Related by context. All words. (Click for frequent words.) 69 neuronal degeneration 69 Smad3 68 overactivation 68 MEF2A 67 VHL gene 67 mutant huntingtin protein 67 upregulates 67 melanocyte 67 FGFs 66 neuronal dysfunction 66 Pten 66 filaggrin 66 podocyte 66 dysregulation 66 epigenetic modifications 66 overactivated 66 c myc gene 66 CHD7 66 SGK1 66 leptin signaling 65 Genetic variation 65 genotoxic stress 65 peroxisome 65 transcriptional activation 65 renal fibrosis 65 Akt signaling 65 Jhdm2a 65 Notch signaling 65 neurite outgrowth 65 stellate cells 65 podocytes 65 transcriptional repressor 65 downregulation 65 NADPH oxidase 65 Htt 65 cystic fibrosis transmembrane conductance 65 genomic instability 65 epigenetic alterations 65 synovial cells 65 MECP2 gene 65 mediated inhibition 65 regulates gene expression 64 excitotoxic 64 Thyroid hormone 64 hypothalamic pituitary adrenal axis 64 synaptogenesis 64 β1 64 gluconeogenesis 64 prodynorphin 64 Polycomb proteins 64 Treg cell 64 LIS1 64 downregulating 64 induced neuronal 64 pleiotropic 64 beta globin gene 64 Genetic mutations 64 hyperactivated 64 hyperactivation 64 histone methylation 64 hyperexcitability 64 FGF signaling 64 chromatin structure 64 microtubule dynamics 64 PI3K signaling 64 dedifferentiation 64 protein misfolding 64 prostaglandin synthesis 63 gene rearrangements 63 WNK1 63 lymphocyte activation 63 neuronal differentiation 63 nNOS 63 MAP kinase 63 Wnt signaling pathway 63 RUNX3 63 inherited mutations 63 epigenetic regulation 63 tumor suppressor PTEN 63 LKB1 63 myofibroblast 63 astrocytic 63 virulence genes 63 neuroinflammation 63 p# activation 63 Ets2 63 DNA demethylation 63 MAP kinase pathway 63 beta1 integrin 63 tumor suppressor protein 63 neuromuscular junction 63 Foxp3 63 transcriptional activity 63 locus coeruleus 63 Genetic predisposition 63 proteolysis 63 Cyclin D1 63 lysosomal 63 motor neuron degeneration 63 Hfq 63 myopathies 63 LRP5 63 chromosomal instability 63 neural crest 63 de novo mutations 63 leukocyte recruitment 63 underlying pathophysiology 63 pRb 63 cardiac fibrosis 63 NKT cell 63 PPARγ 63 MAPK pathway 63 caspase activation 63 nucleoli 63 Wnt proteins 63 disregulation 63 Hh pathway 63 chromosomal rearrangement 62 mutated protein 62 HSF1 62 autosomal dominant disorder 62 neuronal apoptosis 62 uPAR 62 nitric oxide synthase 62 Id1 62 aldose reductase 62 interleukin 1beta 62 chromosome condensation 62 epithelial barrier 62 dystrophin protein 62 IKK2 62 β catenin 62 GABAergic 62 lipid homeostasis 62 excitotoxicity 62 sortilin 62 epigenetic modification 62 Hedgehog signaling 62 cholesterol homeostasis 62 FOXM1 62 nerve degeneration 62 PGC 1α 62 amyloid deposition 62 PTEN protein 62 monogenic 62 epigenetic mechanisms 62 mucosal immune responses 62 posttranslational modification 62 SCN9A 62 Rap1 62 Wnts 62 metabolic enzymes 62 protein encoded 62 cholesterol metabolism 62 osteogenic differentiation 62 