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(Click for frequent words.) 76 pathophysiologic 72 pathogenic mechanisms 71 aetiological 71 etiologic 70 underlying pathophysiology 70 transcriptional regulation 70 pathogenetic 70 etiological 70 renal fibrosis 69 aetiology 69 pathophysiological mechanisms 69 airway remodeling 69 neuroanatomical 69 neuronal dysfunction 69 underlying molecular mechanisms 69 pathophysiology 68 pathogenesis 68 endophenotypes 68 atherogenesis 68 paraneoplastic 68 oncogenesis 67 synaptogenesis 67 Smad3 67 amyloid cascade 67 alexithymia 67 neuroendocrine 67 hypothalamic pituitary 67 proteoglycan 67 prostate carcinogenesis 67 molecular mechanisms underlying 67 neuropathologic 67 clinicopathological 67 hypothalamic pituitary adrenal axis 67 neurotrophic 67 genetic loci 67 nongenetic 67 neuroinflammation 67 biochemical abnormalities 67 lymphocyte activation 66 genetic polymorphisms 66 genetic polymorphism 66 tyrosine phosphorylation 66 metabolic dysfunction 66 psychobiological 66 cAMP signaling 66 cardiac fibrosis 66 neuropsychiatric disorders 66 intestinal microflora 66 lipid metabolism 66 physiologic 66 Dysregulation 66 protein conformation 66 Genetic predisposition 66 motor neuron degeneration 66 DNA demethylation 66 neurite outgrowth 66 plasma lipid 66 modulatory 66 FGFs 66 prognostic significance 66 neurobiological 66 HPA axis 66 fibrotic disease 66 immunomodulation 66 mitochondrial dysfunction 66 pathophysiologic mechanism 66 airway hyperresponsiveness 66 podocyte 66 neurohormonal 66 epigenetic alterations 66 gene polymorphisms 66 glutamatergic 66 intracellular signal transduction 66 autophagic 66 endocannabinoid signaling 66 PTPN# 66 epigenetic regulation 66 cholesterol metabolism 66 dysregulation 66 neuronal differentiation 65 Clusterin 65 overactivation 65 immunoregulatory 65 lipoprotein metabolism 65 mediated inhibition 65 TNFalpha 65 monogenic 65 Leydig cell 65 endothelial activation 65 pathophysiologic mechanisms 65 physiological mechanisms 65 evolutionarily conserved 65 haematopoietic 65 biologic pathways 65 biochemical mechanisms 65 APOE genotype 65 metabolic enzymes 65 physiologic mechanisms 65 Genetic variation 65 proinflammatory 65 neuroactive 65 intestinal epithelium 65 adult neurogenesis 65 epistasis 65 missense mutations 65 myocyte 65 mechanistic explanation 65 chronicity 65 colorectal carcinogenesis 64 glomerular 64 neuropathological 64 phenotypic expression 64 p# activation 64 neoplastic 64 p# MAPK 64 phenotypes 64 retinoid X 64 pleiotropic effects 64 Oxidative damage 64 miRNA expression 64 neuronal plasticity 64 arrhythmogenic 64 signaling cascades 64 IL 1ß 64 mtDNA mutations 64 carbohydrate metabolism 64 Oxidative stress 64 tumorigenicity 64 hematopoiesis 64 ERK signaling 64 innate immune 64 phospholipid membranes 64 multifactorial 64 kinase inhibition 64 germline mutations 64 CHD7 64 glucose homeostasis 64 xenobiotic 64 Sgk1 64 vascular dysfunction 64 hyperinsulinemia 64 focal adhesions 64 potentially modifiable 64 myopathies 64 PTH secretion 64 Genetic variants 64 selective inhibition 64 γ secretase 64 eotaxin 64 ADAMTS# 64 COX2 64 excitotoxic 64 ectopic