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(Click for frequent words.) 69 cellular senescence 61 genomic instability 61 neurogenesis 60 telomere shortening 60 mitosis 60 malignant transformation 59 replicative senescence 59 tumorigenesis 59 apoptosis 59 transdifferentiation 58 senescent 58 myelination 58 synaptogenesis 58 Wnt signaling 58 TGF b 58 neural crest 58 NKT cell 58 senescent cells 57 Smad3 57 proteolysis 57 enzymatic activity 57 melanocyte 57 lysosomal 57 involution 57 Hedgehog signaling 56 synaptic plasticity 56 B lymphocytes 56 p# pathway 56 SIRT6 56 oxidative phosphorylation 56 microtubule dynamics 56 telomeres shorten 56 myofibroblast 56 p# activation 56 ubiquitylation 56 stem cell differentiation 56 neural cells 56 neuronal dysfunction 56 telomerase activity 56 ERK1 2 56 polyamines 55 autophagic 55 β catenin 55 telomere dysfunction 55 nerve degeneration 55 peroxisome 55 hair follicle stem cells 55 neurodegeneration 55 renal fibrosis 55 neuronal degeneration 55 mitotic 55 hepatocyte 55 epigenetic silencing 55 cell motility 55 nodulation 55 pRb 55 keratinocyte 55 focal adhesions 55 osteoclast activity 55 Oxidative stress 55 Notch signaling 55 FOXO1 55 chromosomal instability 55 motor neuron 55 phenotype 55 Klotho 55 phagocytosis 55 mTORC1 55 HGPS 55 dephosphorylation 54 Wnt1 54 excitotoxicity 54 spermatogenesis 54 hedgehog signaling 54 cellular metabolism 54 glycolysis 54 β cell 54 progerin 54 epigenetic alterations 54 C EBP alpha 54 dopamine signaling 54 abscission 54 protein misfolding 54 ERK activation 54 myofibroblasts 54 ectopic expression 54 neuronal differentiation 54 hyperactivation 54 keratinocytes 54 neuron degeneration 54 excitotoxic 54 replicative 54 transgene expression 54 suppressor gene 54 X inactivation 54 apoptotic 54 p# protein 54 mitochondrial respiration 54 mitochondrial mutations 54 acetylation 54 tumor suppressor protein 54 diapause 54 tumor suppressor p# 54 cytokinesis 54 Apoptosis 54 paracrine 54 tumor suppressor genes 54 ERK signaling 53 genotoxic stress 53 MAPK pathway 53 glutamate receptor 53 microglial cells 53 genetic alteration 53 sumoylation 53 synapse formation 53 LKB1 53 cholinergic neurons 53 DNA replication 53 neurite outgrowth 53 metaphase 53 gastrulation 53 menin 53 axonal 53 follicle stem cells 53 c Myc 53 epigenetic inheritance 53 caspase activation 53 Hsp# [001] 53 gene p# 53 angiogenesis 53 Pten 53 autophagy 53 Hh pathway 53 signaling cascades 53 NKT cells 53 telomerase enzyme 53 IL 1β 53 TAp# 53 SOD1 protein 53 cellular respiration 53 undergo apoptosis 53 meiotic 53 Skp2 53 microglial activation 53 catenin 53 melanocyte stem cells 53 CEACAM1 53 skeletal muscle cells 53 cAMP signaling 53 mesenchymal 53 TGF beta pathway 53 neuronal migration 53 leukaemic stem cells 53 neurite 53 neuronal plasticity 53 p# gene 53 oncogenic transformation 53 cyclins 53 Notch1 53 selenoproteins 53 myeloid cells 53 apoptotic cell 53 cyclin B1 53 cardiac myocytes 53 dedifferentiation 53 Cyclin D1 53 circadian clock genes 53 oligodendrocyte 52 SUMOylation 52 adult neurogenesis 52 anaphase 52 Lhx2 52 axonal regeneration 52 granule cells 52 glioma cells 52 neural crest cells 52 Vpr 52 mutant huntingtin protein 52 mammary cells 52 BMP signaling 52 ubiquitination 52 androgen receptor AR 52 antibody mediated 52 signaling pathway 52 inhibition 52 mRNA decay 52 thymocytes 52 astrocyte 52 telomere maintenance 52 NADPH oxidase 52 TSLP 