Related by context. All words. (Click for frequent words.) 69 immunological responses 67 humoral responses 66 chlamydial 66 transgenic rats 65 immunopathology 65 Candida infection 65 innate immune responses 65 Th2 immune 65 EBV infection 65 immunocompetent 65 allergic airway inflammation 65 pleiotropic effects 64 busulfan 64 chitinase 64 physiologic mechanisms 63 SSc 63 antiangiogenic therapy 63 biochemical abnormalities 63 Th2 cytokines 63 interleukins 62 immuno modulatory 62 varicella infection 62 lupus anticoagulant 62 fluoroquinolone resistance 62 pharmacologic approaches 62 antibody mediated 62 Hepatotoxicity 62 interferon γ 62 differential gene expression 62 proliferative disorders 62 microvascular endothelial cells 62 rotaviruses 62 tumorigenicity 62 E. faecalis 62 chromosome aberrations 62 cardiac repolarization 62 plasma kallikrein 62 colorectal adenocarcinoma 62 CMV infections 62 K ras mutations 62 cytomegalovirus infection 61 parasitemia 61 pDCs 61 neutralizing antibody 61 metastatic neuroendocrine tumors 61 S. maltophilia 61 hyperalgesia 61 ALI ARDS 61 serum antibodies 61 receptor inhibitor 61 thrombotic complications 61 experimentally induced 61 poorly immunogenic 61 hypothalamic pituitary adrenal axis 61 biologic pathways 61 antitumor effect 61 angiographically 61 Kinoid 61 immunomodulatory effects 61 pharmacodynamic parameters 61 intracellular bacteria 61 coagulation abnormalities 61 hibernating myocardium 61 CP CPPS 61 antitumor immunity 61 trastuzumab Herceptin ® 61 immunological mechanisms 61 Opportunistic infections 61 isoenzymes 61 plasma pharmacokinetics 61 preclinically 61 murine models 61 isoproterenol 61 fluconazole resistant 61 staphylococcal infections 61 Th2 responses 61 antiandrogens 61 pharmacokinetic interactions 61 adipose derived stem cells 61 herpesviruses 61 selective inhibition 61 airway hyperresponsiveness 61 effector function 61 allergic inflammation 61 CD8 T cell 61 hepatic liver 61 systemic toxicity 61 Aspergillus infections 61 antitumor efficacy 60 G6PD deficiency 60 serologic testing 60 immunoregulation 60 TNFa 60 Chronic pancreatitis 60 Neuropeptide Y 60 FVIII inhibitors 60 beta defensins 60 neutralizing antibody responses 60 adeno associated viruses 60 invasive candidiasis 60 tissue oxygenation 60 coronary stenoses 60 interleukin IL -# 60 follicular lymphomas 60 radioimmunoassay 60 Th1 cells 60 QT interval prolongation 60 lymphoma subtypes 60 T1DM 60 M. catarrhalis 60 thiopurine 60 humoral immune response 60 activated microglia 60 analgesic effects 60 chronic periodontitis 60 epithelial barrier 60 mucosal immunity 60 TH# cells 60 viraemia 60 hypoxic tumors 60 erythropoietic 60 microglial activation 60 HIV HCV coinfected 60 imatinib resistance 60 Magnesium deficiency 60 bronchodilatory 60 renal scarring 60 helminth 60 extramedullary 60 Genetic variants 60 Angiotensin converting enzyme 60 VEGF expression 60 cardiometabolic disorders 60 griseofulvin 60 arterial calcification 60 N. gonorrhoeae 60 relapsed MM 60 cervical lymph nodes 60 serologically 60 neuro degenerative disorders 60 S. aureus colonization 60 candidemia 60 Immune responses 60 cardioprotective effects 60 NMDA antagonists 60 corticosteroid therapy 60 noscapine 60 leukocyte recruitment 60 cytotoxic effects 60 lymphoid cells 60 microglial 60 Alequel 60 idiopathic pulmonary 60 bone marrow stromal cells 60 methicillin susceptible Staphylococcus aureus 60 serum antibody 60 PC# cells 60 lethal arrhythmias 60 