expression 64 organogenesis 64 TGF ß 64 lymphangiogenesis 64 oligomerization 63 humoral immunity 63 neurophysiological 63 Hypothalamic 63 amyloid formation 63 mucosal immune 63 GRP# 63 antibody mediated 63 dysregulated 63 AT1R 63 physiological 63 oligomeric 63 TXNIP 63 intracellular signaling 63 predisposing factor 63 sequence homology 63 DNA methylation patterns 63 steroidogenic 63 heterologous expression 63 CEACAM1 63 epigenetic mechanisms 63 HSF1 63 NKG2D 63 multigenic 63 epithelial barrier 63 TGF β 63 SSc 63 granulomatous 63 neuronal signaling 63 underlying vasculopathy 63 Fas ligand 63 anti fibrotic 63 intracellular bacteria 63 pleiotropic 63 metabolic alterations 63 neuronal degeneration 63 histone modifications 63 malignant transformation 63 podocytes 63 eNOS 63 IL6 63 microdeletion 63 axonal degeneration 63 dopaminergic 63 pharmacologic intervention 63 bone metabolism 63 tumor microenvironment 63 telomere dysfunction 63 neurogenic 63 MAPK pathway 63 systemic inflammation 63 receptor subtypes 63 biogenesis 63 NOD2 63 beta1 integrin 63 upregulates 63 posttranslational modification 63 etiology 63 muscarinic receptors 63 BMP signaling 63 hypothalamic 63 immune dysregulation 63 CagA 63 homodimers 63 PPARγ 63 mutant huntingtin protein 63 glycosyltransferase 63 immunological mechanisms 63 neuropsychiatric diseases 63 epithelia 63 IL 1β 63 pleiotropy 63 de novo mutations 62 neuro endocrine 62 neurobiological mechanisms 62 hypoxia inducible 62 calcium homeostasis 62 Htt 62 LPS induced 62 microglial 62 nitric oxide synthase 62 pharmacodynamic biomarkers 62 synaptic transmission 62 mimetics 62 chromosomal instability 62 astrocytic 62 TRPV4 62 behavioral disinhibition 62 innate immune responses 62 oncogenic transformation 62 apoE 62 plasma lipids 62 neuroinflammatory 62 primary cilia 62 antiapoptotic 62 neural crest 62 cardiogenic 62 natriuretic 62 Six3 62 myeloproliferative diseases 62 gastric carcinoma 62 immunomodulatory effects 62 cardiac myocytes 62 ontogeny 62 serine protease 62 calcineurin 62 phosphatases 62 secretory pathway 62 disregulation 62 NKT cell 62 cytokine signaling 62 cardiolipin 62 protein tyrosine phosphatase 62 MECP2 gene 62 Sjögren syndrome 62 neovascularization 62 immunologic 62 aberrant activation 62 drug metabolizing enzymes 62 PPAR γ 62 extramedullary 62 erythropoiesis 62 prothrombotic 62 c myc gene 62 tissue fibrosis 62 caveolin 62 IFN γ 62 KLF4 62 GABAA receptors 62 neurochemistry 62 gene locus 62 chromosomal rearrangement 62 Treg cell 62 thyroid dysfunction 62 phenotypic variation 62 cytoprotective 62 hyperactivation 62 SLC#A# [002] 62 insulin signaling pathways 62 cathepsins 62 etiologic factors 62 Skeletal muscle 62 ADAM# 62 baroreflex 62 gut microbiota 62 immunological 62 Cyclin E 62 GABAergic 62 epigenetic changes 62 molecular mimicry 62 genomic instability 62 hypometabolism 62 CD1d 62 catenin 62 prostate cancer CaP 62 allergic inflammation 62 virulence genes 62 synaptic function 62 causal pathway 62 TMEM#B 62 carcinogenesis 62 Cognitive impairment 62 sphingolipid 62 posttranslational modifications 62 Notch signaling 62 differential gene expression 62 DLC1 62 leaky gut 62 HGPS 62 ligand