52 induced neuronal 52 neovascularization 52 tyrosine phosphorylation 52 podocytes 52 lymphoid 52 TGFb 52 HSF1 52 abscission layer 52 Cdc# 52 transcriptional repressor 52 CYP#B# 52 primordial germ cells 52 oncoprotein 52 airway remodeling 52 TORC2 52 ERK2 52 metabolic enzymes 52 breast epithelial cells 52 prostate epithelial cells 52 radial glia 52 epigenetic mechanisms 52 epigenetic modifications 52 Th2 52 factor GDNF 52 telomere 52 p#INK#a 52 glutamate receptors 52 vernalization 52 Androgen receptor 52 demethylation 52 homeostatic 52 Autophagy 52 insulin secreting cells 52 neuromuscular junction 52 Wnts 52 UCP2 52 tumor metastasis 52 Sir2 52 acrosome reaction 52 aromatase 52 morphogenesis 52 neuroendocrine 52 chondrocyte 52 protein synthesis 52 bone morphogenetic proteins BMPs 52 mesenchymal cell 52 signaling cascade 51 ciliated 51 spermidine 51 meiosis 51 gluconeogenesis 51 pharmacologic intervention 51 transcriptional activation 51 mitochondrial dysfunction 51 Jhdm2a 51 intestinal epithelium 51 mitogen 51 axonal degeneration 51 mitochondrial function 51 p# MAPK 51 RNAi pathway 51 inhibitory neurons 51 motor neuron degeneration 51 E#F# 51 allergic inflammation 51 MECP2 gene 51 premature senescence 51 terminally differentiated 51 pluripotency 51 cardiac fibroblasts 51 protein p# 51 Akt activation 51 cypin 51 catabolic 51 glycation 51 jasmonate 51 ontogeny 51 posttranslational modification 51 neuronal stem cells 51 p# [001] 51 adipocyte 51 receptor activation 51 somatic motility 51 pro angiogenic 51 BMP4 51 MAPKs 51 receptor signaling 51 amyloid deposition 51 inhibitory 51 ß1 51 ectoderm 51 RhoA 51 ependymal cells 51 cellular pathways 51 neuronal 51 homologous recombination 51 neural progenitor 51 DNA demethylation 51 MEK1 51 FGF# 51 HtrA2 51 activate p# 51 Smoothened 51 phenotypes 51 JAK STAT signaling 51 constitutively 51 tissue homeostasis 51 mesenchymal transition 51 neurotrophic 51 neural plasticity 51 STAT3 signaling 51 DLX5 51 shortened telomeres 51 NF kappaB 51 upregulation 51 hyperactivated 51 estrogen receptor alpha 51 p#Kip# 51 embryonal 51 lung fibroblasts 51 TGF ß1 51 fibrogenesis 51 thymocyte 51 chromatin remodeling 51 TGF ß 51 E cadherin 51 hematopoetic stem cells 51 morphogen 51 uPA 51 plasticity 51 hormonal milieu 51 glutamate signaling 51 amyloid peptide 51 amyloid deposits 51 maturational 51 Aβ 51 chloroplasts 51 photoreceptor cell 51 intercellular communication 51 neuroepithelial cells 51 myogenesis 51 fibrotic 51 retinal ganglion cell 51 leukaemic cells 51 overactivation 51 PDGFR 51 SCD1 51 cell adhesion 51 retinal degeneration 51 dietary restriction 51 hematopoiesis 51 Sertoli cell 51 apoptosis programmed cell 51 hippocampal function 51 divide uncontrollably 51 mutant proteins 51 glutamate neurotransmission 51 RUNX3 51 signaling pathways 51 eukaryotic cells 51 DNA methylation 51 Hh signaling 51 acinar cells 50 telomere attrition 50 IFN gamma 50 overexpression 50 myeloma cells 50 epigenetic changes 50 Rap1 50 NF kB 50 GSK 3ß 50 photorespiration 50 Lkb1 50 genomic imprinting 50 exocytosis 50 conceptus 50 tumorigenic 50 germline stem cells 50 oligodendrocytes 50 HOTAIR 50 GPR# receptor [002] 50 mitochondrial fusion 50 podocyte 50 oncogenic 50 synaptic function 50 hematopoietic cells 50 photoreceptor 50 osteoclast 50 myelin breakdown 50 TGF beta signaling 50 TGFbeta 50 motoneurons 50 oligomerization 50 trophoblasts 50 mutated protein 50 desiccation 