subcutaneous immunoglobulin 59 bacterial virulence 59 prostate cancer CaP 59 mitochondrial toxicity 59 squamous cell lung cancer 59 HepG2 cells 59 subclinical disease 59 mucosal immune responses 59 pharmacodynamic effects 59 mycobacterial 59 prostate cancer PCa 59 immune globulins 59 Human cl 59 lichen planus 59 CA MRSA infections 59 riociguat 59 metabolic alterations 59 FGFs 59 immune reconstitution syndrome 59 inhibiting COX 59 p# activation 59 antirheumatic 59 pharmacokinetic interaction 59 LCMV infection 59 paricalcitol 59 trophoblast cells 59 rhITF 59 nephrogenic 59 endotoxemia 59 flavopiridol 59 antiplatelet therapies 59 uricase 59 enteroviral infection 59 ergot alkaloids 59 HHV 6 59 4CMenB 59 cranial irradiation 59 acetylcysteine 59 molecular determinants 59 bronchial epithelial cells 59 atherothrombotic 59 tryptase 59 CYP#A# enzyme 59 selective modulator 59 highly immunogenic 59 neoplastic diseases 59 amyloid toxicity 59 etiologic 59 allogeneic HSCT 59 genital ulcer disease 59 potent neuroprotective 59 lymphocyte counts 59 gene rearrangements 59 Epstein Barr virus EBV 59 haematopoietic 59 beta1 integrin 59 platelet dysfunction 59 reactogenicity 59 cisplatin resistant 59 immunostimulatory effects 59 p#NTR 59 inducible nitric oxide synthase 59 proinflammatory cytokine 59 immunosuppressed patients 59 cardioprotection 59 kidney urologic 59 IGFBP 3 59 neuro endocrine 59 cAMP signaling 59 overactivation 59 hyperacute 59 adaptive immunity 59 Aspergillus species 59 mTOR inhibition 59 cytoprotective 59 C. perfringens 59 electrophysiologic 59 myopathy rhabdomyolysis 59 allograft rejection 59 ELISpot 59 antiphospholipid antibodies 59 humoral immunity 59 microvascular dysfunction 59 molecularly targeted therapies 59 antiproliferative effects 59 airway hyper responsiveness 59 environmental toxicants 59 conjugate vaccines 59 mutated K ras 59 Valproic acid 59 cytopenias 59 glioblastoma tumor 59 Plasmodium falciparum malaria 59 cSSSIs 59 anticholinergic agents 59 IFN γ 59 renal toxicity 59 A. fumigatus 59 pheochromocytoma 59 immunomodulation 59 chromosomal rearrangement 59 Rimantadine 59 breast cancer metastasis 59 DHEA supplementation 59 enterococcal 59 Respiratory Syncytial Virus RSV 58 viral kinetics 58 LRP5 58 melanocytic nevi 58 Non inferiority 58 Plasmodium infection 58 BALB c mice 58 malignant lymphomas 58 NF kB pathway 58 C. pneumoniae 58 IgG1 antibodies 58 IgG4 58 GPx 58 hyperprolactinemia 58 malignant ascites 58 hypoperfusion 58 aT cell 58 repolarization 58 nonhuman primate model 58 therapeutic regimens 58 HER2 overexpression 58 CMV infection 58 Enterobacter cloacae 58 basophils 58 dose proportionality 58 recurrent venous thromboembolism 58 Immunohistochemical analysis 58 hematopoietic cells 58 hypocalcaemia 58 ENMD # 58 endocrine dysfunction 58 pulmonary metastases 58 diagnose coronary artery 58 neurotrophic 58 bullous 58 murine antibodies 58 glycolytic 58 salivary proteins 58 orchitis 58 rhinovirus infection 58 lymphoid organs 58 mTOR inhibitors 58 potentiation 58 immunotoxins 58 Torsades de Pointes 58 Epstein Barr Virus EBV 58 prolactin elevation 58 induced anemia 58 renal cell carcinomas 58 probiotic supplementation 58 allergic dermatitis 58 coagulopathy 58 somatostatin 58 adenovirus infection 58 antioxidant supplementation 58 developmental neurotoxicity 58 renal fibrosis 58 prion infected 58 thrombotic thrombocytopenic purpura TTP 58 MYCN amplification 58 allergic airway 58 acute tubular necrosis 