induced 62 substrate specificity 62 2A receptor 62 hypogonadotropic hypogonadism 62 ERK1 2 62 chromosome condensation 62 Brain derived neurotrophic 62 WNK1 62 Nod1 62 adipogenic 62 chromatin remodeling 62 downregulation 62 tumorigenesis 62 membrane fusion 62 coagulation cascade 62 metabolomic profiles 62 lysosomal 61 vasodilatory 61 ultrastructure 61 serotonergic 61 beta globin gene 61 interleukins 61 cell signaling pathways 61 PON1 61 cardiometabolic syndrome 61 myeloproliferative 61 eicosanoids 61 cellular pathways 61 LRP5 61 clinicopathologic 61 familial clustering 61 somatostatin 61 epigenetic modification 61 CTGF 61 protein misfolding 61 C1q 61 acetylcholine receptor 61 microvascular dysfunction 61 noradrenergic 61 lung epithelium 61 glutamate receptors 61 neuroimaging studies 61 demyelinating 61 P cadherin 61 hippocampal function 61 subclinical atherosclerosis 61 Endothelial dysfunction 61 morphogenetic 61 excitotoxicity 61 catabolism 61 pro angiogenic 61 Alzheimer pathology 61 murine model 61 clonal expansion 61 folate metabolism 61 JNK1 61 Cdc7 61 TGF b 61 CYP#C# gene 61 enzymatic pathways 61 neurocognitive deficits 61 genetic heterogeneity 61 thrombophilia 61 ESR1 61 cholinergic 61 isoenzymes 61 morphologic 61 proapoptotic 61 retinal ganglion cell 61 histone methylation 61 Rab5 61 nosology 61 osteogenic differentiation 61 neuritic 61 catecholamine 61 histopathological 61 ACh 61 gastric mucosa 61 CaM kinase II 61 Prox1 61 LIS1 61 autoregulation 61 CNTNAP2 61 adipocyte 61 protein tyrosine kinase 61 FGF2 61 activin 61 bacterial virulence 61 demyelination 61 allelic variation 61 mechanistically 61 mitochondrial metabolism 61 biopsychosocial 61 circadian clock genes 61 lipid homeostasis 61 P#X# receptor 61 Wnt signaling pathway 61 cell adhesion molecules 61 plasma kallikrein 61 antiphospholipid antibodies 61 effector function 61 metabolic abnormalities 61 proinflammatory cytokine 61 Amino acid 61 epigenetic modifications 61 IL 1beta 61 TGFß 61 PARP inhibition 61 Genetic variations 61 tumor suppressor protein 61 ERK pathway 61 MGUS 61 NMDAR 61 neurobiological basis 61 Angiotensin II 61 melatonin receptor 61 demyelinating diseases 61 intercellular communication 61 transgenic mouse model 61 RAS RAF MEK 61 SMAD4 61 GABAergic interneurons 61 adipokines 61 mineralocorticoid 61 VIPR2 61 glycogen metabolism 61 estrogen metabolism 61 hormone aldosterone 61 isotypes 61 cellular metabolism 61 vaso occlusive crisis 61 nicotinic receptor 61 TRPV1 receptors 61 Fc receptor 61 differentially regulated 61 leukocyte recruitment 61 physico chemical properties 61 antitumor efficacy 61 ENaC 61 eicosanoid 61 vascularisation 61 GABAB receptors 61 colon carcinogenesis 61 tumor hypoxia 61 alkalosis 61 lung fibrosis 61 circadian genes 61 hsp# 61 muscular dystrophies 61 Symadex 61 mitochondrial enzyme 61 neurosteroids 61 GPx 61 phenotypic 61 endotoxemia 61 thyrotropin 61 p#/CBP 61 potent inhibitors 61 β amyloid 61 humoral 61 amyloid deposition 61 maturational 61 cerebral ischemia 61 comorbid disorders 61 proteolysis 61 autosomal dominant disorder 61 Notch1 61 telomere maintenance 61 osmotic stress 61 intestinal microbiota 61 neuro