50 procaspase 3 50 fibril formation 50 Sox9 50 Prox1 50 calcineurin 50 actin remodeling 50 CCR7 50 germline cells 50 autoreactive 50 mammalian cells 50 neuroinflammatory 50 IKKa 50 membrane fusion 50 mitotic catastrophe 50 huntingtin protein 50 STAT3 50 H#K# methylation 50 embryogenesis 50 GABAergic neurons 50 proto oncogene 50 genes encode proteins 50 TGFβ 50 islet beta 50 anabolism 50 thymus 50 TGF β 50 centrosomes 50 catecholamine 50 cyclin 50 RNA splicing 50 hippocampal neurons 50 mitogen activated protein kinase 50 RNA silencing 50 EGFR signaling 50 neuronal function 50 Alu RNA 50 merozoites 50 adaptive immunity 50 presenilin 50 photosynthesis 50 selfing 50 microglial 50 fusiform 50 carcinogenesis 50 genetic recombination 50 phenotypic plasticity 50 intracellular signaling 50 paxillin 50 ES cells 50 phosphorylation 50 TGF beta 50 NFkB 50 transthyretin 50 pathophysiological 50 hindbrain 50 Karlseder 50 SGK1 50 nucleolar dominance 50 NF κB activation 50 hormone secretion 50 male hormone androgen 50 neuronal connections 50 hyperexcitability 50 neurone 50 Akt signaling 50 dopaminergic neurons 50 APOBEC3G 50 induce apoptosis 50 fatty acid oxidation 50 epigenetically 50 chimeric mice 50 acinar 50 leukemic stem cells 50 MAPK 50 proteasome 50 caloric restriction 50 stomatal 50 multipotent 50 cytokinin 50 metabolic 50 organogenesis 50 neurotransmitter GABA 50 neuronal circuits 50 endocytosis 50 PGC 1α 50 transcriptional regulation 50 MAP kinase 50 neuroblasts 50 deleterious mutations 50 innate immunity 50 Rab5 50 p# mutations 50 RANKL 50 SRY gene 50 β amyloid 50 epidermal stem cells 50 E3 ligase 50 germ cells 50 CPEB 50 collagen synthesis 50 humoral immunity 50 cytosolic 50 fatty acid synthesis 50 epigenetic reprogramming 50 P. gingivalis 50 IGF1 50 gliosis 50 VSMCs 50 Wnt proteins 50 progranulin 50 Pin1 50 cytochrome c 50 epithelial barrier 50 NF kB pathway 50 SIRT3 50 adipogenesis 50 TNFa 50 hematopoietic progenitors 50 NMDA receptor 50 nitric oxide synthase 50 KCNE2 50 neurites 50 metabolic processes 50 neural stem cells 50 hypothalamus pituitary 50 IL 1ß 50 germline 50 Leydig cells 49 Akt1 49 Robo4 49 biochemical mechanisms 49 c Abl 49 Htt 49 osteoblast 49 costimulatory 49 Myc protein 49 mutant huntingtin 49 γδ T cells 49 insulin signaling pathway 49 Foxp3 49 downstream effectors 49 telomeric DNA 49 cardiac fibrosis 49 osmotic stress 49 palmitoylation 49 neuronal apoptosis 49 MDSCs 49 multicellular organisms 49 gene expression 49 Immune cells 49 proteolytic cleavage 49 suppressor cells 49 centrioles 49 IFN γ 49 apoptotic pathways 49 neurological degeneration 49 induced pluripotent stem cell 49 nerve axons 49 epigenetic 49 potent inducer 49 neuron 49 SOCS1 49 suppressor genes 49 LIS1 49 PHD2 49 beta amyloid accumulation 49 neurodegenerative diseases 49 PECAM 1 49 PrPC 49 beta catenin 49 invadopodia formation 49 transmembrane protein 49 BRAF gene 49 lymphoid organs 49 cofilin 49 AMPA receptors 49 neurofibrillary tangles 49 IGFBP7 49 connexin# 49 gonadal 49 molecular pathway 49 astrocytic 49 gene silencing 49 HCV replication 49 fruit ripening 49 innate immune responses 49 DLC1 49 planaria 49 oxidative DNA 49 mutant protein 49 structural rearrangements 49 BDNF protein 49 ChR2 49 hyperinsulinemia 49 regulated kinase ERK 49 hormonal stimulation 49 autoimmunity 49 SIR2 gene 49 amyloid plaque formation 49 dentate gyrus 49 Oct4 49 NR2B 49 oxidative stress 49 JAK2 enzyme 