58 sonographic diagnosis 58 autoimmune reactions 58 physiologic responses 58 hematopoietic cancers 58 IL 1ß 58 causative mutation 58 Tumor Response 58 leucocytes 58 rhinovirus infections 58 Observational studies 58 KLF4 58 elastase 58 endothelial activation 58 Cryptococcus neoformans 58 selenium supplementation 58 liposomal amphotericin B 58 TNF α 58 beta adrenergic receptors 58 immunosuppressive regimens 58 airway epithelial cells 58 PROCHYMAL 58 hepatic toxicity 58 haematologic 58 globulins 58 mucosal inflammation 58 CYP #A# 58 R. equi 58 basal cell nevus syndrome 58 miRs 58 chorioamnionitis 58 pharmacodynamic PD 58 respiratory viral infections 58 activin 58 antitumour 58 alpha1 antitrypsin deficiency 58 cellular prion protein 58 transfusion transmitted 58 nosocomial hospital 58 metabolic dysfunction 58 periodontal tissues 58 neurologic sequelae 58 serum leptin 58 capsular polysaccharide 58 gastric adenocarcinoma 58 outer membrane proteins 58 pathophysiological effects 58 immune modulating 58 PCNSL 58 von Willebrand 58 clevidipine 58 induces antibodies 58 pulmonary dysfunction 58 metaplasia 58 TRAIL induced apoptosis 58 thromboembolic complications 58 lymphoproliferative disease 58 nutlin 3a 58 hemodynamic variables 58 experimental allergic encephalomyelitis 58 microangiopathy 58 nodal metastasis 58 hemorrhagic cystitis 58 hereditary predisposition 58 STAT3 signaling 58 nephrotoxicity 58 thyrotropin 58 fibrate drugs 58 taxane resistant 58 Eisenmenger syndrome 58 IL 1β 58 vascular dysfunction 58 upper gastrointestinal bleeding 58 HER2 expression 58 HBV replication 58 metastatic lymph nodes 58 subchronic 58 Pseudomonas aeruginosa infections 58 Gleevec resistant 58 radiosensitivity 58 S. suis 58 bovine thrombin 58 recurrent glioblastoma multiforme 58 PI3K Akt 58 thiazide 58 interstitial pneumonia 58 CTLs 58 lesional 58 P vivax 58 neuroendocrine cancers 58 postexposure prophylaxis 58 monocytes macrophages 58 metabolomic profiles 58 ß blockers 58 TGF ß 58 Cardiotoxicity 58 metastatic uveal melanoma 58 pentoxifylline 58 IFN beta 58 neuropsychiatric diseases 57 chromium picolinate supplementation 57 dysrhythmias 57 vasogenic edema 57 inflammatory biomarkers 57 induced hepatotoxicity 57 sporadic Creutzfeldt Jakob 57 P selectin 57 antibody IgE 57 underlying molecular mechanisms 57 torsade de pointes 57 bronchopulmonary dysplasia BPD 57 HSV1 57 bacterial pneumonias 57 antiresorptive 57 neurosteroid 57 cardiopulmonary bypass surgery 57 fulminant hepatic failure 57 Trypanosoma 57 dopamine transporter DAT 57 adrenal suppression 57 C. trachomatis 57 mGluR5 antagonist 57 urothelial cancer 57 granzyme B 57 ischemia reperfusion 57 plasminogen activators 57 T. cruzi 57 hepatorenal syndrome 57 db db mice 57 radiolabeled TM# 57 postoperative AF 57 genital herpes infections 57 eotaxin 57 anti androgens 57 skeletal metastases 57 respiratory pathogens 57 S aureus 57 solithromycin 57 HBV vaccine 57 HER2 positive cancers 57 immune responses 57 anti CD3 antibody 57 carcinoid tumors 57 hemolytic 57 hemorrhagic colitis 57 endometrial hyperplasia 57 alveolar epithelial cells 57 immunosuppressive therapies 57 viral bacterial 57 cis retinoic acid 57 teratogens 57 prothrombotic 57 cyclophilin D 57 mitochondrial metabolism 57 nonpharmacologic 57 nutrient supplementation 57 fibrin deposition 57 pathogenic mechanisms 57 serologic tests 57 parainfluenza virus 57 ovarian carcinoma 57 vivo potency 57 endogenous ligands 57 Vacc 4x 57 comorbid