cytokine signaling 62 progranulin gene 62 dopamine signaling 62 HIF 1α 62 neuronal synapses 62 ubiquitylation 62 intracellular signal transduction 62 synapse formation 62 glutamate signaling 62 autophagic 62 matriptase 62 Dystrophin 62 p# MAPK 62 neuron degeneration 62 NF KappaB 62 Wnt signaling 62 excess glutamate 62 PTPN# 62 fatty acid synthesis 62 amyloid β 62 C EBP alpha 62 mitochondrial enzyme 62 tumor suppressor p# 62 missense mutation 62 insulin signaling pathway 62 pleiotropic effects 62 protein conformation 62 ouabain 62 COL#A# 62 NEIL1 62 Clusterin 62 FOXO 62 CaMKII 62 IRS1 62 calcineurin 62 TFIIH 62 tyrosine phosphorylation 62 HMGCR 62 lung epithelium 62 TGFß 62 dendritic spine 62 brain neurotransmitter 62 upregulating 62 downstream effectors 61 proteinases 61 transcriptional regulation 61 Helicobacter 61 Oxidative stress 61 steroidogenic 61 COX enzymes 61 connexin 61 nephron 61 hormone secretion 61 ERK1 2 61 amyloid cascade 61 HER2 neu 61 SIRT1 gene 61 deacetylation 61 lymphatic vasculature 61 phenotypic expression 61 TGF ß 61 DNMT1 61 SIRT6 61 alpha synuclein gene 61 DGAT1 61 modulatory 61 proto oncogene 61 JAK STAT 61 NF KB 61 GAB2 61 BCL#A 61 SH2 B 61 airway remodeling 61 GABAA receptors 61 SIRT1 protein 61 NOTCH1 61 IDH mutations 61 ectopic expression 61 IL 1β 61 Six3 61 downregulates 61 potent inducer 61 transthyretin 61 dopaminergic cells 61 proinflammatory 61 cAMP signaling 61 histone modification 61 calpain 61 SIRT3 61 RCAN1 61 adipocyte 61 NFkB 61 downregulate 61 ADAMTS# 61 somatic mutation 61 SMAD4 61 lipid synthesis 61 intestinal epithelium 61 fibrogenesis 61 neurotransmitter receptor 61 CPEB 61 myelin insulation 61 pituitary hormone 61 transmembrane receptor 61 CFTR gene 61 retinoblastoma Rb 61 protein kinase C 61 NF kappaB activation 61 cyclic nucleotide 61 biochemical abnormalities 61 SCD1 61 FANCD2 61 genetic polymorphism 61 EphB2 61 biogenesis 61 Sox9 61 BMP signaling 61 gonadotrophin releasing hormone 61 receptor gamma 61 carbohydrate metabolism 61 cystic fibrosis transmembrane 61 Kv#.# 61 nodulation 61 aberrant activation 61 Wnt1 61 abnormal angiogenesis 61 cyclin B1 61 insulin receptors 61 catenin 61 prefrontal cortical 61 Sonic hedgehog 61 CaM kinase II 61 mice lacking 61 TSLP 61 dysregulated 61 HPA axis 61 H#K# methylation 61 MC4R gene 61 HDAC2 61 granulosa cell 61 misfolding 61 Rb#/p# 61 NKX#.# 61 humoral immunity 61 γ secretase 61 HIF1 alpha 61 sphingolipid 61 thyrotropin 61 PTEN gene 61 epigenetic silencing 61 neurofibromin 61 telomere maintenance 61 MAP kinases 61 selective inhibition 61 GATA3 61 epithelial stem cells 61 SOD2 61 NFAT 61 Chronic inflammation 61 Shp2 61 micro RNAs 60 GABAergic interneurons 60 Pdx1 60 constitutively expressed 60 endoplasmic reticulum stress 60 synaptic function 60 biochemical imbalances 60 digesting enzymes 60 polyglutamine diseases 60 beta adrenergic receptors 60 HIV reverse transcriptase 60 PTHrP 60 