degeneration 61 causative genes 61 Neurodegenerative diseases 61 molecular biomarkers 61 polygenic 61 axon guidance 61 Thyroid hormone 61 phenotype 61 prognostic markers 61 physicochemical 61 neuronal function 61 multigene 61 PDGFR 61 STAT4 61 biofilm formation 61 Bardet Biedl Syndrome 61 cognitive affective 61 intercellular signaling 61 inflammatory cytokine 61 radiographic findings 61 androgen deficiency 61 intestinal motility 61 metaplasia 61 transgene expression 61 endocannabinoid system 61 transgenic mouse models 61 mechanistic insights 61 FGFR3 61 fatty acid oxidation 61 miR #a [001] 61 neurobiological underpinnings 61 vasomotor 61 pituitary hormone 61 PB1 F2 61 mitochondrial toxicity 61 druggable target 61 Proteostasis Network 61 melanocortin receptors 60 Kv#.# 60 CYP #A# 60 GPR# [002] 60 mitogen activated protein kinase 60 chromatin structure 60 dystroglycan 60 transgenic mice expressing 60 pharmacological interventions 60 platelet activation 60 hyperalgesia 60 ultrastructural 60 S#A# [002] 60 neurodegeneration 60 galectin 60 bile acid metabolism 60 mechanotransduction 60 ovarian hormones 60 stochastic resonance 60 peroxisome 60 apoptosis pathway 60 H#K#me# 60 molecular mechanisms 60 antiangiogenic 60 Neuronal 60 redox reactions 60 mRNA expression 60 Chlamydia pneumoniae 60 protein misfolding diseases 60 familial aggregation 60 HbF 60 VE cadherin 60 Neuroprotective 60 IL#R 60 histone acetylation 60 fatty acid synthase 60 plasma lipoprotein 60 choroidal neovascularization 60 metabolic disturbances 60 paracrine 60 cardioprotection 60 enzyme cofactor 60 pathogenetic mechanisms 60 nAChR 60 LVNC 60 costimulatory 60 subcellular compartments 60 molecular underpinnings 60 inactivating mutations 60 oxidases 60 dietary interventions 60 serotonin receptor 60 RIP1 60 Pim kinases 60 mesenchymal transition 60 ABL1 60 phosphate S1P 60 kinase domain 60 downstream effector 60 mechanistic studies 60 NF kappaB pathway 60 LPA1 receptor 60 Wnt beta catenin 60 physico chemical 60 pathophysiological processes 60 TCF#L# 60 COX enzymes 60 nucleolar 60 molecular pathways 60 non coding RNA 60 exocrine 60 biologic plausibility 60 Aβ 60 cofactors 60 neuroligins 60 cardioprotective effects 60 ERK1 60 hemolytic 60 acinar cells 60 subcellular localization 60 nephron 60 protein kinase C 60 microRNA expression 60 ontogenetic 60 DARPP 60 mGluR5 inhibition 60 MAPKs 60 Vascular endothelial growth 60 synovial cells 60 glucocorticoid receptors 60 pDCs 60 palytoxin 60 microstructural 60 inflammasome 60 biologies 60 chromosome #p#.# 60 adrenal cortex 60 unmeasured confounders 60 c MET 60 androgen receptor AR 60 molecular mechanism 60 neoplastic transformation 60 EBV infection 60 fibrotic 60 impaired cognition 60 synuclein 60 CB2 receptor 60 synovial tissue 60 glucocorticoid hormones 60 CDK inhibitor 60 myofibroblast 60 Zollinger Ellison Syndrome 60 ABCA1 60 adenosine receptors 60 myocardial fibrosis 60 cardiac biomarkers 60 N glycan 60 neuro protective 60 proteinases 60 Pseudomonas aeruginosa infections 60 alpha7 NNR 60 RUNX3 60 matrix metalloproteinases 60 autonomic dysfunction 60 cardiac hypertrophy 60 Alternative splicing 60 tryptase 60 