disorders 57 perfusion abnormalities 57 bronchoalveolar 57 airway responsiveness 57 urticaria hives 57 IgM antibodies 57 transgene expression 57 perioperatively 57 mtDNA mutations 57 thrombocytopenic 57 oxysterols 57 suppressor cells 57 osteoporotic vertebral compression fractures 57 hypoxemia 57 S. aureus infection 57 chromosomal mutations 57 antibody titer 57 ERK1 2 57 lenalidomide dexamethasone 57 KRAS status 57 brain lesions 57 chimeric antibody 57 pharmacodynamic profile 57 prostate carcinogenesis 57 chromosomal aberrations 57 androgen suppression 57 gonococcal infection 57 IFN gamma 57 adrenoceptor 57 IFNg 57 motor neuron degeneration 57 pyridostigmine 57 cervical neoplasia 57 lymphoid tumors 57 Soy isoflavones 57 lactate dehydrogenase 57 Mesothelin 57 myopathies 57 serine proteases 57 hydatid disease 57 HbF 57 Fc receptor 57 synovial cells 57 missense mutations 57 dermatophytes 57 intracranial hemorrhage ICH 57 Acute Bacterial Sinusitis ABS 57 neuroleptic 57 GRNCM1 57 mycosis 57 pneumococci 57 serum urate levels 57 bronchoalveolar lavage 57 recurrent glioblastoma multiforme GBM 57 vivax 57 MAGE A3 ASCI 57 Hematologic toxicity 57 OHR/AVR# 57 hepatotoxic 57 neurodevelopmental outcomes 57 Staphylococci 57 hepatic fibrosis 57 hyper responsiveness 57 anatomical abnormalities 57 intravenous bisphosphonates 57 steroidogenic 57 postoperative atrial fibrillation 57 HuR 57 de novo mutations 57 LAB CGRP 57 P. acnes 57 humoral antibody 57 hyperbilirubinemia 57 mycophenolate mofetil MMF 57 KRAS oncogene 57 Lipoic acid 57 inotropes 57 IgG antibodies 57 encephalomyelitis 57 bacterium Neisseria meningitidis 57 renal tumors 57 granulomatous 57 leukocytosis 57 adrenocortical 57 molecular abnormalities 57 microglial cells 57 inhibitory effects 57 pertussis toxin 57 C#BL 6 mice 57 antitumor effects 57 Umbilical cord stem cells 57 pharmacologic intervention 57 Heavy menstrual bleeding 57 CMV reactivation 57 glucocorticoid receptors 57 monogenic 57 Severe Primary IGFD 57 pneumococcal infection 57 neurologic symptoms 57 antiviral efficacy 57 metaanalysis 57 atypical neuroleptics 57 Th1 type 57 sirtuin activators 57 Staphylococcus aureus infections 57 conventional DMARDs 57 myeloproliferative diseases 57 p# MAPK 57 Clostridium difficile infections 57 leptin deficiency 57 Varicella zoster virus 57 TTR gene 57 vasodilatation 57 berberine 57 periodontal infection 57 Febrile neutropenia 57 mitochondrial mutations 57 combination antiretroviral therapy 57 E selectin 57 ALT elevations 57 antiangiogenic agents 57 esophageal gastric 57 bacterium Mycobacterium tuberculosis 57 NAbs 57 glycated hemoglobin levels 57 unresectable tumors 57 TLR signaling 57 LTBI 57 somatostatin analogs 57 CXCR2 57 Thiovir 57 bronchoalveolar lavage fluid 57 Streptococcus pneumonia 57 JAK2 enzyme 57 Intussusception 57 receptor subtypes 57 neuro developmental disorders 57 fibrogenesis 57 ImmuKnow 57 pig islets 57 pretransplant 57 DRG neurons 57 Clostridia 57 iron chelators 57 etiologic agent 57 Ribavirin causes 57 platelet activation 57 potent stimulator 57 nosocomial infection 57 PBMCs 57 Plasmin 57 IDH mutations 57 bronchial inflammation 57 rheumatic disorders 57 tumor subtype 57 vaccinees 57 asthmatic airways 56 carcinoid 56 fetal malformations 56 prion infections 56 GH deficiency 56 pharmacodynamic markers 56 myeloperoxidase 56 myocardial dysfunction 56 pDC 56 acute respiratory tract infections 56 eIF4E 56 S. neurona 56 inhibiting mTOR 56 immunodeficiency