hypocretin neurons 60 prostaglandin E2 60 habenula 60 IRE1 60 DNA hypomethylation 60 intimal hyperplasia 60 isoenzymes 60 TGF beta signaling 60 JNK1 60 Runx1 60 myelination 60 P cadherin 60 fatty acid oxidation 60 anaphase promoting complex 60 alkalosis 60 huntingtin gene 60 CYP #A# 60 proapoptotic 60 neurotrophic 60 collagen VI 60 predisposing factor 60 Fas ligand 60 encodes protein 60 STAT3 signaling 60 epigenetic changes 60 hypothalamic pituitary 60 neurotransmitter glutamate 60 oncogenic transformation 60 metabolic abnormality 60 APOBEC3G 60 frataxin gene 60 Genetic mutation 60 cardiolipin 60 HDAC3 60 alternative splicing 60 IFN γ 60 Dysregulation 60 epigenetic inheritance 60 efferent 60 mTORC1 60 MT1 MMP 60 toxic beta amyloid 60 gastric distention 60 Angiotensin II 60 MIF gene 60 leptin resistance 60 protein p# 60 neuronal receptors 60 hepatic lipase 60 TGF b 60 SMN1 60 XBP1 60 Cx# [001] 60 Angiotensin converting enzyme 60 DLX5 60 mRNA decay 60 tumor metastasis 60 huntingtin protein 60 Leydig cell 60 IRF6 60 IGFBP2 60 glucocorticoid receptors 60 meningeal 60 mitochondrial mutations 60 Vangl2 60 functional polymorphism 60 Frontal lobe 60 Dpp 60 mRNA degradation 60 leptin receptor 60 mitogen activated protein kinases 60 Oxidative damage 60 beta amyloid peptide 60 BubR1 60 neuro degeneration 60 neural pathway 60 antibody mediated 60 μ opioid receptor 60 synapse maturation 60 keratinocyte 60 peroxisomal 60 gliosis 60 Cystic Fibrosis Transmembrane conductance 60 leptin deficiency 60 CDK5 60 cardiac hypertrophy 60 erythropoiesis 60 p#Kip# 60 huntingtin 60 PB1 F2 60 upregulation 60 Arp2 3 60 RIP1 60 transcriptional repression 60 EGFR signaling 60 ERK pathway 60 chitinase 60 neuronal migration 60 H#Y 60 cypin 60 androgen receptor AR 60 galanin 60 prostate carcinogenesis 60 secretory pathway 60 endocannabinoid signaling 60 N Myc 60 sensory neuron 60 Th2 immune 60 growth hormone secretion 60 globin 60 neuronal plasticity 60 HGPS 60 proline rich 60 ERK2 60 E#F# 60 transgene expression 60 TGF ß1 60 tropomyosin 60 TRPV4 60 Vpr 60 Sonic Hedgehog 60 leukocyte adhesion 60 epigenetically 60 fibrotic disease 60 hypothalamus pituitary 60 adrenocortical 60 NF kappaB 60 protein acetylation 60 Nf1 60 primary cilia 60 Upregulation 60 multisystem disorder 60 RAS RAF MEK 60 mevalonate 60 malignant phenotype 60 biochemical cascade 60 adult neurogenesis 60 microdeletion 60 neuroendocrine 60 Genetic variants 60 MMP9 60 fatty acid synthase 60 heme oxygenase 1 60 Hsp# [001] 60 innate immune responses 60 penile erection 60 mPGES 1 60 demethylation 60 mitochondrial dysfunction 60 V2 receptor 59 apoptosis induced 59 muscular dystrophies 59 spongiform encephalopathies 59 cathepsins 59 progranulin 59 proinflammatory cytokines 59 c myc 59 PGC 1a 59 proteosome 59 axon guidance 59 neuronal cell 59 Androgen receptor 59 GATA4 59 overactivity 59 hippocampal function 59 GLI1 59 lung epithelial cells 59 cyclins 