HCV replication 60 mitochondrial oxidative 60 coexpression 60 miRs 60 endogenous opioid 60 gliosis 60 catabolic 60 Hedgehog signaling 60 tau phosphorylation 60 ABCB1 60 estrogen receptor beta 60 constitutively expressed 60 apoptotic pathway 60 phenotypic variability 60 act synergistically 60 metabolic acidosis 60 cell adhesion molecule 60 FOXO3a 60 renal tubular 60 conformational changes 60 multidrug resistance 60 natriuretic peptides 60 polycystin 1 60 symptomatology 60 mesenchymal cell 60 TGF beta signaling 60 metabolic abnormality 60 pRb 60 mRNA decay 60 microcephalin 60 coagulopathy 60 TNF α 60 E#F# 60 Alzheimer disease pathogenesis 60 upregulating 60 laterality 60 sortilin 60 myogenesis 60 PON1 gene 60 airway responsiveness 60 PKC inhibitors 60 PPARg 60 intestinal permeability 60 amino acid substitutions 60 AMPA receptor 60 vascular endothelial 60 BMAL1 60 obesity insulin resistance 60 myocardial ischaemia 60 oocyte maturation 60 splice variants 60 vimentin 60 deacetylation 60 telomerase activation 60 immunopathology 60 Wnts 60 p#INK#a 60 intestinal mucosa 60 methylation patterns 60 peroxynitrite 60 gastric carcinogenesis 60 transcriptional activation 60 ERK2 60 striatal dopamine 60 IntroductionThe 60 epigenetic markers 60 molecular abnormalities 60 prolyl 60 IFRD1 60 #ß 60 functional gastrointestinal disorders 60 gene loci 60 osteoblast 60 cellular prion protein 60 spermidine 60 Prognostic factors 60 DNA hypermethylation 60 miR# 60 activate p# 60 prostaglandin synthesis 60 inverse agonist 60 SCD1 60 heritable disorders 60 chromosomal translocations 60 Cytotoxic T 60 arterial calcification 60 prognostic indicators 60 protein biosynthesis 59 mTOR signaling 59 cellular senescence 59 hypothalamic pituitary adrenal HPA 59 cholesterol homeostasis 59 myeloproliferative disorders 59 adrenocortical 59 leptin signaling 59 neurexins 59 Dopaminergic 59 TSLP 59 neurochemical 59 glucocorticoid receptor 59 gastrointestinal dysfunction 59 functional polymorphism 59 cell adhesion 59 Th2 responses 59 neuromuscular junction 59 proteasome inhibition 59 genotype phenotype 59 STAT3 signaling 59 HMG CoA reductase 59 hypoperfusion 59 bone marrow mesenchymal stem 59 periodontal tissues 59 mesenchymal stromal cells 59 protein tyrosine phosphatases 59 microbiota 59 proteolytic 59 autoantigen 59 nitrotyrosine 59 progressive neurodegenerative disorder 59 Helicobacter 59 hamartomas 59 Hh pathway 59 potent inhibition 59 glutamate signaling 59 morphological 59 pathologic 59 cypin 59 mediated apoptosis 59 mucosal immunity 59 #q#.# [002] 59 Androgen receptor 59 perilipin 59 genetic determinants 59 glycosylation 59 causal pathways 59 inflammatory demyelinating 59 HBx 59 FGFR2 59 galectins 59 amyloidogenic 59 emotional dysregulation 59 hypocretin neurons 59 renin angiotensin aldosterone 59 MMPs 59 gene rearrangements 59 hormone secretion 59 EGFR inhibition 59 chromatin modifications 59 peroxidation 59 CK2 59 TRPV3 59 histologic findings 59 autoimmunity 59 lymphocytic 59 hedgehog signaling 59 mitogenic 59 Vpr 59 erythropoietic 59 ADPKD 59 collagen degradation 59 cytoskeletal 59 V#F mutation 59 iNOS 59 Nedd4 59 oncogenic 59 S nitrosylation 