49 autoregulation 49 endogenous 49 axon guidance 49 p#NTR 49 muscarinic receptors 49 cholinergic tone 49 reactive oxygen species 49 telomerase activation 49 epithelial tissues 49 eukaryotic cell 49 mitochondrial enzyme 49 PML RARA 49 Oxidative damage 49 induced apoptosis 49 MECP2 49 abscisic acid 49 P cadherin 49 fruitflies 49 multicellular organism 49 Th1 cells 49 ribozyme 49 conformational 49 Cdk5 49 nematode worms 49 endocannabinoid signaling 49 apoptotic pathway 49 TGFß 49 telomerase 49 EZH2 49 microchimerism 49 androgen receptor 49 constitutively active 49 testis 49 florigen 49 tumor suppressor 49 caspases 49 nerve cells 49 sensory nerve fibers 49 caveolin 1 49 intestinal mucosa 49 effector functions 49 proinflammatory cytokines 49 effector cells 49 SAPAP3 49 ovarian function 49 phenotypic expression 49 mutant SOD1 49 transgenic mice expressing 49 SIRT1 gene 49 Cdc7 49 oocyte 49 SIRT1 49 interferon pathway 49 frontotemporal 49 cytokine secretion 49 NKG2D 49 HbF 49 phosphatases 49 brain derived neurotrophic 49 plastid 49 oncoproteins 49 mesenchymal cells 49 mesenchyme 49 spermatogonial stem 49 retinal cells 49 Dicer enzyme 49 eNOS 49 endoplasmic reticulum stress 49 oxidative damage 49 oncogenesis 49 preadipocytes 49 innate immune 49 HSCs 49 Wnt beta catenin 49 Aß 49 Calorie restriction 49 sensory cortex 49 DNMT1 49 cellular prion protein 49 transiently 49 myelin insulation 49 enzymatic pathways 49 Dictyostelium discoideum 49 haematopoietic 49 compensatory mechanisms 49 endoderm 49 steroidogenesis 49 anti apoptotic proteins 49 autocrine 49 S#K# 49 Smad7 49 neural progenitor cells 49 MMP2 49 ras gene 49 sphingolipid 49 MyoD 49 catabolism 49 evolutionarily conserved 49 progressive neurodegenerative disorder 49 Rac1 49 mutant p# 49 immunological tolerance 49 mesoderm 49 epicardial cells 49 neural crest stem cells 49 IKK2 49 recessive trait 49 plasma fibrinogen 49 Nf1 49 prostaglandin synthesis 49 microvascular endothelial cells 49 glucocorticoid receptors 49 DNA methylation patterns 49 downregulation 49 adipose cells 49 conformational changes 49 inhibitory receptors 49 myocardial tissue 49 Treg cells 49 NF1 49 lysosome 49 JNK1 49 lymphangiogenesis 49 NF κB 49 Wnt pathway 49 beta1 integrin 49 clonogenic 49 Induced pluripotent stem cells 49 tumor suppressor gene 49 MEF2 49 neuro degeneration 49 cholinergic 49 JAK STAT 49 apoptosis induced 49 ovarian hormones 49 vagus 49 T lymphocytes 49 habenula 49 GPR# [002] 49 osteogenic differentiation 49 cardiomyocyte 49 effector T 49 myocyte 49 Id1 49 meristem 49 premature ovarian 49 anergy 49 secretory 49 cdk5 49 PKM2 49 degenerative diseases 49 hypoxia inducible transcription 49 aldose reductase 48 proteolytic 48 inflammatory cytokine 48 autoimmune encephalitis 48 NRG1 48 B lymphocyte 48 growth hormone secretion 48 transcriptionally 48 beta globin 48 Nrf2 48 male reproductive tract 48 COX2 48 cell signaling pathway 48 unspecialized cells 48 catalase 48 tau proteins 48 pancreatic islet 48 mitochondrial proteins 48 Myc 48 GBM tumors 48 tumorigenicity 48 N Myc 48 PIP3 48 dauer 48 remyelination 48 γ secretase 48 fibroblasts 48 corpus luteum 48 anagen phase 48 hydroxylation 48 neuronal cell 48 epithelial mesenchymal transition 48 prestin 48 triggers apoptosis 48 serine protease 48 MeCP2 gene 48 cPLA2 48 glial derived neurotrophic 48 primordial follicles 48 #BP# 48 rod photoreceptors 48 H#K# [001] 48 LRRK2 48 PKC alpha 48 platelet