59 NFKBIA 59 neurotransmission 59 Myostatin 59 LMNA 59 JAK STAT signaling 59 HBx 59 beta arrestin 59 Lyn kinase 59 hypocretin 59 toxic amyloid beta 59 cathelicidin 59 adrenal cortex 59 anergy 59 EBNA1 59 p# pathway 59 glutamatergic 59 RNA splicing 59 excitatory neurotransmitter 59 actin dynamics 59 endocrine dysfunction 59 phosphatases 59 ERK signaling 59 caveolin 1 59 transcriptional repressors 59 neurodegenerative disorder 59 acetylcholine receptor 59 JAK2 enzyme 59 pancreatic endocrine 59 striatal neurons 59 TSC1 59 intracellular proteins 59 autocrine 59 GCN2 59 neuroinflammatory 59 adhesion proteins 59 TrkB 59 polyglutamine 59 Th2 59 neurofibrillary 59 homeostatic mechanism 59 ErbB4 59 lysosomal enzyme 59 apoE 59 Cryptococcus neoformans 59 ornithine decarboxylase 59 constitutively active 59 lipoprotein metabolism 59 NOD2 59 retinal ganglion cell 59 leaky gut 59 chimeric mice 59 LRP1 59 Treg cells 59 LMNA gene 59 glucokinase 59 metabolizing enzymes 59 protein tau 59 paxillin 59 PPARg 59 DUX4 59 intracellular signaling 59 FGF2 59 cyclic AMP cAMP 59 chondrocyte 59 myocyte 59 phosphorylates 59 c Myb 59 induced apoptosis 59 iNOS 59 chromosomal aberrations 59 Prolactin 59 histone deacetylases 59 Sertoli cell 59 AT1R 59 lymphangiogenesis 59 oxidases 59 CEACAM1 59 TGF beta pathway 59 NKG2D 59 fusiform 59 PEPCK 59 NFκB 59 mechanotransduction 59 AhR 59 c MYC 59 tryptase 59 genus Plasmodium 59 androgen signaling 59 oncogenesis 59 apoE4 59 inhibitory neurotransmitters 59 proteoglycan 59 mitochondrial proteins 59 cell adhesion molecules 59 antiapoptotic 59 hyperstimulation 59 S#K# 59 signaling cascades 59 mitogen activated protein kinase 59 FOXO3a 59 MeCP2 gene 59 progerin 59 HepG2 cells 59 shortened telomeres 59 mTOR pathway 59 eotaxin 59 coagulation cascade 59 cytoskeletal protein 59 γδ T cells 59 hyperalgesia 59 dominantly inherited 59 noncoding RNA 59 redox active 59 ovarian hormones 59 adrenal hormones 59 vitamin D receptors 59 metalloproteinases 59 Inappropriate activation 59 KCNE2 59 atherogenesis 59 bacterial virulence 59 lung fibrosis 59 enzymatic activity 59 TTR gene 59 eicosanoid 59 TGF β 59 cellular senescence 59 cortical excitability 59 beta globin 59 regulating gene expression 59 muscarinic receptors 59 neuronal signaling 59 alveolar macrophages 59 activin 59 S nitrosylation 59 VSMC 59 CHD5 59 kalirin 59 gene p# 59 4E BP1 59 Ashwell receptor 59 genes encode proteins 59 serotonin signaling 59 inflammatory cytokine 59 HMGA2 59 mitochondrial metabolism 59 dystroglycan 59 metabolize cholesterol 59 TGF beta1 59 Zinc deficiency 59 promoter hypermethylation 59 MC4R 59 sRNA 59 PIP2 59 tumorigenesis 59 Acetylcholine 59 SUMOylation 59 Rho GTPases 59 photoreceptor cell 59 SMN2 59 GABAergic neurons 59 intracellular bacteria 59 casein kinase 59 ankyrin B 59 multiply uncontrollably 59 incompletely understood 59 hyperinsulinemia 59 cAMP pathway 59 allergic inflammation 59 PrP 