59 vascular cognitive impairment 59 histone deacetylases 59 5 HT1A 59 transcriptional regulator 59 interferon γ 59 glycolipids 59 FoxO1 59 kinase pathway 59 IGFBP2 59 mitochondrial mutations 59 neutrophilic 59 beta amyloid peptides 59 metalloprotease 59 PI3K signaling 59 C. pneumoniae 59 β1 59 repolarization 59 immuno modulatory 59 anti atherogenic 59 neuroprotection 59 neural substrates 59 quasispecies 59 AhR 59 developmental neurotoxicity 59 glycosylated 59 telomere shortening 59 Lambris 59 upregulation 59 tRNA synthetases 59 biological pathways 59 microglial activation 59 fatty acid metabolism 59 chondrocyte 59 hepatic stellate cells 59 herpesviruses 59 tumor metastasis 59 neuropathology 59 murine models 59 autoantigens 59 axonal damage 59 Parkinsonian 59 hepatocyte 59 transcriptional repressor 59 MAP kinase pathway 59 intracellular signaling pathways 59 osteoclast activity 59 abscisic acid 59 ß1 59 induced neuronal 59 psychopharmacologic 59 glycan structures 59 Histone 59 inducible nitric oxide synthase 59 postsynaptic 59 tumoral 59 neuropsychiatric disorder 59 diathesis 59 receptor signaling 59 noncoding RNAs 59 TOP2A gene 59 FKBP# 59 HepG2 cells 59 MTHFR 59 G6PD deficiency 59 p#NTR 59 steroidogenesis 59 neuronal circuits 59 MAP kinase 59 prefrontal cortical 59 remyelination 59 TrkB 59 H#K# [002] 59 protein phosphorylation 59 thioredoxin 59 diabetes dyslipidemia 59 adaptive immunity 59 neurosensory 59 monoclonal gammopathy 59 metabolic 59 Fibroblast growth 59 JAK STAT pathway 59 lymphoid cells 59 CD# expression [001] 59 IL #p# 59 histocompatibility 59 hypothalamus pituitary 59 MT1 MMP 59 cyclin E 59 TGFβ 59 prefrontal regions 59 proteomic analysis 59 γδ T cells 59 Th2 immune 59 N Myc 59 channelopathies 59 synthases 59 ischemia reperfusion injury 59 serum PTH 59 epilepsies 59 premorbid 59 amyloid peptide 59 synapse formation 59 kallikrein 59 NADPH oxidase 59 PEDF 59 stem cell differentiation 59 prion strains 59 nephrogenic 59 fibrogenesis 59 downregulating 59 myofibroblasts 59 genomewide 59 p# mutations 59 anterior temporal lobe 59 Oncogenic 59 A3 adenosine receptor 59 CD#b 59 hyperexcitability 59 SOD2 59 beta adrenergic receptors 59 uPA 59 somatoform disorders 59 lymphatic vessel 59 autocrine 59 receptor kinase 59 dopamine signaling 59 microvascular endothelial cells 59 immunoregulation 59 Purkinje cell 59 developmental abnormalities 59 residual confounding 59 molecular determinants 59 NF kB signaling 59 kidney urologic 59 FGF signaling 59 dendritic spine 59 CCR2 59 FGFR1 59 engineered RAP peptides 59 vidofludimus 59 glial tumors 59 evolvability 59 antiproliferative effects 59 cis regulatory 59 IGF IR 59 Aldosterone 59 imatinib resistance 59 arachidonic acid AA 59 osteoblastic 59 glycolipid 59 mycobacterial 59 mirror neuron system 59 biologic pathway 59 resolvins 59 vasoactive 59 Hashimoto thyroiditis 59 fetal microchimerism 59 pDC 59 receptor inhibitor 59 gonadal hormones 59 dedifferentiation 59 thrombogenic 59 C5aR 59 BMP4 59 pharmacological therapies 59 neuroprotective effects 59 HBV genotypes 59 mTORC1 59 cerebellar 59 glucose transporter 59 PDE#A 59 apoE4 59 leukocyte adhesion 59 inflammatory cascade