activation 48 cyclin E 48 netrin 1 48 thyroid hormones 48 PGE2 48 neurodegenerative 48 Sgk1 48 amyloid β 48 beta globin gene 48 VSMC 48 photoreceptor cells 48 Pax6 48 nucleoli 48 neural circuitry 48 actin cytoskeleton 48 ADAMTS# 48 neural precursor 48 undifferentiated cells 48 retinoic acid 48 Oncogenic 48 glial scar 48 microglia 48 neuronal signaling 48 STAT1 48 causative genes 48 lung fibrosis 48 Leydig cell 48 pDCs 48 TXNIP 48 CD8 T cells 48 kappa opioid receptor 48 FUS1 48 neurons degenerate 48 WNT pathway 48 Schwann cells 48 Rb protein 48 Nedd4 48 membrane protein 48 amyloid accumulation 48 humoral 48 FGF2 48 ADDLs 48 meningeal 48 Nod1 48 neuronal pathways 48 dopaminergic nerve 48 pyruvate kinase 48 eusociality 48 β cells 48 cyclization 48 phosphorylate 48 sulfation 48 morphogens 48 palladin 48 deacetylation 48 Wnt signaling pathway 48 hippocampal synapses 48 pancreatic tissue 48 tau protein 48 interneurons 48 epithelial cell 48 gamete formation 48 lymphocyte activation 48 dopamine neurons 48 CD#c 48 Histone deacetylase 48 superoxide dismutase 48 normal prion protein 48 aerobic metabolism 48 progenitor cell 48 amyloid beta plaque 48 Src 48 PDE1 48 metalloproteinases 48 biochemical processes 48 histone modification 48 calpain 48 ALDH2 48 RAS RAF MEK 48 Notch pathway 48 Dpp 48 axonal damage 48 fibroblast 48 vWF 48 Phosphorylation 48 E cadherin expression 48 dyskeratosis congenita 48 KLF# 48 sortilin 48 MRL mouse 48 protein SIRT1 48 histone methylation 48 telomerase gene 48 epithelia 48 siRNA mediated 48 stemness 48 epidermal cells 48 Abeta 48 gene transcription 48 outcrossing 48 microtubule 48 PPAR alpha 48 Mdm2 48 corticospinal 48 AChE 48 TRPV1 receptor 48 IGFBP2 48 mechanistically 48 monocytes macrophages 48 noncoding RNA 48 antioxidant enzyme 48 secretase 48 adipogenic 48 histone modifications 48 anthocyanin pigments 48 inverse agonist 48 giant danio 48 receptor kinases 48 GSK3 48 Peutz Jeghers syndrome 48 misregulation 48 skin fibroblasts 48 dendritic spine 48 Jagged1 48 Src kinase 48 RKIP 48 neural progenitors 48 glycosylation 48 prion gene 48 histone acetylation 48 protein biosynthesis 48 axon regeneration 48 neurotransmission 48 mouse embryonic fibroblasts 48 GCN2 48 immunological 48 activin 48 CD#L 48 inflammatory cascade 48 MMP# 48 metastasis 48 PIP2 48 neurodegenerative disease 48 chromosomal rearrangement 48 CHD7 48 epigenetic marks 48 axon outgrowth 48 prophase 48 glutamatergic 48 genetic alterations 48 FTLD 48 pyrimidines 48 H#K# [002] 48 basal cells 48 multipotent stem cells 48 Methylation 48 ErbB2 48 IGF 1R 48 Male pattern baldness 48 Sirt1 48 overexpressing 48 Klf4 48 adult neural stem 48 inflammatory mediators 48 NFAT 48 neuroblastoma cells 48 transgenic mouse model 48 de novo mutations 48 Wnt 48 inherited retinal degeneration 48 fungus infects 48 excitatory synapses 48 sporulation 48 proNGF 48 fibroblast cells 48 Genetic variation 48 HDAC5 48 transduction 48 glial cell 48 CLL cells 48 TMEM#B 48 Kv#.# 48 opsin 48 T lymphocyte 48 TRPV3 48 NF kappaB activation 48 filamentous fungus 48 nutrient uptake 48 rhodopsin 48 secretion 48 BCL#A 48 neural substrates 48 Klotho gene 48 neural degeneration 48 FGFs 48 granulocytes 48 Mcl 1 48 superoxide 48 Smad4 48 NF KappaB 48 phenotypic variability 48 amoeboid 48 osteopontin 48 tumor suppressors 48 mammalian embryos 48 multicellularity 48 TORC1 48 TGF β1 48 UVB induced 48 Eg5 48 collagen degradation 48 ACh