59 cyclooxygenase 2 59 neuritic plaques 59 palmitoylation 59 fatty acid metabolism 59 Aβ peptide 59 sequence homology 59 oligomerization 59 NKX2 59 COX2 59 coiled coil domain 59 guanine nucleotide exchange 59 endogenous opioid 58 mosaicism 58 ryanodine receptor 58 STAT4 58 calcium homeostasis 58 fibril formation 58 exocrine glands 58 proinflammatory cytokine 58 Amino acid 58 PDGFR 58 DICER1 58 osmotic stress 58 adrenal hormone 58 selenoproteins 58 Hypothalamic 58 Neurofibromatosis type 58 NK1R 58 Prox1 58 Kufs disease 58 myofibroblasts 58 FOXP3 58 IRAK1 58 serine threonine kinase 58 DISC1 58 Genetic variations 58 dephosphorylation 58 coexpression 58 telomere dysfunction 58 Brain derived neurotrophic 58 cells secrete 58 pathophysiological mechanisms 58 STAT1 58 KLF# 58 cyclooxygenase COX 58 adipokines 58 demyelination 58 DNA methylation patterns 58 caveolin 58 cholinergic neurons 58 transcriptional regulator 58 endothelial nitric oxide 58 DUX4 gene 58 HbF 58 fibrillin 1 58 cytochrome c 58 MTHFR 58 nociception 58 vasodilatation 58 MMP# 58 prothrombotic 58 Pax6 58 hypoxia inducible transcription 58 neurosteroid 58 genetic alteration 58 TXNIP 58 TMEM#B 58 dyskeratosis congenita 58 LXRs 58 activate p# 58 Hh signaling 58 metabolic dysfunction 58 dystrophin gene 58 corpus luteum 58 cellular prion protein 58 PINK1 58 impair fertility 58 neuro endocrine 58 KATP channel 58 pleiotropy 58 ADAM# 58 gene encodes 58 MMP2 58 vacuolar 58 oncomodulin 58 upregulate 58 tubule 58 prion infection 58 polycystin 58 protein CETP 58 cytoskeletal 58 PKC alpha 58 paralogs 58 MECP2 58 BMAL1 58 genomic imprinting 58 cellular pathways 58 Sir2 58 CNTNAP2 gene 58 fusogen 58 Diabetic neuropathy 58 intracellularly 58 hyperinsulinism 58 TRPV1 receptors 58 PECAM 1 58 adaptive immunity 58 ACh 58 reductase 58 macrophage migration 58 apoptotic cell 58 microglial 58 cell motility 58 Overexpression 58 Phosphorylation 58 amino acid tyrosine 58 UCP1 58 NF kB signaling 58 intercellular communication 58 Notch1 58 eNOS 58 exocrine 58 RKIP 58 receptor kinase 58 neural degeneration 58 FGFR3 58 Nup# 58 amyloid ß 58 PGC1 58 osteocalcin protein 58 BMP4 58 actin cytoskeleton 58 pharmacological inhibition 58 PAK1 58 CYP#D# gene 58 cyclase 58 synaptic transmission 58 beta adrenergic receptor 58 nonhereditary 58 cholesterol biosynthesis 58 autoregulation 58 resolvin E1 58 tumor suppressor gene 58 Sgk1 58 PTP1B 58 microglial activation 58 haematopoietic 58 glycolipids 58 paracrine 58 previously uncharacterized 58 Prefrontal 58 LPS induced 58 spontaneous mutation 58 phospholipid membranes 58 hedgehog signaling 58 protein tyrosine phosphatase 58 adipogenesis 58 mitogenic 58 nonvascular 58 neuronal stem cells 58 immune dysregulation 58 pathological hallmark 58 histone deacetylation 58 pre mRNA splicing 58 aP2 58 GSK 3ß 58 tau protein 58 cytochrome c oxidase 58 misregulated 58 KLF4 58 replicase 58 VEGF expression 58 dysgenesis 