disorders 56 Fibroblast 56 ovarian hormones 56 CYP #D# 56 bone marrow suppression 56 phenotypic expression 56 inactivated influenza vaccines 56 cytopathic 56 interstitial fibrosis 56 antiphospholipid syndrome 56 Wnts 56 NOD mouse 56 Thyroid disorders 56 colony stimulating factors 56 sCD# 56 L lysine 56 inhaled bronchodilators 56 cardiotoxic effects 56 cytokine Interleukin 56 myocardial regeneration 56 splenic 56 nonvascular 56 causative organisms 56 levodopa induced 56 HMG CoA reductase inhibitors 56 hyperactivated 56 autoreactive T cells 56 TGF β 56 chemosensitivity 56 cholangiocarcinoma 56 eosinophilic 56 acute myocarditis 56 M1 muscarinic 56 β blockers 56 DFMO 56 aldosterone hormone 56 PPARγ 56 TRP channels 56 GABHS 56 hamartomas 56 systemic amyloidosis 56 APOE genotype 56 anthracycline chemotherapy 56 Anticholinergic 56 TPMT 56 Treg cells 56 Novavax VLP vaccine 56 refore 56 herpes simplex encephalitis 56 renal cysts 56 PR interval prolongation 56 endocrine tumors 56 antifibrotic 56 malignant lymphoma 56 myelomas 56 RAS mutations 56 neovascularisation 56 muscarinic receptors 56 Leydig cells 56 reproductive endocrine 56 polyglutamine diseases 56 transfusion syndrome 56 H pylori 56 allergen immunotherapy 56 Francisella 56 aerosolized KL4 surfactant 56 chlamydial infection 56 poliovirus vaccine 56 endocrine therapies 56 infliximab Remicade 56 skeletal myoblasts 56 colorectal tumor 56 aldosterone antagonist 56 TGF beta signaling 56 antifungal medications 56 neurocognitive deficits 56 velafermin 56 mecamylamine 56 vesicoureteral reflux 56 arginase 56 urothelial carcinoma 56 Leukemias 56 cerebral vasospasm 56 cynomolgus macaques 56 macrovascular events 56 neoplastic 56 teratogenic 56 neuropathologic 56 intranasally administered 56 Chronic lymphocytic leukemia 56 viral etiology 56 stem cell transplantations 56 vWD 56 IFN ß 56 chest radiographs 56 enterovirus infection 56 mycotic 56 pharmacologic therapies 56 uPAR 56 acute humoral rejection 56 modifier genes 56 H. influenzae 56 KSHV 56 toxicologic 56 Urinary tract 56 Legg Calvé Perthes disease 56 cancerdefine 56 intravascular hemolysis 56 intestinal microflora 56 da mage 56 neurologic complications 56 prion infection 56 GABRA2 56 Hypotension 56 triglyceride lowering 56 polymicrobial 56 ABCB1 56 ERK signaling 56 periodontal bacteria 56 C. difficile toxins 56 virological response 56 ischemia reperfusion injury 56 Adverse effects 56 antidepressant efficacy 56 digestive disturbances 56 lymphomas leukemias 56 cholestasis 56 alpha thalassemia 56 dietary interventions 56 lytic 56 MDSCs 56 untreated celiac disease 56 cerebral oxygenation 56 FGF2 56 prenatal exposures 56 lymphoid tissues 56 neoplasias 56 cytopenia 56 hyperhomocysteinemia 56 lung fibrosis 56 hypertrophic scarring 56 AAV2 56 statins cholesterol lowering 56 prostate carcinoma 56 osteosarcomas 56 ERalpha 56 eosinophilia 56 fatty acid biosynthesis 56 Hp2 2 56 Latent TB 56 Candida infections 56 PDGF B 56 TNFR1 56 miRNA expression 56 ESBLs 56 venous thromboembolic disease 56 oncologic diseases 56 paraneoplastic 56 FGFR1 56 dyslipidemias 56 percutaneous biopsy 56 heme oxygenase 1 56 molecular biomarkers 56 cardio metabolic diseases 56 mononuclear cells 56 antiangiogenic drugs 56 intermittent hypoxia 56 arteritis 56 glial tumors 56 NF kappaB activation 56 monocyte macrophage 56 hemagglutination inhibition 56 helminths 56 oligodendrocyte progenitor cells 56 preterm neonates 56 remyelination 56 CD# expression [002] 56 Poly ICLC 56 neuronal dysfunction 56 Th2 cells 56 anti angiogenic agents 56 cytotoxic therapies 56 lavage fluid 56 postoperative infections 56 mediated immunity 56 mucosal immune 56 node metastases 56 causative organism 56 myeloablative 56 mononuclear 56 Epidemiologic studies 56 EGFR tyrosine kinase inhibitors 56 CCL# 56 mediated inhibition 56 included exfoliative dermatitis 56 metabolic derangements 56 Symptom severity 56 Enterococcus faecalis 56 malarial anemia 56 β2 56 Gag polymorphisms 56 induced oxidative stress 56 neurotrophic factors 56 vulvovaginal candidiasis 56 leiomyomas 56 VEGF inhibitors 56 gastroduodenal 56 P. falciparum malaria 56 nonallergic rhinitis 56 lung fibroblasts 56 etiologic factors 56 Nitric oxide NO 56 functional neuroimaging 56 pharmacokinetic characteristics 56 Meta analyzes 56 eosinophil count 56 GSK3B 56 autoreactive 56 fibrosarcoma 56 pulmonary toxicity 56 intestinal epithelial cells 56 polymorphic ventricular tachycardia 56 silibinin 56 osteoblast activity 56 activated lymphocytes 56 Helicobacter 56 pathogenetic 56 nonbacterial 56 adipokines 56 biomarker identification 56 bacteria Pseudomonas 56 Symadex 56 steroid refractory 56 Aethlon Hemopurifier R 56 inflammatory demyelinating 56 IgE mediated 56 Genetic mutation 56 Orthostatic hypotension 56 TGF β1 56 antiinflammatory 56 clade B 56 nociceptive pain 56 #HT#A receptor 56 osteogenesis 56 immunodeficiencies 56 mycobacterial infection 56 Beta catenin pathway 56 Candida species 56 DAS# [001] 56 acute aortic dissection 56 Anaplasmosis 56 pharmacological approaches 56 TNFalpha 56 GIST tumors 56 tumor histology 56 histological subtype 56 airway narrowing 56 Iron deficiency anemia 56 Multivariate logistic regression 56 S. enterica 56 treating neuropathic pain 56 esophageal squamous cell carcinoma 56 seminomas 56 Skeletal muscle 56 OGG1 56 Foxp3 56 lupus scleroderma 56 neurological sequelae 56 ductal adenocarcinoma 56 pelvic irradiation 56 hormone angiotensin 56 sonographic appearance 56 GBA mutations 56 interindividual variability 56 maladaptive behaviors 56 β1 56 eicosanoids 56 CD8 responses 56 liver histology 56 TNF alpha antagonist 56 opportunistic pathogens 56 CPVT 56 serogroup B 55 epigenetic alterations 55 neuropsychological impairments 55 PTLD 55 missense mutation 55 bacterial overgrowth 55 CHIKV 55 Toxicities 55 Demodex 55 inhibits platelet aggregation 55 arachidonic acid AA 55 metabolomic profiling 55 prostaglandin E2 55 chlamydial infections 55 Lyme arthritis 55 steroid dexamethasone 55 IFN β 55 neutropenic patients 55 cytotoxic T lymphocyte 55 Dr. Rivella 55 CYP#D# genotype 55 heparanase 55 deacetylation 55 liver metastasis 55 LVNC 55 CYP#D# inhibitor 55 validate biomarkers 55 antisense inhibitors 55 BCL#A 55 Multiple logistic regression 55 therapeutically useful 55 thyroid deficiency 55 histologically proven 55 prognostic markers 55 epithelial tumors 55 eradicate H. pylori 55 Chlamydia psittaci 55 glutamic acid decarboxylase 55 psychosocial variables 55 immune modulatory 55 ADPKD 55 humoral immune responses 55 causative mutations 55 neurite outgrowth 55 elevated CRP 55 mutant huntingtin protein 55 prostate carcinomas 55 radioimmunotherapy RIT 55 Glioblastoma Multiforme GBM 55 malignant pleural mesothelioma 55 psychostimulant 55 HCV replication 55 pathogenetic mechanisms 55 bronchial hyperresponsiveness 55 Malignant glioma 55 effector molecules 55 PDE4 inhibitors 55 anemias 55 incidentalomas 55 proteoglycan