiatric disorder 56 PTEN protein 55 ENPP1 55 non coding RNAs 55 JAK mutations 55 neurofibromatosis type 55 small molecule defensin 55 signaling cascades 55 LPS induced 55 coding RNA 55 hypothalamic pituitary adrenal axis 55 MetAP2 55 exomes 55 HCV protease 55 IgA deficiency 55 HMG CoA reductase 55 chromosome rearrangements 55 neurofibromin 55 CYP#D# gene 55 CHEK2 55 biologic pathway 55 spontaneous mutations 55 chronic eosinophilic leukemia 55 Nedd4 55 APOC3 55 osteopontin 55 genetic underpinnings 55 cyclin dependent kinase inhibitor 55 glucocorticoid receptor 55 colorectal adenoma 55 primate genomes 55 extracellular signal 55 immune modulating 55 inflammation thrombosis oncology 55 antiproliferative effects 55 multi factorial disease 55 amnestic mild cognitive impairment 55 cardio metabolic diseases 55 #beta HSD 1 55 microcephalin 55 Src kinases 55 genetic variations 55 A2 Lp PLA2 55 genomewide association studies 55 linkage disequilibrium 55 BMPR2 55 breast cancer genes BRCA1 55 pleiotropic 55 Dr. Fred Volkmar 55 AT1R 55 transmembrane protein 55 underlying pathophysiology 55 herpesviruses 55 Kufs disease 55 orally bioavailable mimics 55 androgen receptor gene 55 kallikrein 55 ubiquitination 55 ERalpha 55 aggregated Abeta 55 transthyretin 55 potent inhibitors 55 upregulates 55 TGF β 55 3'UTR 55 preclinically 55 #p#.# [002] 55 MAP kinases 55 cytokines IL 55 methyl D aspartate 55 genes CYP#C# 55 GLI1 55 HIF 1α 55 hyperphosphorylated tau 55 p# Shc 55 channelopathies 55 palladin 55 mediating pathological inflammation 55 germline mutation 55 mammaglobin 55 KIBRA 55 galectin 3 55 Li Fraumeni syndrome 55 activating mutations 55 gene mutations 55 pathogenesis 55 immunohistochemical 55 Wnt#b 55 Factor VEGF 55 plasma lipid 55 biomarker 55 EZH2 55 prostate cancer CaP 55 splice junctions 55 ribosomal RNA rRNA 55 lymphocyte activation 55 circadian genes 55 FOXO3a 55 Epigenomics proprietary 55 syngeneic 55 AAG geldanamycin analog 55 epigenetic enzymes 55 E3 ubiquitin ligase 55 STAT3 55 TOP2A 55 catenin 55 metabolizing enzymes 55 CCL#L# 55 amyloid beta proteins 55 Yamanaka recipe 55 RIP1 55 genomewide association study 55 c myc gene 55 tic severity 55 Galectin 3 55 prodynorphin 55 microRNAs 55 C1q 55 estrogen receptor 55 BMP2 55 amyloid cascade 55 FTIs 55 5 HT4 55 NADPH oxidase 55 neurodegenerative disease 55 Coronary artery calcification 55 Akt1 55 glucose homeostasis 55 systemic lupus erythematosus SLE 55 PKM2 55 Relapsing remitting 55 apolipoprotein E gene 55 hyperphosphorylation 55 cause cardiac channelopathies 55 synaptic function 55 molecular determinants 55 antisense inhibitor 55 malignant phenotype 55 cystic fibrosis transmembrane conductance 55 non alcoholic steatohepatitis 55 diabetes hyperlipidemia 55 receptor protein 55 survivin 55 BDNF gene 55 granzyme B 55 receptor gamma 55 Treg cell 55 acute humoral rejection 55 mediated inhibition 55 Methylation 55 catechol O methyltransferase COMT 55 haplotypes 55 Marc Weisskopf 55 DHFR 55 adiponectin 55 melanocyte 55 Cholangiocarcinoma 55 LPA1 55 nitric oxide synthase 55 gamma secretase 55 siRNA sequences

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