58 elastic fibers 58 fibrin deposition 58 homocystinuria 58 embryonic tissues 58 glomerular 58 LDL receptor 58 mutant proteins 58 HIF 1alpha 58 dopaminergic neurons 58 interferon pathway 58 globin genes 58 mTOR signaling pathway 58 microRNAs miRNAs 58 promyelocytic leukemia 58 mucosal immune 58 potent inhibition 58 glial derived neurotrophic 58 degrading enzyme 58 TCF4 58 receptor tyrosine kinase 58 GPC5 58 isoenzyme 58 FOXO1a 58 outer membrane proteins 58 pathophysiological 58 neurons degenerate 58 misfolded protein 58 clefting 58 metabolizing enzyme 58 epigenetic markers 58 superantigens 58 FoxO1 58 NFkappaB 58 morphogen 58 estrogen receptor alpha 58 underlying vasculopathy 58 recessive trait 58 Dicer enzyme 58 nitric oxide synthase NOS 58 PON1 58 NF κB 58 oncogenic signaling 58 plasma kallikrein 58 cell adhesion molecule 58 potent stimulator 58 ErbB receptors 58 transactivation 58 mtDNA mutations 58 microglial cells 58 liver scarring 58 EP3 receptor 58 plasminogen 58 fatty acid biosynthesis 58 BDNF gene 58 FGF# 58 p# mutations 58 NF κB activation 58 microvessel 58 chaperone proteins 58 amyloid peptide 58 chromatin remodeling 58 inhibiting COX 58 lipogenesis 58 Cdx2 58 BRAF protein 58 overexpressing 58 pathogenic mechanisms 58 molecular mimicry 58 amyloid plaque formation 58 filaggrin gene 58 mineralocorticoid 58 Skeletal muscle 58 Flt3 58 renal tubules 58 SMN protein 58 glycogen metabolism 58 phosphoinositide 58 molecular determinants 58 amyloid protein plaques 58 pathological hallmarks 58 glucagon secretion 58 dysfunctioning 58 monocyte 58 ARNT 58 acetylation 58 serotonin transporter 58 branching morphogenesis 58 cohesin 58 JAK STAT pathway 58 UCP2 58 FMRP 58 Mdm2 58 receptor signaling 58 HFE gene 58 Keap1 58 mitogen 58 p#NTR 58 PDGFR alpha 58 effector molecules 58 striated muscle 58 P#X# receptor 58 gamma oscillations 58 brain hypothalamus 58 multifactorial disease 58 pro inflammatory cytokines 58 stathmin 58 synaptic dysfunction 58 secretase 58 SOCS1 58 lymphoid cells 58 hormone aldosterone 57 Aâ 57 HIF 1a 57 resistin 57 microRNA molecules 57 oxidized lipids 57 VE cadherin 57 regulate gene expression 57 SOD1 protein 57 obligate intracellular 57 PDGF CC 57 FMR1 gene 57 granzyme B 57 prion proteins 57 NQO1 57 acyl CoA 57 GluR1 57 rRNA 57 E3 ubiquitin ligase 57 underlying molecular mechanisms 57 oxidant stress 57 intracellular protein 57 multigenic 57 apoptotic pathway 57 telomere DNA 57 T lymphocyte 57 mitochondrial oxidative phosphorylation 57 mitochondrial membrane 57 lamin 57 tau pathology 57 transgenic mice expressing 57 PU.1 57 globin gene 57 TGFBR1 57 Mitochondrial dysfunction 57 adipose cells 57 suppressor gene 57 neurodegeneration 57 dopaminergic neuron 57 NF kB pathway 57 C. pneumoniae 57 missense mutations 57 CPT1c 57 SLC#A# [002] 57 transferase 57 torsade de pointes 57 menin 57 lymphoid organs 57 Jagged1 57 retinoblastoma protein 57 kidney tubules 57 MSH2